5THE

Crystal structure of the C-terminal lobe of a budding yeast Argonaute

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Ribonuclease H-like	8053674	3000143	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	Ribonuclease H-like	8053674	3000143	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	Ribonuclease H-like	8053674	3000143	SCOP2B (2022-06-29)
G	SCOP2B Superfamily	Ribonuclease H-like	8053674	3000143	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
E	PF02171	e5theE1	A: mixed a+b and a/b	X: Ribonuclease H-like	H: Ribonuclease H-like (From Topology)	T: Ribonuclease H-like	F: PF02171	ECOD (1.6)
G	F_UNCLASSIFIED	e5theG2	A: a/b three-layered sandwiches	X: Middle domain in Argonaute homologs (From Topology)	H: Middle domain in Argonaute homologs (From Topology)	T: Middle domain in Argonaute homologs	F: F_UNCLASSIFIED	ECOD (1.6)
G	PF02171	e5theG1	A: mixed a+b and a/b	X: Ribonuclease H-like	H: Ribonuclease H-like (From Topology)	T: Ribonuclease H-like	F: PF02171	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, C, E, G	PF02171	Piwi domain (Piwi)	Piwi domain	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, C, E, G	Uncharacterized protein	RNA binding binding organic cyclic compound binding nucleic acid binding	-	-
B, D, F, H	RNA (5'-R(PUPAPAPAPAPAPAPA)-3')	-	-	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, C, E, G	IPR040937	Argonaute, N-terminal	Domain
A, C, E, G	IPR036397	Ribonuclease H superfamily	Homologous Superfamily
A, C, E, G	IPR036085	PAZ domain superfamily	Homologous Superfamily
A, C, E, G	IPR040588	Argonaute, N domain	Domain
A, C, E, G	IPR003165	Piwi domain	Domain
A, C, E, G	IPR003100	PAZ domain	Domain
A, C, E, G	IPR012337	Ribonuclease H-like superfamily	Homologous Superfamily

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.