5T4N

Crystal Structure of Human Protocadherin-15 EC3-5 D414A Variant

External Resource: Annotation

Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	F_UNCLASSIFIED	e5t4nA2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: F_UNCLASSIFIED	ECOD (1.6)
A	PF00028	e5t4nA3	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF00028	ECOD (1.6)
B	F_UNCLASSIFIED	e5t4nB1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: F_UNCLASSIFIED	ECOD (1.6)
B	PF00028	e5t4nB2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF00028	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
B	2.60.40.60	Mainly Beta	Sandwich	Immunoglobulin-like	Cadherins	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF00028	Cadherin domain (Cadherin)	Cadherin domain	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	Protocadherin-15	cation binding ion binding binding calcium ion binding metal ion binding small molecule binding	multicellular organismal process multicellular organismal-level homeostasis homeostatic process anatomical structure homeostasis tissue homeostasis retina homeostasis photoreceptor cell maintenance system process nervous system process sensory perception neuromuscular process equilibrioception neuromuscular process controlling balance sensory perception of sound multicellular organismal process multicellular organismal-level homeostasis homeostatic process anatomical structure homeostasis tissue homeostasis retina homeostasis photoreceptor cell maintenance system process nervous system process sensory perception neuromuscular process equilibrioception neuromuscular process controlling balance sensory perception of sound sensory perception of mechanical stimulus cell adhesion cellular process developmental process ear development sensory organ development inner ear development animal organ development anatomical structure development cell-cell adhesion cell-cell adhesion via plasma-membrane adhesion molecules homophilic cell adhesion via plasma membrane adhesion molecules sensory perception of light stimulus	cell-cell junction anchoring junction cell junction cellular anatomical entity extracellular region synapse cell periphery plasma membrane membrane cell projection stereocilium actin-based cell projection organelle stereocilium bundle cell-cell junction anchoring junction cell junction cellular anatomical entity extracellular region synapse cell periphery plasma membrane membrane cell projection stereocilium actin-based cell projection organelle stereocilium bundle neuron projection cluster of actin-based cell projections plasma membrane bounded cell projection extracellular space membrane-bounded organelle non-motile cilium 9+0 non-motile cilium cilium photoreceptor outer segment photoreceptor cell cilium

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR015919	Cadherin-like superfamily	Homologous Superfamily
A, B	IPR020894	Cadherin conserved site	Conserved Site
A, B	IPR030718	Extracellular cadherin domain superfamily	Homologous Superfamily
A, B	IPR041149	Extracellular cadherin domain	Domain
A, B	IPR002126	Cadherin-like	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B	Pharos: Q96QU1	Usher syndrome nonsyndromic genetic deafness Usher syndrome type 1F autosomal recessive nonsyndromic deafness 23 retinitis pigmentosa Usher syndrome type 3 Usher syndrome, type 1F cochlear disease Usher syndrome type 1D astrocytic tumor substance-related disorder cone-rod dystrophy non-small cell lung carcinoma pilocytic astrocytoma retinitis pigmentosa-deafness syndrome Usher syndrome nonsyndromic genetic deafness Usher syndrome type 1F autosomal recessive nonsyndromic deafness 23 retinitis pigmentosa Usher syndrome type 3 Usher syndrome, type 1F cochlear disease Usher syndrome type 1D astrocytic tumor substance-related disorder cone-rod dystrophy non-small cell lung carcinoma pilocytic astrocytoma retinitis pigmentosa-deafness syndrome substance dependence attention deficit hyperactivity disorder, inattentive type Usher syndrome type 1B Usher syndrome type 1G lung adenocarcinoma pituitary gland adenoma retinal degeneration substance abuse Usher syndrome type 2 drug dependence hearing loss disorder lung carcinoma

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.