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Crystal structure of SeMet-Substituted CurJ carbon methyltransferase External Resource: Annotation Chains Family Name Domain Identifier Architecture Possible Homology Homology Topology Family Provenance Source (Version) A PF18558 e5thyA1 A: alpha arrays X: HTH H: HTH T: winged F: PF18558 ECOD (1.6) A PF08242 e5thyA2 A: a/b three-layered sandwiches X: Rossmann-like H: Rossmann-related T: S-adenosyl-L-methionine-dependent methyltransferases F: PF08242 ECOD (1.6) B PF18558 e5thyB1 A: alpha arrays X: HTH H: HTH T: winged F: PF18558 ECOD (1.6) B PF08242 e5thyB2 A: a/b three-layered sandwiches X: Rossmann-like H: Rossmann-related T: S-adenosyl-L-methionine-dependent methyltransferases F: PF08242 ECOD (1.6)
Chains Accession Name Description Comments Source PF08242 Methyltransferase domain (Methyltransf_12) Methyltransferase domain Members of this family are SAM dependent methyltransferases. Domain PF18558 Helix-turn-helix domain (HTH_51) Helix-turn-helix domain This is helix turn helix domain found in polyketide synthases (PKSs) in fungi. They are multidomain enzymes that biosynthesize a wide range of natural products. Family members include citrinin polyketide synthases which contain a C-methyltransferase ... This is helix turn helix domain found in polyketide synthases (PKSs) in fungi. They are multidomain enzymes that biosynthesize a wide range of natural products. Family members include citrinin polyketide synthases which contain a C-methyltransferase (CMeT) domain Pfam:PF08242 that adds one or more S-adenosylmethionine (SAM)-derived methyl groups to the carbon framework [1]. Less Domain
Chains Polymer Molecular Function Biological Process Cellular Component CurJ -
Chains Accession Name Type IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase Homologous Superfamily IPR014031 Beta-ketoacyl synthase, C-terminal Domain IPR049490 C883_1060-like, ketoreductase domain, N-terminal Domain IPR032821 Polyketide synthase, C-terminal extension Domain IPR009081 Phosphopantetheine binding ACP domain Domain IPR013217 Methyltransferase type 12 Domain IPR020807 Polyketide synthase, dehydratase domain Domain IPR014030 Beta-ketoacyl synthase, N-terminal Domain IPR049552 Polyketide synthase, dehydratase domain, N-terminal Domain IPR029063 S-adenosyl-L-methionine-dependent methyltransferase superfamily Homologous Superfamily IPR049551 Polyketide synthase, dehydratase domain, C-terminal Domain IPR013968 Polyketide synthase, ketoreductase domain Domain IPR016039 Thiolase-like Homologous Superfamily IPR001227 Acyl transferase domain superfamily Homologous Superfamily IPR016036 Malonyl-CoA ACP transacylase, ACP-binding Homologous Superfamily IPR036291 NAD(P)-binding domain superfamily Homologous Superfamily IPR020806 Polyketide synthase, phosphopantetheine-binding domain Domain IPR014043 Acyl transferase Domain IPR018201 Beta-ketoacyl synthase, active site Active Site IPR020841 Polyketide synthase, beta-ketoacyl synthase domain Domain IPR036736 ACP-like superfamily Homologous Superfamily