5OM0

CH2 chimera of human 14-3-3 sigma with the Gli1 phosphopeptide around Ser640

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations
Protein Modification Annotation

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
B	SCOP2B Superfamily	14-3-3 protein	8082819	3001329	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	14-3-3 protein	8082819	3001329	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
B	PF00244	e5om0B1	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: PF00244	ECOD (1.6)
A	PF00244	e5om0A1	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: PF00244	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
B	1.20.190.20	Mainly Alpha	Up-down Bundle	Delta-Endotoxin	domain 1	CATH (4.3.0)
A	1.20.190.20	Mainly Alpha	Up-down Bundle	Delta-Endotoxin	domain 1	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF00244	14-3-3 protein (14-3-3)	14-3-3 protein	-	Repeat

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	14-3-3 protein sigma,Zinc finger protein GLI1	DNA binding sequence-specific DNA binding sequence-specific double-stranded DNA binding transcription cis-regulatory region binding binding double-stranded DNA binding organic cyclic compound binding nucleic acid binding transcription regulatory region nucleic acid binding DNA-binding transcription factor activity, RNA polymerase II-specific transcription regulator activity DNA-binding transcription factor activity cytoskeletal protein binding microtubule binding DNA binding sequence-specific DNA binding sequence-specific double-stranded DNA binding transcription cis-regulatory region binding binding double-stranded DNA binding organic cyclic compound binding nucleic acid binding transcription regulatory region nucleic acid binding DNA-binding transcription factor activity, RNA polymerase II-specific transcription regulator activity DNA-binding transcription factor activity cytoskeletal protein binding microtubule binding protein binding tubulin binding DNA-binding transcription activator activity, RNA polymerase II-specific DNA-binding transcription activator activity cation binding ion binding metal ion binding small molecule binding RNA polymerase II transcription regulatory region sequence-specific DNA binding cis-regulatory region sequence-specific DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding protein-containing complex binding chromatin binding phosphoprotein binding phosphoserine residue binding protein phosphorylated amino acid binding enzyme regulator activity protein kinase inhibitor activity molecular function inhibitor activity molecular function regulator activity enzyme inhibitor activity protein kinase C inhibitor activity protein kinase regulator activity protein serine/threonine kinase inhibitor activity kinase inhibitor activity kinase regulator activity molecular sequestering activity protein sequestering activity kinase binding enzyme binding protein kinase binding cell adhesion molecule binding cadherin binding identical protein binding	developmental process multicellular organismal process reproductive system development prostate gland development reproductive process gland development animal organ development urogenital system development developmental process involved in reproduction multicellular organism development anatomical structure development reproductive structure development system development regulation of hepatocyte proliferation developmental process multicellular organismal process reproductive system development prostate gland development reproductive process gland development animal organ development urogenital system development developmental process involved in reproduction multicellular organism development anatomical structure development reproductive structure development system development regulation of hepatocyte proliferation regulation of cellular process liver development gland morphogenesis animal organ morphogenesis epithelial cell proliferation liver morphogenesis regulation of biological process cell population proliferation biological regulation epithelial cell proliferation involved in liver morphogenesis anatomical structure morphogenesis hepatocyte proliferation regulation of cell population proliferation hepaticobiliary system development cellular process regulation of epithelial cell proliferation regulation of growth positive regulation of cell population proliferation regulation of cardiac muscle tissue growth regulation of developmental process developmental growth cardiac muscle cell proliferation positive regulation of biological process organ growth striated muscle tissue development positive regulation of developmental process positive regulation of cardiac muscle cell proliferation regulation of organ growth regulation of heart growth regulation of cardiac muscle cell proliferation muscle cell proliferation regulation of multicellular organismal process cardiac muscle tissue growth muscle tissue development positive regulation of developmental growth positive regulation of cellular process striated muscle cell proliferation positive regulation of heart growth heart development heart growth regulation of multicellular organismal development regulation of developmental growth cardiac muscle tissue development positive regulation of organ growth growth tissue development circulatory system development positive regulation of growth positive regulation of cardiac muscle tissue growth positive regulation of multicellular organismal process dorsal/ventral pattern formation pattern specification process regionalization cellular response to stimulus response to stimulus signaling negative regulation of signaling regulation of canonical Wnt signaling pathway canonical Wnt signaling pathway negative regulation of biological process regulation of signal transduction negative regulation of cell communication cell communication negative regulation of Wnt signaling pathway negative regulation of cellular process signal transduction Wnt signaling pathway regulation of signaling cell surface receptor signaling pathway regulation of Wnt signaling pathway negative regulation of response to stimulus negative regulation of signal transduction negative regulation of canonical Wnt signaling pathway regulation of response to stimulus regulation of cell communication positive regulation of DNA replication regulation of primary metabolic process nucleobase-containing compound metabolic process positive regulation of metabolic process organic substance metabolic process positive regulation of macromolecule metabolic process regulation of nucleobase-containing compound metabolic process positive regulation of nucleobase-containing compound metabolic process primary metabolic process DNA metabolic process regulation of macromolecule metabolic process nucleic acid metabolic process organic cyclic compound metabolic process DNA replication positive regulation of DNA metabolic process metabolic process macromolecule metabolic process regulation of metabolic process regulation of DNA metabolic process regulation of DNA replication cerebellum morphogenesis cerebellar cortex morphogenesis head development hindbrain morphogenesis brain development nervous system development cerebellar cortex development cerebellum development central nervous system development metencephalon development hindbrain development forebrain development endocrine system development pituitary gland development diencephalon development ventral midline development spermatid development spermatid differentiation sexual reproduction cellular developmental process spermatogenesis multicellular organismal reproductive process cell development cellular process involved in reproduction in multicellular organism gamete generation male gamete generation cell differentiation germ cell development cellular biosynthetic process RNA metabolic process RNA biosynthetic process nucleic acid biosynthetic process DNA-templated transcription regulation of RNA metabolic process organic substance biosynthetic process regulation of RNA biosynthetic process regulation of biosynthetic process cellular metabolic process regulation of cellular metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process regulation of cellular biosynthetic process regulation of gene expression biosynthetic process organic cyclic compound biosynthetic process regulation of macromolecule biosynthetic process regulation of DNA-templated transcription response to stress response to wounding digestive system development tube development digestive tract development tube morphogenesis digestive tract morphogenesis epithelium development epidermal cell differentiation epidermis development epithelial cell differentiation notochord regression embryonic organ morphogenesis embryonic morphogenesis notochord morphogenesis embryo development anatomical structure regression embryonic organ development notochord development positive regulation of macromolecule biosynthetic process transcription by RNA polymerase II regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II positive regulation of RNA metabolic process positive regulation of DNA-templated transcription positive regulation of cellular metabolic process positive regulation of biosynthetic process positive regulation of RNA biosynthetic process positive regulation of cellular biosynthetic process regulation of osteoblast differentiation regulation of cell differentiation osteoblast differentiation ossification smoothened signaling pathway regulation of smoothened signaling pathway respiratory tube development lung development respiratory system development positive regulation of cell communication positive regulation of signal transduction positive regulation of response to stimulus positive regulation of smoothened signaling pathway positive regulation of signaling animal organ regeneration regeneration liver regeneration positive regulation of locomotion regulation of cell motility positive regulation of cell migration regulation of locomotion positive regulation of cell motility regulation of cell migration cell migration cell motility locomotion regulation of cell cycle phase transition regulation of cell cycle process cell cycle phase transition regulation of cell cycle G1/S phase transition cell cycle G1/S phase transition positive regulation of cell cycle positive regulation of cell cycle G1/S phase transition positive regulation of cell cycle phase transition positive regulation of cell cycle process cell cycle regulation of cell cycle cell cycle process proximal/distal pattern formation regulation of cellular component organization positive regulation of cell growth regulation of cell growth cell growth cellular component organization cellular component organization or biogenesis negative regulation of hydrolase activity negative regulation of proteolysis regulation of catalytic activity negative regulation of catalytic activity regulation of programmed cell death negative regulation of endopeptidase activity negative regulation of peptidase activity regulation of cysteine-type endopeptidase activity involved in apoptotic process regulation of proteolysis proteolysis regulation of endopeptidase activity negative regulation of cysteine-type endopeptidase activity involved in apoptotic process protein metabolic process negative regulation of protein metabolic process negative regulation of macromolecule metabolic process regulation of cysteine-type endopeptidase activity organonitrogen compound metabolic process negative regulation of programmed cell death regulation of protein metabolic process regulation of apoptotic process negative regulation of metabolic process regulation of peptidase activity negative regulation of molecular function cell death regulation of molecular function negative regulation of apoptotic process regulation of hydrolase activity negative regulation of cysteine-type endopeptidase activity apoptotic process programmed cell death protein localization cellular localization establishment of protein localization nitrogen compound transport nucleocytoplasmic transport transport nuclear transport organic substance transport intracellular transport protein export from nucleus establishment of localization localization protein transport establishment of localization in cell cellular macromolecule localization macromolecule localization nuclear export intracellular protein transport epidermal cell division cell division regulation of epidermal cell division regulation of cell division establishment of skin barrier skin development skin epidermis development regulation of defense response regulation of response to biotic stimulus biological process involved in interspecies interaction between organisms negative regulation of response to biotic stimulus regulation of response to external stimulus response to biotic stimulus regulation of response to stress innate immune response regulation of immune system process response to external biotic stimulus immune response response to other organism defense response regulation of innate immune response negative regulation of immune response defense response to symbiont response to external stimulus negative regulation of immune system process immune system process defense response to other organism negative regulation of response to external stimulus negative regulation of defense response regulation of immune response negative regulation of innate immune response keratinocyte proliferation intracellular signal transduction protein kinase A signaling negative regulation of cell population proliferation regulation of stem cell proliferation negative regulation of stem cell proliferation stem cell proliferation regulation of transferase activity negative regulation of cellular metabolic process negative regulation of kinase activity negative regulation of transferase activity regulation of phosphate metabolic process phosphate-containing compound metabolic process negative regulation of protein modification process phosphorus metabolic process protein modification process protein phosphorylation phosphorylation regulation of kinase activity negative regulation of protein phosphorylation macromolecule modification regulation of phosphorus metabolic process regulation of protein modification process regulation of protein phosphorylation negative regulation of phosphate metabolic process negative regulation of protein kinase activity regulation of protein kinase activity negative regulation of phosphorus metabolic process regulation of phosphorylation negative regulation of phosphorylation regulation of localization regulation of protein localization positive regulation of nucleocytoplasmic transport positive regulation of establishment of protein localization positive regulation of protein transport positive regulation of intracellular transport regulation of protein export from nucleus regulation of intracellular transport regulation of transport regulation of establishment of protein localization regulation of nucleocytoplasmic transport regulation of protein transport positive regulation of protein export from nucleus positive regulation of transport regulation of cellular localization positive regulation of protein localization regulation of intracellular protein transport positive regulation of intracellular protein transport apoptotic signaling pathway cellular response to stress DNA damage response intrinsic apoptotic signaling pathway in response to DNA damage intrinsic apoptotic signaling pathway keratinization keratinocyte differentiation keratinocyte development epithelial cell development regulation of keratinocyte proliferation negative regulation of keratinocyte proliferation negative regulation of epithelial cell proliferation negative regulation of RNA biosynthetic process negative regulation of nucleobase-containing compound metabolic process negative regulation of DNA-templated transcription negative regulation of transcription by RNA polymerase II negative regulation of cellular biosynthetic process negative regulation of macromolecule biosynthetic process negative regulation of RNA metabolic process negative regulation of biosynthetic process apoptotic mitochondrial changes release of cytochrome c from mitochondria organelle organization mitochondrion organization regulation of epidermal cell differentiation regulation of epithelial cell differentiation positive regulation of cell differentiation positive regulation of epidermis development positive regulation of epithelial cell differentiation regulation of epidermis development positive regulation of epidermal cell differentiation	membrane-bounded organelle intracellular anatomical structure axoneme ciliary plasm cilium cellular anatomical entity cytoplasmic region plasma membrane bounded cell projection cytoplasm plasma membrane bounded cell projection intracellular organelle cell projection cytoskeleton organelle intracellular non-membrane-bounded organelle membrane-bounded organelle intracellular anatomical structure axoneme ciliary plasm cilium cellular anatomical entity cytoplasmic region plasma membrane bounded cell projection cytoplasm plasma membrane bounded cell projection intracellular organelle cell projection cytoskeleton organelle intracellular non-membrane-bounded organelle cytoplasm non-membrane-bounded organelle cytosol ciliary tip protein-containing complex GLI-SUFU complex nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen ciliary base extracellular exosome extracellular vesicle extracellular organelle extracellular region extracellular space vesicle extracellular membrane-bounded organelle

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR013087	Zinc finger C2H2-type	Domain
A, B	IPR043359	C2H2-type zinc-finger protein GLI-like	Family
A, B	IPR036236	Zinc finger C2H2 superfamily	Homologous Superfamily
A, B	IPR023409	14-3-3 protein, conserved site	Conserved Site
A, B	IPR023410	14-3-3 domain	Domain
A, B	IPR037435	14-3-3 protein sigma	Family
A, B	IPR036815	14-3-3 domain superfamily	Homologous Superfamily
A, B	IPR000308	14-3-3 protein	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B	Pharos: P31947	acute promyelocytic leukemia diffuse large B-cell lymphoma peripheral nervous system disease urinary bladder cancer peripheral neuropathy cancer gastrointestinal stromal tumor glioblastoma Liver carcinoma medulloblastoma atypical teratoid rhabdoid tumor Ellis-van Creveld syndrome heart disease malignant mesothelioma nevoid basal cell carcinoma syndrome acute promyelocytic leukemia diffuse large B-cell lymphoma peripheral nervous system disease urinary bladder cancer peripheral neuropathy cancer gastrointestinal stromal tumor glioblastoma Liver carcinoma medulloblastoma atypical teratoid rhabdoid tumor Ellis-van Creveld syndrome heart disease malignant mesothelioma nevoid basal cell carcinoma syndrome urinary bladder neoplasm hepatocellular carcinoma osteosarcoma psoriasis esophageal squamous cell carcinoma squamous cell carcinoma esophageal cancer Lymphatic Metastasis keloid lung adenocarcinoma malignant pancreatic neoplasm non-small cell lung carcinoma ovarian cancer pancreatic intraductal papillary-mucinous neoplasm sarcoidosis cystic fibrosis interstitial cystitis malignant mesothelioma oral cavity neoplasm pancreatic ductal adenocarcinoma pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia atypical teratoid rhabdoid tumor spina bifida diabetes mellitus malignant ependymoma neoplasm of esophagus osteosarcoma pancreatic intraductal papillary-mucinous carcinoma psoriasis breast cancer ductal breast carcinoma in situ hepatocellular carcinoma large cell medulloblastoma lung cancer malignant glioma

Protein Modification Annotation

Modified Residue(s)
Chain	Residue(s)	Description
A, B	SEP	Parent Component: SER RESID: AA0037 PSI-MOD : O-phospho-L-serine MOD:00046

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.