5OQL

Cryo-EM structure of the 90S pre-ribosome from Chaetomium thermophilum


Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

ChainsTypeFamily Name Domain Identifier Family IdentifierProvenance Source (Version)
ASCOP2B SuperfamilyUTPB complex component-like8056020 3002330 SCOP2B (2022-06-29)
JSCOP2B SuperfamilyUTPB complex component-like8056022 3002330 SCOP2B (2022-06-29)
OSCOP2B SuperfamilyUTPB complex component-like8056021 3002330 SCOP2B (2022-06-29)
RSCOP2B SuperfamilyS-adenosyl-L-methionine-dependent methyltransferases8065682 3000118 SCOP2B (2022-06-29)
SSCOP2 FamilyFibrillarin homologue8065681 4000661 SCOP2 (2022-06-29)
SSCOP2 SuperfamilyS-adenosyl-L-methionine-dependent methyltransferases8065682 3000118 SCOP2 (2022-06-29)
VSCOP2B SuperfamilyL30e-like8063954 3001739 SCOP2B (2022-06-29)
WSCOP2 FamilyL30e/L7ae ribosomal proteins8063953 4001513 SCOP2 (2022-06-29)
WSCOP2 SuperfamilyL30e-like8063954 3001739 SCOP2 (2022-06-29)
BA [auth b]SCOP2B SuperfamilyClass II aaRS ABD-related8095989 3000465 SCOP2B (2022-06-29)
BA [auth b]SCOP2B SuperfamilyClass II aaRS ABD-related8095988 3000465 SCOP2B (2022-06-29)
EA [auth e]SCOP2B Superfamilyalpha/beta knot8094639 3001122 SCOP2B (2022-06-29)
FA [auth f]SCOP2B Superfamilyalpha/beta knot8094639 3001122 SCOP2B (2022-06-29)
LA [auth l]SCOP2B SuperfamilyRibosomal S3Ae-like8094667 3002166 SCOP2B (2022-06-29)
NA [auth n]SCOP2B SuperfamilyRibosomal protein S78095683 3000799 SCOP2B (2022-06-29)
TA [auth t]SCOP2B SuperfamilyTranslational machinery components8095757 3000571 SCOP2B (2022-06-29)
UA [auth u]SCOP2B SuperfamilyRibosomal protein S5 domain 2-like8097794 3000100 SCOP2B (2022-06-29)
WA [auth w]SCOP2B SuperfamilyRibosomal protein S88095563 3000709 SCOP2B (2022-06-29)
YA [auth y]SCOP2 FamilyRibosomal protein S24e8098445 4003636 SCOP2 (2022-06-29)
YA [auth y]SCOP2 SuperfamilyRibosomal proteins S24e L23 and L15e8098446 3000210 SCOP2 (2022-06-29)
ZA [auth z]SCOP2B SuperfamilyNucleic acid-binding proteins8095187 3000135 SCOP2B (2022-06-29)
ISCOP2B SuperfamilyUTPB complex component-like8056019 3002330 SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
APF00400e5oqlA3 A: beta duplicates or obligate multimersX: beta-propeller-likeH: beta-propellerT: 7-bladedF: PF00400ECOD (1.6)
APF04003e5oqlA1 A: alpha superhelicesX: Repetitive alpha hairpinsH: C-terminal tetramerization domain of Utp1/Utp21/Utp12/Utp13 (From Topology)T: C-terminal tetramerization domain of Utp1/Utp21/Utp12/Utp13F: PF04003ECOD (1.6)
JPF08625e5oqlJ1 A: alpha superhelicesX: Repetitive alpha hairpinsH: C-terminal tetramerization domain of Utp1/Utp21/Utp12/Utp13 (From Topology)T: C-terminal tetramerization domain of Utp1/Utp21/Utp12/Utp13F: PF08625ECOD (1.6)
LPF00400e5oqlL1 A: beta duplicates or obligate multimersX: beta-propeller-likeH: beta-propellerT: 8-bladedF: PF00400ECOD (1.6)
MPF00400e5oqlM1 A: beta duplicates or obligate multimersX: beta-propeller-likeH: beta-propellerT: 8-bladedF: PF00400ECOD (1.6)
OF_UNCLASSIFIEDe5oqlO3 A: beta duplicates or obligate multimersX: beta-propeller-likeH: beta-propellerT: 7-bladedF: F_UNCLASSIFIEDECOD (1.6)
OPF00400e5oqlO2 A: beta duplicates or obligate multimersX: beta-propeller-likeH: beta-propellerT: 7-bladedF: PF00400ECOD (1.6)
OPF04192e5oqlO1 A: alpha superhelicesX: Repetitive alpha hairpinsH: C-terminal tetramerization domain of Utp1/Utp21/Utp12/Utp13 (From Topology)T: C-terminal tetramerization domain of Utp1/Utp21/Utp12/Utp13F: PF04192ECOD (1.6)
QPF00687e5oqlQ1 A: a+b two layersX: a+b domain in Ribosomal protein L1 (From Topology)H: a+b domain in Ribosomal protein L1 (From Topology)T: a+b domain in Ribosomal protein L1F: PF00687ECOD (1.6)
QPF00687e5oqlQ2 A: a/b three-layered sandwichesX: Flavodoxin-likeH: Rossmann-like domain in Ribosomal protein L1 (From Topology)T: Rossmann-like domain in Ribosomal protein L1F: PF00687ECOD (1.6)
RPF01269e5oqlR1 A: a/b three-layered sandwichesX: Rossmann-likeH: Rossmann-relatedT: S-adenosyl-L-methionine-dependent methyltransferasesF: PF01269ECOD (1.6)
SPF01269e5oqlS1 A: a/b three-layered sandwichesX: Rossmann-likeH: Rossmann-relatedT: S-adenosyl-L-methionine-dependent methyltransferasesF: PF01269ECOD (1.6)
TPF01798e5oqlT3 A: alpha arraysX: HhH/H2THH: SAM/DNA-glycosylaseT: Nop C-terminal domainF: PF01798ECOD (1.6)
TPF01798e5oqlT1 A: alpha complex topologyX: Nop N-terminal domain (From Topology)H: Nop N-terminal domain (From Topology)T: Nop N-terminal domainF: PF01798ECOD (1.6)
TPF08156e5oqlT2 A: mixed a+b and a/bX: Nop N-terminal domain (From Topology)H: Nop N-terminal domain (From Topology)T: Nop N-terminal domainF: PF08156ECOD (1.6)
VPF01248e5oqlV1 A: a+b three layersX: Bacillus chorismate mutase-likeH: L30e-like (From Topology)T: L30e-likeF: PF01248ECOD (1.6)
WPF01248e5oqlW1 A: a+b three layersX: Bacillus chorismate mutase-likeH: L30e-like (From Topology)T: L30e-likeF: PF01248ECOD (1.6)
XPF00400e5oqlX1 A: beta duplicates or obligate multimersX: beta-propeller-likeH: beta-propellerT: 7-bladedF: PF00400ECOD (1.6)
YPF01137e5oqlY1 A: a+b two layersX: IF3-likeH: EPT/RTPC-like (From Topology)T: EPT/RTPC-likeF: PF01137ECOD (1.6)
YPF05189e5oqlY2 A: a+b three layersX: Thioredoxin-likeH: RNA 3'-terminal phosphate cyclase, RPTC, insert domain (From Topology)T: RNA 3'-terminal phosphate cyclase, RPTC, insert domainF: PF05189ECOD (1.6)
AA [auth a]PF00163,PF01479e5oqla1 A: a+b two layersX: beta-GraspH: Ubiquitin-relatedT: Alpha-L RNA-binding motifF: PF00163,PF01479ECOD (1.6)
EA [auth e]PF03587e5oqle1 A: a/b three-layered sandwichesX: alpha/beta knot (From Topology)H: alpha/beta knot (From Topology)T: alpha/beta knotF: PF03587ECOD (1.6)
FA [auth f]PF03587e5oqlf1 A: a/b three-layered sandwichesX: alpha/beta knot (From Topology)H: alpha/beta knot (From Topology)T: alpha/beta knotF: PF03587ECOD (1.6)
GA [auth g]PF17903e5oqlg2 A: a+b two layersX: Alpha-lytic protease prodomain-likeH: KH-domainsT: Eukaryotic type KH-domain (KH-domain type I)F: PF17903ECOD (1.6)
GA [auth g]PF21800e5oqlg1 A: a+b two layersX: Alpha-lytic protease prodomain-likeH: KH-domainsT: Eukaryotic type KH-domain (KH-domain type I)F: PF21800ECOD (1.6)
HA [auth h]F_UNCLASSIFIEDe5oqlh1 A: a+b two layersX: Alpha-lytic protease prodomain-likeH: KH-domainsT: Eukaryotic type KH-domain (KH-domain type I)F: F_UNCLASSIFIEDECOD (1.6)
HA [auth h]PF22891e5oqlh2 A: a+b two layersX: Alpha-lytic protease prodomain-likeH: KH-domainsT: Eukaryotic type KH-domain (KH-domain type I)F: PF22891ECOD (1.6)
JA [auth j]PF13725e5oqlj3 A: alpha arraysX: HTHH: HTHT: tri-helicalF: PF13725ECOD (1.6)
JA [auth j]PF13718,PF13725e5oqlj1 A: a+b three layersX: Nat/IvyH: Acyl-CoA N-acyltransferases (Nat) (From Topology)T: Acyl-CoA N-acyltransferases (Nat)F: PF13718,PF13725ECOD (1.6)
JA [auth j]PF05127e5oqlj2 A: a/b three-layered sandwichesX: P-loop domains-likeH: P-loop domains-relatedT: P-loop containing nucleoside triphosphate hydrolasesF: PF05127ECOD (1.6)
JA [auth j]PF08351e5oqlj4 A: a/b three-layered sandwichesX: P-loop domains-likeH: P-loop domains-relatedT: P-loop containing nucleoside triphosphate hydrolasesF: PF08351ECOD (1.6)
IA [auth i]PF13725e5oqli3 A: alpha arraysX: HTHH: HTHT: tri-helicalF: PF13725ECOD (1.6)
IA [auth i]PF13718,PF13725e5oqli1 A: a+b three layersX: Nat/IvyH: Acyl-CoA N-acyltransferases (Nat) (From Topology)T: Acyl-CoA N-acyltransferases (Nat)F: PF13718,PF13725ECOD (1.6)
IA [auth i]PF05127e5oqli4 A: a/b three-layered sandwichesX: P-loop domains-likeH: P-loop domains-relatedT: P-loop containing nucleoside triphosphate hydrolasesF: PF05127ECOD (1.6)
IA [auth i]PF08351e5oqli2 A: a/b three-layered sandwichesX: P-loop domains-likeH: P-loop domains-relatedT: P-loop containing nucleoside triphosphate hydrolasesF: PF08351ECOD (1.6)
LA [auth l]PF01015e5oqll2 A: beta barrelsX: Ribosomal protein L25-likeH: 40S ribosomal protein S3A N-terminal domain (From Topology)T: 40S ribosomal protein S3A N-terminal domainF: PF01015ECOD (1.6)
LA [auth l]PF01015e5oqll1 A: a+b two layersX: T-foldH: 40S ribosomal protein S3A C-terminal domain (From Topology)T: 40S ribosomal protein S3A C-terminal domainF: PF01015ECOD (1.6)
MA [auth m]PF00900e5oqlm1 A: beta barrelsX: OB-foldH: Nucleic acid-binding proteins (From Topology)T: Nucleic acid-binding proteinsF: PF00900ECOD (1.6)
MA [auth m]PF00467,PF16121e5oqlm2 A: beta barrelsX: SH3H: SH3T: SH3F: PF00467,PF16121ECOD (1.6)
MA [auth m]PF00900,PF01479,PF08071e5oqlm3 A: a+b two layersX: beta-GraspH: Ubiquitin-relatedT: Alpha-L RNA-binding motifF: PF00900,PF01479,PF08071ECOD (1.6)
NA [auth n]PF00177e5oqln1 A: alpha arraysX: Ribosomal protein S7 (From Topology)H: Ribosomal protein S7 (From Topology)T: Ribosomal protein S7F: PF00177ECOD (1.6)
OA [auth o]PF01092e5oqlo1 A: beta barrelsX: Ribosomal protein L25-likeH: Ribosomal protein L25-like (From Topology)T: Ribosomal protein L25-likeF: PF01092ECOD (1.6)
PA [auth p]PF01251e5oqlp1 A: a+b two layersX: Alpha-lytic protease prodomain-likeH: 40S ribosomal protein S7-A (From Topology)T: 40S ribosomal protein S7-AF: PF01251ECOD (1.6)
QA [auth q]PF01201e5oqlq1 A: beta barrelsX: Ribosomal protein L14-likeH: Ribosomal protein L14-related (From Topology)T: Ribosomal protein L14-relatedF: PF01201ECOD (1.6)
DPF00400e5oqlD1 A: beta duplicates or obligate multimersX: beta-propeller-likeH: beta-propellerT: 7-bladedF: PF00400ECOD (1.6)
RA [auth r]PF00163,PF01479e5oqlr1 A: a+b two layersX: beta-GraspH: Ubiquitin-relatedT: Alpha-L RNA-binding motifF: PF00163,PF01479ECOD (1.6)
SA [auth s]PF00312e5oqls1 A: alpha arraysX: S15/NS1 RNA-binding domain (From Topology)H: S15/NS1 RNA-binding domain (From Topology)T: S15/NS1 RNA-binding domainF: PF00312ECOD (1.6)
TA [auth t]PF00411e5oqlt1 A: mixed a+b and a/bX: Ribonuclease H-likeH: Ribonuclease H-like (From Topology)T: Ribonuclease H-likeF: PF00411ECOD (1.6)
UA [auth u]PF00380e5oqlu1 A: a+b two layersX: Ribosomal protein S5 domain 2-like (From Topology)H: Ribosomal protein S5 domain 2-like (From Topology)T: Ribosomal protein S5 domain 2-likeF: PF00380ECOD (1.6)
VA [auth v]PF00366,PF16205e5oqlv1 A: beta barrelsX: OB-foldH: Nucleic acid-binding proteins (From Topology)T: Nucleic acid-binding proteinsF: PF00366,PF16205ECOD (1.6)
WA [auth w]PF00410e5oqlw1 A: a+b two layersX: R3H domain-likeH: Ribosomal protein S8, N-terminal domain (From Topology)T: Ribosomal protein S8, N-terminal domainF: PF00410ECOD (1.6)
WA [auth w]PF00410e5oqlw2 A: a+b two layersX: Ribosomal protein S8, C-terminal domain (From Topology)H: Ribosomal protein S8, C-terminal domain (From Topology)T: Ribosomal protein S8, C-terminal domainF: PF00410ECOD (1.6)
XA [auth x]PF00164e5oqlx1 A: beta barrelsX: OB-foldH: Nucleic acid-binding proteins (From Topology)T: Nucleic acid-binding proteinsF: PF00164ECOD (1.6)
YA [auth y]PF01282e5oqly1 A: a+b two layersX: Alpha-beta plaitsH: Ribosomal proteins S24e, L23 and L15e (From Topology)T: Ribosomal proteins S24e, L23 and L15eF: PF01282ECOD (1.6)
ZA [auth z]PF01200e5oqlz1 A: beta barrelsX: OB-foldH: Nucleic acid-binding proteins (From Topology)T: Nucleic acid-binding proteinsF: PF01200ECOD (1.6)
EPF08640e5oqlE1 A: alpha superhelicesX: Repetitive alpha hairpinsH: ARM repeat (From Topology)T: ARM repeatF: PF08640ECOD (1.6)
GPF12397e5oqlG1 A: alpha superhelicesX: Repetitive alpha hairpinsH: ARM repeat (From Topology)T: ARM repeatF: PF12397ECOD (1.6)
IPF04003e5oqlI1 A: alpha superhelicesX: Repetitive alpha hairpinsH: C-terminal tetramerization domain of Utp1/Utp21/Utp12/Utp13 (From Topology)T: C-terminal tetramerization domain of Utp1/Utp21/Utp12/Utp13F: PF04003ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
PF04003Dip2/Utp12 Family (Utp12)Dip2/Utp12 Family- Family
PF00400WD domain, G-beta repeat (WD40)WD domain, G-beta repeat- Repeat
PF08625Utp13 specific WD40 associated domain (Utp13)Utp13 specific WD40 associated domainUtp13 is a component of the five protein Pwp2 complex that forms part of a stable particle subunit independent of the U3 small nucleolar ribonucleoprotein that is essential for the initial assembly steps of the 90S pre-ribosome [1]. Pwp2 is capable o ...Utp13 is a component of the five protein Pwp2 complex that forms part of a stable particle subunit independent of the U3 small nucleolar ribonucleoprotein that is essential for the initial assembly steps of the 90S pre-ribosome [1]. Pwp2 is capable of interacting directly with the 35 S pre-rRNA 5' end [1].
Domain
PF04615Utp14 protein (Utp14)Utp14 protein- Family
PF00400WD domain, G-beta repeat (WD40)WD domain, G-beta repeat- Repeat
PF00400WD domain, G-beta repeat (WD40)WD domain, G-beta repeat- Repeat
PF00400WD domain, G-beta repeat (WD40)WD domain, G-beta repeat- Repeat
PF04900Fcf1 (Fcf1)Fcf1- Family
PF00687Ribosomal protein L1p/L10e family (Ribosomal_L1)Ribosomal protein L1p/L10e familyThis family includes prokaryotic L1 and eukaryotic L10.Domain
R, S
PF01269Fibrillarin (Fibrillarin)Fibrillarin- Domain
PF08156NOP5NT (NUC127) domain (NOP5NT)NOP5NT (NUC127) domainThis N terminal domain is found in RNA-binding proteins of the NOP5 family [1].Domain
PF01798snoRNA binding domain, fibrillarin (Nop)snoRNA binding domain, fibrillarin- Family
PF04147Nop14-like family (Nop14)Nop14-like family- Family
PF08156NOP5NT (NUC127) domain (NOP5NT)NOP5NT (NUC127) domainThis N terminal domain is found in RNA-binding proteins of the NOP5 family [1].Domain
PF01798snoRNA binding domain, fibrillarin (Nop)snoRNA binding domain, fibrillarin- Family
V, W
PF01248Ribosomal protein L7Ae/L30e/S12e/Gadd45 family (Ribosomal_L7Ae)Ribosomal protein L7Ae/L30e/S12e/Gadd45 familyThis family includes: Ribosomal L7A from metazoa, Ribosomal L8-A and L8-B from fungi, 30S ribosomal protein HS6 from archaebacteria, 40S ribosomal protein S12 from eukaryotes, Ribosomal protein L30 from eukaryotes and archaebacteria. Gadd45 and MyD11 ...This family includes: Ribosomal L7A from metazoa, Ribosomal L8-A and L8-B from fungi, 30S ribosomal protein HS6 from archaebacteria, 40S ribosomal protein S12 from eukaryotes, Ribosomal protein L30 from eukaryotes and archaebacteria. Gadd45 and MyD118 [1].
Domain
PF00400WD domain, G-beta repeat (WD40)WD domain, G-beta repeat- Repeat
PF05189RNA 3'-terminal phosphate cyclase (RTC), insert domain (RTC_insert)RNA 3'-terminal phosphate cyclase (RTC), insert domainRNA cyclases are a family of RNA-modifying enzymes that are conserved in all cellular organisms. They catalyse the ATP-dependent conversion of the 3'-phosphate to the 2',3'-cyclic phosphodiester at the end of RNA, in a reaction involving formation o ...RNA cyclases are a family of RNA-modifying enzymes that are conserved in all cellular organisms. They catalyse the ATP-dependent conversion of the 3'-phosphate to the 2',3'-cyclic phosphodiester at the end of RNA, in a reaction involving formation of the covalent AMP-cyclase intermediate [1]. The structure of RTC demonstrates that RTCs are comprised two domain. The larger domain contains an insert domain of approximately 100 amino acids [1].
Domain
PF01137RNA 3'-terminal phosphate cyclase (RTC)RNA 3'-terminal phosphate cyclaseRNA cyclases are a family of RNA-modifying enzymes that are conserved in all cellular organisms. They catalyse the ATP-dependent conversion of the 3'-phosphate to the 2',3'-cyclic phosphodiester at the end of RNA, in a reaction involving formation o ...RNA cyclases are a family of RNA-modifying enzymes that are conserved in all cellular organisms. They catalyse the ATP-dependent conversion of the 3'-phosphate to the 2',3'-cyclic phosphodiester at the end of RNA, in a reaction involving formation of the covalent AMP-cyclase intermediate [1]. The structure of RTC demonstrates that RTCs are comprised two domain. The larger domain contains an insert domain of approximately 100 amino acids [1].
Domain
PF08142AARP2CN (NUC121) domain (AARP2CN)AARP2CN (NUC121) domainThis domain is the central domain of AARP2. It is weakly similar to the GTP-binding domain of elongation factor TU [1].Domain
AA [auth a]PF00163Ribosomal protein S4/S9 N-terminal domain (Ribosomal_S4)Ribosomal protein S4/S9 N-terminal domain- Family
AA [auth a]PF01479S4 domain (S4)S4 domainThe S4 domain is a small domain consisting of 60-65 amino acid residues that was detected in the bacterial ribosomal protein S4, eukaryotic ribosomal S9, two families of pseudouridine synthases, a novel family of predicted RNA methylases, a yeast pro ...The S4 domain is a small domain consisting of 60-65 amino acid residues that was detected in the bacterial ribosomal protein S4, eukaryotic ribosomal S9, two families of pseudouridine synthases, a novel family of predicted RNA methylases, a yeast protein containing a pseudouridine synthetase and a deaminase domain, bacterial tyrosyl-tRNA synthetases, and a number of uncharacterized, small proteins that may be involved in translation regulation [1]. The S4 domain probably mediates binding to RNA.
Domain
BA [auth b]PF04427Brix domain (Brix)Brix domain- Domain
CA [auth c]PF04006Mpp10 protein (Mpp10)Mpp10 protein- Family
DA [auth d]PF04158Sof1-like domain (Sof1)Sof1-like domain- Family
DA [auth d]PF00400WD domain, G-beta repeat (WD40)WD domain, G-beta repeat- Repeat
EA [auth e],
FA [auth f]
PF03587EMG1/NEP1 methyltransferase (EMG1)EMG1/NEP1 methyltransferase- Family
PF09368Sas10 C-terminal domain (Sas10)Sas10 C-terminal domainSas10 is an Essential subunit of U3-containing Small Subunit (SSU) processome complex involved in the production of the 18S rRNA and assembly of the small ribosomal subunit.Domain
GA [auth g]PF17903Krr1 KH1 domain (KH_8)Krr1 KH1 domainThis entry represents the first KH domain in the KRR1 protein [1]. Krr1 is a ribosomal assembly factor. The KH1 domain is a divergent KH domain that lacks the RNA-binding GXXG motif and is involved in binding another assembly factor, Kri1 [1].Domain
GA [auth g]PF21800KRR1 small subunit processome component, second KH domain (KRR1-like_KH2)KRR1 small subunit processome component, second KH domainThis is the second K homology domain (KH2) found in KRR1 small subunit processome component from the fungus Chaetomium thermophilum and similar eukaryotic sequences.Domain
IA [auth i],
JA [auth j]
PF13725Possible tRNA binding domain (tRNA_bind_2)Possible tRNA binding domain- Family
IA [auth i],
JA [auth j]
PF08351tRNA(Met) cytidine acetyltransferase TmcA, N-terminal (TmcA_N)tRNA(Met) cytidine acetyltransferase TmcA, N-terminal- Family
IA [auth i],
JA [auth j]
PF13718GNAT acetyltransferase 2 (GNAT_acetyltr_2)GNAT acetyltransferase 2- Family
IA [auth i],
JA [auth j]
PF05127Helicase (Helicase_RecD)HelicaseThis domain contains a P-loop (Walker A) motif, suggesting that it has ATPase activity, and a Walker B motif. In tRNA(Met) cytidine acetyltransferase (TmcA) it may function as an RNA helicase motor (driven by ATP hydrolysis) which delivers the wobble ...This domain contains a P-loop (Walker A) motif, suggesting that it has ATPase activity, and a Walker B motif. In tRNA(Met) cytidine acetyltransferase (TmcA) it may function as an RNA helicase motor (driven by ATP hydrolysis) which delivers the wobble base to the active centre of the GCN5-related N-acetyltransferase (GNAT) domain [1]. It is found in the bacterial exodeoxyribonuclease V alpha chain (RecD), which has 5'-3' helicase activity. It is structurally similar to the motor domain 1A in other SF1 helicases [2].
Domain
KA [auth k]PF08698Fcf2 pre-rRNA processing (Fcf2)Fcf2 pre-rRNA processing- Family
LA [auth l]PF01015Ribosomal S3Ae family (Ribosomal_S3Ae)Ribosomal S3Ae family- Family
MA [auth m]PF00900Ribosomal family S4e (Ribosomal_S4e)Ribosomal family S4e- Family
MA [auth m]PF1612140S ribosomal protein S4 C-terminus (40S_S4_C)40S ribosomal protein S4 C-terminus- Family
MA [auth m]PF08071RS4NT (NUC023) domain (RS4NT)RS4NT (NUC023) domainThis is the N-terminal domain of Ribosomal S4 / S4e proteins. This domain is associated with S4 and KOW domains [1].Domain
MA [auth m]PF00467KOW motif (KOW)KOW motif- Family
NA [auth n]PF00177Ribosomal protein S7p/S5e (Ribosomal_S7)Ribosomal protein S7p/S5eThis family contains ribosomal protein S7 from prokaryotes and S5 from eukaryotes.Domain
OA [auth o]PF01092Ribosomal protein S6e (Ribosomal_S6e)Ribosomal protein S6e- Family
PA [auth p]PF01251Ribosomal protein S7e (Ribosomal_S7e)Ribosomal protein S7e- Family
QA [auth q]PF01201Ribosomal protein S8e (Ribosomal_S8e)Ribosomal protein S8e- Family
PF00400WD domain, G-beta repeat (WD40)WD domain, G-beta repeat- Repeat
RA [auth r]PF00163Ribosomal protein S4/S9 N-terminal domain (Ribosomal_S4)Ribosomal protein S4/S9 N-terminal domain- Family
RA [auth r]PF01479S4 domain (S4)S4 domainThe S4 domain is a small domain consisting of 60-65 amino acid residues that was detected in the bacterial ribosomal protein S4, eukaryotic ribosomal S9, two families of pseudouridine synthases, a novel family of predicted RNA methylases, a yeast pro ...The S4 domain is a small domain consisting of 60-65 amino acid residues that was detected in the bacterial ribosomal protein S4, eukaryotic ribosomal S9, two families of pseudouridine synthases, a novel family of predicted RNA methylases, a yeast protein containing a pseudouridine synthetase and a deaminase domain, bacterial tyrosyl-tRNA synthetases, and a number of uncharacterized, small proteins that may be involved in translation regulation [1]. The S4 domain probably mediates binding to RNA.
Domain
SA [auth s]PF00312Ribosomal protein S15 (Ribosomal_S15)Ribosomal protein S15- Domain
TA [auth t]PF00411Ribosomal protein S11 (Ribosomal_S11)Ribosomal protein S11- Family
UA [auth u]PF00380Ribosomal protein S9/S16 (Ribosomal_S9)Ribosomal protein S9/S16- Family
VA [auth v]PF00366Ribosomal protein S17 (Ribosomal_S17)Ribosomal protein S17- Domain
VA [auth v]PF16205Ribosomal_S17 N-terminal (Ribosomal_S17_N)Ribosomal_S17 N-terminal- Family
WA [auth w]PF00410Ribosomal protein S8 (Ribosomal_S8)Ribosomal protein S8- Domain
XA [auth x]PF00164Ribosomal protein S12/S23 (Ribosom_S12_S23)Ribosomal protein S12/S23- Family
YA [auth y]PF01282Ribosomal protein S24e (Ribosomal_S24e)Ribosomal protein S24e- Family
ZA [auth z]PF01200Ribosomal protein S28e (Ribosomal_S28e)Ribosomal protein S28e- Family
PF08640U3 small nucleolar RNA-associated protein 6 (U3_assoc_6)U3 small nucleolar RNA-associated protein 6- Family
PF08149BING4CT (NUC141) domain (BING4CT)BING4CT (NUC141) domainThis C terminal domain is found in the BING4 family of nucleolar WD40 repeat proteins [1].Domain
PF00400WD domain, G-beta repeat (WD40)WD domain, G-beta repeat- Repeat
PF12397U3 small nucleolar RNA-associated protein 10 (U3snoRNP10)U3 small nucleolar RNA-associated protein 10- Family
PF03998Utp11 protein (Utp11)Utp11 protein- Family
PF04003Dip2/Utp12 Family (Utp12)Dip2/Utp12 Family- Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

ChainsPolymerMolecular FunctionBiological ProcessCellular Component
Periodic tryptophan protein 2-like protein-
Utp13-
Utp14-
Utp15-
Utp17-
Utp18-
Putative U3 snoRNP protein-
Utp24
Utp30- -
R, S
Nop1 -
Putative nucleolar protein
Utp2-
Nop58
V, W
Snu13
Rrp9 - -
RNA 3'-terminal phosphate cyclase-like protein
Bms1
AA [auth a]Imp3
BA [auth b]Putative U3 small nucleolar ribonucleoprotein
CA [auth c]Putative U3 small nucleolar ribonucleoprotein protein-
DA [auth d]Sof1-
EA [auth e],
FA [auth f]
Emg1 -
Utp3- - -
GA [auth g]KRR1 small subunit processome component
HA [auth h]Pre-rRNA-processing protein PNO1
IA [auth i],
JA [auth j]
RNA cytidine acetyltransferase
KA [auth k]Fcf2- -
LA [auth l]40S ribosomal protein S1
MA [auth m]40S ribosomal protein S4
NA [auth n]40S ribosomal protein s5-like protein
OA [auth o]40S ribosomal protein S6
PA [auth p]40S ribosomal protein S7-like protein
QA [auth q]40S ribosomal protein S8
Utp4- - -
RA [auth r]40S ribosomal protein s9-like protein
SA [auth s]40S ribosomal protein S13-like protein
TA [auth t]40S ribosomal protein S14-like protein
UA [auth u]40S ribosomal protein S16-like protein
VA [auth v]40S ribosomal protein S11-like protein
WA [auth w]40S ribosomal protein S22-like protein
XA [auth x]40S ribosomal protein s23-like protein
YA [auth y]40S ribosomal protein S24
ZA [auth z]40S ribosomal protein S28-like protein
AB [auth 0]Faf1- - -
Utp6
BB [auth 1]35S rRNA---
CB [auth 2]U3 snoRNA---
Utp7- -
Utp10-
U3 small nucleolar RNA-associated protein 11-
Utp12-

InterPro: Protein Family Classification InterPro Database Homepage

ChainsAccessionNameType
IPR001680WD40 repeatRepeat
IPR019775WD40 repeat, conserved siteConserved Site
IPR011044Quinoprotein amine dehydrogenase, beta chain-likeHomologous Superfamily
IPR007148Small-subunit processome, Utp12Domain
IPR020472G-protein beta WD-40 repeatRepeat
IPR036322WD40-repeat-containing domain superfamilyHomologous Superfamily
IPR015943WD40/YVTN repeat-like-containing domain superfamilyHomologous Superfamily
IPR027145Periodic tryptophan protein 2Family
IPR001680WD40 repeatRepeat
IPR019775WD40 repeat, conserved siteConserved Site
IPR013934U3 small nucleolar RNA-associated protein 13, C-terminalDomain
IPR020472G-protein beta WD-40 repeatRepeat
IPR036322WD40-repeat-containing domain superfamilyHomologous Superfamily
IPR015943WD40/YVTN repeat-like-containing domain superfamilyHomologous Superfamily
IPR006709Small-subunit processome, Utp14Family
IPR001680WD40 repeatRepeat
IPR019775WD40 repeat, conserved siteConserved Site
IPR018983U3 small nucleolar RNA-associated protein 15, C-terminalDomain
IPR020472G-protein beta WD-40 repeatRepeat
IPR036322WD40-repeat-containing domain superfamilyHomologous Superfamily
IPR015943WD40/YVTN repeat-like-containing domain superfamilyHomologous Superfamily
IPR001680WD40 repeatRepeat
IPR036322WD40-repeat-containing domain superfamilyHomologous Superfamily
IPR015943WD40/YVTN repeat-like-containing domain superfamilyHomologous Superfamily
IPR001680WD40 repeatRepeat
IPR036322WD40-repeat-containing domain superfamilyHomologous Superfamily
IPR015943WD40/YVTN repeat-like-containing domain superfamilyHomologous Superfamily
IPR045161U3 small nucleolar RNA-associated protein 18Family
IPR011047Quinoprotein alcohol dehydrogenase-like superfamilyHomologous Superfamily
IPR007319Small-subunit processome, Utp21Domain
IPR001680WD40 repeatRepeat
IPR019775WD40 repeat, conserved siteConserved Site
IPR015943WD40/YVTN repeat-like-containing domain superfamilyHomologous Superfamily
IPR002716PIN domainDomain
IPR029060PIN-like domain superfamilyHomologous Superfamily
IPR006984rRNA-processing protein Fcf1/Utp23Family
IPR037503rRNA-processing protein Fcf1, PIN domainDomain
IPR016095Large ribosomal subunit protein uL1, 3-layer alpha/beta-sandwich domainHomologous Superfamily
IPR023674Ribosomal protein uL1-likeHomologous Superfamily
IPR028364Ribosomal protein uL1/ribosomal biogenesis proteinFamily
R, S
IPR000692rRNA 2'-O-methyltransferase fibrillarin-likeFamily
R, S
IPR020813Fibrillarin, conserved siteConserved Site
R, S
IPR029063S-adenosyl-L-methionine-dependent methyltransferase superfamilyHomologous Superfamily
IPR042239Nop, C-terminal domainHomologous Superfamily
IPR036070Nop domain superfamilyHomologous Superfamily
IPR045056Nucleolar protein Nop56/Nop58Family
IPR012974Nucleolar protein 58/56, N-terminalDomain
IPR002687Nop domainDomain
IPR012976NOSICDomain
IPR007276Nucleolar protein 14Family
IPR042239Nop, C-terminal domainHomologous Superfamily
IPR036070Nop domain superfamilyHomologous Superfamily
IPR045056Nucleolar protein Nop56/Nop58Family
IPR012974Nucleolar protein 58/56, N-terminalDomain
IPR002687Nop domainDomain
IPR012976NOSICDomain
V, W
IPR002415H/ACA ribonucleoprotein complex, subunit Nhp2-likeFamily
V, W
IPR004038Ribosomal protein eL8/eL30/eS12/Gadd45Domain
V, W
IPR004037Large ribosomal subunit protein eL8-like, conserved siteConserved Site
V, W
IPR029064Ribosomal protein eL30-like superfamilyHomologous Superfamily
V, W
IPR018492Ribosomal protein eL8/Nhp2 familyFamily
IPR039241Ribosomal RNA-processing protein Rrp9-likeFamily
IPR001680WD40 repeatRepeat
IPR036322WD40-repeat-containing domain superfamilyHomologous Superfamily
IPR015943WD40/YVTN repeat-like-containing domain superfamilyHomologous Superfamily
IPR013792RNA 3'-terminal phosphate cyclase/enolpyruvate transferase, alpha/betaHomologous Superfamily
IPR023797RNA 3'-terminal phosphate cyclase domainDomain
IPR000228RNA 3'-terminal phosphate cyclaseFamily
IPR037136RNA 3'-terminal phosphate cyclase domain superfamilyHomologous Superfamily
IPR016443RNA 3'-terminal phosphate cyclase type 2Family
IPR013791RNA 3'-terminal phosphate cyclase, insert domainDomain
IPR036553RNA 3'-terminal phosphate cyclase, insert domain superfamilyHomologous Superfamily
IPR007034Ribosome biogenesis protein BMS1/TSR1, C-terminalDomain
IPR030387Bms1/Tsr1-type G domainDomain
IPR039761Ribosome biogenesis protein Bms1/Tsr1Family
IPR012948AARP2CNDomain
IPR037875Ribosome biogenesis protein Bms1, N-terminalDomain
IPR027417P-loop containing nucleoside triphosphate hydrolaseHomologous Superfamily
AA [auth a]IPR002942RNA-binding S4 domainDomain
AA [auth a]IPR001912Small ribosomal subunit protein uS4, N-terminalDomain
AA [auth a]IPR036986RNA-binding S4 domain superfamilyHomologous Superfamily
AA [auth a]IPR022801Small ribosomal subunit protein uS4Family
BA [auth b]IPR044281U3 snoRNP protein/Ribosome production factor 1Family
BA [auth b]IPR007109Brix domainDomain
CA [auth c]IPR012173U3 small nucleolar ribonucleoprotein complex, subunit Mpp10Family
DA [auth d]IPR001680WD40 repeatRepeat
DA [auth d]IPR019775WD40 repeat, conserved siteConserved Site
DA [auth d]IPR007287Sof1-like proteinDomain
DA [auth d]IPR020472G-protein beta WD-40 repeatRepeat
DA [auth d]IPR036322WD40-repeat-containing domain superfamilyHomologous Superfamily
DA [auth d]IPR015943WD40/YVTN repeat-like-containing domain superfamilyHomologous Superfamily
EA [auth e],
FA [auth f]
IPR029026tRNA (guanine-N1-)-methyltransferase, N-terminalHomologous Superfamily
EA [auth e],
FA [auth f]
IPR029028Alpha/beta knot methyltransferasesHomologous Superfamily
EA [auth e],
FA [auth f]
IPR005304Ribosomal biogenesis, methyltransferase, EMG1/NEP1Family
IPR018972Sas10 C-terminal domainDomain
IPR007146Sas10/Utp3/C1DFamily
GA [auth g]IPR004087K Homology domainDomain
GA [auth g]IPR048550KRR1 small subunit processome component, first KH domain, eukaryotesDomain
GA [auth g]IPR041174KRR1 small subunit processome component, first KH domainDomain
GA [auth g]IPR036612K Homology domain, type 1 superfamilyHomologous Superfamily
GA [auth g]IPR048548KRR1 small subunit processome component, second KH domainDomain
GA [auth g]IPR024166Ribosomal RNA assembly KRR1Family
GA [auth g]IPR048549KRR1 small subunit processome component, second KH domain, eukaryotesDomain
HA [auth h]IPR004087K Homology domainDomain
HA [auth h]IPR036612K Homology domain, type 1 superfamilyHomologous Superfamily
IA [auth i],
JA [auth j]
IPR027992Possible tRNA binding domainDomain
IA [auth i],
JA [auth j]
IPR032672TmcA/NAT10/Kre33Family
IA [auth i],
JA [auth j]
IPR013562tRNA(Met) cytidine acetyltransferase TmcA, N-terminalDomain
IA [auth i],
JA [auth j]
IPR033688RNA cytidine acetyltransferase NAT10Family
IA [auth i],
JA [auth j]
IPR000182GNAT domainDomain
IA [auth i],
JA [auth j]
IPR007807Helicase domainDomain
IA [auth i],
JA [auth j]
IPR027417P-loop containing nucleoside triphosphate hydrolaseHomologous Superfamily
KA [auth k]IPR039883Fcf2/DNTTIP2Family
KA [auth k]IPR014810Fcf2 pre-rRNA processing, C-terminalDomain
LA [auth l]IPR001593Small ribosomal subunit protein eS1Family
LA [auth l]IPR018281Small ribosomal subunit protein eS1, conserved siteConserved Site
LA [auth l]IPR027500Small ribosomal subunit protein eS1, eukaryotesFamily
MA [auth m]IPR018199Small ribosomal subunit protein eS4, N-terminal, conserved siteConserved Site
MA [auth m]IPR013843Small ribosomal subunit protein eS4, N-terminalDomain
MA [auth m]IPR032277Small ribosomal subunit protein eS4, C-terminal domainDomain
MA [auth m]IPR002942RNA-binding S4 domainDomain
MA [auth m]IPR013845Small ribosomal subunit protein eS4, central regionDomain
MA [auth m]IPR000876Small ribosomal subunit protein eS4Family
MA [auth m]IPR014722Large ribosomal subunit protein uL2, domain 2Homologous Superfamily
MA [auth m]IPR038237Small ribosomal subunit protein eS4, central domain superfamilyHomologous Superfamily
MA [auth m]IPR041982Small ribosomal subunit protein eS4, KOW domainDomain
MA [auth m]IPR036986RNA-binding S4 domain superfamilyHomologous Superfamily
MA [auth m]IPR005824KOWDomain
NA [auth n]IPR020606Small ribosomal subunit protein uS7, conserved siteConserved Site
NA [auth n]IPR000235Small ribosomal subunit protein uS7Family
NA [auth n]IPR036823Small ribosomal subunit protein uS7 domain superfamilyHomologous Superfamily
NA [auth n]IPR023798Small ribosomal subunit protein uS7 domainDomain
NA [auth n]IPR005716Ribosomal protein uS7, eukaryotic/archaealFamily
OA [auth o]IPR014401Small ribosomal subunit protein eS6-likeFamily
OA [auth o]IPR001377Small ribosomal subunit protein eS6Family
OA [auth o]IPR018282Small ribosomal subunit protein eS6, conserved siteConserved Site
PA [auth p]IPR000554Small ribosomal subunit protein eS7Family
PA [auth p]IPR047861Small ribosomal subunit protein eS7, conserved siteConserved Site
QA [auth q]IPR001047Small ribosomal subunit protein eS8Family
QA [auth q]IPR042563Small ribosomal subunit protein eS8 subdomain, eukaryotesHomologous Superfamily
QA [auth q]IPR022309Ribosomal protein eS8/ribosomal biogenesis NSA2Family
IPR018391Pyrrolo-quinoline quinone beta-propeller repeatRepeat
IPR011047Quinoprotein alcohol dehydrogenase-like superfamilyHomologous Superfamily
IPR001680WD40 repeatRepeat
IPR015943WD40/YVTN repeat-like-containing domain superfamilyHomologous Superfamily
RA [auth r]IPR018079Small ribosomal subunit protein uS4, conserved siteConserved Site
RA [auth r]IPR002942RNA-binding S4 domainDomain
RA [auth r]IPR001912Small ribosomal subunit protein uS4, N-terminalDomain
RA [auth r]IPR005710Small ribosomal subunit protein uS4, eukaryotic/archaealFamily
RA [auth r]IPR036986RNA-binding S4 domain superfamilyHomologous Superfamily
RA [auth r]IPR022801Small ribosomal subunit protein uS4Family
SA [auth s]IPR012606Small ribosomal subunit protein uS15, N-terminalDomain
SA [auth s]IPR009068uS15/NS1, RNA-binding domain superfamilyHomologous Superfamily
SA [auth s]IPR023029Small ribosomal subunit protein uS15, archaea/eukaryotesFamily
SA [auth s]IPR000589Small ribosomal subunit protein uS15Family
TA [auth t]IPR001971Small ribosomal subunit protein uS11Family
TA [auth t]IPR036967Small ribosomal subunit protein uS11 superfamilyHomologous Superfamily
TA [auth t]IPR018102Small ribosomal subunit protein uS11, conserved siteConserved Site
UA [auth u]IPR020574Small ribosomal subunit protein uS9, conserved siteConserved Site
UA [auth u]IPR020568Ribosomal protein uS5 domain 2-type superfamilyHomologous Superfamily
UA [auth u]IPR000754Small ribosomal subunit protein uS9Family
UA [auth u]IPR014721Small ribosomal subunit protein uS5 domain 2-type fold, subgroupHomologous Superfamily
VA [auth v]IPR019979Small ribosomal subunit protein uS17, conserved siteConserved Site
VA [auth v]IPR012340Nucleic acid-binding, OB-foldHomologous Superfamily
VA [auth v]IPR000266Small ribosomal subunit protein uS17Family
VA [auth v]IPR032440Small ribosomal subunit protein uS17, N-terminalDomain
VA [auth v]IPR028333Small ribosomal subunit protein uS17, archaeal/eukaryoticFamily
WA [auth w]IPR000630Small ribosomal subunit protein uS8Family
WA [auth w]IPR047863Small ribosomal subunit protein uS8, conserved siteConserved Site
WA [auth w]IPR035987Small ribosomal subunit protein uS8 superfamilyHomologous Superfamily
XA [auth x]IPR006032Small ribosomal subunit protein uS12Family
XA [auth x]IPR012340Nucleic acid-binding, OB-foldHomologous Superfamily
XA [auth x]IPR005680Small ribosomal subunit protein uS12, eukaryotic/archaealFamily
YA [auth y]IPR001976Small ribosomal subunit protein eS24Family
YA [auth y]IPR012678Ribosomal protein uL23/eL15/eS24 core domain superfamilyHomologous Superfamily
YA [auth y]IPR018098Small ribosomal subunit protein eS24 conserved siteConserved Site
ZA [auth z]IPR028626Ribosomal protein eS28 conserved siteConserved Site
ZA [auth z]IPR012340Nucleic acid-binding, OB-foldHomologous Superfamily
ZA [auth z]IPR000289Small ribosomal subunit protein eS28Family
IPR003107HAT (Half-A-TPR) repeatRepeat
IPR011990Tetratricopeptide-like helical domain superfamilyHomologous Superfamily
IPR013949U3 small nucleolar RNA-associated protein 6Family
IPR012952BING4, C-terminal domainDomain
IPR001680WD40 repeatRepeat
IPR019775WD40 repeat, conserved siteConserved Site
IPR036322WD40-repeat-containing domain superfamilyHomologous Superfamily
IPR015943WD40/YVTN repeat-like-containing domain superfamilyHomologous Superfamily
IPR040315WD repeat-containing protein WDR46/Utp7Family
IPR011989Armadillo-like helicalHomologous Superfamily
IPR016024Armadillo-type foldHomologous Superfamily
IPR040191U3 small nucleolar RNA-associated protein 10Family
IPR022125U3 small nucleolar RNA-associated protein 10, N-terminalDomain
IPR012954BP28, C-terminal domainDomain
IPR007144Small-subunit processome, Utp11Family
IPR011047Quinoprotein alcohol dehydrogenase-like superfamilyHomologous Superfamily
IPR001680WD40 repeatRepeat
IPR019775WD40 repeat, conserved siteConserved Site
IPR007148Small-subunit processome, Utp12Domain
IPR020472G-protein beta WD-40 repeatRepeat
IPR036322WD40-repeat-containing domain superfamilyHomologous Superfamily
IPR015943WD40/YVTN repeat-like-containing domain superfamilyHomologous Superfamily