Annotations: 5TFM

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d5tfma1	All beta proteins	Immunoglobulin-like beta-sandwich	Cadherin-like	automated matches	automated matches	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF00028	e5tfmA2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF00028	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF00028	Cadherin domain (Cadherin)	Cadherin domain	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Cadherin-23	cation binding ion binding binding calcium ion binding metal ion binding small molecule binding cell adhesion molecule binding cadherin binding protein binding	cell adhesion cell-cell adhesion cellular process cell-cell adhesion via plasma-membrane adhesion molecules developmental process ear development sensory organ development inner ear development cochlea development animal organ development anatomical structure development multicellular organismal process inner ear receptor cell development cell projection organization cell adhesion cell-cell adhesion cellular process cell-cell adhesion via plasma-membrane adhesion molecules developmental process ear development sensory organ development inner ear development cochlea development animal organ development anatomical structure development multicellular organismal process inner ear receptor cell development cell projection organization epidermis development auditory receptor cell stereocilium organization neuron projection development epithelial cell differentiation hair cell differentiation multicellular organism development neuron differentiation cell differentiation animal organ morphogenesis system development embryonic organ morphogenesis mechanoreceptor differentiation epithelium development epidermal cell differentiation embryonic morphogenesis nervous system development tissue development inner ear receptor cell differentiation generation of neurons auditory receptor cell development cellular developmental process cell development embryo development cell morphogenesis cellular component organization neurogenesis cellular component organization or biogenesis auditory receptor cell morphogenesis embryonic organ development ear morphogenesis plasma membrane bounded cell projection organization inner ear auditory receptor cell differentiation cell morphogenesis involved in neuron differentiation anatomical structure morphogenesis sensory organ morphogenesis neuron development inner ear morphogenesis inner ear receptor cell stereocilium organization behavior locomotory behavior sensory perception of light stimulus system process sensory perception nervous system process inorganic ion homeostasis intracellular calcium ion homeostasis homeostatic process calcium ion homeostasis regulation of cytosolic calcium ion concentration cellular homeostasis chemical homeostasis intracellular monoatomic cation homeostasis monoatomic ion homeostasis intracellular chemical homeostasis monoatomic cation homeostasis intracellular monoatomic ion homeostasis response to stimulus multicellular organismal-level homeostasis anatomical structure homeostasis tissue homeostasis retina homeostasis photoreceptor cell maintenance neuromuscular process equilibrioception neuromuscular process controlling balance sensory perception of sound sensory perception of mechanical stimulus visual perception homophilic cell adhesion via plasma membrane adhesion molecules localization transport monoatomic ion transport monoatomic cation transport establishment of localization calcium ion transport metal ion transport calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules	membrane cellular anatomical entity photoreceptor inner segment cell projection stereocilium actin-based cell projection organelle stereocilium tip stereocilium bundle neuron projection cluster of actin-based cell projections plasma membrane bounded cell projection intracellular organelle centrosome membrane cellular anatomical entity photoreceptor inner segment cell projection stereocilium actin-based cell projection organelle stereocilium tip stereocilium bundle neuron projection cluster of actin-based cell projections plasma membrane bounded cell projection intracellular organelle centrosome microtubule organizing center intracellular anatomical structure cytoskeleton intracellular non-membrane-bounded organelle microtubule cytoskeleton non-membrane-bounded organelle cell periphery protein-containing complex extrinsic component of plasma membrane catenin complex plasma membrane protein complex plasma membrane membrane protein complex extrinsic component of membrane membrane-bounded organelle 9+2 non-motile cilium non-motile cilium cilium kinocilium photoreceptor ribbon synapse synapse cell junction ribbon synapse cochlear hair cell ribbon synapse

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR015919	Cadherin-like superfamily	Homologous Superfamily
A	IPR039808	Cadherin	Family
A	IPR020894	Cadherin conserved site	Conserved Site
A	IPR002126	Cadherin-like	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: Q9H251	Usher syndrome autosomal recessive nonsyndromic deafness 12 nonsyndromic genetic deafness Usher syndrome, type 1D pituitary adenoma 5, multiple types Usher syndrome type 1D X-linked mixed deafness with perilymphatic gusher bagassosis pneumoconiosis retinitis pigmentosa attention deficit hyperactivity disorder, inattentive type cone-rod dystrophy intellectual disability malignant glioma prolactin-producing pituitary gland adenoma Usher syndrome autosomal recessive nonsyndromic deafness 12 nonsyndromic genetic deafness Usher syndrome, type 1D pituitary adenoma 5, multiple types Usher syndrome type 1D X-linked mixed deafness with perilymphatic gusher bagassosis pneumoconiosis retinitis pigmentosa attention deficit hyperactivity disorder, inattentive type cone-rod dystrophy intellectual disability malignant glioma prolactin-producing pituitary gland adenoma TSH-secreting pituitary adenoma Usher syndrome type 1B vitiligo Cushing disease due to pituitary adenoma lung carcinoma medulloblastoma retinal degeneration Cushing syndrome malignant ependymoma

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.