Annotations: 5TTH

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Cna B-type domain-like	8092056	3000862	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF17802	e5tthA5	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Prealbumin-like	F: PF17802	ECOD (1.6)
A	PF00183	e5tthA2	A: a+b two layers	X: Ribosomal protein S5 domain 2-like (From Topology)	H: Ribosomal protein S5 domain 2-like (From Topology)	T: Ribosomal protein S5 domain 2-like	F: PF00183	ECOD (1.6)
A	PF13589	e5tthA1	A: a+b two layers	X: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase-like	H: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase (From Topology)	T: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	F: PF13589	ECOD (1.6)
A	PF00183	e5tthA4	A: a/b three-layered sandwiches	X: HSP90 C-terminal a/b domain (From Topology)	H: HSP90 C-terminal a/b domain (From Topology)	T: HSP90 C-terminal a/b domain	F: PF00183	ECOD (1.6)
A	PF00183	e5tthA3	A: mixed a+b and a/b	X: Zincin-like	H: HSP90 C-terminal domain (C-terminal part of Pfam 00183) (From Topology)	T: HSP90 C-terminal domain (C-terminal part of Pfam 00183)	F: PF00183	ECOD (1.6)
B	PF00183	e5tthB3	A: a+b two layers	X: Ribosomal protein S5 domain 2-like (From Topology)	H: Ribosomal protein S5 domain 2-like (From Topology)	T: Ribosomal protein S5 domain 2-like	F: PF00183	ECOD (1.6)
B	PF13589	e5tthB4	A: a+b two layers	X: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase-like	H: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase (From Topology)	T: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	F: PF13589	ECOD (1.6)
B	PF00183	e5tthB2	A: a/b three-layered sandwiches	X: HSP90 C-terminal a/b domain (From Topology)	H: HSP90 C-terminal a/b domain (From Topology)	T: HSP90 C-terminal a/b domain	F: PF00183	ECOD (1.6)
B	PF00183	e5tthB1	A: mixed a+b and a/b	X: Zincin-like	H: HSP90 C-terminal domain (C-terminal part of Pfam 00183) (From Topology)	T: HSP90 C-terminal domain (C-terminal part of Pfam 00183)	F: PF00183	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.30.565.10	Alpha Beta	2-Layer Sandwich	Heat Shock Protein 90	Histidine kinase-like ATPase, C-terminal domain	CATH (4.3.0)
A	3.30.230.80	Alpha Beta	2-Layer Sandwich	Ribosomal Protein S5	domain 2	CATH (4.3.0)
A	3.40.50.11260	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold		CATH (4.3.0)
A	1.20.120.790	Mainly Alpha	Up-down Bundle	Four Helix Bundle (Hemerythrin (Met), subunit A)	Heat shock protein 90, C-terminal domain	CATH (4.3.0)
A	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF00183	Hsp90 protein (HSP90)	Hsp90 protein	-	Family
A	PF17802	Prealbumin-like fold domain (SpaA)	Prealbumin-like fold domain	This entry contains a prealbumin-like domain from a wide variety of bacterial surface proteins. This entry corresponds to domain 1 and domain 3 of SpaA from Corynebacterium diphtheriae [1]. Some members of this family contain an isopeptide bond.	Domain
A	PF02986	Fibronectin binding repeat (Fn_bind)	Fibronectin binding repeat	-	Motif
A	PF13589	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c_3)	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	This family represents, additionally, the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.	Domain
B	PF00183	Hsp90 protein (HSP90)	Hsp90 protein	-	Family
B	PF13589	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c_3)	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	This family represents, additionally, the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	C-terminal SpyCatcher fusion of wildtype zebrafish TNF receptor-associated protein 1	cation binding magnesium ion binding ion binding binding metal ion binding small molecule binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding purine nucleotide binding organic cyclic compound binding anion binding cation binding magnesium ion binding ion binding binding metal ion binding small molecule binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding calcium ion binding unfolded protein binding protein binding kinase binding enzyme binding protein kinase binding pyrophosphatase activity ATP hydrolysis activity ribonucleoside triphosphate phosphatase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity hydrolase activity, acting on acid anhydrides catalytic activity ATP-dependent activity ATP-dependent protein folding chaperone protein folding chaperone identical protein binding	nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process metabolic process primary metabolic process macromolecule metabolic process nucleic acid metabolic process organonitrogen compound metabolic process cellular biosynthetic process cellular metabolic process gene expression macromolecule biosynthetic process protein maturation protein folding nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process metabolic process primary metabolic process macromolecule metabolic process nucleic acid metabolic process organonitrogen compound metabolic process cellular biosynthetic process cellular metabolic process gene expression macromolecule biosynthetic process protein maturation protein folding biosynthetic process organic substance biosynthetic process cellular process protein metabolic process	membrane-bounded organelle mitochondrial membrane intracellular anatomical structure organelle inner membrane mitochondrion membrane cellular anatomical entity intracellular membrane-bounded organelle mitochondrial inner membrane intracellular organelle organelle envelope mitochondrial envelope organelle cytoplasm membrane-bounded organelle mitochondrial membrane intracellular anatomical structure organelle inner membrane mitochondrion membrane cellular anatomical entity intracellular membrane-bounded organelle mitochondrial inner membrane intracellular organelle organelle envelope mitochondrial envelope organelle cytoplasm organelle membrane
B	C-terminal Spytag fusion of R417A zebrafish TNF receptor-associated protein 1	cation binding magnesium ion binding ion binding binding metal ion binding small molecule binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding purine nucleotide binding organic cyclic compound binding anion binding cation binding magnesium ion binding ion binding binding metal ion binding small molecule binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding calcium ion binding unfolded protein binding protein binding kinase binding enzyme binding protein kinase binding pyrophosphatase activity ATP hydrolysis activity ribonucleoside triphosphate phosphatase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity hydrolase activity, acting on acid anhydrides catalytic activity ATP-dependent activity ATP-dependent protein folding chaperone protein folding chaperone identical protein binding	nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process metabolic process primary metabolic process macromolecule metabolic process nucleic acid metabolic process organonitrogen compound metabolic process cellular biosynthetic process cellular metabolic process gene expression macromolecule biosynthetic process protein maturation protein folding nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process metabolic process primary metabolic process macromolecule metabolic process nucleic acid metabolic process organonitrogen compound metabolic process cellular biosynthetic process cellular metabolic process gene expression macromolecule biosynthetic process protein maturation protein folding biosynthetic process organic substance biosynthetic process cellular process protein metabolic process	membrane-bounded organelle mitochondrial membrane intracellular anatomical structure organelle inner membrane mitochondrion membrane cellular anatomical entity intracellular membrane-bounded organelle mitochondrial inner membrane intracellular organelle organelle envelope mitochondrial envelope organelle cytoplasm membrane-bounded organelle mitochondrial membrane intracellular anatomical structure organelle inner membrane mitochondrion membrane cellular anatomical entity intracellular membrane-bounded organelle mitochondrial inner membrane intracellular organelle organelle envelope mitochondrial envelope organelle cytoplasm organelle membrane

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR003594	Histidine kinase/HSP90-like ATPase	Domain
A	IPR020575	Heat shock protein Hsp90, N-terminal	Domain
A	IPR036890	Histidine kinase/HSP90-like ATPase superfamily	Homologous Superfamily
A	IPR037196	HSP90, C-terminal domain	Homologous Superfamily
A	IPR020568	Ribosomal protein uS5 domain 2-type superfamily	Homologous Superfamily
A	IPR001404	Heat shock protein Hsp90 family	Family
A	IPR013783	Immunoglobulin-like fold	Homologous Superfamily
A	IPR041033	Prealbumin-like fold domain	Domain
A	IPR008454	Collagen-binding surface protein Cna-like, B-type domain	Domain
A	IPR004237	Fibronectin binding repeat	Repeat
A	IPR023849	TQXA domain	Domain
A	IPR013552	Thioester domain	Domain
B	IPR003594	Histidine kinase/HSP90-like ATPase	Domain
B	IPR020575	Heat shock protein Hsp90, N-terminal	Domain
B	IPR036890	Histidine kinase/HSP90-like ATPase superfamily	Homologous Superfamily
B	IPR037196	HSP90, C-terminal domain	Homologous Superfamily
B	IPR020568	Ribosomal protein uS5 domain 2-type superfamily	Homologous Superfamily
B	IPR001404	Heat shock protein Hsp90 family	Family
B	IPR013783	Immunoglobulin-like fold	Homologous Superfamily
B	IPR041033	Prealbumin-like fold domain	Domain
B	IPR008454	Collagen-binding surface protein Cna-like, B-type domain	Domain
B	IPR004237	Fibronectin binding repeat	Repeat
B	IPR023849	TQXA domain	Domain
B	IPR013552	Thioester domain	Domain