5T0C

Structural basis for dynamic regulation of the human 26S proteasome

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
T [auth AH]	SCOP2B Superfamily	Class II glutamine amidotransferases	8064014	3000131	SCOP2B (2022-06-29)
ZA [auth BH]	SCOP2B Superfamily	Class II glutamine amidotransferases	8064014	3000131	SCOP2B (2022-06-29)
AB [auth BI]	SCOP2B Superfamily	Class II glutamine amidotransferases	8064036	3000131	SCOP2B (2022-06-29)
U [auth AI]	SCOP2B Superfamily	Class II glutamine amidotransferases	8064036	3000131	SCOP2B (2022-06-29)
BB [auth BJ]	SCOP2B Superfamily	Class II glutamine amidotransferases	8064004	3000131	SCOP2B (2022-06-29)
V [auth AJ]	SCOP2B Superfamily	Class II glutamine amidotransferases	8064004	3000131	SCOP2B (2022-06-29)
CB [auth BK]	SCOP2B Superfamily	Class II glutamine amidotransferases	8064022	3000131	SCOP2B (2022-06-29)
W [auth AK]	SCOP2B Superfamily	Class II glutamine amidotransferases	8064022	3000131	SCOP2B (2022-06-29)
DB [auth BL]	SCOP2B Superfamily	Class II glutamine amidotransferases	8064060	3000131	SCOP2B (2022-06-29)
X [auth AL]	SCOP2B Superfamily	Class II glutamine amidotransferases	8064060	3000131	SCOP2B (2022-06-29)
EB [auth BM]	SCOP2B Superfamily	Class II glutamine amidotransferases	8064054	3000131	SCOP2B (2022-06-29)
Y [auth AM]	SCOP2B Superfamily	Class II glutamine amidotransferases	8064054	3000131	SCOP2B (2022-06-29)
FB [auth BN]	SCOP2B Superfamily	Class II glutamine amidotransferases	8079175	3000131	SCOP2B (2022-06-29)
Z [auth AN]	SCOP2B Superfamily	Class II glutamine amidotransferases	8079175	3000131	SCOP2B (2022-06-29)
AA [auth AO]	SCOP2B Superfamily	Class II glutamine amidotransferases	8064074	3000131	SCOP2B (2022-06-29)
GB [auth BO]	SCOP2B Superfamily	Class II glutamine amidotransferases	8064074	3000131	SCOP2B (2022-06-29)
DA [auth AR]	SCOP2B Superfamily	Class II glutamine amidotransferases	8079492	3000131	SCOP2B (2022-06-29)
JB [auth BR]	SCOP2B Superfamily	Class II glutamine amidotransferases	8079492	3000131	SCOP2B (2022-06-29)
D [auth AX]	SCOP2B Superfamily	Winged helix DNA-binding domain	8067905	3000034	SCOP2B (2022-06-29)
JA [auth BX]	SCOP2B Superfamily	Winged helix DNA-binding domain	8067905	3000034	SCOP2B (2022-06-29)
E [auth AY]	SCOP2B Superfamily	TPR-like	8057045	3001345	SCOP2B (2022-06-29)
E [auth AY]	SCOP2B Superfamily	Winged helix DNA-binding domain	8057047	3000034	SCOP2B (2022-06-29)
KA [auth BY]	SCOP2B Superfamily	Winged helix DNA-binding domain	8057047	3000034	SCOP2B (2022-06-29)
KA [auth BY]	SCOP2B Superfamily	TPR-like	8057045	3001345	SCOP2B (2022-06-29)
F [auth AZ]	SCOP2B Superfamily	EIF3 subunit F C-terminal domain-like	8053251	3002167	SCOP2B (2022-06-29)
F [auth AZ]	SCOP2B Superfamily	JAB1/MPN domain-like	8053252	3001105	SCOP2B (2022-06-29)
LA [auth BZ]	SCOP2B Superfamily	JAB1/MPN domain-like	8053252	3001105	SCOP2B (2022-06-29)
LA [auth BZ]	SCOP2B Superfamily	EIF3 subunit F C-terminal domain-like	8053251	3002167	SCOP2B (2022-06-29)
I [auth Ac]	SCOP2B Superfamily	JAB1/MPN domain-like	8053255	3001105	SCOP2B (2022-06-29)
I [auth Ac]	SCOP2B Superfamily	EIF3 subunit F C-terminal domain-like	8053254	3002167	SCOP2B (2022-06-29)
OA [auth Bc]	SCOP2B Superfamily	EIF3 subunit F C-terminal domain-like	8053254	3002167	SCOP2B (2022-06-29)
OA [auth Bc]	SCOP2B Superfamily	JAB1/MPN domain-like	8053255	3001105	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A [auth AU]	PF18004	e5t0cAU3	A: beta sandwiches	X: 26S proteasome subunit Rpn2 C-terminal domain (From Topology)	H: 26S proteasome subunit Rpn2 C-terminal domain (From Topology)	T: 26S proteasome subunit Rpn2 C-terminal domain	F: PF18004	ECOD (1.6)
A [auth AU]	PF21505	e5t0cAU1	A: alpha superhelices	X: Repetitive alpha hairpins	H: 26S proteasome subunit Rpn2 N-terminal domain (From Topology)	T: 26S proteasome subunit Rpn2 N-terminal domain	F: PF21505	ECOD (1.6)
A [auth AU]	PF01851	e5t0cAU2	A: alpha superhelices	X: Repetitive alpha hairpins	H: Proteasome/cyclosome (PC) repeat (From Topology)	T: Proteasome/cyclosome (PC) repeat	F: PF01851	ECOD (1.6)
GA [auth BU]	PF18004	e5t0cBU1	A: beta sandwiches	X: 26S proteasome subunit Rpn2 C-terminal domain (From Topology)	H: 26S proteasome subunit Rpn2 C-terminal domain (From Topology)	T: 26S proteasome subunit Rpn2 C-terminal domain	F: PF18004	ECOD (1.6)
GA [auth BU]	PF21505	e5t0cBU2	A: alpha superhelices	X: Repetitive alpha hairpins	H: 26S proteasome subunit Rpn2 N-terminal domain (From Topology)	T: 26S proteasome subunit Rpn2 N-terminal domain	F: PF21505	ECOD (1.6)
GA [auth BU]	PF01851	e5t0cBU3	A: alpha superhelices	X: Repetitive alpha hairpins	H: Proteasome/cyclosome (PC) repeat (From Topology)	T: Proteasome/cyclosome (PC) repeat	F: PF01851	ECOD (1.6)
J [auth Ad]	PF10075	e5t0cAd1	A: alpha arrays	X: HTH	H: HTH	T: winged	F: PF10075	ECOD (1.6)
J [auth Ad]	PF10075	e5t0cAd2	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: PF10075	ECOD (1.6)
PA [auth Bd]	PF10075	e5t0cBd1	A: alpha arrays	X: HTH	H: HTH	T: winged	F: PF10075	ECOD (1.6)
PA [auth Bd]	PF10075	e5t0cBd2	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: PF10075	ECOD (1.6)
L [auth Af]	PF17781	e5t0cAf2	A: alpha superhelices	X: Repetitive alpha hairpins	H: 26S proteasome subunit Rpn2 N-terminal domain (From Topology)	T: 26S proteasome subunit Rpn2 N-terminal domain	F: PF17781	ECOD (1.6)
L [auth Af]	PF01851	e5t0cAf3	A: alpha superhelices	X: Repetitive alpha hairpins	H: Proteasome/cyclosome (PC) repeat (From Topology)	T: Proteasome/cyclosome (PC) repeat	F: PF01851	ECOD (1.6)
RA [auth Bf]	PF17781	e5t0cBf2	A: alpha superhelices	X: Repetitive alpha hairpins	H: 26S proteasome subunit Rpn2 N-terminal domain (From Topology)	T: 26S proteasome subunit Rpn2 N-terminal domain	F: PF17781	ECOD (1.6)
RA [auth Bf]	PF01851	e5t0cBf3	A: alpha superhelices	X: Repetitive alpha hairpins	H: Proteasome/cyclosome (PC) repeat (From Topology)	T: Proteasome/cyclosome (PC) repeat	F: PF01851	ECOD (1.6)
M [auth AA]	PF17862	e5t0cAA1	A: alpha arrays	X: Histone-like	H: Histone-related	T: AAA+ ATPase lid domain	F: PF17862	ECOD (1.6)
M [auth AA]	PF00004	e5t0cAA3	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: PF00004	ECOD (1.6)
SA [auth BA]	PF17862	e5t0cBA2	A: alpha arrays	X: Histone-like	H: Histone-related	T: AAA+ ATPase lid domain	F: PF17862	ECOD (1.6)
SA [auth BA]	PF00004	e5t0cBA1	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: PF00004	ECOD (1.6)
N [auth AB]	PF16450	e5t0cAB2	A: beta barrels	X: OB-fold	H: Nucleic acid-binding proteins (From Topology)	T: Nucleic acid-binding proteins	F: PF16450	ECOD (1.6)
N [auth AB]	PF17862	e5t0cAB1	A: alpha arrays	X: Histone-like	H: Histone-related	T: AAA+ ATPase lid domain	F: PF17862	ECOD (1.6)
N [auth AB]	PF00004	e5t0cAB3	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: PF00004	ECOD (1.6)
TA [auth BB]	PF16450	e5t0cBB1	A: beta barrels	X: OB-fold	H: Nucleic acid-binding proteins (From Topology)	T: Nucleic acid-binding proteins	F: PF16450	ECOD (1.6)
TA [auth BB]	PF17862	e5t0cBB3	A: alpha arrays	X: Histone-like	H: Histone-related	T: AAA+ ATPase lid domain	F: PF17862	ECOD (1.6)
TA [auth BB]	PF00004	e5t0cBB2	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: PF00004	ECOD (1.6)
O [auth AD]	PF16450	e5t0cAD3	A: beta barrels	X: OB-fold	H: Nucleic acid-binding proteins (From Topology)	T: Nucleic acid-binding proteins	F: PF16450	ECOD (1.6)
O [auth AD]	PF17862	e5t0cAD2	A: alpha arrays	X: Histone-like	H: Histone-related	T: AAA+ ATPase lid domain	F: PF17862	ECOD (1.6)
O [auth AD]	PF00004	e5t0cAD1	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: PF00004	ECOD (1.6)
UA [auth BD]	PF16450	e5t0cBD2	A: beta barrels	X: OB-fold	H: Nucleic acid-binding proteins (From Topology)	T: Nucleic acid-binding proteins	F: PF16450	ECOD (1.6)
UA [auth BD]	PF17862	e5t0cBD1	A: alpha arrays	X: Histone-like	H: Histone-related	T: AAA+ ATPase lid domain	F: PF17862	ECOD (1.6)
UA [auth BD]	PF00004	e5t0cBD3	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: PF00004	ECOD (1.6)
P [auth AE]	PF16450	e5t0cAE3	A: beta barrels	X: OB-fold	H: Nucleic acid-binding proteins (From Topology)	T: Nucleic acid-binding proteins	F: PF16450	ECOD (1.6)
P [auth AE]	PF17862	e5t0cAE1	A: alpha arrays	X: Histone-like	H: Histone-related	T: AAA+ ATPase lid domain	F: PF17862	ECOD (1.6)
P [auth AE]	PF00004	e5t0cAE2	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: PF00004	ECOD (1.6)
VA [auth BE]	PF16450	e5t0cBE2	A: beta barrels	X: OB-fold	H: Nucleic acid-binding proteins (From Topology)	T: Nucleic acid-binding proteins	F: PF16450	ECOD (1.6)
VA [auth BE]	PF17862	e5t0cBE3	A: alpha arrays	X: Histone-like	H: Histone-related	T: AAA+ ATPase lid domain	F: PF17862	ECOD (1.6)
VA [auth BE]	PF00004	e5t0cBE1	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: PF00004	ECOD (1.6)
Q [auth AF]	PF16450	e5t0cAF3	A: beta barrels	X: OB-fold	H: Nucleic acid-binding proteins (From Topology)	T: Nucleic acid-binding proteins	F: PF16450	ECOD (1.6)
Q [auth AF]	F_UNCLASSIFIED	e5t0cAF4	A: alpha arrays	X: Histone-like	H: Histone-related	T: AAA+ ATPase lid domain	F: F_UNCLASSIFIED	ECOD (1.6)
Q [auth AF]	PF17862	e5t0cAF2	A: alpha arrays	X: Histone-like	H: Histone-related	T: AAA+ ATPase lid domain	F: PF17862	ECOD (1.6)
Q [auth AF]	PF00004	e5t0cAF1	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: PF00004	ECOD (1.6)
WA [auth BF]	PF16450	e5t0cBF3	A: beta barrels	X: OB-fold	H: Nucleic acid-binding proteins (From Topology)	T: Nucleic acid-binding proteins	F: PF16450	ECOD (1.6)
WA [auth BF]	F_UNCLASSIFIED	e5t0cBF4	A: alpha arrays	X: Histone-like	H: Histone-related	T: AAA+ ATPase lid domain	F: F_UNCLASSIFIED	ECOD (1.6)
WA [auth BF]	PF17862	e5t0cBF2	A: alpha arrays	X: Histone-like	H: Histone-related	T: AAA+ ATPase lid domain	F: PF17862	ECOD (1.6)
WA [auth BF]	PF00004	e5t0cBF1	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: PF00004	ECOD (1.6)
R [auth AC]	PF16450	e5t0cAC2	A: beta barrels	X: OB-fold	H: Nucleic acid-binding proteins (From Topology)	T: Nucleic acid-binding proteins	F: PF16450	ECOD (1.6)
R [auth AC]	PF17862	e5t0cAC1	A: alpha arrays	X: Histone-like	H: Histone-related	T: AAA+ ATPase lid domain	F: PF17862	ECOD (1.6)
R [auth AC]	PF00004	e5t0cAC3	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: PF00004	ECOD (1.6)
XA [auth BC]	PF16450	e5t0cBC1	A: beta barrels	X: OB-fold	H: Nucleic acid-binding proteins (From Topology)	T: Nucleic acid-binding proteins	F: PF16450	ECOD (1.6)
XA [auth BC]	PF17862	e5t0cBC2	A: alpha arrays	X: Histone-like	H: Histone-related	T: AAA+ ATPase lid domain	F: PF17862	ECOD (1.6)
XA [auth BC]	PF00004	e5t0cBC3	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: PF00004	ECOD (1.6)
S [auth AG]	PF00227,PF10584	e5t0cAG1	A: a+b four layers	X: Ntn/PP2C	H: Ntn	T: Proteasome subunits	F: PF00227,PF10584	ECOD (1.6)
YA [auth BG]	PF00227,PF10584	e5t0cBG1	A: a+b four layers	X: Ntn/PP2C	H: Ntn	T: Proteasome subunits	F: PF00227,PF10584	ECOD (1.6)
B [auth AV]	PF01399	e5t0cAV1	A: alpha arrays	X: HTH	H: HTH	T: winged	F: PF01399	ECOD (1.6)
B [auth AV]	F_UNCLASSIFIED	e5t0cAV3	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: F_UNCLASSIFIED	ECOD (1.6)
B [auth AV]	PF08375	e5t0cAV2	A: extended segments	X: 26S proteasome regulatory subunits C-terminal helices	H: 26S proteasome regulatory subunit RPN3 C-terminal helix (From Topology)	T: 26S proteasome regulatory subunit RPN3 C-terminal helix	F: PF08375	ECOD (1.6)
HA [auth BV]	PF01399	e5t0cBV3	A: alpha arrays	X: HTH	H: HTH	T: winged	F: PF01399	ECOD (1.6)
HA [auth BV]	F_UNCLASSIFIED	e5t0cBV1	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: F_UNCLASSIFIED	ECOD (1.6)
HA [auth BV]	PF08375	e5t0cBV2	A: extended segments	X: 26S proteasome regulatory subunits C-terminal helices	H: 26S proteasome regulatory subunit RPN3 C-terminal helix (From Topology)	T: 26S proteasome regulatory subunit RPN3 C-terminal helix	F: PF08375	ECOD (1.6)
T [auth AH]	PF00227,PF10584	e5t0cAH1	A: a+b four layers	X: Ntn/PP2C	H: Ntn	T: Proteasome subunits	F: PF00227,PF10584	ECOD (1.6)
ZA [auth BH]	PF00227,PF10584	e5t0cBH1	A: a+b four layers	X: Ntn/PP2C	H: Ntn	T: Proteasome subunits	F: PF00227,PF10584	ECOD (1.6)
AB [auth BI]	PF00227,PF10584	e5t0cBI1	A: a+b four layers	X: Ntn/PP2C	H: Ntn	T: Proteasome subunits	F: PF00227,PF10584	ECOD (1.6)
U [auth AI]	PF00227,PF10584	e5t0cAI1	A: a+b four layers	X: Ntn/PP2C	H: Ntn	T: Proteasome subunits	F: PF00227,PF10584	ECOD (1.6)
BB [auth BJ]	PF00227,PF10584	e5t0cBJ1	A: a+b four layers	X: Ntn/PP2C	H: Ntn	T: Proteasome subunits	F: PF00227,PF10584	ECOD (1.6)
V [auth AJ]	PF00227,PF10584	e5t0cAJ1	A: a+b four layers	X: Ntn/PP2C	H: Ntn	T: Proteasome subunits	F: PF00227,PF10584	ECOD (1.6)
CB [auth BK]	PF00227,PF10584	e5t0cBK1	A: a+b four layers	X: Ntn/PP2C	H: Ntn	T: Proteasome subunits	F: PF00227,PF10584	ECOD (1.6)
W [auth AK]	PF00227,PF10584	e5t0cAK1	A: a+b four layers	X: Ntn/PP2C	H: Ntn	T: Proteasome subunits	F: PF00227,PF10584	ECOD (1.6)
DB [auth BL]	PF00227,PF10584	e5t0cBL1	A: a+b four layers	X: Ntn/PP2C	H: Ntn	T: Proteasome subunits	F: PF00227,PF10584	ECOD (1.6)
X [auth AL]	PF00227,PF10584	e5t0cAL1	A: a+b four layers	X: Ntn/PP2C	H: Ntn	T: Proteasome subunits	F: PF00227,PF10584	ECOD (1.6)
EB [auth BM]	PF00227,PF10584	e5t0cBM1	A: a+b four layers	X: Ntn/PP2C	H: Ntn	T: Proteasome subunits	F: PF00227,PF10584	ECOD (1.6)
Y [auth AM]	PF00227,PF10584	e5t0cAM1	A: a+b four layers	X: Ntn/PP2C	H: Ntn	T: Proteasome subunits	F: PF00227,PF10584	ECOD (1.6)
FB [auth BN]	PF00227	e5t0cBN1	A: a+b four layers	X: Ntn/PP2C	H: Ntn	T: Proteasome subunits	F: PF00227	ECOD (1.6)
Z [auth AN]	PF00227	e5t0cAN1	A: a+b four layers	X: Ntn/PP2C	H: Ntn	T: Proteasome subunits	F: PF00227	ECOD (1.6)
AA [auth AO]	PF00227,PF12465	e5t0cAO1	A: a+b four layers	X: Ntn/PP2C	H: Ntn	T: Proteasome subunits	F: PF00227,PF12465	ECOD (1.6)
GB [auth BO]	PF00227,PF12465	e5t0cBO1	A: a+b four layers	X: Ntn/PP2C	H: Ntn	T: Proteasome subunits	F: PF00227,PF12465	ECOD (1.6)
BA [auth AP]	PF00227	e5t0cAP1	A: a+b four layers	X: Ntn/PP2C	H: Ntn	T: Proteasome subunits	F: PF00227	ECOD (1.6)
HB [auth BP]	PF00227	e5t0cBP1	A: a+b four layers	X: Ntn/PP2C	H: Ntn	T: Proteasome subunits	F: PF00227	ECOD (1.6)
CA [auth AQ]	PF00227	e5t0cAQ1	A: a+b four layers	X: Ntn/PP2C	H: Ntn	T: Proteasome subunits	F: PF00227	ECOD (1.6)
IB [auth BQ]	PF00227	e5t0cBQ1	A: a+b four layers	X: Ntn/PP2C	H: Ntn	T: Proteasome subunits	F: PF00227	ECOD (1.6)
C [auth AW]	PF01399	e5t0cAW1	A: alpha arrays	X: HTH	H: HTH	T: winged	F: PF01399	ECOD (1.6)
C [auth AW]	PF22241	e5t0cAW2	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: PF22241	ECOD (1.6)
C [auth AW]	PF18098	e5t0cAW3	A: extended segments	X: 26S proteasome regulatory subunits C-terminal helices	H: 26S proteasome regulatory subunit RPN5 C-terminal helix (From Topology)	T: 26S proteasome regulatory subunit RPN5 C-terminal helix	F: PF18098	ECOD (1.6)
IA [auth BW]	PF01399	e5t0cBW1	A: alpha arrays	X: HTH	H: HTH	T: winged	F: PF01399	ECOD (1.6)
IA [auth BW]	PF22241	e5t0cBW3	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: PF22241	ECOD (1.6)
IA [auth BW]	PF18098	e5t0cBW2	A: extended segments	X: 26S proteasome regulatory subunits C-terminal helices	H: 26S proteasome regulatory subunit RPN5 C-terminal helix (From Topology)	T: 26S proteasome regulatory subunit RPN5 C-terminal helix	F: PF18098	ECOD (1.6)
DA [auth AR]	PF00227	e5t0cAR1	A: a+b four layers	X: Ntn/PP2C	H: Ntn	T: Proteasome subunits	F: PF00227	ECOD (1.6)
JB [auth BR]	PF00227	e5t0cBR1	A: a+b four layers	X: Ntn/PP2C	H: Ntn	T: Proteasome subunits	F: PF00227	ECOD (1.6)
EA [auth AS]	PF00227	e5t0cAS1	A: a+b four layers	X: Ntn/PP2C	H: Ntn	T: Proteasome subunits	F: PF00227	ECOD (1.6)
KB [auth BS]	PF00227	e5t0cBS1	A: a+b four layers	X: Ntn/PP2C	H: Ntn	T: Proteasome subunits	F: PF00227	ECOD (1.6)
FA [auth AT]	PF00227	e5t0cAT1	A: a+b four layers	X: Ntn/PP2C	H: Ntn	T: Proteasome subunits	F: PF00227	ECOD (1.6)
LB [auth BT]	PF00227	e5t0cBT1	A: a+b four layers	X: Ntn/PP2C	H: Ntn	T: Proteasome subunits	F: PF00227	ECOD (1.6)
D [auth AX]	PF01399	e5t0cAX1	A: alpha arrays	X: HTH	H: HTH	T: winged	F: PF01399	ECOD (1.6)
D [auth AX]	PF18055	e5t0cAX3	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: PF18055	ECOD (1.6)
D [auth AX]	PF18503	e5t0cAX2	A: extended segments	X: 26S proteasome regulatory subunits C-terminal helices	H: 26S proteasome regulatory subunit RPN6 C-termial helix (From Topology)	T: 26S proteasome regulatory subunit RPN6 C-termial helix	F: PF18503	ECOD (1.6)
JA [auth BX]	PF01399	e5t0cBX1	A: alpha arrays	X: HTH	H: HTH	T: winged	F: PF01399	ECOD (1.6)
JA [auth BX]	PF18055	e5t0cBX2	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: PF18055	ECOD (1.6)
JA [auth BX]	PF18503	e5t0cBX3	A: extended segments	X: 26S proteasome regulatory subunits C-terminal helices	H: 26S proteasome regulatory subunit RPN6 C-termial helix (From Topology)	T: 26S proteasome regulatory subunit RPN6 C-termial helix	F: PF18503	ECOD (1.6)
E [auth AY]	PF01399	e5t0cAY1	A: alpha arrays	X: HTH	H: HTH	T: winged	F: PF01399	ECOD (1.6)
E [auth AY]	PF10602	e5t0cAY2	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: PF10602	ECOD (1.6)
E [auth AY]	PF21154	e5t0cAY3	A: extended segments	X: 26S proteasome regulatory subunits C-terminal helices	H: 26S proteasome regulatory subunit RPN7 C-terminal helix (From Topology)	T: 26S proteasome regulatory subunit RPN7 C-terminal helix	F: PF21154	ECOD (1.6)
KA [auth BY]	PF01399	e5t0cBY2	A: alpha arrays	X: HTH	H: HTH	T: winged	F: PF01399	ECOD (1.6)
KA [auth BY]	PF10602	e5t0cBY3	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: PF10602	ECOD (1.6)
KA [auth BY]	PF21154	e5t0cBY1	A: extended segments	X: 26S proteasome regulatory subunits C-terminal helices	H: 26S proteasome regulatory subunit RPN7 C-terminal helix (From Topology)	T: 26S proteasome regulatory subunit RPN7 C-terminal helix	F: PF21154	ECOD (1.6)
F [auth AZ]	PF01398	e5t0cAZ2	A: a+b three layers	X: Cytidine deaminase-like (From Topology)	H: Cytidine deaminase-like (From Topology)	T: Cytidine deaminase-like	F: PF01398	ECOD (1.6)
F [auth AZ]	PF13012	e5t0cAZ1	A: extended segments	X: 26S proteasome regulatory subunit RPN8/RPN11 C-terminal domain (From Topology)	H: 26S proteasome regulatory subunit RPN8/RPN11 C-terminal domain (From Topology)	T: 26S proteasome regulatory subunit RPN8/RPN11 C-terminal domain	F: PF13012	ECOD (1.6)
LA [auth BZ]	PF01398	e5t0cBZ1	A: a+b three layers	X: Cytidine deaminase-like (From Topology)	H: Cytidine deaminase-like (From Topology)	T: Cytidine deaminase-like	F: PF01398	ECOD (1.6)
LA [auth BZ]	PF13012	e5t0cBZ2	A: extended segments	X: 26S proteasome regulatory subunit RPN8/RPN11 C-terminal domain (From Topology)	H: 26S proteasome regulatory subunit RPN8/RPN11 C-terminal domain (From Topology)	T: 26S proteasome regulatory subunit RPN8/RPN11 C-terminal domain	F: PF13012	ECOD (1.6)
G [auth Aa]	PF01399	e5t0cAa3	A: alpha arrays	X: HTH	H: HTH	T: winged	F: PF01399	ECOD (1.6)
G [auth Aa]	PF22037	e5t0cAa2	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: PF22037	ECOD (1.6)
G [auth Aa]	F_UNCLASSIFIED	e5t0cAa1	A: extended segments	X: 26S proteasome regulatory subunits C-terminal helices	H: 26S proteasome regulatory subunit RPN9 C-terminal helix (From Topology)	T: 26S proteasome regulatory subunit RPN9 C-terminal helix	F: F_UNCLASSIFIED	ECOD (1.6)
MA [auth Ba]	PF01399	e5t0cBa2	A: alpha arrays	X: HTH	H: HTH	T: winged	F: PF01399	ECOD (1.6)
MA [auth Ba]	PF22037	e5t0cBa1	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: PF22037	ECOD (1.6)
MA [auth Ba]	F_UNCLASSIFIED	e5t0cBa3	A: extended segments	X: 26S proteasome regulatory subunits C-terminal helices	H: 26S proteasome regulatory subunit RPN9 C-terminal helix (From Topology)	T: 26S proteasome regulatory subunit RPN9 C-terminal helix	F: F_UNCLASSIFIED	ECOD (1.6)
H [auth Ab]	PF13519	e5t0cAb1	A: a/b three-layered sandwiches	X: HAD domain-like	H: HAD domain-related	T: vWA-like	F: PF13519	ECOD (1.6)
NA [auth Bb]	PF13519	e5t0cBb1	A: a/b three-layered sandwiches	X: HAD domain-like	H: HAD domain-related	T: vWA-like	F: PF13519	ECOD (1.6)
I [auth Ac]	PF01398	e5t0cAc2	A: a+b three layers	X: Cytidine deaminase-like (From Topology)	H: Cytidine deaminase-like (From Topology)	T: Cytidine deaminase-like	F: PF01398	ECOD (1.6)
I [auth Ac]	F_UNCLASSIFIED	e5t0cAc1	A: extended segments	X: 26S proteasome regulatory subunit RPN8/RPN11 C-terminal domain (From Topology)	H: 26S proteasome regulatory subunit RPN8/RPN11 C-terminal domain (From Topology)	T: 26S proteasome regulatory subunit RPN8/RPN11 C-terminal domain	F: F_UNCLASSIFIED	ECOD (1.6)
OA [auth Bc]	PF01398	e5t0cBc2	A: a+b three layers	X: Cytidine deaminase-like (From Topology)	H: Cytidine deaminase-like (From Topology)	T: Cytidine deaminase-like	F: PF01398	ECOD (1.6)
OA [auth Bc]	F_UNCLASSIFIED	e5t0cBc1	A: extended segments	X: 26S proteasome regulatory subunit RPN8/RPN11 C-terminal domain (From Topology)	H: 26S proteasome regulatory subunit RPN8/RPN11 C-terminal domain (From Topology)	T: 26S proteasome regulatory subunit RPN8/RPN11 C-terminal domain	F: F_UNCLASSIFIED	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A [auth AU], GA [auth BU]	PF13646	HEAT repeats (HEAT_2)	HEAT repeats	-	Repeat
A [auth AU], GA [auth BU]	PF18004	26S proteasome regulatory subunit RPN2 C-terminal domain (RPN2_C)	26S proteasome regulatory subunit RPN2 C-terminal domain	This is the C-terminal domain found in S. cerevisiae Rpn2 (26S proteasome regulatory subunit RPN2) as well as other eukaryotic species. A study revealed that the C-terminal 52 residues of the Rpn2 C-terminal domain are responsible for mediating inter ...	This is the C-terminal domain found in S. cerevisiae Rpn2 (26S proteasome regulatory subunit RPN2) as well as other eukaryotic species. A study revealed that the C-terminal 52 residues of the Rpn2 C-terminal domain are responsible for mediating interactions with the ubiquitin-binding subunit Rpn13. Futhermore, the extreme C-terminal 20 or 21 residues of Rpn2 (926-945 or 925-945) of S. cerevisiae, were shown to be equally effective at binding Rpn13. Multiple sequence alignments indicate that Rpn2 orthologs are highly conserved in this C-terminal region and share characteristic acidic, aromatic, and proline residues, suggesting a common function. In the structure of Rpn2 from S. cerevisiae , this region is exposed and disordered, and is thus accessible for associating with Rpn13. The Rpn2 binding surface of human Rpn13 has been mapped by nuclear magnetic resonance titration to one surface of its Pru domain [1].	Domain
A [auth AU], GA [auth BU]	PF01851	Proteasome/cyclosome repeat (PC_rep)	Proteasome/cyclosome repeat	-	Repeat
J [auth Ad], PA [auth Bd]	PF10075	CSN8/PSMD8/EIF3K family (CSN8_PSD8_EIF3K)	CSN8/PSMD8/EIF3K family	-	Family
K [auth Ae], QA [auth Be]	PF05160	DSS1/SEM1 family (DSS1_SEM1)	DSS1/SEM1 family	-	Family
L [auth Af], RA [auth Bf]	PF01851	Proteasome/cyclosome repeat (PC_rep)	Proteasome/cyclosome repeat	-	Repeat
L [auth Af], RA [auth Bf]	PF18051	26S proteasome non-ATPase regulatory subunit RPN1 C-terminal (RPN1_C)	26S proteasome non-ATPase regulatory subunit RPN1 C-terminal	This is the C-terminal domain found in RPN1 proteins (26S proteasome non-ATPase regulatory subunit 2). The 26S proteasome holocomplex consists of a 28-subunit barrel-shaped core particle (CP) in the center capped at the top and bottom by 19-subunit ...	This is the C-terminal domain found in RPN1 proteins (26S proteasome non-ATPase regulatory subunit 2). The 26S proteasome holocomplex consists of a 28-subunit barrel-shaped core particle (CP) in the center capped at the top and bottom by 19-subunit regulatory particles (RPs). The CP forms the catalytic chamber and the RP is formed from two subcomplexes known as the lid and the base [1]. The lid comprises nine Rpn subunits in yeast (Rpn3/5/6/7/8/9/11/12/15) and the base comprises three Rpn subunits (Rpn1/2/13) and six ATPases (Rpt1-6) [2].	Domain
M [auth AA], SA [auth BA]	PF17862	AAA+ lid domain (AAA_lid_3)	AAA+ lid domain	This entry represents the alpha helical AAA+ lid domain that is found to the C-terminus of AAA domains.	Domain
M [auth AA], SA [auth BA]	PF21236	26S proteasome regulatory subunit 7, OB domain (PRS7_OB)	26S proteasome regulatory subunit 7, OB domain	This is the OB domain from 26S proteasome regulatory subunit 7 (PRS7, also known as PSMC2, Rpt1 or MSS1), a component of the 19S proteasome cap [1-5]. These are one of six ATPases of the regulatory particle that form a heterohexameric ring. This doma ...	This is the OB domain from 26S proteasome regulatory subunit 7 (PRS7, also known as PSMC2, Rpt1 or MSS1), a component of the 19S proteasome cap [1-5]. These are one of six ATPases of the regulatory particle that form a heterohexameric ring. This domain mediates interactions with USP14 or Ubp6 [2,4].	Domain
M [auth AA], SA [auth BA]	PF00004	ATPase family associated with various cellular activities (AAA) (AAA)	ATPase family associated with various cellular activities (AAA)	AAA family proteins often perform chaperone-like functions that assist in the assembly, operation, or disassembly of protein complexes [2].	Domain
N [auth AB], TA [auth BB]	PF16450	Proteasomal ATPase OB C-terminal domain (Prot_ATP_ID_OB_C)	Proteasomal ATPase OB C-terminal domain	This is the C-terminal interdomain (ID) or oligonucleotide binding (OB) domain of proteasomal ATPase [1-2]	Domain
N [auth AB], TA [auth BB]	PF17862	AAA+ lid domain (AAA_lid_3)	AAA+ lid domain	This entry represents the alpha helical AAA+ lid domain that is found to the C-terminus of AAA domains.	Domain
N [auth AB], TA [auth BB]	PF00004	ATPase family associated with various cellular activities (AAA) (AAA)	ATPase family associated with various cellular activities (AAA)	AAA family proteins often perform chaperone-like functions that assist in the assembly, operation, or disassembly of protein complexes [2].	Domain
O [auth AD], UA [auth BD]	PF16450	Proteasomal ATPase OB C-terminal domain (Prot_ATP_ID_OB_C)	Proteasomal ATPase OB C-terminal domain	This is the C-terminal interdomain (ID) or oligonucleotide binding (OB) domain of proteasomal ATPase [1-2]	Domain
O [auth AD], UA [auth BD]	PF17862	AAA+ lid domain (AAA_lid_3)	AAA+ lid domain	This entry represents the alpha helical AAA+ lid domain that is found to the C-terminus of AAA domains.	Domain
O [auth AD], UA [auth BD]	PF00004	ATPase family associated with various cellular activities (AAA) (AAA)	ATPase family associated with various cellular activities (AAA)	AAA family proteins often perform chaperone-like functions that assist in the assembly, operation, or disassembly of protein complexes [2].	Domain
P [auth AE], VA [auth BE]	PF16450	Proteasomal ATPase OB C-terminal domain (Prot_ATP_ID_OB_C)	Proteasomal ATPase OB C-terminal domain	This is the C-terminal interdomain (ID) or oligonucleotide binding (OB) domain of proteasomal ATPase [1-2]	Domain
P [auth AE], VA [auth BE]	PF17862	AAA+ lid domain (AAA_lid_3)	AAA+ lid domain	This entry represents the alpha helical AAA+ lid domain that is found to the C-terminus of AAA domains.	Domain
P [auth AE], VA [auth BE]	PF00004	ATPase family associated with various cellular activities (AAA) (AAA)	ATPase family associated with various cellular activities (AAA)	AAA family proteins often perform chaperone-like functions that assist in the assembly, operation, or disassembly of protein complexes [2].	Domain
Q [auth AF], WA [auth BF]	PF16450	Proteasomal ATPase OB C-terminal domain (Prot_ATP_ID_OB_C)	Proteasomal ATPase OB C-terminal domain	This is the C-terminal interdomain (ID) or oligonucleotide binding (OB) domain of proteasomal ATPase [1-2]	Domain
Q [auth AF], WA [auth BF]	PF17862	AAA+ lid domain (AAA_lid_3)	AAA+ lid domain	This entry represents the alpha helical AAA+ lid domain that is found to the C-terminus of AAA domains.	Domain
Q [auth AF], WA [auth BF]	PF00004	ATPase family associated with various cellular activities (AAA) (AAA)	ATPase family associated with various cellular activities (AAA)	AAA family proteins often perform chaperone-like functions that assist in the assembly, operation, or disassembly of protein complexes [2].	Domain
R [auth AC], XA [auth BC]	PF16450	Proteasomal ATPase OB C-terminal domain (Prot_ATP_ID_OB_C)	Proteasomal ATPase OB C-terminal domain	This is the C-terminal interdomain (ID) or oligonucleotide binding (OB) domain of proteasomal ATPase [1-2]	Domain
R [auth AC], XA [auth BC]	PF17862	AAA+ lid domain (AAA_lid_3)	AAA+ lid domain	This entry represents the alpha helical AAA+ lid domain that is found to the C-terminus of AAA domains.	Domain
R [auth AC], XA [auth BC]	PF00004	ATPase family associated with various cellular activities (AAA) (AAA)	ATPase family associated with various cellular activities (AAA)	AAA family proteins often perform chaperone-like functions that assist in the assembly, operation, or disassembly of protein complexes [2].	Domain
S [auth AG], YA [auth BG]	PF00227	Proteasome subunit (Proteasome)	Proteasome subunit	The proteasome is a multisubunit structure that degrades proteins. Protein degradation is an essential component of regulation because proteins can become misfolded, damaged, or unnecessary. Proteasomes and their homologues vary greatly in complexity ...	The proteasome is a multisubunit structure that degrades proteins. Protein degradation is an essential component of regulation because proteins can become misfolded, damaged, or unnecessary. Proteasomes and their homologues vary greatly in complexity: from HslV (heat shock locus v), which is encoded by 1 gene in bacteria, to the eukaryotic 20S proteasome, which is encoded by more than 14 genes [1]. Recently evidence of two novel groups of bacterial proteasomes was proposed. The first is Anbu, which is sparsely distributed among cyanobacteria and proteobacteria [1]. The second is call beta-proteobacteria proteasome homologue (BPH) [1].	Domain
S [auth AG], YA [auth BG]	PF10584	Proteasome subunit A N-terminal signature (Proteasome_A_N)	Proteasome subunit A N-terminal signature	-	Family
B [auth AV], HA [auth BV]	PF08375	Proteasome regulatory subunit C-terminal (Rpn3_C)	Proteasome regulatory subunit C-terminal	-	Family
B [auth AV], HA [auth BV]	PF01399	PCI domain (PCI)	PCI domain	This domain has also been called the PINT motif (Proteasome, Int-6, Nip-1 and TRIP-15) [1].	Domain
T [auth AH], ZA [auth BH]	PF00227	Proteasome subunit (Proteasome)	Proteasome subunit	The proteasome is a multisubunit structure that degrades proteins. Protein degradation is an essential component of regulation because proteins can become misfolded, damaged, or unnecessary. Proteasomes and their homologues vary greatly in complexity ...	The proteasome is a multisubunit structure that degrades proteins. Protein degradation is an essential component of regulation because proteins can become misfolded, damaged, or unnecessary. Proteasomes and their homologues vary greatly in complexity: from HslV (heat shock locus v), which is encoded by 1 gene in bacteria, to the eukaryotic 20S proteasome, which is encoded by more than 14 genes [1]. Recently evidence of two novel groups of bacterial proteasomes was proposed. The first is Anbu, which is sparsely distributed among cyanobacteria and proteobacteria [1]. The second is call beta-proteobacteria proteasome homologue (BPH) [1].	Domain
T [auth AH], ZA [auth BH]	PF10584	Proteasome subunit A N-terminal signature (Proteasome_A_N)	Proteasome subunit A N-terminal signature	-	Family
AB [auth BI], U [auth AI]	PF00227	Proteasome subunit (Proteasome)	Proteasome subunit	The proteasome is a multisubunit structure that degrades proteins. Protein degradation is an essential component of regulation because proteins can become misfolded, damaged, or unnecessary. Proteasomes and their homologues vary greatly in complexity ...	The proteasome is a multisubunit structure that degrades proteins. Protein degradation is an essential component of regulation because proteins can become misfolded, damaged, or unnecessary. Proteasomes and their homologues vary greatly in complexity: from HslV (heat shock locus v), which is encoded by 1 gene in bacteria, to the eukaryotic 20S proteasome, which is encoded by more than 14 genes [1]. Recently evidence of two novel groups of bacterial proteasomes was proposed. The first is Anbu, which is sparsely distributed among cyanobacteria and proteobacteria [1]. The second is call beta-proteobacteria proteasome homologue (BPH) [1].	Domain
AB [auth BI], U [auth AI]	PF10584	Proteasome subunit A N-terminal signature (Proteasome_A_N)	Proteasome subunit A N-terminal signature	-	Family
BB [auth BJ], V [auth AJ]	PF00227	Proteasome subunit (Proteasome)	Proteasome subunit	The proteasome is a multisubunit structure that degrades proteins. Protein degradation is an essential component of regulation because proteins can become misfolded, damaged, or unnecessary. Proteasomes and their homologues vary greatly in complexity ...	The proteasome is a multisubunit structure that degrades proteins. Protein degradation is an essential component of regulation because proteins can become misfolded, damaged, or unnecessary. Proteasomes and their homologues vary greatly in complexity: from HslV (heat shock locus v), which is encoded by 1 gene in bacteria, to the eukaryotic 20S proteasome, which is encoded by more than 14 genes [1]. Recently evidence of two novel groups of bacterial proteasomes was proposed. The first is Anbu, which is sparsely distributed among cyanobacteria and proteobacteria [1]. The second is call beta-proteobacteria proteasome homologue (BPH) [1].	Domain
BB [auth BJ], V [auth AJ]	PF10584	Proteasome subunit A N-terminal signature (Proteasome_A_N)	Proteasome subunit A N-terminal signature	-	Family
CB [auth BK], W [auth AK]	PF00227	Proteasome subunit (Proteasome)	Proteasome subunit	The proteasome is a multisubunit structure that degrades proteins. Protein degradation is an essential component of regulation because proteins can become misfolded, damaged, or unnecessary. Proteasomes and their homologues vary greatly in complexity ...	The proteasome is a multisubunit structure that degrades proteins. Protein degradation is an essential component of regulation because proteins can become misfolded, damaged, or unnecessary. Proteasomes and their homologues vary greatly in complexity: from HslV (heat shock locus v), which is encoded by 1 gene in bacteria, to the eukaryotic 20S proteasome, which is encoded by more than 14 genes [1]. Recently evidence of two novel groups of bacterial proteasomes was proposed. The first is Anbu, which is sparsely distributed among cyanobacteria and proteobacteria [1]. The second is call beta-proteobacteria proteasome homologue (BPH) [1].	Domain
CB [auth BK], W [auth AK]	PF10584	Proteasome subunit A N-terminal signature (Proteasome_A_N)	Proteasome subunit A N-terminal signature	-	Family
DB [auth BL], X [auth AL]	PF00227	Proteasome subunit (Proteasome)	Proteasome subunit	The proteasome is a multisubunit structure that degrades proteins. Protein degradation is an essential component of regulation because proteins can become misfolded, damaged, or unnecessary. Proteasomes and their homologues vary greatly in complexity ...	The proteasome is a multisubunit structure that degrades proteins. Protein degradation is an essential component of regulation because proteins can become misfolded, damaged, or unnecessary. Proteasomes and their homologues vary greatly in complexity: from HslV (heat shock locus v), which is encoded by 1 gene in bacteria, to the eukaryotic 20S proteasome, which is encoded by more than 14 genes [1]. Recently evidence of two novel groups of bacterial proteasomes was proposed. The first is Anbu, which is sparsely distributed among cyanobacteria and proteobacteria [1]. The second is call beta-proteobacteria proteasome homologue (BPH) [1].	Domain
DB [auth BL], X [auth AL]	PF10584	Proteasome subunit A N-terminal signature (Proteasome_A_N)	Proteasome subunit A N-terminal signature	-	Family
EB [auth BM], Y [auth AM]	PF00227	Proteasome subunit (Proteasome)	Proteasome subunit	The proteasome is a multisubunit structure that degrades proteins. Protein degradation is an essential component of regulation because proteins can become misfolded, damaged, or unnecessary. Proteasomes and their homologues vary greatly in complexity ...	The proteasome is a multisubunit structure that degrades proteins. Protein degradation is an essential component of regulation because proteins can become misfolded, damaged, or unnecessary. Proteasomes and their homologues vary greatly in complexity: from HslV (heat shock locus v), which is encoded by 1 gene in bacteria, to the eukaryotic 20S proteasome, which is encoded by more than 14 genes [1]. Recently evidence of two novel groups of bacterial proteasomes was proposed. The first is Anbu, which is sparsely distributed among cyanobacteria and proteobacteria [1]. The second is call beta-proteobacteria proteasome homologue (BPH) [1].	Domain
EB [auth BM], Y [auth AM]	PF10584	Proteasome subunit A N-terminal signature (Proteasome_A_N)	Proteasome subunit A N-terminal signature	-	Family
FB [auth BN], Z [auth AN]	PF00227	Proteasome subunit (Proteasome)	Proteasome subunit	The proteasome is a multisubunit structure that degrades proteins. Protein degradation is an essential component of regulation because proteins can become misfolded, damaged, or unnecessary. Proteasomes and their homologues vary greatly in complexity ...	The proteasome is a multisubunit structure that degrades proteins. Protein degradation is an essential component of regulation because proteins can become misfolded, damaged, or unnecessary. Proteasomes and their homologues vary greatly in complexity: from HslV (heat shock locus v), which is encoded by 1 gene in bacteria, to the eukaryotic 20S proteasome, which is encoded by more than 14 genes [1]. Recently evidence of two novel groups of bacterial proteasomes was proposed. The first is Anbu, which is sparsely distributed among cyanobacteria and proteobacteria [1]. The second is call beta-proteobacteria proteasome homologue (BPH) [1].	Domain
AA [auth AO], GB [auth BO]	PF00227	Proteasome subunit (Proteasome)	Proteasome subunit	The proteasome is a multisubunit structure that degrades proteins. Protein degradation is an essential component of regulation because proteins can become misfolded, damaged, or unnecessary. Proteasomes and their homologues vary greatly in complexity ...	The proteasome is a multisubunit structure that degrades proteins. Protein degradation is an essential component of regulation because proteins can become misfolded, damaged, or unnecessary. Proteasomes and their homologues vary greatly in complexity: from HslV (heat shock locus v), which is encoded by 1 gene in bacteria, to the eukaryotic 20S proteasome, which is encoded by more than 14 genes [1]. Recently evidence of two novel groups of bacterial proteasomes was proposed. The first is Anbu, which is sparsely distributed among cyanobacteria and proteobacteria [1]. The second is call beta-proteobacteria proteasome homologue (BPH) [1].	Domain
AA [auth AO], GB [auth BO]	PF12465	Proteasome beta subunits C terminal (Pr_beta_C)	Proteasome beta subunits C terminal	-	Family
BA [auth AP], HB [auth BP]	PF00227	Proteasome subunit (Proteasome)	Proteasome subunit	The proteasome is a multisubunit structure that degrades proteins. Protein degradation is an essential component of regulation because proteins can become misfolded, damaged, or unnecessary. Proteasomes and their homologues vary greatly in complexity ...	The proteasome is a multisubunit structure that degrades proteins. Protein degradation is an essential component of regulation because proteins can become misfolded, damaged, or unnecessary. Proteasomes and their homologues vary greatly in complexity: from HslV (heat shock locus v), which is encoded by 1 gene in bacteria, to the eukaryotic 20S proteasome, which is encoded by more than 14 genes [1]. Recently evidence of two novel groups of bacterial proteasomes was proposed. The first is Anbu, which is sparsely distributed among cyanobacteria and proteobacteria [1]. The second is call beta-proteobacteria proteasome homologue (BPH) [1].	Domain
CA [auth AQ], IB [auth BQ]	PF00227	Proteasome subunit (Proteasome)	Proteasome subunit	The proteasome is a multisubunit structure that degrades proteins. Protein degradation is an essential component of regulation because proteins can become misfolded, damaged, or unnecessary. Proteasomes and their homologues vary greatly in complexity ...	The proteasome is a multisubunit structure that degrades proteins. Protein degradation is an essential component of regulation because proteins can become misfolded, damaged, or unnecessary. Proteasomes and their homologues vary greatly in complexity: from HslV (heat shock locus v), which is encoded by 1 gene in bacteria, to the eukaryotic 20S proteasome, which is encoded by more than 14 genes [1]. Recently evidence of two novel groups of bacterial proteasomes was proposed. The first is Anbu, which is sparsely distributed among cyanobacteria and proteobacteria [1]. The second is call beta-proteobacteria proteasome homologue (BPH) [1].	Domain
C [auth AW], IA [auth BW]	PF18098	26S proteasome regulatory subunit RPN5 C-terminal domain (RPN5_C)	26S proteasome regulatory subunit RPN5 C-terminal domain	This is the C-terminal domain of the 26S proteasome regulatory subunit RPN5 proteins.This helical domain can be found adjacent to Pfam:PF01399. The 26S proteasome is the major ATP-dependent protease in eukaryotes. Three subcomplexes form this degrada ...	This is the C-terminal domain of the 26S proteasome regulatory subunit RPN5 proteins.This helical domain can be found adjacent to Pfam:PF01399. The 26S proteasome is the major ATP-dependent protease in eukaryotes. Three subcomplexes form this degradation machine: the lid, the base, and the core. The helices found at the C terminus of each lid subunit form a helical bundle that directs the ordered self-assembly of the lid subcomplex. This domain which comprises the tail of RPN5 along with the tail of Rpn9, are important for Rpn12 binding to the lid [1].	Domain
C [auth AW], IA [auth BW]	PF01399	PCI domain (PCI)	PCI domain	This domain has also been called the PINT motif (Proteasome, Int-6, Nip-1 and TRIP-15) [1].	Domain
DA [auth AR], JB [auth BR]	PF00227	Proteasome subunit (Proteasome)	Proteasome subunit	The proteasome is a multisubunit structure that degrades proteins. Protein degradation is an essential component of regulation because proteins can become misfolded, damaged, or unnecessary. Proteasomes and their homologues vary greatly in complexity ...	The proteasome is a multisubunit structure that degrades proteins. Protein degradation is an essential component of regulation because proteins can become misfolded, damaged, or unnecessary. Proteasomes and their homologues vary greatly in complexity: from HslV (heat shock locus v), which is encoded by 1 gene in bacteria, to the eukaryotic 20S proteasome, which is encoded by more than 14 genes [1]. Recently evidence of two novel groups of bacterial proteasomes was proposed. The first is Anbu, which is sparsely distributed among cyanobacteria and proteobacteria [1]. The second is call beta-proteobacteria proteasome homologue (BPH) [1].	Domain
EA [auth AS], KB [auth BS]	PF00227	Proteasome subunit (Proteasome)	Proteasome subunit	The proteasome is a multisubunit structure that degrades proteins. Protein degradation is an essential component of regulation because proteins can become misfolded, damaged, or unnecessary. Proteasomes and their homologues vary greatly in complexity ...	The proteasome is a multisubunit structure that degrades proteins. Protein degradation is an essential component of regulation because proteins can become misfolded, damaged, or unnecessary. Proteasomes and their homologues vary greatly in complexity: from HslV (heat shock locus v), which is encoded by 1 gene in bacteria, to the eukaryotic 20S proteasome, which is encoded by more than 14 genes [1]. Recently evidence of two novel groups of bacterial proteasomes was proposed. The first is Anbu, which is sparsely distributed among cyanobacteria and proteobacteria [1]. The second is call beta-proteobacteria proteasome homologue (BPH) [1].	Domain
FA [auth AT], LB [auth BT]	PF00227	Proteasome subunit (Proteasome)	Proteasome subunit	The proteasome is a multisubunit structure that degrades proteins. Protein degradation is an essential component of regulation because proteins can become misfolded, damaged, or unnecessary. Proteasomes and their homologues vary greatly in complexity ...	The proteasome is a multisubunit structure that degrades proteins. Protein degradation is an essential component of regulation because proteins can become misfolded, damaged, or unnecessary. Proteasomes and their homologues vary greatly in complexity: from HslV (heat shock locus v), which is encoded by 1 gene in bacteria, to the eukaryotic 20S proteasome, which is encoded by more than 14 genes [1]. Recently evidence of two novel groups of bacterial proteasomes was proposed. The first is Anbu, which is sparsely distributed among cyanobacteria and proteobacteria [1]. The second is call beta-proteobacteria proteasome homologue (BPH) [1].	Domain
D [auth AX], JA [auth BX]	PF18055	26S proteasome regulatory subunit RPN6 N-terminal domain (RPN6_N)	26S proteasome regulatory subunit RPN6 N-terminal domain	-	Repeat
D [auth AX], JA [auth BX]	PF18503	26S proteasome subunit RPN6 C-terminal helix domain (RPN6_C_helix)	26S proteasome subunit RPN6 C-terminal helix domain	This is the C-terminal helix domain found in RPN6, a component of the 26S proteasome. The C-terminal helices are essential for lid assembly [1, 2].	Domain
D [auth AX], JA [auth BX]	PF01399	PCI domain (PCI)	PCI domain	This domain has also been called the PINT motif (Proteasome, Int-6, Nip-1 and TRIP-15) [1].	Domain
E [auth AY], KA [auth BY]	PF21154	26S proteasome regulatory subunit RPN7/PSMD6 C-terminal helix (RPN7_PSMD6_C)	26S proteasome regulatory subunit RPN7/PSMD6 C-terminal helix	RPN7/PSDM6 are regulatory subunits from the 26S proteasome. This entry represents the C-terminal helix.	Domain
E [auth AY], KA [auth BY]	PF10602	26S proteasome subunit RPN7 (RPN7)	26S proteasome subunit RPN7	-	Repeat
E [auth AY], KA [auth BY]	PF01399	PCI domain (PCI)	PCI domain	This domain has also been called the PINT motif (Proteasome, Int-6, Nip-1 and TRIP-15) [1].	Domain
F [auth AZ], LA [auth BZ]	PF13012	Maintenance of mitochondrial structure and function (MitMem_reg)	Maintenance of mitochondrial structure and function	-	Family
F [auth AZ], LA [auth BZ]	PF01398	JAB1/Mov34/MPN/PAD-1 ubiquitin protease (JAB)	JAB1/Mov34/MPN/PAD-1 ubiquitin protease	-	Family
G [auth Aa], MA [auth Ba]	PF01399	PCI domain (PCI)	PCI domain	This domain has also been called the PINT motif (Proteasome, Int-6, Nip-1 and TRIP-15) [1].	Domain
H [auth Ab], NA [auth Bb]	PF13519	von Willebrand factor type A domain (VWA_2)	von Willebrand factor type A domain	-	Domain
I [auth Ac], OA [auth Bc]	PF01398	JAB1/Mov34/MPN/PAD-1 ubiquitin protease (JAB)	JAB1/Mov34/MPN/PAD-1 ubiquitin protease	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A [auth AU], GA [auth BU]	26S proteasome non-ATPase regulatory subunit 1	ubiquitin protein ligase binding protein binding binding ubiquitin-like protein ligase binding enzyme binding enzyme regulator activity molecular function regulator activity	organonitrogen compound catabolic process regulation of biological process organonitrogen compound metabolic process catabolic process regulation of protein metabolic process biological regulation primary metabolic process regulation of macromolecule metabolic process protein catabolic process regulation of catabolic process macromolecule catabolic process regulation of primary metabolic process organic substance metabolic process metabolic process organonitrogen compound catabolic process regulation of biological process organonitrogen compound metabolic process catabolic process regulation of protein metabolic process biological regulation primary metabolic process regulation of macromolecule metabolic process protein catabolic process regulation of catabolic process macromolecule catabolic process regulation of primary metabolic process organic substance metabolic process metabolic process protein metabolic process macromolecule metabolic process regulation of metabolic process organic substance catabolic process regulation of protein catabolic process proteolysis involved in protein catabolic process proteasomal protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis ubiquitin-dependent protein catabolic process	proteasome accessory complex protein-containing complex intracellular anatomical structure catalytic complex peptidase complex proteasome complex endopeptidase complex cellular anatomical entity intracellular protein-containing complex membrane proteasome regulatory particle extracellular region proteasome regulatory particle, base subcomplex cytoplasm proteasome accessory complex protein-containing complex intracellular anatomical structure catalytic complex peptidase complex proteasome complex endopeptidase complex cellular anatomical entity intracellular protein-containing complex membrane proteasome regulatory particle extracellular region proteasome regulatory particle, base subcomplex cytoplasm cytosol membrane-bounded organelle lytic vacuole intracellular vesicle membrane-enclosed lumen cytoplasmic vesicle lumen vacuolar lumen endomembrane system intracellular organelle lumen intracellular organelle cytoplasmic vesicle vesicle lysosome vesicle lumen azurophil granule vacuole intracellular membrane-bounded organelle secretory granule lumen azurophil granule lumen organelle lumen organelle secretory granule primary lysosome secretory vesicle intracellular non-membrane-bounded organelle proteasome storage granule non-membrane-bounded organelle nucleus nucleoplasm nuclear lumen
J [auth Ad], PA [auth Bd]	26S proteasome non-ATPase regulatory subunit 8	-	organonitrogen compound catabolic process organonitrogen compound metabolic process catabolic process proteolysis involved in protein catabolic process primary metabolic process proteasomal protein catabolic process protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process macromolecule catabolic process organic substance metabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis ubiquitin-dependent protein catabolic process organonitrogen compound catabolic process organonitrogen compound metabolic process catabolic process proteolysis involved in protein catabolic process primary metabolic process proteasomal protein catabolic process protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process macromolecule catabolic process organic substance metabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis ubiquitin-dependent protein catabolic process metabolic process protein metabolic process macromolecule metabolic process organic substance catabolic process	intracellular anatomical structure cytoplasm cellular anatomical entity cytosol proteasome accessory complex protein-containing complex catalytic complex peptidase complex proteasome complex endopeptidase complex intracellular protein-containing complex proteasome regulatory particle proteasome regulatory particle, lid subcomplex membrane-bounded organelle intracellular anatomical structure cytoplasm cellular anatomical entity cytosol proteasome accessory complex protein-containing complex catalytic complex peptidase complex proteasome complex endopeptidase complex intracellular protein-containing complex proteasome regulatory particle proteasome regulatory particle, lid subcomplex membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle nucleoplasm organelle lumen organelle nuclear lumen
K [auth Ae], QA [auth Be]	26S proteasome complex subunit DSS1	-	cellular response to stimulus double-strand break repair response to stimulus DNA recombination primary metabolic process DNA metabolic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process cellular response to stress DNA damage response response to stress recombinational repair cellular response to stimulus double-strand break repair response to stimulus DNA recombination primary metabolic process DNA metabolic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process cellular response to stress DNA damage response response to stress recombinational repair metabolic process cellular process macromolecule metabolic process double-strand break repair via homologous recombination DNA repair organonitrogen compound catabolic process organonitrogen compound metabolic process catabolic process proteolysis involved in protein catabolic process proteasomal protein catabolic process protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process macromolecule catabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis ubiquitin-dependent protein catabolic process protein metabolic process organic substance catabolic process cellular localization nitrogen compound transport nucleocytoplasmic transport transport cellular biosynthetic process nuclear transport mRNA transport localization mRNA export from nucleus establishment of localization in cell organic substance biosynthetic process RNA localization nuclear export nucleobase-containing compound transport RNA transport organic substance transport cellular metabolic process nucleic acid transport intracellular transport gene expression establishment of localization macromolecule biosynthetic process RNA export from nucleus establishment of RNA localization biosynthetic process macromolecule localization cellular component organization cellular component biogenesis proteasome assembly cellular component assembly protein-containing complex organization protein-containing complex assembly cellular component organization or biogenesis	intracellular anatomical structure cytoplasm cellular anatomical entity cytosol protein-containing complex catalytic complex peptidase complex proteasome complex endopeptidase complex intracellular protein-containing complex proteasome regulatory particle proteasome regulatory particle, lid subcomplex proteasome accessory complex membrane-bounded organelle intracellular anatomical structure cytoplasm cellular anatomical entity cytosol protein-containing complex catalytic complex peptidase complex proteasome complex endopeptidase complex intracellular protein-containing complex proteasome regulatory particle proteasome regulatory particle, lid subcomplex proteasome accessory complex membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle nucleoplasm organelle lumen organelle nuclear lumen
L [auth Af], RA [auth Bf]	26S proteasome non-ATPase regulatory subunit 2	enzyme regulator activity molecular function regulator activity	organonitrogen compound catabolic process regulation of biological process organonitrogen compound metabolic process catabolic process regulation of protein metabolic process biological regulation primary metabolic process regulation of macromolecule metabolic process protein catabolic process regulation of catabolic process macromolecule catabolic process regulation of primary metabolic process organic substance metabolic process metabolic process organonitrogen compound catabolic process regulation of biological process organonitrogen compound metabolic process catabolic process regulation of protein metabolic process biological regulation primary metabolic process regulation of macromolecule metabolic process protein catabolic process regulation of catabolic process macromolecule catabolic process regulation of primary metabolic process organic substance metabolic process metabolic process protein metabolic process macromolecule metabolic process regulation of metabolic process organic substance catabolic process regulation of protein catabolic process proteolysis involved in protein catabolic process proteasomal protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis ubiquitin-dependent protein catabolic process	proteasome accessory complex protein-containing complex intracellular anatomical structure catalytic complex peptidase complex proteasome complex endopeptidase complex cellular anatomical entity intracellular protein-containing complex membrane proteasome regulatory particle extracellular region proteasome regulatory particle, base subcomplex extracellular exosome proteasome accessory complex protein-containing complex intracellular anatomical structure catalytic complex peptidase complex proteasome complex endopeptidase complex cellular anatomical entity intracellular protein-containing complex membrane proteasome regulatory particle extracellular region proteasome regulatory particle, base subcomplex extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle organelle extracellular space vesicle extracellular membrane-bounded organelle vesicle lumen intracellular vesicle membrane-enclosed lumen cytoplasmic vesicle lumen secretory granule lumen intracellular membrane-bounded organelle endomembrane system intracellular organelle lumen intracellular organelle cytoplasmic vesicle organelle lumen secretory granule secretory vesicle cytoplasm cytosol intracellular non-membrane-bounded organelle proteasome storage granule non-membrane-bounded organelle ficolin-1-rich granule ficolin-1-rich granule lumen nucleus nucleoplasm nuclear lumen
M [auth AA], SA [auth BA]	26S protease regulatory subunit 7	binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding pyrophosphatase activity ATP hydrolysis activity ribonucleoside triphosphate phosphatase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity hydrolase activity, acting on acid anhydrides catalytic activity ATP-dependent activity proteasome-activating activity	developmental process multicellular organismal process cellular developmental process ossification cell differentiation cellular process osteoblast differentiation positive regulation of proteasomal protein catabolic process catabolic process positive regulation of protein metabolic process proteolysis involved in protein catabolic process positive regulation of biological process macromolecule catabolic process regulation of primary metabolic process developmental process multicellular organismal process cellular developmental process ossification cell differentiation cellular process osteoblast differentiation positive regulation of proteasomal protein catabolic process catabolic process positive regulation of protein metabolic process proteolysis involved in protein catabolic process positive regulation of biological process macromolecule catabolic process regulation of primary metabolic process positive regulation of metabolic process organic substance metabolic process regulation of proteolysis regulation of proteolysis involved in protein catabolic process proteolysis positive regulation of macromolecule metabolic process protein metabolic process organonitrogen compound catabolic process regulation of biological process organonitrogen compound metabolic process regulation of protein metabolic process biological regulation primary metabolic process proteasomal protein catabolic process regulation of macromolecule metabolic process protein catabolic process regulation of catabolic process positive regulation of protein catabolic process positive regulation of proteolysis involved in protein catabolic process positive regulation of catabolic process positive regulation of proteolysis regulation of proteasomal protein catabolic process metabolic process macromolecule metabolic process regulation of metabolic process organic substance catabolic process regulation of protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process ubiquitin-dependent protein catabolic process	proteasome accessory complex protein-containing complex intracellular anatomical structure catalytic complex peptidase complex proteasome complex endopeptidase complex cellular anatomical entity intracellular protein-containing complex membrane proteasome regulatory particle proteasome regulatory particle, base subcomplex cytoplasm cytosol proteasome accessory complex protein-containing complex intracellular anatomical structure catalytic complex peptidase complex proteasome complex endopeptidase complex cellular anatomical entity intracellular protein-containing complex membrane proteasome regulatory particle proteasome regulatory particle, base subcomplex cytoplasm cytosol membrane-bounded organelle membrane-enclosed lumen intracellular vesicle ficolin-1-rich granule intracellular membrane-bounded organelle endomembrane system intracellular organelle lumen intracellular organelle organelle lumen cytoplasmic vesicle ficolin-1-rich granule lumen organelle secretory granule secretory vesicle vesicle nucleus nucleoplasm nuclear lumen intracellular non-membrane-bounded organelle cytoplasmic ribonucleoprotein granule supramolecular complex non-membrane-bounded organelle ribonucleoprotein granule extracellular region vesicle lumen cytoplasmic vesicle lumen secretory granule lumen P-body
N [auth AB], TA [auth BB]	26S protease regulatory subunit 4	binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding pyrophosphatase activity ATP hydrolysis activity ribonucleoside triphosphate phosphatase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity hydrolase activity, acting on acid anhydrides catalytic activity ATP-dependent activity RNA binding nucleic acid binding proteasome-activating activity	organonitrogen compound catabolic process organonitrogen compound metabolic process catabolic process proteolysis involved in protein catabolic process primary metabolic process proteasomal protein catabolic process protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process macromolecule catabolic process organic substance metabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis ubiquitin-dependent protein catabolic process organonitrogen compound catabolic process organonitrogen compound metabolic process catabolic process proteolysis involved in protein catabolic process primary metabolic process proteasomal protein catabolic process protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process macromolecule catabolic process organic substance metabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis ubiquitin-dependent protein catabolic process metabolic process protein metabolic process macromolecule metabolic process organic substance catabolic process	proteasome accessory complex protein-containing complex intracellular anatomical structure catalytic complex peptidase complex proteasome complex endopeptidase complex cellular anatomical entity intracellular protein-containing complex membrane proteasome regulatory particle proteasome regulatory particle, base subcomplex cytoplasm cytosol proteasome accessory complex protein-containing complex intracellular anatomical structure catalytic complex peptidase complex proteasome complex endopeptidase complex cellular anatomical entity intracellular protein-containing complex membrane proteasome regulatory particle proteasome regulatory particle, base subcomplex cytoplasm cytosol membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle nucleoplasm organelle lumen organelle nuclear lumen
O [auth AD], UA [auth BD]	26S protease regulatory subunit 6B	binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding pyrophosphatase activity ATP hydrolysis activity ribonucleoside triphosphate phosphatase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity hydrolase activity, acting on acid anhydrides catalytic activity ATP-dependent activity proteasome-activating activity	developmental process multicellular organism development multicellular organismal process embryo development ending in birth or egg hatching chordate embryonic development anatomical structure development embryo development in utero embryonic development blastocyst development organic substance metabolic process organonitrogen compound metabolic process proteolysis metabolic process primary metabolic process developmental process multicellular organism development multicellular organismal process embryo development ending in birth or egg hatching chordate embryonic development anatomical structure development embryo development in utero embryonic development blastocyst development organic substance metabolic process organonitrogen compound metabolic process proteolysis metabolic process primary metabolic process protein metabolic process macromolecule metabolic process organonitrogen compound catabolic process catabolic process proteolysis involved in protein catabolic process proteasomal protein catabolic process protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process macromolecule catabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process ubiquitin-dependent protein catabolic process organic substance catabolic process	proteasome accessory complex protein-containing complex intracellular anatomical structure catalytic complex peptidase complex proteasome complex endopeptidase complex cellular anatomical entity intracellular protein-containing complex membrane proteasome regulatory particle proteasome regulatory particle, base subcomplex cytoplasm cytosol proteasome accessory complex protein-containing complex intracellular anatomical structure catalytic complex peptidase complex proteasome complex endopeptidase complex cellular anatomical entity intracellular protein-containing complex membrane proteasome regulatory particle proteasome regulatory particle, base subcomplex cytoplasm cytosol membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle nucleoplasm organelle lumen organelle nuclear lumen
P [auth AE], VA [auth BE]	26S protease regulatory subunit 10B	protein-macromolecule adaptor activity molecular adaptor activity binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding protein-macromolecule adaptor activity molecular adaptor activity binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding pyrophosphatase activity ATP hydrolysis activity ribonucleoside triphosphate phosphatase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity hydrolase activity, acting on acid anhydrides catalytic activity ATP-dependent activity identical protein binding protein binding proteasome-activating activity	positive regulation of proteasomal protein catabolic process catabolic process positive regulation of protein metabolic process proteolysis involved in protein catabolic process positive regulation of biological process macromolecule catabolic process regulation of primary metabolic process positive regulation of metabolic process organic substance metabolic process regulation of proteolysis regulation of proteolysis involved in protein catabolic process proteolysis positive regulation of macromolecule metabolic process protein metabolic process positive regulation of proteasomal protein catabolic process catabolic process positive regulation of protein metabolic process proteolysis involved in protein catabolic process positive regulation of biological process macromolecule catabolic process regulation of primary metabolic process positive regulation of metabolic process organic substance metabolic process regulation of proteolysis regulation of proteolysis involved in protein catabolic process proteolysis positive regulation of macromolecule metabolic process protein metabolic process organonitrogen compound catabolic process regulation of biological process organonitrogen compound metabolic process regulation of protein metabolic process biological regulation primary metabolic process proteasomal protein catabolic process regulation of macromolecule metabolic process protein catabolic process regulation of catabolic process positive regulation of protein catabolic process positive regulation of proteolysis involved in protein catabolic process positive regulation of catabolic process positive regulation of proteolysis regulation of proteasomal protein catabolic process metabolic process macromolecule metabolic process regulation of metabolic process organic substance catabolic process regulation of protein catabolic process positive regulation of cellular component organization regulation of cellular process regulation of cellular component organization positive regulation of cellular component biogenesis regulation of inclusion body assembly inclusion body assembly regulation of cellular component biogenesis cellular component organization cellular component biogenesis cellular component assembly positive regulation of inclusion body assembly cellular process cellular component organization or biogenesis positive regulation of cellular process transcription preinitiation complex assembly positive regulation of macromolecule biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription regulation of DNA-templated transcription initiation regulation of RNA metabolic process transcription by RNA polymerase II organic substance biosynthetic process regulation of nucleobase-containing compound metabolic process transcription initiation at RNA polymerase II promoter regulation of transcription by RNA polymerase II positive regulation of nucleobase-containing compound metabolic process cellular metabolic process regulation of cellular metabolic process positive regulation of transcription by RNA polymerase II positive regulation of DNA-templated transcription initiation positive regulation of RNA metabolic process organic cyclic compound metabolic process regulation of gene expression biosynthetic process organic cyclic compound biosynthetic process RNA polymerase II preinitiation complex assembly regulation of macromolecule biosynthetic process regulation of DNA-templated transcription regulation of RNA polymerase II transcription preinitiation complex assembly cellular biosynthetic process positive regulation of DNA-templated transcription RNA metabolic process positive regulation of cellular metabolic process protein-DNA complex organization RNA biosynthetic process nucleic acid biosynthetic process regulation of protein-containing complex assembly positive regulation of protein-containing complex assembly positive regulation of biosynthetic process protein-containing complex assembly regulation of RNA biosynthetic process regulation of biosynthetic process positive regulation of RNA polymerase II transcription preinitiation complex assembly protein-containing complex organization positive regulation of transcription initiation by RNA polymerase II protein-DNA complex assembly nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process DNA-templated transcription initiation nucleic acid metabolic process regulation of cellular biosynthetic process positive regulation of RNA biosynthetic process regulation of transcription initiation by RNA polymerase II positive regulation of cellular biosynthetic process proteasome-mediated ubiquitin-dependent protein catabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process ubiquitin-dependent protein catabolic process	proteasome accessory complex protein-containing complex intracellular anatomical structure catalytic complex peptidase complex proteasome complex endopeptidase complex cellular anatomical entity intracellular protein-containing complex membrane proteasome regulatory particle proteasome regulatory particle, base subcomplex extracellular exosome membrane-bounded organelle proteasome accessory complex protein-containing complex intracellular anatomical structure catalytic complex peptidase complex proteasome complex endopeptidase complex cellular anatomical entity intracellular protein-containing complex membrane proteasome regulatory particle proteasome regulatory particle, base subcomplex extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle extracellular space vesicle extracellular membrane-bounded organelle cytoplasm cytosol inclusion body nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle nucleoplasm organelle lumen nuclear lumen cytosolic proteasome complex
Q [auth AF], WA [auth BF]	26S protease regulatory subunit 6A	binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding pyrophosphatase activity ATP hydrolysis activity ribonucleoside triphosphate phosphatase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity hydrolase activity, acting on acid anhydrides catalytic activity ATP-dependent activity identical protein binding protein binding proteasome-activating activity	viral gene expression biological process involved in interspecies interaction between organisms negative regulation by host of viral transcription modulation by host of symbiont process negative regulation by host of viral process biological process involved in symbiotic interaction modulation by host of viral transcription modulation by host of viral process viral process biological process involved in interaction with symbiont viral transcription positive regulation of proteasomal protein catabolic process catabolic process positive regulation of protein metabolic process viral gene expression biological process involved in interspecies interaction between organisms negative regulation by host of viral transcription modulation by host of symbiont process negative regulation by host of viral process biological process involved in symbiotic interaction modulation by host of viral transcription modulation by host of viral process viral process biological process involved in interaction with symbiont viral transcription positive regulation of proteasomal protein catabolic process catabolic process positive regulation of protein metabolic process proteolysis involved in protein catabolic process positive regulation of biological process macromolecule catabolic process regulation of primary metabolic process positive regulation of metabolic process organic substance metabolic process regulation of proteolysis regulation of proteolysis involved in protein catabolic process proteolysis positive regulation of macromolecule metabolic process protein metabolic process organonitrogen compound catabolic process regulation of biological process organonitrogen compound metabolic process regulation of protein metabolic process biological regulation primary metabolic process proteasomal protein catabolic process regulation of macromolecule metabolic process protein catabolic process regulation of catabolic process positive regulation of protein catabolic process positive regulation of proteolysis involved in protein catabolic process positive regulation of catabolic process positive regulation of proteolysis regulation of proteasomal protein catabolic process metabolic process macromolecule metabolic process regulation of metabolic process organic substance catabolic process regulation of protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process ubiquitin-dependent protein catabolic process regulation of cellular process positive regulation of macromolecule biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription regulation of RNA metabolic process transcription by RNA polymerase II organic substance biosynthetic process regulation of nucleobase-containing compound metabolic process regulation of transcription by RNA polymerase II positive regulation of nucleobase-containing compound metabolic process cellular metabolic process regulation of cellular metabolic process positive regulation of transcription by RNA polymerase II positive regulation of RNA metabolic process organic cyclic compound metabolic process regulation of gene expression biosynthetic process organic cyclic compound biosynthetic process regulation of macromolecule biosynthetic process regulation of DNA-templated transcription positive regulation of DNA-templated transcription cellular biosynthetic process RNA metabolic process positive regulation of cellular metabolic process RNA biosynthetic process nucleic acid biosynthetic process positive regulation of biosynthetic process positive regulation of cellular process regulation of RNA biosynthetic process regulation of biosynthetic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process regulation of cellular biosynthetic process positive regulation of RNA biosynthetic process cellular process positive regulation of cellular biosynthetic process	proteasome accessory complex protein-containing complex intracellular anatomical structure catalytic complex peptidase complex proteasome complex endopeptidase complex cellular anatomical entity intracellular protein-containing complex membrane proteasome regulatory particle proteasome regulatory particle, base subcomplex cytoplasm cytosol proteasome accessory complex protein-containing complex intracellular anatomical structure catalytic complex peptidase complex proteasome complex endopeptidase complex cellular anatomical entity intracellular protein-containing complex membrane proteasome regulatory particle proteasome regulatory particle, base subcomplex cytoplasm cytosol membrane-bounded organelle membrane-enclosed lumen intracellular vesicle ficolin-1-rich granule intracellular membrane-bounded organelle endomembrane system intracellular organelle lumen intracellular organelle organelle lumen cytoplasmic vesicle ficolin-1-rich granule lumen organelle secretory granule secretory vesicle vesicle nucleus nucleoplasm nuclear lumen extracellular region vesicle lumen cytoplasmic vesicle lumen secretory granule lumen cytoplasmic ribonucleoprotein granule ribonucleoprotein granule intracellular non-membrane-bounded organelle supramolecular complex P-body non-membrane-bounded organelle
R [auth AC], XA [auth BC]	26S protease regulatory subunit 8	transcription factor binding protein binding binding general transcription initiation factor binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding transcription factor binding protein binding binding general transcription initiation factor binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding DNA-binding transcription factor binding pyrophosphatase activity ATP hydrolysis activity ribonucleoside triphosphate phosphatase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity hydrolase activity, acting on acid anhydrides catalytic activity ATP-dependent activity peptide hormone receptor binding signaling receptor binding G protein-coupled receptor binding thyrotropin-releasing hormone receptor binding hormone receptor binding proteasome-activating activity	regulation of cellular process negative regulation of biological process negative regulation of cellular metabolic process regulation of primary metabolic process negative regulation of RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription regulation of RNA metabolic process organic substance biosynthetic process negative regulation of nucleobase-containing compound metabolic process regulation of nucleobase-containing compound metabolic process negative regulation of DNA-templated transcription regulation of biological process cellular metabolic process regulation of cellular process negative regulation of biological process negative regulation of cellular metabolic process regulation of primary metabolic process negative regulation of RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription regulation of RNA metabolic process organic substance biosynthetic process negative regulation of nucleobase-containing compound metabolic process regulation of nucleobase-containing compound metabolic process negative regulation of DNA-templated transcription regulation of biological process cellular metabolic process negative regulation of metabolic process primary metabolic process regulation of cellular metabolic process negative regulation of cellular biosynthetic process organic cyclic compound metabolic process regulation of gene expression biosynthetic process negative regulation of macromolecule biosynthetic process organic cyclic compound biosynthetic process metabolic process regulation of macromolecule biosynthetic process macromolecule metabolic process regulation of DNA-templated transcription regulation of metabolic process negative regulation of RNA metabolic process cellular biosynthetic process RNA metabolic process RNA biosynthetic process nucleic acid biosynthetic process organic substance metabolic process negative regulation of cellular process regulation of RNA biosynthetic process negative regulation of macromolecule metabolic process regulation of biosynthetic process biological regulation regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process regulation of cellular biosynthetic process negative regulation of biosynthetic process cellular process positive regulation of proteasomal protein catabolic process catabolic process positive regulation of protein metabolic process proteolysis involved in protein catabolic process positive regulation of biological process macromolecule catabolic process positive regulation of metabolic process regulation of proteolysis regulation of proteolysis involved in protein catabolic process proteolysis positive regulation of macromolecule metabolic process protein metabolic process organonitrogen compound catabolic process organonitrogen compound metabolic process regulation of protein metabolic process proteasomal protein catabolic process protein catabolic process regulation of catabolic process positive regulation of protein catabolic process positive regulation of proteolysis involved in protein catabolic process positive regulation of catabolic process positive regulation of proteolysis regulation of proteasomal protein catabolic process organic substance catabolic process regulation of protein catabolic process negative regulation of programmed cell death regulation of programmed cell death cell death programmed cell death proteasome-mediated ubiquitin-dependent protein catabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process ubiquitin-dependent protein catabolic process positive regulation of macromolecule biosynthetic process positive regulation of nucleobase-containing compound metabolic process positive regulation of RNA metabolic process positive regulation of DNA-templated transcription positive regulation of cellular metabolic process positive regulation of biosynthetic process positive regulation of cellular process positive regulation of RNA biosynthetic process positive regulation of cellular biosynthetic process transcription by RNA polymerase II regulation of transcription by RNA polymerase II	proteasome accessory complex protein-containing complex intracellular anatomical structure catalytic complex peptidase complex proteasome complex endopeptidase complex cellular anatomical entity intracellular protein-containing complex membrane proteasome regulatory particle proteasome regulatory particle, base subcomplex extracellular exosome membrane-bounded organelle proteasome accessory complex protein-containing complex intracellular anatomical structure catalytic complex peptidase complex proteasome complex endopeptidase complex cellular anatomical entity intracellular protein-containing complex membrane proteasome regulatory particle proteasome regulatory particle, base subcomplex extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle extracellular space vesicle extracellular membrane-bounded organelle cytoplasm cytosol nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle nucleoplasm organelle lumen nuclear lumen cytoplasmic vesicle intracellular vesicle blood microparticle
S [auth AG], YA [auth BG]	Proteasome subunit alpha type-6	transcription factor binding RNA polymerase II-specific DNA-binding transcription factor binding protein binding binding DNA-binding transcription factor binding NF-kappaB binding RNA binding organic cyclic compound binding nucleic acid binding peptidase activity catalytic activity, acting on a protein hydrolase activity catalytic activity endopeptidase activity transcription factor binding RNA polymerase II-specific DNA-binding transcription factor binding protein binding binding DNA-binding transcription factor binding NF-kappaB binding RNA binding organic cyclic compound binding nucleic acid binding peptidase activity catalytic activity, acting on a protein hydrolase activity catalytic activity endopeptidase activity purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding anion binding heterocyclic compound binding small molecule binding	organonitrogen compound catabolic process organonitrogen compound metabolic process catabolic process proteolysis involved in protein catabolic process proteasomal protein catabolic process primary metabolic process protein catabolic process macromolecule catabolic process organic substance metabolic process proteolysis metabolic process protein metabolic process macromolecule metabolic process organic substance catabolic process organonitrogen compound catabolic process organonitrogen compound metabolic process catabolic process proteolysis involved in protein catabolic process proteasomal protein catabolic process primary metabolic process protein catabolic process macromolecule catabolic process organic substance metabolic process proteolysis metabolic process protein metabolic process macromolecule metabolic process organic substance catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process ubiquitin-dependent protein catabolic process positive regulation of DNA-binding transcription factor activity regulation of cellular process cellular biosynthetic process positive regulation of NF-kappaB transcription factor activity RNA metabolic process regulation of primary metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process positive regulation of molecular function nucleic acid biosynthetic process DNA-templated transcription regulation of RNA metabolic process organic substance biosynthetic process regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process regulation of biosynthetic process regulation of biological process cellular metabolic process biological regulation regulation of cellular metabolic process regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process regulation of cellular biosynthetic process regulation of molecular function organic cyclic compound metabolic process regulation of gene expression biosynthetic process regulation of DNA-binding transcription factor activity organic cyclic compound biosynthetic process regulation of macromolecule biosynthetic process cellular process regulation of DNA-templated transcription regulation of metabolic process regulation of defense response response to stimulus regulation of response to external stimulus defense response regulation of inflammatory response response to external stimulus regulation of response to stimulus response to stress regulation of response to stress inflammatory response	membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle lumen intracellular organelle organelle lumen organelle nuclear periphery nuclear lumen nuclear matrix protein-containing complex membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle lumen intracellular organelle organelle lumen organelle nuclear periphery nuclear lumen nuclear matrix protein-containing complex proteasome core complex, alpha-subunit complex catalytic complex peptidase complex proteasome complex endopeptidase complex proteasome core complex intracellular protein-containing complex extracellular exosome extracellular vesicle extracellular organelle extracellular region extracellular space vesicle extracellular membrane-bounded organelle cytoplasm cytosol nucleoplasm intracellular non-membrane-bounded organelle ribosome non-membrane-bounded organelle sarcomere contractile muscle fiber supramolecular fiber myofibril supramolecular polymer supramolecular complex cytoplasmic ribonucleoprotein granule ribonucleoprotein granule P-body
B [auth AV], HA [auth BV]	26S proteasome non-ATPase regulatory subunit 3	enzyme regulator activity molecular function regulator activity	organonitrogen compound catabolic process organonitrogen compound metabolic process catabolic process proteolysis involved in protein catabolic process primary metabolic process protein catabolic process macromolecule catabolic process organic substance metabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis ubiquitin-dependent protein catabolic process metabolic process protein metabolic process organonitrogen compound catabolic process organonitrogen compound metabolic process catabolic process proteolysis involved in protein catabolic process primary metabolic process protein catabolic process macromolecule catabolic process organic substance metabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis ubiquitin-dependent protein catabolic process metabolic process protein metabolic process macromolecule metabolic process organic substance catabolic process regulation of biological process regulation of protein metabolic process biological regulation regulation of macromolecule metabolic process regulation of catabolic process regulation of primary metabolic process regulation of metabolic process regulation of protein catabolic process proteasomal protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process	proteasome accessory complex protein-containing complex intracellular anatomical structure catalytic complex peptidase complex proteasome complex endopeptidase complex cellular anatomical entity intracellular protein-containing complex membrane extracellular region extracellular exosome membrane-bounded organelle extracellular vesicle proteasome accessory complex protein-containing complex intracellular anatomical structure catalytic complex peptidase complex proteasome complex endopeptidase complex cellular anatomical entity intracellular protein-containing complex membrane extracellular region extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle organelle extracellular space vesicle extracellular membrane-bounded organelle vesicle lumen intracellular vesicle membrane-enclosed lumen cytoplasmic vesicle lumen secretory granule lumen intracellular membrane-bounded organelle endomembrane system intracellular organelle lumen intracellular organelle cytoplasmic vesicle organelle lumen secretory granule secretory vesicle cytoplasm cytosol proteasome regulatory particle proteasome regulatory particle, lid subcomplex ficolin-1-rich granule ficolin-1-rich granule lumen nucleus nucleoplasm nuclear lumen
T [auth AH], ZA [auth BH]	Proteasome subunit alpha type-2	-	organonitrogen compound catabolic process organonitrogen compound metabolic process catabolic process proteolysis involved in protein catabolic process proteasomal protein catabolic process primary metabolic process protein catabolic process macromolecule catabolic process organic substance metabolic process proteolysis metabolic process protein metabolic process macromolecule metabolic process organic substance catabolic process organonitrogen compound catabolic process organonitrogen compound metabolic process catabolic process proteolysis involved in protein catabolic process proteasomal protein catabolic process primary metabolic process protein catabolic process macromolecule catabolic process organic substance metabolic process proteolysis metabolic process protein metabolic process macromolecule metabolic process organic substance catabolic process biological process involved in interspecies interaction between organisms response to stimulus response to other organism response to external stimulus response to external biotic stimulus response to virus response to biotic stimulus proteasome-mediated ubiquitin-dependent protein catabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process ubiquitin-dependent protein catabolic process	protein-containing complex catalytic complex peptidase complex proteasome complex endopeptidase complex intracellular protein-containing complex extracellular region cellular anatomical entity intracellular anatomical structure proteasome core complex, alpha-subunit complex proteasome core complex extracellular exosome membrane-bounded organelle extracellular vesicle protein-containing complex catalytic complex peptidase complex proteasome complex endopeptidase complex intracellular protein-containing complex extracellular region cellular anatomical entity intracellular anatomical structure proteasome core complex, alpha-subunit complex proteasome core complex extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle organelle extracellular space vesicle extracellular membrane-bounded organelle vesicle lumen intracellular vesicle membrane-enclosed lumen cytoplasmic vesicle lumen secretory granule lumen intracellular membrane-bounded organelle endomembrane system intracellular organelle lumen intracellular organelle cytoplasmic vesicle organelle lumen secretory granule secretory vesicle cytoplasm cytosol cytoplasmic ribonucleoprotein granule ribonucleoprotein granule intracellular non-membrane-bounded organelle supramolecular complex P-body non-membrane-bounded organelle ficolin-1-rich granule ficolin-1-rich granule lumen nucleus nucleoplasm nuclear lumen
AB [auth BI], U [auth AI]	Proteasome subunit alpha type-4	-	organonitrogen compound catabolic process organonitrogen compound metabolic process catabolic process proteolysis involved in protein catabolic process proteasomal protein catabolic process primary metabolic process protein catabolic process macromolecule catabolic process organic substance metabolic process proteolysis metabolic process protein metabolic process macromolecule metabolic process organic substance catabolic process organonitrogen compound catabolic process organonitrogen compound metabolic process catabolic process proteolysis involved in protein catabolic process proteasomal protein catabolic process primary metabolic process protein catabolic process macromolecule catabolic process organic substance metabolic process proteolysis metabolic process protein metabolic process macromolecule metabolic process organic substance catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process ubiquitin-dependent protein catabolic process	protein-containing complex catalytic complex peptidase complex proteasome complex endopeptidase complex intracellular protein-containing complex intracellular anatomical structure proteasome core complex, alpha-subunit complex proteasome core complex cellular anatomical entity extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle protein-containing complex catalytic complex peptidase complex proteasome complex endopeptidase complex intracellular protein-containing complex intracellular anatomical structure proteasome core complex, alpha-subunit complex proteasome core complex cellular anatomical entity extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle extracellular space vesicle extracellular membrane-bounded organelle cytoplasm cytosol intracellular organelle intracellular membrane-bounded organelle cytoplasmic ribonucleoprotein granule ribonucleoprotein granule intracellular non-membrane-bounded organelle supramolecular complex P-body non-membrane-bounded organelle nucleus membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen
BB [auth BJ], V [auth AJ]	Proteasome subunit alpha type-7	identical protein binding protein binding binding	organonitrogen compound catabolic process organonitrogen compound metabolic process catabolic process proteolysis involved in protein catabolic process proteasomal protein catabolic process primary metabolic process protein catabolic process macromolecule catabolic process organic substance metabolic process proteolysis metabolic process protein metabolic process macromolecule metabolic process organic substance catabolic process organonitrogen compound catabolic process organonitrogen compound metabolic process catabolic process proteolysis involved in protein catabolic process proteasomal protein catabolic process primary metabolic process protein catabolic process macromolecule catabolic process organic substance metabolic process proteolysis metabolic process protein metabolic process macromolecule metabolic process organic substance catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process ubiquitin-dependent protein catabolic process	protein-containing complex catalytic complex peptidase complex proteasome complex endopeptidase complex intracellular protein-containing complex intracellular anatomical structure proteasome core complex, alpha-subunit complex proteasome core complex cellular anatomical entity extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle protein-containing complex catalytic complex peptidase complex proteasome complex endopeptidase complex intracellular protein-containing complex intracellular anatomical structure proteasome core complex, alpha-subunit complex proteasome core complex cellular anatomical entity extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle extracellular space vesicle extracellular membrane-bounded organelle cytoplasm cytosol postsynapse synapse cell junction nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle nucleoplasm organelle lumen nuclear lumen
CB [auth BK], W [auth AK]	Proteasome subunit alpha type-5	-	organonitrogen compound catabolic process organonitrogen compound metabolic process catabolic process proteolysis involved in protein catabolic process proteasomal protein catabolic process primary metabolic process protein catabolic process macromolecule catabolic process organic substance metabolic process proteolysis metabolic process protein metabolic process macromolecule metabolic process organic substance catabolic process organonitrogen compound catabolic process organonitrogen compound metabolic process catabolic process proteolysis involved in protein catabolic process proteasomal protein catabolic process primary metabolic process protein catabolic process macromolecule catabolic process organic substance metabolic process proteolysis metabolic process protein metabolic process macromolecule metabolic process organic substance catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process ubiquitin-dependent protein catabolic process	protein-containing complex catalytic complex peptidase complex proteasome complex endopeptidase complex intracellular protein-containing complex extracellular region cellular anatomical entity intracellular anatomical structure proteasome core complex, alpha-subunit complex proteasome core complex extracellular exosome membrane-bounded organelle extracellular vesicle protein-containing complex catalytic complex peptidase complex proteasome complex endopeptidase complex intracellular protein-containing complex extracellular region cellular anatomical entity intracellular anatomical structure proteasome core complex, alpha-subunit complex proteasome core complex extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle organelle extracellular space vesicle extracellular membrane-bounded organelle vesicle lumen intracellular vesicle membrane-enclosed lumen cytoplasmic vesicle lumen secretory granule lumen intracellular membrane-bounded organelle endomembrane system intracellular organelle lumen intracellular organelle cytoplasmic vesicle organelle lumen secretory granule secretory vesicle cytoplasm cytosol ficolin-1-rich granule ficolin-1-rich granule lumen nucleus nucleoplasm nuclear lumen
DB [auth BL], X [auth AL]	Proteasome subunit alpha type-1	binding lipid binding lipopolysaccharide binding carbohydrate derivative binding	immune system process regulation of defense response response to stimulus regulation of response to external stimulus negative regulation of inflammatory response negative regulation of biological process inflammatory response to antigenic stimulus response to stress regulation of response to stress regulation of immune system process negative regulation of inflammatory response to antigenic stimulus regulation of biological process defense response immune response immune system process regulation of defense response response to stimulus regulation of response to external stimulus negative regulation of inflammatory response negative regulation of biological process inflammatory response to antigenic stimulus response to stress regulation of response to stress regulation of immune system process negative regulation of inflammatory response to antigenic stimulus regulation of biological process defense response immune response negative regulation of response to stimulus negative regulation of immune response regulation of inflammatory response to antigenic stimulus biological regulation response to external stimulus regulation of inflammatory response regulation of response to stimulus negative regulation of immune system process negative regulation of response to external stimulus negative regulation of defense response regulation of immune response inflammatory response organonitrogen compound catabolic process organonitrogen compound metabolic process catabolic process proteolysis involved in protein catabolic process proteasomal protein catabolic process primary metabolic process protein catabolic process macromolecule catabolic process organic substance metabolic process proteolysis metabolic process protein metabolic process macromolecule metabolic process organic substance catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process ubiquitin-dependent protein catabolic process	protein-containing complex catalytic complex peptidase complex proteasome complex endopeptidase complex intracellular protein-containing complex intracellular anatomical structure proteasome core complex, alpha-subunit complex proteasome core complex cellular anatomical entity extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle protein-containing complex catalytic complex peptidase complex proteasome complex endopeptidase complex intracellular protein-containing complex intracellular anatomical structure proteasome core complex, alpha-subunit complex proteasome core complex cellular anatomical entity extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle extracellular space vesicle extracellular membrane-bounded organelle intracellular organelle centrosome microtubule organizing center cytoskeleton intracellular non-membrane-bounded organelle microtubule cytoskeleton non-membrane-bounded organelle cytoplasm cytosol nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen
EB [auth BM], Y [auth AM]	Proteasome subunit alpha type-3	ubiquitin protein ligase binding protein binding binding ubiquitin-like protein ligase binding enzyme binding	organonitrogen compound catabolic process organonitrogen compound metabolic process catabolic process proteolysis involved in protein catabolic process proteasomal protein catabolic process primary metabolic process protein catabolic process macromolecule catabolic process organic substance metabolic process proteolysis metabolic process protein metabolic process macromolecule metabolic process organic substance catabolic process organonitrogen compound catabolic process organonitrogen compound metabolic process catabolic process proteolysis involved in protein catabolic process proteasomal protein catabolic process primary metabolic process protein catabolic process macromolecule catabolic process organic substance metabolic process proteolysis metabolic process protein metabolic process macromolecule metabolic process organic substance catabolic process regulation of biological process regulation of catalytic activity regulation of protein metabolic process regulation of peptidase activity biological regulation regulation of macromolecule metabolic process regulation of primary metabolic process regulation of molecular function regulation of proteolysis regulation of hydrolase activity regulation of endopeptidase activity regulation of metabolic process proteasome-mediated ubiquitin-dependent protein catabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process ubiquitin-dependent protein catabolic process	protein-containing complex catalytic complex peptidase complex proteasome complex endopeptidase complex intracellular protein-containing complex intracellular anatomical structure proteasome core complex, alpha-subunit complex proteasome core complex cellular anatomical entity extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle protein-containing complex catalytic complex peptidase complex proteasome complex endopeptidase complex intracellular protein-containing complex intracellular anatomical structure proteasome core complex, alpha-subunit complex proteasome core complex cellular anatomical entity extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle extracellular space vesicle extracellular membrane-bounded organelle synapse cell junction cytoplasm cytosol nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle nucleoplasm organelle lumen nuclear lumen
FB [auth BN], Z [auth AN]	Proteasome subunit beta type-6	cell adhesion molecule binding cadherin binding protein binding binding peptidase activity catalytic activity, acting on a protein threonine-type peptidase activity hydrolase activity catalytic activity endopeptidase activity threonine-type endopeptidase activity	organonitrogen compound catabolic process organonitrogen compound metabolic process catabolic process proteolysis involved in protein catabolic process proteasomal protein catabolic process primary metabolic process protein catabolic process macromolecule catabolic process organic substance metabolic process proteolysis metabolic process protein metabolic process macromolecule metabolic process organic substance catabolic process organonitrogen compound catabolic process organonitrogen compound metabolic process catabolic process proteolysis involved in protein catabolic process proteasomal protein catabolic process primary metabolic process protein catabolic process macromolecule catabolic process organic substance metabolic process proteolysis metabolic process protein metabolic process macromolecule metabolic process organic substance catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process ubiquitin-dependent protein catabolic process	membrane-bounded organelle intracellular organelle intracellular anatomical structure mitochondrion organelle cytoplasm cellular anatomical entity intracellular membrane-bounded organelle protein-containing complex catalytic complex peptidase complex proteasome complex endopeptidase complex intracellular protein-containing complex membrane-bounded organelle intracellular organelle intracellular anatomical structure mitochondrion organelle cytoplasm cellular anatomical entity intracellular membrane-bounded organelle protein-containing complex catalytic complex peptidase complex proteasome complex endopeptidase complex intracellular protein-containing complex extracellular exosome extracellular vesicle extracellular organelle extracellular region extracellular space vesicle extracellular membrane-bounded organelle cytosol proteasome core complex proteasome core complex, beta-subunit complex nucleus membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen
AA [auth AO], GB [auth BO]	Proteasome subunit beta type-7	peptidase activity catalytic activity, acting on a protein threonine-type peptidase activity hydrolase activity catalytic activity endopeptidase activity threonine-type endopeptidase activity	organonitrogen compound catabolic process organonitrogen compound metabolic process catabolic process proteolysis involved in protein catabolic process proteasomal protein catabolic process primary metabolic process protein catabolic process macromolecule catabolic process organic substance metabolic process proteolysis metabolic process protein metabolic process macromolecule metabolic process organic substance catabolic process organonitrogen compound catabolic process organonitrogen compound metabolic process catabolic process proteolysis involved in protein catabolic process proteasomal protein catabolic process primary metabolic process protein catabolic process macromolecule catabolic process organic substance metabolic process proteolysis metabolic process protein metabolic process macromolecule metabolic process organic substance catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process ubiquitin-dependent protein catabolic process	protein-containing complex catalytic complex peptidase complex proteasome complex endopeptidase complex intracellular protein-containing complex extracellular region cellular anatomical entity membrane-bounded organelle vesicle lumen intracellular anatomical structure intracellular vesicle membrane-enclosed lumen cytoplasmic vesicle lumen protein-containing complex catalytic complex peptidase complex proteasome complex endopeptidase complex intracellular protein-containing complex extracellular region cellular anatomical entity membrane-bounded organelle vesicle lumen intracellular anatomical structure intracellular vesicle membrane-enclosed lumen cytoplasmic vesicle lumen secretory granule lumen intracellular membrane-bounded organelle endomembrane system intracellular organelle lumen intracellular organelle cytoplasmic vesicle organelle lumen organelle secretory granule secretory vesicle cytoplasm vesicle cytosol proteasome core complex proteasome core complex, beta-subunit complex nucleus nuclear body nucleoplasm nuclear lumen ficolin-1-rich granule ficolin-1-rich granule lumen
BA [auth AP], HB [auth BP]	Proteasome subunit beta type-3	-	organonitrogen compound catabolic process organonitrogen compound metabolic process catabolic process proteolysis involved in protein catabolic process proteasomal protein catabolic process primary metabolic process protein catabolic process macromolecule catabolic process organic substance metabolic process proteolysis metabolic process protein metabolic process macromolecule metabolic process organic substance catabolic process organonitrogen compound catabolic process organonitrogen compound metabolic process catabolic process proteolysis involved in protein catabolic process proteasomal protein catabolic process primary metabolic process protein catabolic process macromolecule catabolic process organic substance metabolic process proteolysis metabolic process protein metabolic process macromolecule metabolic process organic substance catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process ubiquitin-dependent protein catabolic process	protein-containing complex catalytic complex peptidase complex proteasome complex endopeptidase complex intracellular protein-containing complex extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle extracellular space cellular anatomical entity protein-containing complex catalytic complex peptidase complex proteasome complex endopeptidase complex intracellular protein-containing complex extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle extracellular space cellular anatomical entity vesicle extracellular membrane-bounded organelle intracellular anatomical structure cytoplasm cytosol proteasome core complex proteasome core complex, beta-subunit complex nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle nucleoplasm organelle lumen nuclear lumen
CA [auth AQ], IB [auth BQ]	Proteasome subunit beta type-2	-	response to organic substance response to stimulus response to organonitrogen compound response to chemical response to nitrogen compound organonitrogen compound catabolic process organonitrogen compound metabolic process catabolic process proteolysis involved in protein catabolic process proteasomal protein catabolic process primary metabolic process protein catabolic process macromolecule catabolic process organic substance metabolic process response to organic substance response to stimulus response to organonitrogen compound response to chemical response to nitrogen compound organonitrogen compound catabolic process organonitrogen compound metabolic process catabolic process proteolysis involved in protein catabolic process proteasomal protein catabolic process primary metabolic process protein catabolic process macromolecule catabolic process organic substance metabolic process proteolysis metabolic process protein metabolic process macromolecule metabolic process organic substance catabolic process response to organic cyclic compound proteasome-mediated ubiquitin-dependent protein catabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process ubiquitin-dependent protein catabolic process	protein-containing complex catalytic complex peptidase complex proteasome complex endopeptidase complex intracellular protein-containing complex membrane cellular anatomical entity extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle protein-containing complex catalytic complex peptidase complex proteasome complex endopeptidase complex intracellular protein-containing complex membrane cellular anatomical entity extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle extracellular space vesicle extracellular membrane-bounded organelle intracellular anatomical structure cytoplasm cytosol proteasome core complex proteasome core complex, beta-subunit complex nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle nucleoplasm organelle lumen nuclear lumen
C [auth AW], IA [auth BW]	26S proteasome non-ATPase regulatory subunit 12	-	organonitrogen compound catabolic process organonitrogen compound metabolic process catabolic process proteolysis involved in protein catabolic process primary metabolic process proteasomal protein catabolic process protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process macromolecule catabolic process organic substance metabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis ubiquitin-dependent protein catabolic process organonitrogen compound catabolic process organonitrogen compound metabolic process catabolic process proteolysis involved in protein catabolic process primary metabolic process proteasomal protein catabolic process protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process macromolecule catabolic process organic substance metabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis ubiquitin-dependent protein catabolic process metabolic process protein metabolic process macromolecule metabolic process organic substance catabolic process	proteasome accessory complex protein-containing complex intracellular anatomical structure catalytic complex peptidase complex proteasome complex endopeptidase complex cellular anatomical entity intracellular protein-containing complex membrane proteasome regulatory particle extracellular region extracellular exosome membrane-bounded organelle proteasome accessory complex protein-containing complex intracellular anatomical structure catalytic complex peptidase complex proteasome complex endopeptidase complex cellular anatomical entity intracellular protein-containing complex membrane proteasome regulatory particle extracellular region extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle organelle extracellular space vesicle extracellular membrane-bounded organelle vesicle lumen intracellular vesicle membrane-enclosed lumen cytoplasmic vesicle lumen secretory granule lumen intracellular membrane-bounded organelle endomembrane system intracellular organelle lumen intracellular organelle cytoplasmic vesicle organelle lumen secretory granule secretory vesicle cytoplasm cytosol proteasome regulatory particle, lid subcomplex ficolin-1-rich granule ficolin-1-rich granule lumen nucleus nucleoplasm nuclear lumen
DA [auth AR], JB [auth BR]	Proteasome subunit beta type-5	peptidase activity catalytic activity, acting on a protein threonine-type peptidase activity hydrolase activity catalytic activity endopeptidase activity threonine-type endopeptidase activity	organonitrogen compound catabolic process organonitrogen compound metabolic process catabolic process proteolysis involved in protein catabolic process proteasomal protein catabolic process primary metabolic process protein catabolic process macromolecule catabolic process organic substance metabolic process proteolysis metabolic process protein metabolic process macromolecule metabolic process organic substance catabolic process organonitrogen compound catabolic process organonitrogen compound metabolic process catabolic process proteolysis involved in protein catabolic process proteasomal protein catabolic process primary metabolic process protein catabolic process macromolecule catabolic process organic substance metabolic process proteolysis metabolic process protein metabolic process macromolecule metabolic process organic substance catabolic process response to oxidative stress response to stimulus response to stress proteasome-mediated ubiquitin-dependent protein catabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process ubiquitin-dependent protein catabolic process	protein-containing complex catalytic complex peptidase complex proteasome complex endopeptidase complex intracellular protein-containing complex extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle extracellular space cellular anatomical entity protein-containing complex catalytic complex peptidase complex proteasome complex endopeptidase complex intracellular protein-containing complex extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle extracellular space cellular anatomical entity vesicle extracellular membrane-bounded organelle intracellular organelle centrosome microtubule organizing center intracellular anatomical structure cytoskeleton intracellular non-membrane-bounded organelle microtubule cytoskeleton non-membrane-bounded organelle cytoplasm cytosol proteasome core complex proteasome core complex, beta-subunit complex nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen
EA [auth AS], KB [auth BS]	Proteasome subunit beta type-1	-	organonitrogen compound catabolic process organonitrogen compound metabolic process catabolic process proteolysis involved in protein catabolic process primary metabolic process proteasomal protein catabolic process protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process macromolecule catabolic process organic substance metabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis ubiquitin-dependent protein catabolic process organonitrogen compound catabolic process organonitrogen compound metabolic process catabolic process proteolysis involved in protein catabolic process primary metabolic process proteasomal protein catabolic process protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process macromolecule catabolic process organic substance metabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis ubiquitin-dependent protein catabolic process metabolic process protein metabolic process macromolecule metabolic process organic substance catabolic process	protein-containing complex catalytic complex peptidase complex proteasome complex endopeptidase complex intracellular protein-containing complex extracellular region cellular anatomical entity extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle organelle extracellular space protein-containing complex catalytic complex peptidase complex proteasome complex endopeptidase complex intracellular protein-containing complex extracellular region cellular anatomical entity extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle organelle extracellular space vesicle extracellular membrane-bounded organelle vesicle lumen intracellular anatomical structure intracellular vesicle membrane-enclosed lumen cytoplasmic vesicle lumen secretory granule lumen intracellular membrane-bounded organelle endomembrane system intracellular organelle lumen intracellular organelle cytoplasmic vesicle organelle lumen secretory granule secretory vesicle cytoplasm cytosol proteasome core complex proteasome core complex, beta-subunit complex ficolin-1-rich granule ficolin-1-rich granule lumen nucleus nucleoplasm nuclear lumen
FA [auth AT], LB [auth BT]	Proteasome subunit beta type-4	binding lipid binding lipopolysaccharide binding carbohydrate derivative binding	regulation of defense response response to stimulus regulation of response to external stimulus negative regulation of inflammatory response negative regulation of biological process inflammatory response to antigenic stimulus response to stress regulation of response to stress regulation of immune system process negative regulation of inflammatory response to antigenic stimulus regulation of biological process defense response immune response negative regulation of response to stimulus regulation of defense response response to stimulus regulation of response to external stimulus negative regulation of inflammatory response negative regulation of biological process inflammatory response to antigenic stimulus response to stress regulation of response to stress regulation of immune system process negative regulation of inflammatory response to antigenic stimulus regulation of biological process defense response immune response negative regulation of response to stimulus negative regulation of immune response regulation of inflammatory response to antigenic stimulus biological regulation response to external stimulus regulation of inflammatory response regulation of response to stimulus negative regulation of immune system process immune system process negative regulation of response to external stimulus negative regulation of defense response regulation of immune response inflammatory response organonitrogen compound catabolic process organonitrogen compound metabolic process catabolic process proteolysis involved in protein catabolic process proteasomal protein catabolic process primary metabolic process protein catabolic process macromolecule catabolic process organic substance metabolic process proteolysis metabolic process protein metabolic process macromolecule metabolic process organic substance catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process ubiquitin-dependent protein catabolic process	membrane-bounded organelle intracellular organelle intracellular anatomical structure mitochondrion organelle cytoplasm cellular anatomical entity intracellular membrane-bounded organelle protein-containing complex catalytic complex peptidase complex proteasome complex endopeptidase complex intracellular protein-containing complex membrane-bounded organelle intracellular organelle intracellular anatomical structure mitochondrion organelle cytoplasm cellular anatomical entity intracellular membrane-bounded organelle protein-containing complex catalytic complex peptidase complex proteasome complex endopeptidase complex intracellular protein-containing complex extracellular exosome extracellular vesicle extracellular organelle extracellular region extracellular space vesicle extracellular membrane-bounded organelle cytosol proteasome core complex proteasome core complex, beta-subunit complex nucleus membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen cilium plasma membrane bounded cell projection ciliary basal body cell projection microtubule organizing center cytoskeleton intracellular non-membrane-bounded organelle microtubule cytoskeleton non-membrane-bounded organelle
D [auth AX], JA [auth BX]	26S proteasome non-ATPase regulatory subunit 11	structural molecule activity	organonitrogen compound catabolic process organonitrogen compound metabolic process catabolic process proteolysis involved in protein catabolic process primary metabolic process protein catabolic process macromolecule catabolic process organic substance metabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis ubiquitin-dependent protein catabolic process metabolic process protein metabolic process organonitrogen compound catabolic process organonitrogen compound metabolic process catabolic process proteolysis involved in protein catabolic process primary metabolic process protein catabolic process macromolecule catabolic process organic substance metabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis ubiquitin-dependent protein catabolic process metabolic process protein metabolic process macromolecule metabolic process organic substance catabolic process cellular component organization cellular component biogenesis proteasome assembly cellular component assembly protein-containing complex organization protein-containing complex assembly cellular process cellular component organization or biogenesis developmental process stem cell differentiation cellular developmental process cell differentiation proteasomal protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process	proteasome accessory complex protein-containing complex intracellular anatomical structure catalytic complex peptidase complex proteasome complex endopeptidase complex cellular anatomical entity intracellular protein-containing complex membrane extracellular region membrane-bounded organelle vesicle lumen intracellular vesicle proteasome accessory complex protein-containing complex intracellular anatomical structure catalytic complex peptidase complex proteasome complex endopeptidase complex cellular anatomical entity intracellular protein-containing complex membrane extracellular region membrane-bounded organelle vesicle lumen intracellular vesicle membrane-enclosed lumen cytoplasmic vesicle lumen secretory granule lumen intracellular membrane-bounded organelle endomembrane system intracellular organelle lumen intracellular organelle cytoplasmic vesicle organelle lumen organelle secretory granule secretory vesicle cytoplasm vesicle cytosol proteasome regulatory particle proteasome regulatory particle, lid subcomplex ficolin-1-rich granule ficolin-1-rich granule lumen nucleus nucleoplasm nuclear lumen
E [auth AY], KA [auth BY]	26S proteasome non-ATPase regulatory subunit 6	-	organonitrogen compound catabolic process organonitrogen compound metabolic process catabolic process proteolysis involved in protein catabolic process primary metabolic process proteasomal protein catabolic process protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process macromolecule catabolic process organic substance metabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis ubiquitin-dependent protein catabolic process organonitrogen compound catabolic process organonitrogen compound metabolic process catabolic process proteolysis involved in protein catabolic process primary metabolic process proteasomal protein catabolic process protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process macromolecule catabolic process organic substance metabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis ubiquitin-dependent protein catabolic process metabolic process protein metabolic process macromolecule metabolic process organic substance catabolic process	proteasome accessory complex protein-containing complex intracellular anatomical structure catalytic complex peptidase complex proteasome complex endopeptidase complex cellular anatomical entity intracellular protein-containing complex proteasome regulatory particle extracellular region membrane-bounded organelle vesicle lumen intracellular vesicle proteasome accessory complex protein-containing complex intracellular anatomical structure catalytic complex peptidase complex proteasome complex endopeptidase complex cellular anatomical entity intracellular protein-containing complex proteasome regulatory particle extracellular region membrane-bounded organelle vesicle lumen intracellular vesicle membrane-enclosed lumen cytoplasmic vesicle lumen secretory granule lumen intracellular membrane-bounded organelle endomembrane system intracellular organelle lumen intracellular organelle cytoplasmic vesicle organelle lumen organelle secretory granule secretory vesicle cytoplasm vesicle cytosol ficolin-1-rich granule ficolin-1-rich granule lumen nucleus nucleoplasm nuclear lumen
F [auth AZ], LA [auth BZ]	26S proteasome non-ATPase regulatory subunit 7	identical protein binding protein binding binding protein homodimerization activity protein dimerization activity	organonitrogen compound catabolic process organonitrogen compound metabolic process catabolic process proteolysis involved in protein catabolic process primary metabolic process proteasomal protein catabolic process protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process macromolecule catabolic process organic substance metabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis ubiquitin-dependent protein catabolic process organonitrogen compound catabolic process organonitrogen compound metabolic process catabolic process proteolysis involved in protein catabolic process primary metabolic process proteasomal protein catabolic process protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process macromolecule catabolic process organic substance metabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis ubiquitin-dependent protein catabolic process metabolic process protein metabolic process macromolecule metabolic process organic substance catabolic process	protein-containing complex catalytic complex peptidase complex proteasome complex endopeptidase complex intracellular protein-containing complex membrane cellular anatomical entity proteasome accessory complex intracellular anatomical structure proteasome regulatory particle extracellular region extracellular exosome membrane-bounded organelle protein-containing complex catalytic complex peptidase complex proteasome complex endopeptidase complex intracellular protein-containing complex membrane cellular anatomical entity proteasome accessory complex intracellular anatomical structure proteasome regulatory particle extracellular region extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle organelle extracellular space vesicle extracellular membrane-bounded organelle vesicle lumen intracellular vesicle membrane-enclosed lumen cytoplasmic vesicle lumen secretory granule lumen intracellular membrane-bounded organelle endomembrane system intracellular organelle lumen intracellular organelle cytoplasmic vesicle organelle lumen secretory granule secretory vesicle cytoplasm cytosol ficolin-1-rich granule ficolin-1-rich granule lumen nucleus nucleoplasm nuclear lumen
G [auth Aa], MA [auth Ba]	26S proteasome non-ATPase regulatory subunit 13	structural molecule activity	organonitrogen compound catabolic process organonitrogen compound metabolic process catabolic process proteolysis involved in protein catabolic process primary metabolic process protein catabolic process macromolecule catabolic process organic substance metabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis ubiquitin-dependent protein catabolic process metabolic process protein metabolic process organonitrogen compound catabolic process organonitrogen compound metabolic process catabolic process proteolysis involved in protein catabolic process primary metabolic process protein catabolic process macromolecule catabolic process organic substance metabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis ubiquitin-dependent protein catabolic process metabolic process protein metabolic process macromolecule metabolic process organic substance catabolic process sexual reproduction reproductive process meiotic cell cycle organelle fission meiotic cell cycle process cellular component organization nuclear division organelle organization meiosis I meiosis I cell cycle process cellular process meiotic nuclear division cell cycle cellular component organization or biogenesis cell cycle process proteasomal protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process	proteasome accessory complex protein-containing complex intracellular anatomical structure catalytic complex peptidase complex proteasome complex endopeptidase complex cellular anatomical entity intracellular protein-containing complex membrane proteasome regulatory particle extracellular region membrane-bounded organelle vesicle lumen proteasome accessory complex protein-containing complex intracellular anatomical structure catalytic complex peptidase complex proteasome complex endopeptidase complex cellular anatomical entity intracellular protein-containing complex membrane proteasome regulatory particle extracellular region membrane-bounded organelle vesicle lumen intracellular vesicle membrane-enclosed lumen cytoplasmic vesicle lumen secretory granule lumen intracellular membrane-bounded organelle endomembrane system intracellular organelle lumen intracellular organelle cytoplasmic vesicle organelle lumen organelle secretory granule secretory vesicle cytoplasm vesicle cytosol proteasome regulatory particle, lid subcomplex ficolin-1-rich granule ficolin-1-rich granule lumen nucleus nucleoplasm nuclear lumen
H [auth Ab], NA [auth Bb]	26S proteasome non-ATPase regulatory subunit 4	polyubiquitin modification-dependent protein binding protein binding binding modification-dependent protein binding molecular adaptor activity RNA binding organic cyclic compound binding nucleic acid binding identical protein binding	organonitrogen compound catabolic process organonitrogen compound metabolic process catabolic process proteolysis involved in protein catabolic process primary metabolic process proteasomal protein catabolic process protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process macromolecule catabolic process organic substance metabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis ubiquitin-dependent protein catabolic process organonitrogen compound catabolic process organonitrogen compound metabolic process catabolic process proteolysis involved in protein catabolic process primary metabolic process proteasomal protein catabolic process protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process macromolecule catabolic process organic substance metabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis ubiquitin-dependent protein catabolic process metabolic process protein metabolic process macromolecule metabolic process organic substance catabolic process	proteasome accessory complex protein-containing complex intracellular anatomical structure catalytic complex peptidase complex proteasome complex endopeptidase complex cellular anatomical entity intracellular protein-containing complex proteasome regulatory particle proteasome regulatory particle, base subcomplex cytoplasm cytosol membrane-bounded organelle proteasome accessory complex protein-containing complex intracellular anatomical structure catalytic complex peptidase complex proteasome complex endopeptidase complex cellular anatomical entity intracellular protein-containing complex proteasome regulatory particle proteasome regulatory particle, base subcomplex cytoplasm cytosol membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle nucleoplasm organelle lumen organelle nuclear lumen
I [auth Ac], OA [auth Bc]	26S proteasome non-ATPase regulatory subunit 14	peptidase activity catalytic activity, acting on a protein metallopeptidase activity hydrolase activity catalytic activity ubiquitin-like protein peptidase activity metal-dependent deubiquitinase activity deubiquitinase activity K63-linked deubiquitinase activity protein-containing complex binding binding proteasome binding endopeptidase activator activity enzyme regulator activity peptidase activity catalytic activity, acting on a protein metallopeptidase activity hydrolase activity catalytic activity ubiquitin-like protein peptidase activity metal-dependent deubiquitinase activity deubiquitinase activity K63-linked deubiquitinase activity protein-containing complex binding binding proteasome binding endopeptidase activator activity enzyme regulator activity enzyme activator activity peptidase regulator activity molecular function activator activity molecular function regulator activity peptidase activator activity endopeptidase regulator activity cation binding ion binding metal ion binding small molecule binding	protein deubiquitination organonitrogen compound metabolic process protein K63-linked deubiquitination primary metabolic process organic substance metabolic process protein modification by small protein removal macromolecule modification metabolic process protein metabolic process macromolecule metabolic process post-translational protein modification protein modification process protein modification by small protein conjugation or removal organonitrogen compound catabolic process protein deubiquitination organonitrogen compound metabolic process protein K63-linked deubiquitination primary metabolic process organic substance metabolic process protein modification by small protein removal macromolecule modification metabolic process protein metabolic process macromolecule metabolic process post-translational protein modification protein modification process protein modification by small protein conjugation or removal organonitrogen compound catabolic process catabolic process proteolysis involved in protein catabolic process proteasomal protein catabolic process protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process macromolecule catabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis ubiquitin-dependent protein catabolic process organic substance catabolic process response to organic substance response to stimulus response to alcohol response to chemical response to oxygen-containing compound response to ethanol cellular response to stimulus double-strand break repair DNA recombination DNA metabolic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process cellular response to stress DNA damage response response to stress recombinational repair cellular process double-strand break repair via homologous recombination DNA repair regulation of primary metabolic process regulation of proteolysis involved in protein catabolic process regulation of proteolysis regulation of biological process regulation of protein metabolic process biological regulation regulation of macromolecule metabolic process regulation of catabolic process regulation of proteasomal protein catabolic process regulation of metabolic process regulation of protein catabolic process double-strand break repair via nonhomologous end joining	proteasome accessory complex protein-containing complex intracellular anatomical structure catalytic complex peptidase complex proteasome complex endopeptidase complex cellular anatomical entity intracellular protein-containing complex cytoplasm cytosol proteasome regulatory particle proteasome regulatory particle, lid subcomplex membrane-bounded organelle proteasome accessory complex protein-containing complex intracellular anatomical structure catalytic complex peptidase complex proteasome complex endopeptidase complex cellular anatomical entity intracellular protein-containing complex cytoplasm cytosol proteasome regulatory particle proteasome regulatory particle, lid subcomplex membrane-bounded organelle membrane-enclosed lumen intracellular vesicle ficolin-1-rich granule intracellular membrane-bounded organelle endomembrane system intracellular organelle lumen intracellular organelle organelle lumen cytoplasmic vesicle ficolin-1-rich granule lumen organelle secretory granule secretory vesicle vesicle nucleus nucleoplasm nuclear lumen cytosolic proteasome complex extracellular region vesicle lumen cytoplasmic vesicle lumen secretory granule lumen

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A [auth AU], GA [auth BU]	IPR040623	26S proteasome regulatory subunit RPN2, C-terminal	Domain
A [auth AU], GA [auth BU]	IPR016024	Armadillo-type fold	Homologous Superfamily
A [auth AU], GA [auth BU]	IPR002015	Proteasome/cyclosome repeat	Repeat
A [auth AU], GA [auth BU]	IPR011989	Armadillo-like helical	Homologous Superfamily
A [auth AU], GA [auth BU]	IPR048570	26S proteasome non-ATPase regulatory subunit 1/RPN2, N-terminal domain	Domain
A [auth AU], GA [auth BU]	IPR016642	26S proteasome regulatory complex, non-ATPase subcomplex, Rpn2/Psmd1 subunit	Family
J [auth Ad], PA [auth Bd]	IPR000717	Proteasome component (PCI) domain	Domain
J [auth Ad], PA [auth Bd]	IPR006746	26S proteasome non-ATPase regulatory subunit Rpn12	Family
J [auth Ad], PA [auth Bd]	IPR033464	CSN8/PSMD8/EIF3K	Domain
K [auth Ae], QA [auth Be]	IPR007834	DSS1/SEM1	Family
L [auth Af], RA [auth Bf]	IPR041433	26S proteasome non-ATPase regulatory subunit RPN1, C-terminal	Domain
L [auth Af], RA [auth Bf]	IPR016024	Armadillo-type fold	Homologous Superfamily
L [auth Af], RA [auth Bf]	IPR002015	Proteasome/cyclosome repeat	Repeat
L [auth Af], RA [auth Bf]	IPR016643	26S proteasome regulatory complex, non-ATPase subcomplex, Rpn1 subunit	Family
L [auth Af], RA [auth Bf]	IPR011989	Armadillo-like helical	Homologous Superfamily
L [auth Af], RA [auth Bf]	IPR040892	RPN1, N-terminal	Domain
M [auth AA], SA [auth BA]	IPR003593	AAA+ ATPase domain	Domain
M [auth AA], SA [auth BA]	IPR003959	ATPase, AAA-type, core	Domain
M [auth AA], SA [auth BA]	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily
M [auth AA], SA [auth BA]	IPR048723	26S proteasome regulatory subunit 7-like, OB domain	Domain
M [auth AA], SA [auth BA]	IPR041569	AAA ATPase, AAA+ lid domain	Domain
M [auth AA], SA [auth BA]	IPR003960	ATPase, AAA-type, conserved site	Conserved Site
M [auth AA], SA [auth BA]	IPR012340	Nucleic acid-binding, OB-fold	Homologous Superfamily
N [auth AB], TA [auth BB]	IPR041569	AAA ATPase, AAA+ lid domain	Domain
N [auth AB], TA [auth BB]	IPR032501	Proteasomal ATPase, second OB domain	Domain
N [auth AB], TA [auth BB]	IPR003960	ATPase, AAA-type, conserved site	Conserved Site
N [auth AB], TA [auth BB]	IPR003593	AAA+ ATPase domain	Domain
N [auth AB], TA [auth BB]	IPR003959	ATPase, AAA-type, core	Domain
N [auth AB], TA [auth BB]	IPR012340	Nucleic acid-binding, OB-fold	Homologous Superfamily
N [auth AB], TA [auth BB]	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily
O [auth AD], UA [auth BD]	IPR041569	AAA ATPase, AAA+ lid domain	Domain
O [auth AD], UA [auth BD]	IPR032501	Proteasomal ATPase, second OB domain	Domain
O [auth AD], UA [auth BD]	IPR003960	ATPase, AAA-type, conserved site	Conserved Site
O [auth AD], UA [auth BD]	IPR003593	AAA+ ATPase domain	Domain
O [auth AD], UA [auth BD]	IPR003959	ATPase, AAA-type, core	Domain
O [auth AD], UA [auth BD]	IPR012340	Nucleic acid-binding, OB-fold	Homologous Superfamily
O [auth AD], UA [auth BD]	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily
P [auth AE], VA [auth BE]	IPR003593	AAA+ ATPase domain	Domain
P [auth AE], VA [auth BE]	IPR003959	ATPase, AAA-type, core	Domain
P [auth AE], VA [auth BE]	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily
P [auth AE], VA [auth BE]	IPR041569	AAA ATPase, AAA+ lid domain	Domain
P [auth AE], VA [auth BE]	IPR032501	Proteasomal ATPase, second OB domain	Domain
P [auth AE], VA [auth BE]	IPR003960	ATPase, AAA-type, conserved site	Conserved Site
P [auth AE], VA [auth BE]	IPR012340	Nucleic acid-binding, OB-fold	Homologous Superfamily
Q [auth AF], WA [auth BF]	IPR003593	AAA+ ATPase domain	Domain
Q [auth AF], WA [auth BF]	IPR003959	ATPase, AAA-type, core	Domain
Q [auth AF], WA [auth BF]	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily
Q [auth AF], WA [auth BF]	IPR041569	AAA ATPase, AAA+ lid domain	Domain
Q [auth AF], WA [auth BF]	IPR032501	Proteasomal ATPase, second OB domain	Domain
Q [auth AF], WA [auth BF]	IPR003960	ATPase, AAA-type, conserved site	Conserved Site
Q [auth AF], WA [auth BF]	IPR012340	Nucleic acid-binding, OB-fold	Homologous Superfamily
R [auth AC], XA [auth BC]	IPR003593	AAA+ ATPase domain	Domain
R [auth AC], XA [auth BC]	IPR003959	ATPase, AAA-type, core	Domain
R [auth AC], XA [auth BC]	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily
R [auth AC], XA [auth BC]	IPR041569	AAA ATPase, AAA+ lid domain	Domain
R [auth AC], XA [auth BC]	IPR032501	Proteasomal ATPase, second OB domain	Domain
R [auth AC], XA [auth BC]	IPR003960	ATPase, AAA-type, conserved site	Conserved Site
R [auth AC], XA [auth BC]	IPR012340	Nucleic acid-binding, OB-fold	Homologous Superfamily
S [auth AG], YA [auth BG]	IPR034642	Proteasome subunit alpha6	Family
S [auth AG], YA [auth BG]	IPR000426	Proteasome alpha-subunit, N-terminal domain	Domain
S [auth AG], YA [auth BG]	IPR029055	Nucleophile aminohydrolases, N-terminal	Homologous Superfamily
S [auth AG], YA [auth BG]	IPR023332	Proteasome alpha-type subunit	Family
S [auth AG], YA [auth BG]	IPR001353	Proteasome, subunit alpha/beta	Family
B [auth AV], HA [auth BV]	IPR013586	26S proteasome regulatory subunit, C-terminal	Domain
B [auth AV], HA [auth BV]	IPR011990	Tetratricopeptide-like helical domain superfamily	Homologous Superfamily
B [auth AV], HA [auth BV]	IPR036390	Winged helix DNA-binding domain superfamily	Homologous Superfamily
B [auth AV], HA [auth BV]	IPR000717	Proteasome component (PCI) domain	Domain
T [auth AH], ZA [auth BH]	IPR029055	Nucleophile aminohydrolases, N-terminal	Homologous Superfamily
T [auth AH], ZA [auth BH]	IPR000426	Proteasome alpha-subunit, N-terminal domain	Domain
T [auth AH], ZA [auth BH]	IPR023332	Proteasome alpha-type subunit	Family
T [auth AH], ZA [auth BH]	IPR001353	Proteasome, subunit alpha/beta	Family
AB [auth BI], U [auth AI]	IPR016050	Proteasome beta-type subunit, conserved site	Conserved Site
AB [auth BI], U [auth AI]	IPR029055	Nucleophile aminohydrolases, N-terminal	Homologous Superfamily
AB [auth BI], U [auth AI]	IPR000426	Proteasome alpha-subunit, N-terminal domain	Domain
AB [auth BI], U [auth AI]	IPR023332	Proteasome alpha-type subunit	Family
AB [auth BI], U [auth AI]	IPR001353	Proteasome, subunit alpha/beta	Family
BB [auth BJ], V [auth AJ]	IPR029055	Nucleophile aminohydrolases, N-terminal	Homologous Superfamily
BB [auth BJ], V [auth AJ]	IPR000426	Proteasome alpha-subunit, N-terminal domain	Domain
BB [auth BJ], V [auth AJ]	IPR023332	Proteasome alpha-type subunit	Family
BB [auth BJ], V [auth AJ]	IPR001353	Proteasome, subunit alpha/beta	Family
CB [auth BK], W [auth AK]	IPR029055	Nucleophile aminohydrolases, N-terminal	Homologous Superfamily
CB [auth BK], W [auth AK]	IPR033812	Proteasome subunit alpha5	Family
CB [auth BK], W [auth AK]	IPR000426	Proteasome alpha-subunit, N-terminal domain	Domain
CB [auth BK], W [auth AK]	IPR023332	Proteasome alpha-type subunit	Family
CB [auth BK], W [auth AK]	IPR001353	Proteasome, subunit alpha/beta	Family
DB [auth BL], X [auth AL]	IPR029055	Nucleophile aminohydrolases, N-terminal	Homologous Superfamily
DB [auth BL], X [auth AL]	IPR000426	Proteasome alpha-subunit, N-terminal domain	Domain
DB [auth BL], X [auth AL]	IPR035144	Proteasome subunit alpha 1	Family
DB [auth BL], X [auth AL]	IPR023332	Proteasome alpha-type subunit	Family
DB [auth BL], X [auth AL]	IPR001353	Proteasome, subunit alpha/beta	Family
EB [auth BM], Y [auth AM]	IPR029055	Nucleophile aminohydrolases, N-terminal	Homologous Superfamily
EB [auth BM], Y [auth AM]	IPR000426	Proteasome alpha-subunit, N-terminal domain	Domain
EB [auth BM], Y [auth AM]	IPR023332	Proteasome alpha-type subunit	Family
EB [auth BM], Y [auth AM]	IPR001353	Proteasome, subunit alpha/beta	Family
FB [auth BN], Z [auth AN]	IPR016050	Proteasome beta-type subunit, conserved site	Conserved Site
FB [auth BN], Z [auth AN]	IPR029055	Nucleophile aminohydrolases, N-terminal	Homologous Superfamily
FB [auth BN], Z [auth AN]	IPR023333	Proteasome B-type subunit	Family
FB [auth BN], Z [auth AN]	IPR001353	Proteasome, subunit alpha/beta	Family
FB [auth BN], Z [auth AN]	IPR000243	Peptidase T1A, proteasome beta-subunit	Family
AA [auth AO], GB [auth BO]	IPR016050	Proteasome beta-type subunit, conserved site	Conserved Site
AA [auth AO], GB [auth BO]	IPR029055	Nucleophile aminohydrolases, N-terminal	Homologous Superfamily
AA [auth AO], GB [auth BO]	IPR024689	Proteasome beta subunit, C-terminal	Domain
AA [auth AO], GB [auth BO]	IPR023333	Proteasome B-type subunit	Family
AA [auth AO], GB [auth BO]	IPR001353	Proteasome, subunit alpha/beta	Family
AA [auth AO], GB [auth BO]	IPR000243	Peptidase T1A, proteasome beta-subunit	Family
BA [auth AP], HB [auth BP]	IPR016050	Proteasome beta-type subunit, conserved site	Conserved Site
BA [auth AP], HB [auth BP]	IPR029055	Nucleophile aminohydrolases, N-terminal	Homologous Superfamily
BA [auth AP], HB [auth BP]	IPR023333	Proteasome B-type subunit	Family
BA [auth AP], HB [auth BP]	IPR001353	Proteasome, subunit alpha/beta	Family
BA [auth AP], HB [auth BP]	IPR033811	Proteasome beta 3 subunit	Family
CA [auth AQ], IB [auth BQ]	IPR016050	Proteasome beta-type subunit, conserved site	Conserved Site
CA [auth AQ], IB [auth BQ]	IPR029055	Nucleophile aminohydrolases, N-terminal	Homologous Superfamily
CA [auth AQ], IB [auth BQ]	IPR023333	Proteasome B-type subunit	Family
CA [auth AQ], IB [auth BQ]	IPR001353	Proteasome, subunit alpha/beta	Family
CA [auth AQ], IB [auth BQ]	IPR035206	Proteasome subunit beta 2	Family
C [auth AW], IA [auth BW]	IPR036388	Winged helix-like DNA-binding domain superfamily	Homologous Superfamily
C [auth AW], IA [auth BW]	IPR036390	Winged helix DNA-binding domain superfamily	Homologous Superfamily
C [auth AW], IA [auth BW]	IPR000717	Proteasome component (PCI) domain	Domain
C [auth AW], IA [auth BW]	IPR040896	26S proteasome regulatory subunit RPN5, C-terminal domain	Domain
C [auth AW], IA [auth BW]	IPR040134	26S Proteasome non-ATPase regulatory subunit 12/COP9 signalosome complex subunit 4	Family
DA [auth AR], JB [auth BR]	IPR016050	Proteasome beta-type subunit, conserved site	Conserved Site
DA [auth AR], JB [auth BR]	IPR029055	Nucleophile aminohydrolases, N-terminal	Homologous Superfamily
DA [auth AR], JB [auth BR]	IPR023333	Proteasome B-type subunit	Family
DA [auth AR], JB [auth BR]	IPR001353	Proteasome, subunit alpha/beta	Family
DA [auth AR], JB [auth BR]	IPR000243	Peptidase T1A, proteasome beta-subunit	Family
EA [auth AS], KB [auth BS]	IPR016050	Proteasome beta-type subunit, conserved site	Conserved Site
EA [auth AS], KB [auth BS]	IPR029055	Nucleophile aminohydrolases, N-terminal	Homologous Superfamily
EA [auth AS], KB [auth BS]	IPR023333	Proteasome B-type subunit	Family
EA [auth AS], KB [auth BS]	IPR001353	Proteasome, subunit alpha/beta	Family
FA [auth AT], LB [auth BT]	IPR016050	Proteasome beta-type subunit, conserved site	Conserved Site
FA [auth AT], LB [auth BT]	IPR029055	Nucleophile aminohydrolases, N-terminal	Homologous Superfamily
FA [auth AT], LB [auth BT]	IPR023333	Proteasome B-type subunit	Family
FA [auth AT], LB [auth BT]	IPR016295	Proteasome subunit beta 4	Family
FA [auth AT], LB [auth BT]	IPR001353	Proteasome, subunit alpha/beta	Family
D [auth AX], JA [auth BX]	IPR040780	6S proteasome subunit Rpn6, C-terminal helix domain	Domain
D [auth AX], JA [auth BX]	IPR011990	Tetratricopeptide-like helical domain superfamily	Homologous Superfamily
D [auth AX], JA [auth BX]	IPR036390	Winged helix DNA-binding domain superfamily	Homologous Superfamily
D [auth AX], JA [auth BX]	IPR040773	26S proteasome regulatory subunit Rpn6, N-terminal	Domain
D [auth AX], JA [auth BX]	IPR000717	Proteasome component (PCI) domain	Domain
E [auth AY], KA [auth BY]	IPR011990	Tetratricopeptide-like helical domain superfamily	Homologous Superfamily
E [auth AY], KA [auth BY]	IPR019585	26S proteasome regulatory subunit Rpn7/COP9 signalosome complex subunit 1	Family
E [auth AY], KA [auth BY]	IPR036390	Winged helix DNA-binding domain superfamily	Homologous Superfamily
E [auth AY], KA [auth BY]	IPR049549	26S proteasome regulatory subunit RPN7/PSMD6, C-terminal helix	Domain
E [auth AY], KA [auth BY]	IPR000717	Proteasome component (PCI) domain	Domain
E [auth AY], KA [auth BY]	IPR045135	26S proteasome regulatory subunit Rpn7, N-terminal	Domain
F [auth AZ], LA [auth BZ]	IPR033858	26S Proteasome non-ATPase regulatory subunit 7/8	Family
F [auth AZ], LA [auth BZ]	IPR024969	EIF3F/CSN6-like, C-terminal	Domain
F [auth AZ], LA [auth BZ]	IPR037518	MPN domain	Domain
F [auth AZ], LA [auth BZ]	IPR000555	JAB1/MPN/MOV34 metalloenzyme domain	Domain
G [auth Aa], MA [auth Ba]	IPR036390	Winged helix DNA-binding domain superfamily	Homologous Superfamily
G [auth Aa], MA [auth Ba]	IPR035298	26S Proteasome non-ATPase regulatory subunit 13	Family
G [auth Aa], MA [auth Ba]	IPR000717	Proteasome component (PCI) domain	Domain
H [auth Ab], NA [auth Bb]	IPR036465	von Willebrand factor A-like domain superfamily	Homologous Superfamily
H [auth Ab], NA [auth Bb]	IPR002035	von Willebrand factor, type A	Domain
H [auth Ab], NA [auth Bb]	IPR003903	Ubiquitin interacting motif	Conserved Site
H [auth Ab], NA [auth Bb]	IPR049590	PSMD4, RAZUL domain	Domain
I [auth Ac], OA [auth Bc]	IPR037518	MPN domain	Domain
I [auth Ac], OA [auth Bc]	IPR000555	JAB1/MPN/MOV34 metalloenzyme domain	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A [auth AU], GA [auth BU]	Pharos: Q99460	dermatomyositis osteosarcoma psoriasis lung adenocarcinoma ovarian cancer lung cancer pancreatic intraductal papillary-mucinous neoplasm
J [auth Ad], PA [auth Bd]	Pharos: P48556	HIV infectious disease glioblastoma ovarian cancer Sjogren syndrome HIV Coinfection pancreatic ductal adenocarcinoma plasma cell myeloma
K [auth Ae], QA [auth Be]	Pharos: P60896	squamous cell carcinoma bone disease non-small cell lung carcinoma split hand-foot malformation lung cancer osteoporosis medulloblastoma pneumonia subependymal giant cell astrocytoma
L [auth Af], RA [auth Bf]	Pharos: Q13200	breast cancer ovarian cancer lung cancer psoriasis non-small cell lung carcinoma
M [auth AA], SA [auth BA]	Pharos: P35998	dermatomyositis osteosarcoma plasma cell myeloma lung cancer ovarian cancer psoriasis malignant mesothelioma pancreatic ductal adenocarcinoma
O [auth AD], UA [auth BD]	Pharos: P43686	astrocytic tumor Hodgkins lymphoma diabetes mellitus osteosarcoma glioblastoma ovarian cancer
Q [auth AF], WA [auth BF]	Pharos: P17980	HIV infectious disease cataract HIV Coinfection lung cancer ovarian cancer prostate carcinoma cerebrovascular disorder metabolic syndrome X peripheral neuropathy subependymal giant cell astrocytoma endogenous depression hypertensive disorder open-angle glaucoma plasma cell myeloma
R [auth AC], XA [auth BC]	Pharos: P62195	Stevens-Johnson syndrome HIV infectious disease colorectal cancer plasma cell myeloma toxic epidermal necrolysis Drug-Induced Stevens Johnson Syndrome ovarian cancer
S [auth AG], YA [auth BG]	Pharos: P60900	HIV infectious disease myocardial infarction HIV Coinfection psoriasis
B [auth AV], HA [auth BV]	Pharos: O43242	HIV infectious disease acute lymphoblastic leukemia cervical cancer dermatomyositis lung adenocarcinoma ulcerative colitis allergic rhinitis chronic obstructive pulmonary disease HIV Coinfection rheumatoid arthritis breast carcinoma Crohn disease systemic sclerosis
T [auth AH], ZA [auth BH]	Pharos: P25787	osteoporosis heart disease breast cancer malignant mesothelioma Osteoporosis, Senile psoriasis colorectal cancer ovarian cancer
AB [auth BI], U [auth AI]	Pharos: P25789	Mammary Neoplasms, Experimental sarcomatoid carcinoma adult acute respiratory distress syndrome carcinoma HIV infectious disease liver cancer lung carcinoma mammary neoplasms, animal ovarian cancer polycystic ovary syndrome small cell lung carcinoma abdominal aortic aneurysm bipolar disorder bronchitis chronic obstructive pulmonary disease Mammary Neoplasms, Experimental sarcomatoid carcinoma adult acute respiratory distress syndrome carcinoma HIV infectious disease liver cancer lung carcinoma mammary neoplasms, animal ovarian cancer polycystic ovary syndrome small cell lung carcinoma abdominal aortic aneurysm bipolar disorder bronchitis chronic obstructive pulmonary disease liver neoplasm lymphoplasmacytic lymphoma peripheral arterial disease squamous cell lung carcinoma anorexia nervosa brain aneurysm dental caries lung adenocarcinoma nicotine dependence plasma cell myeloma Sjogren syndrome undifferentiated carcinoma autism spectrum disorder breast cancer dermatomyositis
BB [auth BJ], V [auth AJ]	Pharos: O14818	breast cancer lung cancer pancreatic intraductal papillary-mucinous carcinoma glioblastoma medulloblastoma plasma cell myeloma intellectual disability ovarian cancer Sjogren syndrome
CB [auth BK], W [auth AK]	Pharos: P28066	HIV infectious disease osteoporosis non-small cell lung carcinoma Osteoporosis, Age-Related ovarian cancer pancreatic intraductal papillary-mucinous neoplasm pilocytic astrocytoma Alzheimer disease primitive neuroectodermal tumor cystic fibrosis tuberculosis fatty liver disease glioblastoma lung cancer malignant glioma HIV infectious disease osteoporosis non-small cell lung carcinoma Osteoporosis, Age-Related ovarian cancer pancreatic intraductal papillary-mucinous neoplasm pilocytic astrocytoma Alzheimer disease primitive neuroectodermal tumor cystic fibrosis tuberculosis fatty liver disease glioblastoma lung cancer malignant glioma oligodendroglioma pancreatic ductal adenocarcinoma pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia pituitary cancer astrocytic tumor psoriasis diabetes mellitus gastric cancer hepatocellular carcinoma invasive ductal breast carcinoma lymphoplasmacytic lymphoma medulloblastoma osteosarcoma pancreatic intraductal papillary-mucinous carcinoma Pick disease atypical teratoid rhabdoid tumor gastric carcinoma large cell medulloblastoma malignant ependymoma
DB [auth BL], X [auth AL]	Pharos: P25786	mantle cell lymphoma plasma cell myeloma Systemic AL amyloidosis
EB [auth BM], Y [auth AM]	Pharos: P25788	attention deficit hyperactivity disorder, inattentive type lymphoplasmacytic lymphoma pancreatic ductal adenocarcinoma Sjogren syndrome dermatomyositis osteosarcoma plasma cell myeloma heart disease ovarian cancer psoriasis
FB [auth BN], Z [auth AN]	Pharos: P28072	attention deficit hyperactivity disorder, inattentive type ovarian cancer psoriasis brain aneurysm pancreatic ductal adenocarcinoma Sjogren syndrome lung cancer plasma cell myeloma systemic lupus erythematosus
AA [auth AO], GB [auth BO]	Pharos: Q99436	atrial fibrillation allergic rhinitis hepatocellular carcinoma malignant ependymoma pancreatic intraductal papillary-mucinous carcinoma peripheral nervous system disease plasma cell myeloma astrocytic tumor hypothyroidism oligodendroglioma pancreatic intraductal papillary-mucinous neoplasm peripheral neuropathy vitiligo lymphoplasmacytic lymphoma ovarian cancer atrial fibrillation allergic rhinitis hepatocellular carcinoma malignant ependymoma pancreatic intraductal papillary-mucinous carcinoma peripheral nervous system disease plasma cell myeloma astrocytic tumor hypothyroidism oligodendroglioma pancreatic intraductal papillary-mucinous neoplasm peripheral neuropathy vitiligo lymphoplasmacytic lymphoma ovarian cancer pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia Pick disease
BA [auth AP], HB [auth BP]	Pharos: P49720	chronic obstructive pulmonary disease lymphoplasmacytic lymphoma diabetes mellitus ovarian cancer glioblastoma plasma cell myeloma
CA [auth AQ], IB [auth BQ]	Pharos: P49721	urinary bladder cancer atypical teratoid rhabdoid tumor glioblastoma lung carcinoma osteosarcoma Sjogren syndrome breast cancer invasive ductal breast carcinoma malignant mesothelioma ovarian cancer Systemic AL amyloidosis urinary bladder neoplasm diabetes mellitus large cell medulloblastoma mantle cell lymphoma urinary bladder cancer atypical teratoid rhabdoid tumor glioblastoma lung carcinoma osteosarcoma Sjogren syndrome breast cancer invasive ductal breast carcinoma malignant mesothelioma ovarian cancer Systemic AL amyloidosis urinary bladder neoplasm diabetes mellitus large cell medulloblastoma mantle cell lymphoma plasma cell myeloma systemic lupus erythematosus
C [auth AW], IA [auth BW]	Pharos: O00232	contact dermatitis atypical teratoid rhabdoid tumor intellectual disability non-small cell lung carcinoma pancreatic ductal adenocarcinoma psoriasis invasive ductal breast carcinoma osteosarcoma Parkinson disease Stankiewicz-Isidor syndrome Contact hypersensitivity lung cancer ovarian cancer plasma cell myeloma
DA [auth AR], JB [auth BR]	Pharos: P28074	plasma cell myeloma acute lymphoblastic leukemia diabetes mellitus mantle cell lymphoma ovarian cancer Relapse multiple myeloma B-cell acute lymphoblastic leukemia hypertensive disorder medulloblastoma coronary artery disease lung cancer myocardial ischemia psoriasis
EA [auth AS], KB [auth BS]	Pharos: P20618	acute coronary syndrome peripheral neuropathy plasma cell myeloma peripheral nervous system disease lymphoplasmacytic lymphoma osteoarthritis ovarian cancer dermatomyositis malignant colon neoplasm osteoarthritis susceptibility 1 pancreatic ductal adenocarcinoma glioblastoma mantle cell lymphoma Osteoarthrosis Deformans
FA [auth AT], LB [auth BT]	Pharos: P28070	HIV infectious disease HIV Coinfection lymphoplasmacytic lymphoma plasma cell myeloma Sjogren syndrome major depressive disorder proteasome-associated autoinflammatory syndrome 3 lung cancer ovarian cancer psoriasis
D [auth AX], JA [auth BX]	Pharos: O00231	attention deficit hyperactivity disorder, inattentive type glioblastoma malignant ependymoma osteosarcoma plasma cell myeloma atypical teratoid rhabdoid tumor lung adenocarcinoma malignant glioma ovarian cancer subependymal giant cell astrocytoma breast cancer lung cancer malignant mesothelioma Pick disease tuberculosis
E [auth AY], KA [auth BY]	Pharos: Q15008	HIV infectious disease type 2 diabetes mellitus breast carcinoma osteosarcoma pancreatic intraductal papillary-mucinous carcinoma plasma cell myeloma Diabetes Mellitus, Non-Insulin-Dependent malignant pancreatic neoplasm ovarian cancer pancreatic intraductal papillary-mucinous neoplasm maturity-onset diabetes of the young pancreatic ductal adenocarcinoma pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia
F [auth AZ], LA [auth BZ]	Pharos: P51665	lung cancer psoriasis ovarian cancer pancreatic intraductal papillary-mucinous neoplasm
G [auth Aa], MA [auth Ba]	Pharos: Q9UNM6	HIV infectious disease benign prostatic hyperplasia heart disease osteosarcoma psoriasis brain aneurysm HIV Coinfection ovarian cancer uterine corpus leiomyoma Hashimoto thyroiditis plasma cell myeloma
H [auth Ab], NA [auth Bb]	Pharos: P55036	heart disease ovarian cancer lung cancer plasma cell myeloma myocardial infarction
I [auth Ac], OA [auth Bc]	Pharos: O00487	breast cancer lung cancer ovarian cancer endogenous depression lymphoplasmacytic lymphoma pancreatic intraductal papillary-mucinous neoplasm invasive ductal breast carcinoma medulloblastoma plasma cell myeloma