5T89
Crystal structure of VEGF-A in complex with VEGFR-1 domains D1-6
Domain Annotation: SCOP2 Classification SCOP2 Database Homepage
Chains | Type | Family Name | Domain Identifier | Family Identifier | Provenance Source (Version) |
---|---|---|---|---|---|
C [auth X] | SCOP2B Superfamily | Immunoglobulin (Ig) domain-like | 8054805 | 3000071 | SCOP2B (2022-06-29) |
D [auth Y] | SCOP2B Superfamily | Immunoglobulin (Ig) domain-like | 8054805 | 3000071 | SCOP2B (2022-06-29) |
Domain Annotation: ECOD Classification ECOD Database Homepage
Chains | Family Name | Domain Identifier | Architecture | Possible Homology | Homology | Topology | Family | Provenance Source (Version) |
---|---|---|---|---|---|---|---|---|
A [auth V] | PF00341 | e5t89V1 | A: few secondary structure elements | X: Cystine-knot cytokines (From Topology) | H: Cystine-knot cytokines (From Topology) | T: Cystine-knot cytokines | F: PF00341 | ECOD (1.6) |
B [auth W] | PF00341 | e5t89W1 | A: few secondary structure elements | X: Cystine-knot cytokines (From Topology) | H: Cystine-knot cytokines (From Topology) | T: Cystine-knot cytokines | F: PF00341 | ECOD (1.6) |
C [auth X] | PF00047 | e5t89X3 | A: beta sandwiches | X: Immunoglobulin-like beta-sandwich | H: Immunoglobulin-related | T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like | F: PF00047 | ECOD (1.6) |
C [auth X] | PF13927 | e5t89X5 | A: beta sandwiches | X: Immunoglobulin-like beta-sandwich | H: Immunoglobulin-related | T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like | F: PF13927 | ECOD (1.6) |
C [auth X] | PF13927,PF22971 | e5t89X2 | A: beta sandwiches | X: Immunoglobulin-like beta-sandwich | H: Immunoglobulin-related | T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like | F: PF13927,PF22971 | ECOD (1.6) |
C [auth X] | PF21339 | e5t89X1 | A: beta sandwiches | X: Immunoglobulin-like beta-sandwich | H: Immunoglobulin-related | T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like | F: PF21339 | ECOD (1.6) |
D [auth Y] | PF00047 | e5t89Y3 | A: beta sandwiches | X: Immunoglobulin-like beta-sandwich | H: Immunoglobulin-related | T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like | F: PF00047 | ECOD (1.6) |
D [auth Y] | PF07679,PF22971 | e5t89Y2 | A: beta sandwiches | X: Immunoglobulin-like beta-sandwich | H: Immunoglobulin-related | T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like | F: PF07679,PF22971 | ECOD (1.6) |
D [auth Y] | PF13927 | e5t89Y5 | A: beta sandwiches | X: Immunoglobulin-like beta-sandwich | H: Immunoglobulin-related | T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like | F: PF13927 | ECOD (1.6) |
D [auth Y] | PF21339 | e5t89Y1 | A: beta sandwiches | X: Immunoglobulin-like beta-sandwich | H: Immunoglobulin-related | T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like | F: PF21339 | ECOD (1.6) |
Domain Annotation: CATH CATH Database Homepage
Chain | Domain | Class | Architecture | Topology | Homology | Provenance Source (Version) |
---|---|---|---|---|---|---|
A [auth V] | 2.10.90.10 | Mainly Beta | Ribbon | Cystine Knot Cytokines, subunit B | Cystine-knot cytokines | CATH (4.3.0) |
B [auth W] | 2.10.90.10 | Mainly Beta | Ribbon | Cystine Knot Cytokines, subunit B | Cystine-knot cytokines | CATH (4.3.0) |
Protein Family Annotation Pfam Database Homepage
Chains | Accession | Name | Description | Comments | Source |
---|---|---|---|---|---|
A [auth V], B [auth W] | PF00341 | PDGF/VEGF domain (PDGF) | PDGF/VEGF domain | - | Domain |
C [auth X], D [auth Y] | PF13927 | Immunoglobulin domain (Ig_3) | Immunoglobulin domain | This family contains immunoglobulin-like domains. | Domain |
C [auth X], D [auth Y] | PF07679 | Immunoglobulin I-set domain (I-set) | Immunoglobulin I-set domain | - | Domain |
C [auth X], D [auth Y] | PF21339 | Vascular endothelial growth factor receptor 1-like, Ig-like domain (VEGFR-1-like_Ig-like) | Vascular endothelial growth factor receptor 1-like, Ig-like domain | This domain is found in Vascular endothelial growth factor receptor 1 from humans (VEGFR-1) and similar proteins from animals. VEGFR-1 is a tyrosine kinase receptor for the placental growth factor (PlGF) that plays an essential role in the developmen ... | Domain |
C [auth X], D [auth Y] | PF00047 | Immunoglobulin domain (ig) | Immunoglobulin domain | Members of the immunoglobulin superfamily are found in hundreds of proteins of different functions. Examples include antibodies, the giant muscle kinase titin and receptor tyrosine kinases. Immunoglobulin-like domains may be involved in protein-prot ... | Domain |