5TUV
Crystal structure of the E2F5-DP1-p107 ternary complex
Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage
Chains | Domain Info | Class | Fold | Superfamily | Family | Domain | Species | Provenance Source (Version) |
---|---|---|---|---|---|---|---|---|
E | d5tuve_ | Multi-domain proteins (alpha and beta) | E2F-DP heterodimerization region | E2F-DP heterodimerization region | automated matches | automated matches | Human (Homo sapiens ) [TaxId: 9606 ], | SCOPe (2.08) |
B | d5tuvb_ | Multi-domain proteins (alpha and beta) | E2F-DP heterodimerization region | E2F-DP heterodimerization region | automated matches | automated matches | Human (Homo sapiens ) [TaxId: 9606 ], | SCOPe (2.08) |
Domain Annotation: ECOD Classification ECOD Database Homepage
Chains | Family Name | Domain Identifier | Architecture | Possible Homology | Homology | Topology | Family | Provenance Source (Version) |
---|---|---|---|---|---|---|---|---|
A | PF08781 | e5tuvA1 | A: beta duplicates or obligate multimers | X: E2F-DP heterodimerization region (From Topology) | H: E2F-DP heterodimerization region (From Topology) | T: E2F-DP heterodimerization region | F: PF08781 | ECOD (1.6) |
D | PF08781 | e5tuvD1 | A: beta duplicates or obligate multimers | X: E2F-DP heterodimerization region (From Topology) | H: E2F-DP heterodimerization region (From Topology) | T: E2F-DP heterodimerization region | F: PF08781 | ECOD (1.6) |
E | PF16421 | e5tuvE1 | A: beta duplicates or obligate multimers | X: E2F-DP heterodimerization region (From Topology) | H: E2F-DP heterodimerization region (From Topology) | T: E2F-DP heterodimerization region | F: PF16421 | ECOD (1.6) |
B | PF16421 | e5tuvB1 | A: beta duplicates or obligate multimers | X: E2F-DP heterodimerization region (From Topology) | H: E2F-DP heterodimerization region (From Topology) | T: E2F-DP heterodimerization region | F: PF16421 | ECOD (1.6) |
Protein Family Annotation Pfam Database Homepage
Chains | Accession | Name | Description | Comments | Source |
---|---|---|---|---|---|
PF08781 | Transcription factor DP (DP) | Transcription factor DP | DP forms a heterodimer with E2F and regulates genes involved in cell cycle progression. The transcriptional activity of E2F is inhibited by the retinoblastoma protein which binds to the E2F-DP heterodimer [2] and negatively regulates the G1-S transi ... | Domain | |
PF16421 | E2F transcription factor CC-MB domain (E2F_CC-MB) | E2F transcription factor CC-MB domain | This is the coiled coil (CC) - marked box (MB) domain of E2F transcription factors. This domain forms a heterodimer with the corresponding domain of the DP transcription factor, the heterodimer binds the C-terminus of retinoblastoma protein [1]. | Domain | |
PF08934 | Rb C-terminal domain (Rb_C) | Rb C-terminal domain | The Rb C-terminal domain is required for high-affinity binding to E2F-DP complexes and for maximal repression of E2F-responsive promoters, thereby acting as a growth suppressor by blocking the G1-S transition of the cell cycle. This domain has a stra ... | Domain |