Annotations: 5OK6

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF14836	e5ok6A2	A: a+b two layers	X: beta-Grasp	H: Ubiquitin-related	T: Ubiquitin-like	F: PF14836	ECOD (1.6)
A	PF06337	e5ok6A1	A: a+b complex topology	X: DUSP, domain in ubiquitin-specific proteases (From Topology)	H: DUSP, domain in ubiquitin-specific proteases (From Topology)	T: DUSP, domain in ubiquitin-specific proteases	F: PF06337	ECOD (1.6)
B	PF14836	e5ok6B2	A: a+b two layers	X: beta-Grasp	H: Ubiquitin-related	T: Ubiquitin-like	F: PF14836	ECOD (1.6)
B	PF06337	e5ok6B1	A: a+b complex topology	X: DUSP, domain in ubiquitin-specific proteases (From Topology)	H: DUSP, domain in ubiquitin-specific proteases (From Topology)	T: DUSP, domain in ubiquitin-specific proteases	F: PF06337	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF14836	Ubiquitin-like domain (Ubiquitin_3)	Ubiquitin-like domain	This ubiquitin-like domain is found in several ubiquitin carboxyl-terminal hydrolases [1] and in gametogenetin-binding protein.	Domain
A, B	PF06337	DUSP domain (DUSP)	DUSP domain	The DUSP (domain present in ubiquitin-specific protease) domain is found at the N-terminus of Ubiquitin-specific proteases. The structure of this domain has been solved [1]. Its tripod-like structure consists of a 3-fold alpha-helical bundle supporti ...	The DUSP (domain present in ubiquitin-specific protease) domain is found at the N-terminus of Ubiquitin-specific proteases. The structure of this domain has been solved [1]. Its tripod-like structure consists of a 3-fold alpha-helical bundle supporting a triple-stranded anti-parallel beta-sheet [1].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	Ubiquitin carboxyl-terminal hydrolase 11	cysteine-type peptidase activity ubiquitin-like protein peptidase activity peptidase activity cysteine-type deubiquitinase activity catalytic activity, acting on a protein hydrolase activity catalytic activity deubiquitinase activity transcription factor binding transcription coregulator binding transcription corepressor binding protein binding binding cysteine-type endopeptidase activity cysteine-type peptidase activity ubiquitin-like protein peptidase activity peptidase activity cysteine-type deubiquitinase activity catalytic activity, acting on a protein hydrolase activity catalytic activity deubiquitinase activity transcription factor binding transcription coregulator binding transcription corepressor binding protein binding binding cysteine-type endopeptidase activity endopeptidase activity	protein deubiquitination organonitrogen compound metabolic process primary metabolic process organic substance metabolic process protein modification by small protein removal macromolecule modification metabolic process protein metabolic process macromolecule metabolic process post-translational protein modification protein modification process protein modification by small protein conjugation or removal proteolysis	intracellular organelle intracellular anatomical structure organelle intracellular non-membrane-bounded organelle chromosome cellular anatomical entity non-membrane-bounded organelle cytoplasm cytosol membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle intracellular anatomical structure organelle intracellular non-membrane-bounded organelle chromosome cellular anatomical entity non-membrane-bounded organelle cytoplasm cytosol membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen
C, D	ALA-GLU-GLY-GLU-PHE-TYR-LYS-LEU-LYS-ILE-ARG-THR-PRO-AAR	-	-	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR028889	Ubiquitin specific protease domain	Domain
A, B	IPR028135	Ubiquitin-like domain, USP-type	Domain
A, B	IPR035927	DUSP-like superfamily	Homologous Superfamily
A, B	IPR018200	Ubiquitin specific protease, conserved site	Conserved Site
A, B	IPR006615	Peptidase C19, ubiquitin-specific peptidase, DUSP domain	Domain
A, B	IPR001394	Peptidase C19, ubiquitin carboxyl-terminal hydrolase	Domain
A, B	IPR038765	Papain-like cysteine peptidase superfamily	Homologous Superfamily
A, B	IPR029346	Ubiquitin carboxyl-terminal hydrolase, C-terminal	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B	Pharos: P51784	atypical teratoid rhabdoid tumor lung carcinoma subependymal giant cell astrocytoma juvenile dermatomyositis malignant glioma large cell medulloblastoma ovarian cancer

Protein Modification Annotation

Modified Residue(s)
Chain	Residue(s)	Description
C, D	AAR	Parent Component: ARG RESID: AA0082 PSI-MOD : L-arginine amide MOD:00091

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.