5TJ4

Gasdermin-B C-terminal domain containing the polymorphism residues Gly299:Pro306 fused to maltose binding protein

External Resource: Annotation

Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF17708	e5tj4A1	A: a+b two layers	X: R3H domain-like	H: PUB domain (From Topology)	T: PUB domain	F: PF17708	ECOD (1.6)
A	PF01547	e5tj4A2	A: a/b three-layered sandwiches	X: Periplasmic binding protein-like II (From Topology)	H: Periplasmic binding protein-like II (From Topology)	T: Periplasmic binding protein-like II	F: PF01547	ECOD (1.6)
B	PF17708	e5tj4B2	A: a+b two layers	X: R3H domain-like	H: PUB domain (From Topology)	T: PUB domain	F: PF17708	ECOD (1.6)
B	PF01547	e5tj4B3	A: a/b three-layered sandwiches	X: Periplasmic binding protein-like II (From Topology)	H: Periplasmic binding protein-like II (From Topology)	T: Periplasmic binding protein-like II	F: PF01547	ECOD (1.6)
C	PF17708	e5tj4C2	A: a+b two layers	X: R3H domain-like	H: PUB domain (From Topology)	T: PUB domain	F: PF17708	ECOD (1.6)
C	PF01547	e5tj4C3	A: a/b three-layered sandwiches	X: Periplasmic binding protein-like II (From Topology)	H: Periplasmic binding protein-like II (From Topology)	T: Periplasmic binding protein-like II	F: PF01547	ECOD (1.6)
D	PF17708	e5tj4D1	A: a+b two layers	X: R3H domain-like	H: PUB domain (From Topology)	T: PUB domain	F: PF17708	ECOD (1.6)
D	PF01547	e5tj4D2	A: a/b three-layered sandwiches	X: Periplasmic binding protein-like II (From Topology)	H: Periplasmic binding protein-like II (From Topology)	T: Periplasmic binding protein-like II	F: PF01547	ECOD (1.6)
E	PF17708	e5tj4E2	A: a+b two layers	X: R3H domain-like	H: PUB domain (From Topology)	T: PUB domain	F: PF17708	ECOD (1.6)
E	PF01547	e5tj4E3	A: a/b three-layered sandwiches	X: Periplasmic binding protein-like II (From Topology)	H: Periplasmic binding protein-like II (From Topology)	T: Periplasmic binding protein-like II	F: PF01547	ECOD (1.6)
F	PF17708	e5tj4F2	A: a+b two layers	X: R3H domain-like	H: PUB domain (From Topology)	T: PUB domain	F: PF17708	ECOD (1.6)
F	PF01547	e5tj4F3	A: a/b three-layered sandwiches	X: Periplasmic binding protein-like II (From Topology)	H: Periplasmic binding protein-like II (From Topology)	T: Periplasmic binding protein-like II	F: PF01547	ECOD (1.6)
G	PF17708	e5tj4G1	A: a+b two layers	X: R3H domain-like	H: PUB domain (From Topology)	T: PUB domain	F: PF17708	ECOD (1.6)
G	PF01547	e5tj4G2	A: a/b three-layered sandwiches	X: Periplasmic binding protein-like II (From Topology)	H: Periplasmic binding protein-like II (From Topology)	T: Periplasmic binding protein-like II	F: PF01547	ECOD (1.6)
H	PF17708	e5tj4H2	A: a+b two layers	X: R3H domain-like	H: PUB domain (From Topology)	T: PUB domain	F: PF17708	ECOD (1.6)
H	PF01547	e5tj4H3	A: a/b three-layered sandwiches	X: Periplasmic binding protein-like II (From Topology)	H: Periplasmic binding protein-like II (From Topology)	T: Periplasmic binding protein-like II	F: PF01547	ECOD (1.6)
I	PF17708	e5tj4I1	A: a+b two layers	X: R3H domain-like	H: PUB domain (From Topology)	T: PUB domain	F: PF17708	ECOD (1.6)
I	PF01547	e5tj4I2	A: a/b three-layered sandwiches	X: Periplasmic binding protein-like II (From Topology)	H: Periplasmic binding protein-like II (From Topology)	T: Periplasmic binding protein-like II	F: PF01547	ECOD (1.6)
J	PF17708	e5tj4J1	A: a+b two layers	X: R3H domain-like	H: PUB domain (From Topology)	T: PUB domain	F: PF17708	ECOD (1.6)
J	PF01547	e5tj4J2	A: a/b three-layered sandwiches	X: Periplasmic binding protein-like II (From Topology)	H: Periplasmic binding protein-like II (From Topology)	T: Periplasmic binding protein-like II	F: PF01547	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D, E A, B, C, D, E, F, G, H, I, J	PF17708	Gasdermin PUB domain (Gasdermin_C)	Gasdermin PUB domain	The precise function of this protein is unknown. A deletion/insertion mutation is associated with an autosomal dominant non-syndromic hearing impairment form [1]. In addition, this protein has also been found to contribute to acquired etoposide resis ...	The precise function of this protein is unknown. A deletion/insertion mutation is associated with an autosomal dominant non-syndromic hearing impairment form [1]. In addition, this protein has also been found to contribute to acquired etoposide resistance in melanoma cells [2]. This family also includes the gasdermin protein [3]	Domain
A, B, C, D, E A, B, C, D, E, F, G, H, I, J	PF04598	Gasdermin pore forming domain (Gasdermin)	Gasdermin pore forming domain	The precise function of this protein is unknown. A deletion/insertion mutation is associated with an autosomal dominant non-syndromic hearing impairment form [1]. In addition, this protein has also been found to contribute to acquired etoposide resis ...	The precise function of this protein is unknown. A deletion/insertion mutation is associated with an autosomal dominant non-syndromic hearing impairment form [1]. In addition, this protein has also been found to contribute to acquired etoposide resistance in melanoma cells [2]. This family also includes the gasdermin protein [3]	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D, E A, B, C, D, E, F, G, H, I, J	Sugar ABC transporter substrate-binding protein,Gasdermin-B fusion protein	binding ion binding phosphatidylinositol-4,5-bisphosphate binding anion binding phosphatidylinositol bisphosphate binding phospholipid binding lipid binding phosphatidylinositol phosphate binding phosphatidylinositol binding small molecule binding wide pore channel activity passive transmembrane transporter activity channel activity transporter activity binding ion binding phosphatidylinositol-4,5-bisphosphate binding anion binding phosphatidylinositol bisphosphate binding phospholipid binding lipid binding phosphatidylinositol phosphate binding phosphatidylinositol binding small molecule binding wide pore channel activity passive transmembrane transporter activity channel activity transporter activity transmembrane transporter activity phosphatidylinositol-4-phosphate binding phosphatidylglycerol binding cardiolipin binding modified amino acid binding phosphatidylserine binding	biological process involved in interspecies interaction between organisms response to stimulus response to other organism defense response defense response to symbiont response to external stimulus disruption of cell in another organism response to biotic stimulus biological process involved in symbiotic interaction killing by host of symbiont cells defense response to other organism response to stress cellular process response to external biotic stimulus biological process involved in interspecies interaction between organisms response to stimulus response to other organism defense response defense response to symbiont response to external stimulus disruption of cell in another organism response to biotic stimulus biological process involved in symbiotic interaction killing by host of symbiont cells defense response to other organism response to stress cellular process response to external biotic stimulus disruption of anatomical structure in another organism biological process involved in interaction with symbiont killing of cells of another organism cell killing cytotoxic T cell pyroptotic process pyroptosis cell death programmed cell death defense response to Gram-negative bacterium defense response to bacterium response to bacterium	cell periphery plasma membrane membrane cellular anatomical entity intracellular anatomical structure cytoplasm

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D, E A, B, C, D, E, F, G, H, I, J	IPR040460	Gasdermin, pore forming domain	Domain
A, B, C, D, E A, B, C, D, E, F, G, H, I, J	IPR041263	Gasdermin, PUB domain	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B, C, D, E A, B, C, D, E, F, G, H, I, J	Pharos: Q8TAX9	ulcerative colitis Crohn disease asthma pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia psoriasis systemic sclerosis acute lymphoblastic leukemia atrial fibrillation large cell medulloblastoma malignant ependymoma malignant pancreatic neoplasm pancreatic intraductal papillary-mucinous carcinoma pilocytic astrocytoma rheumatoid arthritis allergic rhinitis ulcerative colitis Crohn disease asthma pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia psoriasis systemic sclerosis acute lymphoblastic leukemia atrial fibrillation large cell medulloblastoma malignant ependymoma malignant pancreatic neoplasm pancreatic intraductal papillary-mucinous carcinoma pilocytic astrocytoma rheumatoid arthritis allergic rhinitis atypical teratoid rhabdoid tumor esophageal adenocarcinoma lung adenocarcinoma malignant glioma osteosarcoma pancreatic intraductal papillary-mucinous neoplasm primary biliary cholangitis systemic lupus erythematosus cervical cancer glioblastoma lung carcinoma Malignant neoplasm of breast pancreatic ductal adenocarcinoma

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5TJ4

Gasdermin-B C-terminal domain containing the polymorphism residues Gly299:Pro306 fused to maltose binding protein

External Resource: Annotation

Domain Annotation: ECOD Classification ECOD Database Homepage

Protein Family Annotation Pfam Database Homepage

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

InterPro: Protein Family Classification InterPro Database Homepage

Pharos: Disease Associations Pharos Homepage Annotation