5OFB

Crystal structure of human MORC2 (residues 1-603) with spinal muscular atrophy mutation S87L

External Resource: Annotation

Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A [auth B]	PF17942	e5ofbB2	A: a+b two layers	X: Ribosomal protein S5 domain 2-like (From Topology)	H: Ribosomal protein S5 domain 2-like (From Topology)	T: Ribosomal protein S5 domain 2-like	F: PF17942	ECOD (1.6)
A [auth B]	PF13589	e5ofbB1	A: a+b two layers	X: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase-like	H: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase (From Topology)	T: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	F: PF13589	ECOD (1.6)
A [auth B]	PF07496	e5ofbB3	A: few secondary structure elements	X: RING/U-box-like	H: RING/U-box-like	T: FYVE/PHD zinc finger	F: PF07496	ECOD (1.6)
B [auth A]	PF17942	e5ofbA1	A: a+b two layers	X: Ribosomal protein S5 domain 2-like (From Topology)	H: Ribosomal protein S5 domain 2-like (From Topology)	T: Ribosomal protein S5 domain 2-like	F: PF17942	ECOD (1.6)
B [auth A]	PF13589	e5ofbA2	A: a+b two layers	X: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase-like	H: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase (From Topology)	T: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	F: PF13589	ECOD (1.6)
B [auth A]	PF07496	e5ofbA3	A: few secondary structure elements	X: RING/U-box-like	H: RING/U-box-like	T: FYVE/PHD zinc finger	F: PF07496	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A [auth B], B [auth A]	PF07496	CW-type Zinc Finger (zf-CW)	CW-type Zinc Finger	This domain appears to be a zinc finger. The alignment shows four conserved cysteine residues and a conserved tryptophan. It was first identified by [1], and is predicted to be a "highly specialised mononuclear four-cysteine zinc finger...that plays ...	This domain appears to be a zinc finger. The alignment shows four conserved cysteine residues and a conserved tryptophan. It was first identified by [1], and is predicted to be a "highly specialised mononuclear four-cysteine zinc finger...that plays a role in DNA binding and/or promoting protein-protein interactions in complicated eukaryotic processes including ...chromatin methylation status and early embryonic development." Weak homology to Pfam:PF00628 further evidences these predictions (personal obs: C Yeats). Twelve different CW-domain-containing protein subfamilies are described, with different subfamilies being characteristic of vertebrates, higher plants and other animals in which these domain is found [1].	Domain
A [auth B], B [auth A]	PF17942	Morc6 ribosomal protein S5 domain 2-like (Morc6_S5)	Morc6 ribosomal protein S5 domain 2-like	-	Family
A [auth B], B [auth A]	PF13589	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c_3)	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	This family represents, additionally, the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A [auth B], B [auth A]	MORC family CW-type zinc finger protein 2	cation binding magnesium ion binding ion binding binding metal ion binding small molecule binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding purine nucleotide binding organic cyclic compound binding anion binding cation binding magnesium ion binding ion binding binding metal ion binding small molecule binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding identical protein binding protein binding protein homodimerization activity protein dimerization activity protein-containing complex binding chromatin binding pyrophosphatase activity ATP hydrolysis activity ribonucleoside triphosphate phosphatase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity hydrolase activity, acting on acid anhydrides catalytic activity ATP-dependent activity transition metal ion binding zinc ion binding	cellular response to stimulus cellular response to stress response to stimulus DNA damage response response to stress cellular process fatty acid metabolic process oxoacid metabolic process cellular metabolic process carboxylic acid metabolic process primary metabolic process organic acid metabolic process organic substance metabolic process cellular lipid metabolic process cellular response to stimulus cellular response to stress response to stimulus DNA damage response response to stress cellular process fatty acid metabolic process oxoacid metabolic process cellular metabolic process carboxylic acid metabolic process primary metabolic process organic acid metabolic process organic substance metabolic process cellular lipid metabolic process metabolic process small molecule metabolic process monocarboxylic acid metabolic process lipid metabolic process positive regulation of organelle organization regulation of cellular process negative regulation of biological process negative regulation of cellular metabolic process cellular component biogenesis chromatin organization organic substance biosynthetic process regulation of heterochromatin formation regulation of biological process regulation of chromatin organization regulation of DNA methylation-dependent heterochromatin formation negative regulation of metabolic process regulation of cellular metabolic process regulation of chromosome organization regulation of organelle organization negative regulation of cellular biosynthetic process positive regulation of chromosome organization regulation of gene expression negative regulation of gene expression biosynthetic process negative regulation of macromolecule biosynthetic process negative regulation of gene expression, epigenetic regulation of macromolecule biosynthetic process macromolecule metabolic process regulation of metabolic process regulation of cellular component organization positive regulation of cellular component organization cellular biosynthetic process positive regulation of biological process positive regulation of DNA methylation-dependent heterochromatin formation cellular component organization protein-DNA complex organization positive regulation of heterochromatin formation negative regulation of cellular process DNA methylation-dependent heterochromatin formation positive regulation of chromatin organization chromatin remodeling cellular component organization or biogenesis positive regulation of cellular process negative regulation of macromolecule metabolic process regulation of biosynthetic process heterochromatin formation protein-containing complex organization positive regulation of cellular component biogenesis epigenetic regulation of gene expression biological regulation chromosome organization regulation of macromolecule metabolic process gene expression regulation of cellular component biogenesis macromolecule biosynthetic process regulation of cellular biosynthetic process organelle organization negative regulation of biosynthetic process facultative heterochromatin formation viral life cycle negative regulation of RNA biosynthetic process regulation of primary metabolic process nucleobase-containing compound metabolic process regulation of RNA metabolic process negative regulation of nucleobase-containing compound metabolic process regulation of nucleobase-containing compound metabolic process single stranded viral RNA replication via double stranded DNA intermediate organic cyclic compound metabolic process viral genome replication organic cyclic compound biosynthetic process negative regulation of RNA metabolic process regulation of single stranded viral RNA replication via double stranded DNA intermediate RNA metabolic process negative regulation of single stranded viral RNA replication via double stranded DNA intermediate RNA biosynthetic process nucleic acid biosynthetic process negative regulation of viral process viral RNA genome replication viral process regulation of RNA biosynthetic process negative regulation of viral genome replication nucleobase-containing compound biosynthetic process nucleic acid metabolic process regulation of viral process regulation of viral life cycle regulation of viral genome replication	membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle lumen intracellular organelle organelle lumen organelle nuclear periphery nuclear lumen nuclear matrix protein-containing complex membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle lumen intracellular organelle organelle lumen organelle nuclear periphery nuclear lumen nuclear matrix protein-containing complex protein-DNA complex chromatin chromosome heterochromatin intracellular non-membrane-bounded organelle non-membrane-bounded organelle cytoplasm cytosol nucleoplasm

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A [auth B], B [auth A]	IPR036890	Histidine kinase/HSP90-like ATPase superfamily	Homologous Superfamily
A [auth B], B [auth A]	IPR041006	Morc, S5 domain 2-like	Domain
A [auth B], B [auth A]	IPR011124	Zinc finger, CW-type	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A [auth B], B [auth A]	Pharos: Q9Y6X9	Charcot-Marie-Tooth disease Charcot-Marie-Tooth disease axonal type 2Z peripheral neuropathy Roussy-Levy Syndrome (disorder) astrocytic tumor Charcot-Marie-Tooth disease type 1A medulloblastoma non-small cell lung carcinoma ovarian cancer Charcot-Marie-Tooth disease type 1B hereditary sensory and autonomic neuropathy type 2 motor peripheral neuropathy oligodendroglioma pancreatic ductal adenocarcinoma psoriasis Charcot-Marie-Tooth disease Charcot-Marie-Tooth disease axonal type 2Z peripheral neuropathy Roussy-Levy Syndrome (disorder) astrocytic tumor Charcot-Marie-Tooth disease type 1A medulloblastoma non-small cell lung carcinoma ovarian cancer Charcot-Marie-Tooth disease type 1B hereditary sensory and autonomic neuropathy type 2 motor peripheral neuropathy oligodendroglioma pancreatic ductal adenocarcinoma psoriasis lung cancer neurodegenerative disease osteosarcoma peripheral nervous system disease

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.