5TII

Comprehensive Analysis of a Novel Ketoreductase for Pentangular Polyphenol Biosynthesis

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
D [auth G]	SCOP2B Superfamily	SDR-like	8063266	3000038	SCOP2B (2022-06-29)
F [auth B]	SCOP2B Superfamily	SDR-like	8063266	3000038	SCOP2B (2022-06-29)
G [auth C]	SCOP2B Superfamily	SDR-like	8063266	3000038	SCOP2B (2022-06-29)
H [auth F]	SCOP2B Superfamily	SDR-like	8063266	3000038	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	SDR-like	8063266	3000038	SCOP2B (2022-06-29)
B [auth D]	SCOP2B Superfamily	SDR-like	8063266	3000038	SCOP2B (2022-06-29)
C [auth E]	SCOP2B Superfamily	SDR-like	8063266	3000038	SCOP2B (2022-06-29)
E [auth H]	SCOP2B Superfamily	SDR-like	8063266	3000038	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
D [auth G]	PF13561	e5tiiG1	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: NAD(P)-binding Rossmann-fold domains	F: PF13561	ECOD (1.6)
F [auth B]	PF13561	e5tiiB1	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: NAD(P)-binding Rossmann-fold domains	F: PF13561	ECOD (1.6)
G [auth C]	PF13561	e5tiiC1	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: NAD(P)-binding Rossmann-fold domains	F: PF13561	ECOD (1.6)
H [auth F]	PF13561	e5tiiF1	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: NAD(P)-binding Rossmann-fold domains	F: PF13561	ECOD (1.6)
A	PF13561	e5tiiA1	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: NAD(P)-binding Rossmann-fold domains	F: PF13561	ECOD (1.6)
B [auth D]	PF13561	e5tiiD1	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: NAD(P)-binding Rossmann-fold domains	F: PF13561	ECOD (1.6)
C [auth E]	PF13561	e5tiiE1	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: NAD(P)-binding Rossmann-fold domains	F: PF13561	ECOD (1.6)
E [auth H]	PF13561	e5tiiH1	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: NAD(P)-binding Rossmann-fold domains	F: PF13561	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
D [auth G]	3.40.50.720	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	NAD(P)-binding Rossmann-like Domain	CATH (4.3.0)
F [auth B]	3.40.50.720	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	NAD(P)-binding Rossmann-like Domain	CATH (4.3.0)
G [auth C]	3.40.50.720	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	NAD(P)-binding Rossmann-like Domain	CATH (4.3.0)
H [auth F]	3.40.50.720	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	NAD(P)-binding Rossmann-like Domain	CATH (4.3.0)
A	3.40.50.720	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	NAD(P)-binding Rossmann-like Domain	CATH (4.3.0)
B [auth D]	3.40.50.720	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	NAD(P)-binding Rossmann-like Domain	CATH (4.3.0)
C [auth E]	3.40.50.720	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	NAD(P)-binding Rossmann-like Domain	CATH (4.3.0)
E [auth H]	3.40.50.720	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	NAD(P)-binding Rossmann-like Domain	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B [auth D], C [auth E], D [auth G], E [auth H], A, B [auth D], C [auth E], D [auth G], E [auth H], F [auth B], G [auth C], H [auth F]	PF13561	Enoyl-(Acyl carrier protein) reductase (adh_short_C2)	Enoyl-(Acyl carrier protein) reductase	This domain is found in Enoyl-(Acyl carrier protein) reductases.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B [auth D], C [auth E], D [auth G], E [auth H], A, B [auth D], C [auth E], D [auth G], E [auth H], F [auth B], G [auth C], H [auth F]	3-oxoacyl-ACP reductase	oxidoreductase activity catalytic activity binding nucleoside phosphate binding organic cyclic compound binding nucleotide binding heterocyclic compound binding small molecule binding	-	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B [auth D], C [auth E], D [auth G], E [auth H], A, B [auth D], C [auth E], D [auth G], E [auth H], F [auth B], G [auth C], H [auth F]	IPR036291	NAD(P)-binding domain superfamily	Homologous Superfamily
A, B [auth D], C [auth E], D [auth G], E [auth H], A, B [auth D], C [auth E], D [auth G], E [auth H], F [auth B], G [auth C], H [auth F]	IPR002347	Short-chain dehydrogenase/reductase SDR	Family
A, B [auth D], C [auth E], D [auth G], E [auth H], A, B [auth D], C [auth E], D [auth G], E [auth H], F [auth B], G [auth C], H [auth F]	IPR020904	Short-chain dehydrogenase/reductase, conserved site	Conserved Site

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.