5TQ1

Phospholipase C gamma-1 C-terminal SH2 domain bound to a phosphopeptide derived from the insulin receptor

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Protein Modification Annotation

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	SH2 domain	8035692	3000197	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF00017	e5tq1A1	A: a+b two layers	X: SH2 (From Topology)	H: SH2 (From Topology)	T: SH2	F: PF00017	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.30.505.10	Alpha Beta	2-Layer Sandwich	SHC Adaptor Protein	SH2 domain	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF00017	SH2 domain (SH2)	SH2 domain	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	cation binding ion binding binding calcium ion binding metal ion binding small molecule binding phosphoric ester hydrolase activity hydrolase activity, acting on ester bonds phosphoric diester hydrolase activity phospholipase C activity hydrolase activity catalytic activity phosphatidylinositol phospholipase C activity phospholipase activity cation binding ion binding binding calcium ion binding metal ion binding small molecule binding phosphoric ester hydrolase activity hydrolase activity, acting on ester bonds phosphoric diester hydrolase activity phospholipase C activity hydrolase activity catalytic activity phosphatidylinositol phospholipase C activity phospholipase activity lipase activity GTPase regulator activity enzyme regulator activity guanyl-nucleotide exchange factor activity nucleoside-triphosphatase regulator activity molecular function regulator activity calcium-dependent phospholipase C activity	lipid catabolic process catabolic process phospholipid catabolic process cellular metabolic process organophosphate catabolic process primary metabolic process cellular lipid catabolic process cellular catabolic process phospholipid metabolic process organic substance metabolic process organophosphate metabolic process cellular lipid metabolic process phosphate-containing compound metabolic process metabolic process lipid catabolic process catabolic process phospholipid catabolic process cellular metabolic process organophosphate catabolic process primary metabolic process cellular lipid catabolic process cellular catabolic process phospholipid metabolic process organic substance metabolic process organophosphate metabolic process cellular lipid metabolic process phosphate-containing compound metabolic process metabolic process cellular process phosphorus metabolic process organic substance catabolic process lipid metabolic process developmental process multicellular organism development multicellular organismal process embryo development ending in birth or egg hatching chordate embryonic development anatomical structure development embryo development in utero embryonic development cellular response to stimulus regulation of biological process regulation of cellular process response to stimulus signaling biological regulation intracellular signal transduction cell communication phosphatidylinositol-mediated signaling signal transduction cell surface receptor signaling pathway cell surface receptor protein tyrosine kinase signaling pathway ERBB signaling pathway epidermal growth factor receptor signaling pathway enzyme-linked receptor protein signaling pathway regulation of localization cellular localization inorganic ion homeostasis intracellular calcium ion homeostasis transport homeostatic process monoatomic ion transmembrane transport negative regulation of biological process calcium ion homeostasis negative regulation of sequestering of calcium ion calcium ion transport metal ion transport maintenance of location in cell monoatomic cation transmembrane transport localization intracellular monoatomic cation homeostasis monoatomic ion homeostasis negative regulation of cellular process monoatomic ion transport intracellular chemical homeostasis monoatomic cation homeostasis monoatomic cation transport regulation of sequestering of calcium ion intracellular monoatomic ion homeostasis calcium ion transmembrane import into cytosol sequestering of calcium ion inorganic ion transmembrane transport establishment of localization inorganic cation transmembrane transport maintenance of location transmembrane transport release of sequestered calcium ion into cytosol cellular homeostasis chemical homeostasis calcium ion transmembrane transport phosphatidylinositol metabolic process glycerophospholipid metabolic process glycerolipid metabolic process cellular response to endogenous stimulus cellular response to growth factor stimulus response to endogenous stimulus cellular response to epidermal growth factor stimulus response to epidermal growth factor response to growth factor cellular response to vascular endothelial growth factor stimulus positive regulation of locomotion regulation of cell motility positive regulation of biological process positive regulation of cell migration positive regulation of epithelial cell migration tissue migration ameboidal-type cell migration positive regulation of cell motility regulation of cell migration cell migration regulation of multicellular organismal process epithelial cell migration cell motility regulation of epithelial cell migration locomotion positive regulation of cellular process epithelium migration regulation of locomotion	cell projection cell leading edge cellular anatomical entity plasma membrane bounded cell projection lamellipodium cell periphery plasma membrane membrane membrane-bounded organelle intracellular organelle protein-containing complex intracellular anatomical structure organelle nucleus cell projection cell leading edge cellular anatomical entity plasma membrane bounded cell projection lamellipodium cell periphery plasma membrane membrane membrane-bounded organelle intracellular organelle protein-containing complex intracellular anatomical structure organelle nucleus nuclear protein-containing complex COP9 signalosome intracellular membrane-bounded organelle cytoplasm ruffle
B	Insulin receptor	amide binding amyloid-beta binding binding peptide binding protein binding peptide hormone binding hormone binding insulin binding molecular transducer activity catalytic activity, acting on a protein kinase activity protein kinase activity signaling receptor activity transferase activity amide binding amyloid-beta binding binding peptide binding protein binding peptide hormone binding hormone binding insulin binding molecular transducer activity catalytic activity, acting on a protein kinase activity protein kinase activity signaling receptor activity transferase activity phosphotransferase activity, alcohol group as acceptor transferase activity, transferring phosphorus-containing groups protein tyrosine kinase activity transmembrane receptor protein tyrosine kinase activity protein-hormone receptor activity transmembrane receptor protein kinase activity transmembrane signaling receptor activity insulin receptor activity catalytic activity protein phosphatase binding phosphatase binding enzyme binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding 3-phosphoinositide-dependent protein kinase binding kinase binding protein kinase binding protein-containing complex binding insulin-like growth factor receptor binding signaling receptor binding protein domain specific binding guanyl nucleotide binding GTP binding guanyl ribonucleotide binding structural molecule activity insulin receptor substrate binding PTB domain binding phosphatidylinositol 3-kinase binding fatty acid binding organic acid binding lipid binding lipoic acid binding carboxylic acid binding monocarboxylic acid binding sulfur compound binding insulin-like growth factor binding insulin-like growth factor II binding growth factor binding cargo receptor activity insulin-like growth factor I binding	regulation of biosynthetic process regulation of nitric oxide biosynthetic process regulation of biological process biological regulation positive regulation of biological process reactive nitrogen species metabolic process positive regulation of nitric oxide metabolic process nitric oxide metabolic process positive regulation of metabolic process nitric oxide biosynthetic process biosynthetic process positive regulation of biosynthetic process metabolic process regulation of nitric oxide metabolic process regulation of biosynthetic process regulation of nitric oxide biosynthetic process regulation of biological process biological regulation positive regulation of biological process reactive nitrogen species metabolic process positive regulation of nitric oxide metabolic process nitric oxide metabolic process positive regulation of metabolic process nitric oxide biosynthetic process biosynthetic process positive regulation of biosynthetic process metabolic process regulation of nitric oxide metabolic process positive regulation of nitric oxide biosynthetic process regulation of metabolic process cellular component disassembly positive regulation of cellular component organization regulation of cellular process regulation of cellular component organization protein-containing complex organization protein-containing complex disassembly regulation of protein-containing complex disassembly cellular component organization cellular process cellular component organization or biogenesis positive regulation of protein-containing complex disassembly positive regulation of cellular process response to organic substance response to ketone response to lipid response to stimulus response to chemical response to oxygen-containing compound response to testosterone response to organic cyclic compound developmental process regulation of growth regulation of developmental growth regulation of developmental process developmental growth growth positive regulation of developmental process positive regulation of growth positive regulation of developmental growth regulation of protein modification process regulation of protein phosphorylation negative regulation of biological process negative regulation of phosphate metabolic process negative regulation of cellular metabolic process regulation of primary metabolic process organic substance metabolic process regulation of phosphate metabolic process phosphate-containing compound metabolic process negative regulation of protein modification process negative regulation of cellular process protein metabolic process protein modification process phosphorus metabolic process negative regulation of protein metabolic process negative regulation of macromolecule metabolic process organonitrogen compound metabolic process protein phosphorylation phosphorylation regulation of protein metabolic process cellular metabolic process negative regulation of metabolic process primary metabolic process regulation of cellular metabolic process regulation of macromolecule metabolic process negative regulation of protein phosphorylation macromolecule modification negative regulation of phosphorus metabolic process regulation of phosphorylation regulation of phosphorus metabolic process macromolecule metabolic process negative regulation of phosphorylation multicellular organismal process head development animal organ development brain development nervous system development multicellular organism development cerebellum development central nervous system development metencephalon development anatomical structure development hindbrain development system development positive regulation of organelle organization regulation of mitotic nuclear division positive regulation of mitotic nuclear division mitotic cell cycle regulation of mitotic cell cycle positive regulation of cell cycle process cell cycle regulation of cell cycle cell cycle process mitotic nuclear division regulation of cell cycle process organelle fission positive regulation of nuclear division regulation of organelle organization positive regulation of cell cycle organelle organization nuclear division mitotic cell cycle process regulation of nuclear division regulation of generation of precursor metabolites and energy organic substance biosynthetic process negative regulation of carbohydrate metabolic process negative regulation of glycogen metabolic process carbohydrate biosynthetic process negative regulation of cellular biosynthetic process negative regulation of macromolecule biosynthetic process energy reserve metabolic process regulation of macromolecule biosynthetic process regulation of glycogen metabolic process regulation of glycogen biosynthetic process negative regulation of glycogen biosynthetic process glucan biosynthetic process energy derivation by oxidation of organic compounds cellular biosynthetic process regulation of glucan biosynthetic process regulation of polysaccharide metabolic process polysaccharide metabolic process glucan metabolic process regulation of carbohydrate metabolic process carbohydrate metabolic process polysaccharide biosynthetic process glycogen metabolic process generation of precursor metabolites and energy glycogen biosynthetic process macromolecule biosynthetic process regulation of cellular biosynthetic process negative regulation of biosynthetic process regulation of polysaccharide biosynthetic process regulation of carbohydrate biosynthetic process cellular response to stimulus response to nutrient levels response to zinc ion starvation cellular response to starvation cellular response to nutrient levels cellular response to stress response to stress response to starvation cellular response to zinc ion starvation RNA metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process nucleic acid biosynthetic process DNA-templated transcription regulation of RNA metabolic process regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process nucleobase-containing compound biosynthetic process gene expression nucleic acid metabolic process organic cyclic compound metabolic process regulation of gene expression organic cyclic compound biosynthetic process regulation of DNA-templated transcription fat cell differentiation cellular developmental process cell differentiation biological process involved in interspecies interaction between organisms symbiont entry into host cell viral process symbiont entry into host viral life cycle biological process involved in interaction with host biological process involved in symbiotic interaction response to vanadate(3-) response to inorganic substance pyridine nucleotide catabolic process oxoacid metabolic process carbohydrate catabolic process carbohydrate derivative metabolic process organophosphate catabolic process nucleoside phosphate catabolic process organic acid metabolic process regulation of ATP metabolic process cellular catabolic process regulation of purine nucleotide catabolic process regulation of small molecule metabolic process regulation of nucleotide metabolic process small molecule metabolic process purine ribonucleotide catabolic process nucleoside phosphate metabolic process organonitrogen compound catabolic process pyruvate metabolic process purine nucleoside diphosphate metabolic process purine-containing compound catabolic process regulation of purine nucleotide metabolic process nucleobase-containing compound catabolic process positive regulation of ATP metabolic process nucleoside diphosphate metabolic process positive regulation of carbohydrate metabolic process monocarboxylic acid metabolic process pyridine-containing compound catabolic process ribose phosphate metabolic process ATP metabolic process positive regulation of purine nucleotide catabolic process positive regulation of cellular metabolic process nucleobase-containing small molecule metabolic process purine ribonucleoside triphosphate metabolic process purine nucleotide catabolic process carbohydrate derivative catabolic process positive regulation of glycolytic process organic cyclic compound catabolic process purine-containing compound metabolic process positive regulation of catabolic process ADP metabolic process purine ribonucleoside diphosphate metabolic process organic substance catabolic process purine ribonucleoside diphosphate catabolic process ribonucleotide catabolic process positive regulation of phosphate metabolic process positive regulation of nucleotide catabolic process glycolytic process pyridine-containing compound metabolic process pyridine nucleotide metabolic process nicotinamide nucleotide metabolic process regulation of carbohydrate catabolic process positive regulation of nucleobase-containing compound metabolic process positive regulation of phosphorus metabolic process nucleotide metabolic process purine nucleoside diphosphate catabolic process nucleoside diphosphate catabolic process regulation of nucleotide catabolic process nucleoside triphosphate metabolic process purine ribonucleotide metabolic process catabolic process positive regulation of nucleotide metabolic process purine nucleotide metabolic process ribonucleotide metabolic process ribonucleoside diphosphate metabolic process ribonucleoside diphosphate catabolic process ribonucleoside triphosphate metabolic process nucleotide catabolic process purine nucleoside triphosphate metabolic process ADP catabolic process carboxylic acid metabolic process regulation of catabolic process regulation of glycolytic process positive regulation of purine nucleotide metabolic process organophosphate metabolic process regulation of cellular catabolic process positive regulation of cellular catabolic process positive regulation of small molecule metabolic process response to metal ion response to manganese ion positive regulation of macromolecule biosynthetic process positive regulation of glycogen metabolic process positive regulation of macromolecule metabolic process hexose metabolic process positive regulation of glucose metabolic process positive regulation of glycogen biosynthetic process monosaccharide metabolic process regulation of glucose metabolic process positive regulation of cellular biosynthetic process glucose metabolic process response to activity epidermis development tissue development gland development animal organ regeneration liver development regeneration hepaticobiliary system development liver regeneration response to hexose response to monosaccharide response to carbohydrate response to glucose reactive oxygen species metabolic process hydrogen peroxide metabolic process regulation of hydrogen peroxide metabolic process regulation of reactive oxygen species metabolic process cell population proliferation positive regulation of cell population proliferation regulation of cell population proliferation dendritic spine maintenance dendritic spine organization postsynapse organization plasma membrane bounded cell projection organization cell projection organization cellular component maintenance cell junction organization neuron projection organization synapse organization adrenal gland development endocrine system development cellular response to nitrogen compound signaling response to peptide hormone insulin receptor signaling pathway cell surface receptor protein tyrosine kinase signaling pathway cell communication cellular response to endogenous stimulus response to hormone cellular response to organic substance signal transduction enzyme-linked receptor protein signaling pathway cellular response to hormone stimulus cell surface receptor signaling pathway response to endogenous stimulus response to organonitrogen compound cellular response to peptide hormone stimulus response to nitrogen compound cellular response to oxygen-containing compound cellular response to chemical stimulus cellular response to organonitrogen compound response to insulin cellular response to insulin stimulus cellular response to growth factor stimulus response to growth factor positive regulation of locomotion regulation of cell motility positive regulation of cell migration regulation of locomotion positive regulation of cell motility regulation of cell migration cell migration cell motility locomotion embryonic organ development embryo development embryonic liver development positive regulation of phosphorylation regulation of embryonic development regulation of multicellular organismal development regulation of multicellular organismal process G protein-coupled receptor signaling pathway negative regulation of gene expression neuron projection maintenance regulation of localization hexose transmembrane transport glucose import transport carbohydrate transport localization positive regulation of transmembrane transport glucose transmembrane transport regulation of glucose import positive regulation of glucose transmembrane transport regulation of transport organic substance transport establishment of localization transmembrane transport regulation of glucose transmembrane transport regulation of transmembrane transport positive regulation of transport monosaccharide transmembrane transport positive regulation of glucose import carbohydrate transmembrane transport response to estradiol gonad development reproductive system development reproductive process sex differentiation developmental process involved in reproduction male gonad development male sex differentiation development of primary male sexual characteristics development of primary sexual characteristics reproductive structure development import into cell receptor internalization receptor-mediated endocytosis endocytosis vesicle-mediated transport heart development heart morphogenesis circulatory system development anatomical structure morphogenesis animal organ morphogenesis digestive system development exocrine pancreas development pancreas development exocrine system development positive regulation of respiratory burst respiratory burst regulation of respiratory burst regulation of meiotic cell cycle sexual reproduction regulation of reproductive process meiotic cell cycle positive regulation of meiotic cell cycle positive regulation of reproductive process response to decreased oxygen levels response to hypoxia response to oxygen levels response to abiotic stimulus chemical homeostasis homeostatic process glucose homeostasis carbohydrate homeostasis response to stilbenoid response to resveratrol gluconeogenesis small molecule biosynthetic process monosaccharide biosynthetic process hexose biosynthetic process regulation of gluconeogenesis forebrain development pallium development telencephalon development hippocampus development limbic system development sex determination male sex determination regulation of receptor internalization positive regulation of endocytosis positive regulation of receptor-mediated endocytosis regulation of endocytosis regulation of receptor-mediated endocytosis regulation of vesicle-mediated transport positive regulation of receptor internalization amyloid-beta clearance positive regulation of glycoprotein metabolic process positive regulation of protein metabolic process organonitrogen compound biosynthetic process regulation of glycoprotein biosynthetic process positive regulation of glycoprotein biosynthetic process carbohydrate derivative biosynthetic process glycoprotein biosynthetic process glycoprotein metabolic process regulation of glycoprotein metabolic process positive regulation of cell communication regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction positive regulation of signal transduction regulation of signal transduction intracellular signal transduction positive regulation of response to stimulus regulation of intracellular signal transduction intracellular signaling cassette regulation of signaling positive regulation of intracellular signal transduction positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction regulation of response to stimulus regulation of cell communication phosphatidylinositol 3-kinase/protein kinase B signal transduction positive regulation of signaling response to corticosteroid response to steroid hormone response to glucocorticoid regulation of gonad development development of primary female sexual characteristics regulation of female gonad development female gonad development female sex differentiation response to alcohol response to ethanol positive regulation of MAPK cascade regulation of MAPK cascade MAPK cascade response to vitamin D response to nutrient response to vitamin positive regulation of RNA metabolic process positive regulation of DNA-templated transcription positive regulation of RNA biosynthetic process positive regulation of protein modification process positive regulation of protein phosphorylation negative regulation of feeding behavior negative regulation of behavior feeding behavior regulation of behavior behavior regulation of feeding behavior negative regulation of multicellular organismal process response to food response to cytokine response to tumor necrosis factor	protein-containing complex receptor complex intracellular anatomical structure cytoplasm cellular anatomical entity yolk membrane microdomain cell periphery membrane raft plasma membrane raft membrane plasma membrane plasma membrane region caveola protein-containing complex receptor complex intracellular anatomical structure cytoplasm cellular anatomical entity yolk membrane microdomain cell periphery membrane raft plasma membrane raft membrane plasma membrane plasma membrane region caveola membrane-bounded organelle intracellular organelle organelle lytic vacuole vacuole intracellular membrane-bounded organelle lysosome cell leading edge neuron projection leading edge membrane plasma membrane bounded cell projection somatodendritic compartment neuron projection membrane cell projection dendrite membrane dendrite dendritic tree cell projection membrane endosome intracellular vesicle endomembrane system cytoplasmic vesicle vesicle late endosome cell surface external side of plasma membrane side of membrane cell body neuronal cell body neuronal cell body membrane cell body membrane axon catalytic complex plasma membrane protein complex membrane protein complex transferase complex protein kinase complex transferase complex, transferring phosphorus-containing groups insulin receptor complex plasma membrane signaling receptor complex

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR035724	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1, SH3 domain	Domain
A	IPR001849	Pleckstrin homology domain	Domain
A	IPR036860	SH2 domain superfamily	Homologous Superfamily
A	IPR035023	PLC-gamma, C-terminal SH2 domain	Domain
A	IPR001711	Phospholipase C, phosphatidylinositol-specific, Y domain	Domain
A	IPR000980	SH2 domain	Domain
A	IPR016279	Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase gamma	Family
A	IPR036028	SH3-like domain superfamily	Homologous Superfamily
A	IPR000008	C2 domain	Domain
A	IPR011993	PH-like domain superfamily	Homologous Superfamily
A	IPR000909	Phosphatidylinositol-specific phospholipase C, X domain	Domain
A	IPR002048	EF-hand domain	Domain
A	IPR011992	EF-hand domain pair	Homologous Superfamily
A	IPR035024	PLC-gamma, N-terminal SH2 domain	Domain
A	IPR018247	EF-Hand 1, calcium-binding site	Binding Site
A	IPR001192	Phosphoinositide phospholipase C family	Family
A	IPR017946	PLC-like phosphodiesterase, TIM beta/alpha-barrel domain superfamily	Homologous Superfamily
A	IPR001452	SH3 domain	Domain
A	IPR035892	C2 domain superfamily	Homologous Superfamily
B	IPR020635	Tyrosine-protein kinase, catalytic domain	Domain
B	IPR000719	Protein kinase domain	Domain
B	IPR006212	Furin-like repeat	Repeat
B	IPR013783	Immunoglobulin-like fold	Homologous Superfamily
B	IPR017441	Protein kinase, ATP binding site	Binding Site
B	IPR001245	Serine-threonine/tyrosine-protein kinase, catalytic domain	Domain
B	IPR002011	Tyrosine-protein kinase, receptor class II, conserved site	Conserved Site
B	IPR009030	Growth factor receptor cysteine-rich domain superfamily	Homologous Superfamily
B	IPR008266	Tyrosine-protein kinase, active site	Active Site
B	IPR036941	Receptor L-domain superfamily	Homologous Superfamily
B	IPR000494	Receptor L-domain	Domain
B	IPR003961	Fibronectin type III	Domain
B	IPR011009	Protein kinase-like domain superfamily	Homologous Superfamily
B	IPR006211	Furin-like cysteine-rich domain	Domain
B	IPR016246	Tyrosine-protein kinase, insulin-like receptor	Family
B	IPR040969	Insulin receptor, trans-membrane domain	Domain
B	IPR036116	Fibronectin type III superfamily	Homologous Superfamily