Annotations: 5OF4

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	RecA-like P-loop NTPases	8054245	3002019	SCOP2B (2022-06-29)
D [auth E]	SCOP2B Superfamily	vWA-like	8057086	3000832	SCOP2B (2022-06-29)
E [auth F]	SCOP2B Superfamily	vWA-like	8054198	3000832	SCOP2B (2022-06-29)
F [auth G]	SCOP2B Superfamily	TFB5-like	8034306	3000733	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
C [auth D]	PF18307	e5of4D1	A: a+b complex topology	X: TFB5-related (From Topology)	H: TFB5-related (From Topology)	T: TFB5-related	F: PF18307	ECOD (1.6)
D [auth E]	PF04056	e5of4E1	A: a/b three-layered sandwiches	X: HAD domain-like	H: HAD domain-related	T: vWA-like	F: PF04056	ECOD (1.6)
E [auth F]	PF03850	e5of4F1	A: a/b three-layered sandwiches	X: HAD domain-like	H: HAD domain-related	T: vWA-like	F: PF03850	ECOD (1.6)
F [auth G]	PF06331	e5of4G1	A: a+b complex topology	X: TFB5-related (From Topology)	H: TFB5-related (From Topology)	T: TFB5-related	F: PF06331	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF04851	Type III restriction enzyme, res subunit (ResIII)	Type III restriction enzyme, res subunit	-	Family
A	PF16203	ERCC3/RAD25/XPB C-terminal helicase (ERCC3_RAD25_C)	ERCC3/RAD25/XPB C-terminal helicase	This is the C-terminal helicase domain of ERCC3, RAD25 and XPB helicases [1].	Domain
B	PF13307	Helicase C-terminal domain (Helicase_C_2)	Helicase C-terminal domain	This domain is found at the C-terminus of DEAD-box helicases.	Domain
B	PF06733	DEAD_2 (DEAD_2)	DEAD_2	-	Family
B	PF06777	Helical and beta-bridge domain (HBB)	Helical and beta-bridge domain	HBB is the domain on DEAD-box eukaryotic DNA repair helicases (EC:3.6.1.-) that appears to be a unique fold. It's conformation is of alpha-helices 12-16 plus a short beta-bridge to the FeS-cluster domain at the N-terminal. The full-length XPD protein ...	HBB is the domain on DEAD-box eukaryotic DNA repair helicases (EC:3.6.1.-) that appears to be a unique fold. It's conformation is of alpha-helices 12-16 plus a short beta-bridge to the FeS-cluster domain at the N-terminal. The full-length XPD protein verifies the presence of damage to DNA and allows DNA repair to proceed. XPD is an assembly of several domains to form a doughnut-shaped molecule that is able to separate two DNA strands and scan the DNA for damage. HBB helps to form the overall DNA-clamping architecture [1]. This family represents a conserved region within a number of eukaryotic DNA repair helicases (EC:3.6.1.-).	Domain
C [auth D]	PF18307	Transcription factor Tfb2 (p52) C-terminal domain (Tfb2_C)	Transcription factor Tfb2 (p52) C-terminal domain	This is the C-terminal domain of Transcription factor Tfb2 present in Saccharomyces cerevisiae. Tfb2 is referred to as p52 in humans. The interaction between p8-Tfb5 and p52-Tfb2 has a key role in the maintenance of the transcription factor TFIIH arc ...	This is the C-terminal domain of Transcription factor Tfb2 present in Saccharomyces cerevisiae. Tfb2 is referred to as p52 in humans. The interaction between p8-Tfb5 and p52-Tfb2 has a key role in the maintenance of the transcription factor TFIIH architecture and TFIIHs function in nucleotide-excision repair (NER) pathway. The C-terminal domain of Tfb2 is thought to have a crucial role in DNA repair [1].	Domain
D [auth E]	PF04056	Ssl1-like (Ssl1)	Ssl1-like	-	Family
E [auth F]	PF03850	Transcription factor Tfb4 (Tfb4)	Transcription factor Tfb4	This family appears to be distantly related to the VWA domain.	Domain
F [auth G]	PF06331	Transcription factor TFIIH complex subunit Tfb5 (Tfb5)	Transcription factor TFIIH complex subunit Tfb5	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	TFIIH basal transcription factor complex helicase XPB subunit,XPB,TFIIH basal transcription factor complex helicase XPB subunit	DNA binding binding organic cyclic compound binding damaged DNA binding nucleic acid binding protein-containing complex binding chromatin binding promoter-specific chromatin binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding DNA binding binding organic cyclic compound binding damaged DNA binding nucleic acid binding protein-containing complex binding chromatin binding promoter-specific chromatin binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding pyrophosphatase activity ATP hydrolysis activity ribonucleoside triphosphate phosphatase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity hydrolase activity, acting on acid anhydrides catalytic activity ATP-dependent activity ATP-dependent activity, acting on DNA DNA helicase activity catalytic activity, acting on DNA catalytic activity, acting on a nucleic acid helicase activity 3'-5' DNA helicase activity	developmental process multicellular organismal process epithelium development epidermal cell differentiation cellular developmental process epidermis development nervous system development tissue development epithelial cell differentiation hair cell differentiation generation of neurons neurogenesis multicellular organism development neuron differentiation cell differentiation developmental process multicellular organismal process epithelium development epidermal cell differentiation cellular developmental process epidermis development nervous system development tissue development epithelial cell differentiation hair cell differentiation generation of neurons neurogenesis multicellular organism development neuron differentiation cell differentiation anatomical structure development cellular process system development protein localization localization cellular localization cellular macromolecule localization macromolecule localization cellular biosynthetic process cellular metabolic process RNA metabolic process primary metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription organic cyclic compound metabolic process nucleic acid biosynthetic process transcription by RNA polymerase II organic substance metabolic process biosynthetic process organic cyclic compound biosynthetic process organic substance biosynthetic process metabolic process macromolecule metabolic process apoptotic process cell death programmed cell death regulation of biological process positive regulation of programmed cell death regulation of cellular process regulation of apoptotic process biological regulation positive regulation of biological process regulation of programmed cell death positive regulation of apoptotic process positive regulation of cellular process chromosome organization DNA conformation change DNA metabolic process cellular component organization DNA topological change organelle organization cellular component organization or biogenesis cellular response to stimulus response to stimulus transcription-coupled nucleotide-excision repair cellular response to stress nucleotide-excision repair DNA damage response response to stress DNA repair response to light stimulus response to radiation response to abiotic stimulus response to UV UV protection animal organ development embryonic organ development embryo development DNA geometric change DNA duplex unwinding nucleotide-excision repair, DNA duplex unwinding regulation of cell cycle phase transition regulation of cell cycle process cell cycle phase transition mitotic cell cycle regulation of mitotic cell cycle phase transition regulation of mitotic cell cycle mitotic cell cycle process cell cycle regulation of cell cycle mitotic cell cycle phase transition cell cycle process transcription initiation at RNA polymerase II promoter DNA-templated transcription initiation response to decreased oxygen levels response to hypoxia response to oxygen levels transcription elongation by RNA polymerase II DNA-templated transcription elongation response to oxidative stress	RNA polymerase II transcription regulator complex membrane-bounded organelle protein-containing complex intracellular anatomical structure transcription factor TFIIH core complex nucleus nuclear protein-containing complex transcription regulator complex intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle organelle transcription preinitiation complex protein-DNA complex RNA polymerase II transcription regulator complex membrane-bounded organelle protein-containing complex intracellular anatomical structure transcription factor TFIIH core complex nucleus nuclear protein-containing complex transcription regulator complex intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle organelle transcription preinitiation complex protein-DNA complex RNA polymerase II, holoenzyme membrane-enclosed lumen transferase complex intracellular organelle lumen nucleoplasm catalytic complex transferase complex, transferring phosphorus-containing groups nuclear DNA-directed RNA polymerase complex organelle lumen RNA polymerase complex transcription factor TFIID complex DNA-directed RNA polymerase complex intracellular protein-containing complex nuclear lumen protein kinase complex transcription factor TFIIH holo complex carboxy-terminal domain protein kinase complex serine/threonine protein kinase complex nucleotide-excision repair factor 3 complex nucleotide-excision repair complex
J [auth X]	Unassigned secondary structure elements (XPB NTE region)	-	-	-
B	TFIIH basal transcription factor complex helicase XPD subunit	iron-sulfur cluster binding binding 4 iron, 4 sulfur cluster binding metal cluster binding small molecule binding protein-macromolecule adaptor activity molecular adaptor activity adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding iron-sulfur cluster binding binding 4 iron, 4 sulfur cluster binding metal cluster binding small molecule binding protein-macromolecule adaptor activity molecular adaptor activity adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding cation binding metal ion binding ATP-dependent activity, acting on DNA DNA helicase activity catalytic activity, acting on DNA 5'-3' DNA helicase activity catalytic activity, acting on a nucleic acid helicase activity catalytic activity ATP-dependent activity DNA binding damaged DNA binding nucleic acid binding pyrophosphatase activity ATP hydrolysis activity ribonucleoside triphosphate phosphatase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity hydrolase activity, acting on acid anhydrides	developmental process stem cell proliferation cell population proliferation cellular developmental process hemopoiesis cell differentiation anatomical structure development hematopoietic stem cell proliferation cell development cellular process multicellular organism development multicellular organismal process embryonic cleavage cell division developmental process stem cell proliferation cell population proliferation cellular developmental process hemopoiesis cell differentiation anatomical structure development hematopoietic stem cell proliferation cell development cellular process multicellular organism development multicellular organismal process embryonic cleavage cell division embryo development ossification bone mineralization animal organ development biomineral tissue development tissue development cellular response to stimulus regulation of biological process regulation of cellular process response to stimulus signaling biological regulation signal transduction by p53 class mediator cell death intracellular signal transduction cell communication apoptotic signaling pathway intrinsic apoptotic signaling pathway by p53 class mediator signal transduction apoptotic process intrinsic apoptotic signaling pathway programmed cell death cell cycle chromosome segregation cell cycle process cellular component organization extracellular matrix organization cellular component organization or biogenesis extracellular structure organization external encapsulating structure organization transcription-coupled nucleotide-excision repair primary metabolic process DNA metabolic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process cellular response to stress nucleotide-excision repair DNA damage response response to stress metabolic process macromolecule metabolic process DNA repair cell surface receptor signaling pathway insulin-like growth factor receptor signaling pathway cell surface receptor protein tyrosine kinase signaling pathway enzyme-linked receptor protein signaling pathway embryo development ending in birth or egg hatching chordate embryonic development in utero embryonic development embryonic organ development regulation of cell cycle phase transition regulation of cell cycle process cell cycle phase transition mitotic cell cycle regulation of mitotic cell cycle phase transition regulation of mitotic cell cycle mitotic cell cycle process regulation of cell cycle mitotic cell cycle phase transition response to decreased oxygen levels response to hypoxia response to oxygen levels response to abiotic stimulus regulation of DNA recombination positive regulation of biological process positive regulation of mitotic recombination regulation of mitotic recombination regulation of primary metabolic process positive regulation of metabolic process positive regulation of macromolecule metabolic process regulation of nucleobase-containing compound metabolic process positive regulation of DNA recombination positive regulation of nucleobase-containing compound metabolic process DNA recombination mitotic recombination regulation of macromolecule metabolic process positive regulation of DNA metabolic process regulation of metabolic process regulation of DNA metabolic process multicellular organism growth developmental growth growth cellular component assembly involved in morphogenesis glial cell development myelin assembly cellular component biogenesis neurogenesis cellular anatomical entity morphogenesis cellular component assembly gliogenesis axon ensheathment ensheathment of neurons system development oligodendrocyte development central nervous system myelination nervous system development central nervous system myelin formation myelination anatomical structure morphogenesis axon ensheathment in central nervous system central nervous system development oligodendrocyte differentiation glial cell differentiation anatomical structure formation involved in morphogenesis epithelium development epidermal cell differentiation epidermis development epithelial cell differentiation hair cell differentiation generation of neurons neuron differentiation spinal cord development ribonucleoprotein complex biogenesis cellular biosynthetic process RNA metabolic process rRNA processing maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) ribosome biogenesis maturation of SSU-rRNA organic substance biosynthetic process RNA processing rRNA metabolic process cellular metabolic process gene expression macromolecule biosynthetic process ribosomal small subunit biogenesis biosynthetic process ncRNA metabolic process nucleic acid catabolic process nucleobase-containing compound biosynthetic process RNA biosynthetic process DNA-templated transcription nucleic acid biosynthetic process transcription by RNA polymerase II organic cyclic compound biosynthetic process response to light stimulus response to radiation response to UV UV protection determination of adult lifespan stem cell differentiation hematopoietic stem cell differentiation hematopoietic progenitor cell differentiation molting cycle process hair cycle developmental maturation skin development anatomical structure maturation skin epidermis development hair follicle development molting cycle hair cycle process hair follicle maturation response to oxidative stress transcription elongation by RNA polymerase I transcription by RNA polymerase I rRNA transcription nucleolar large rRNA transcription by RNA polymerase I DNA-templated transcription elongation post-embryonic development erythrocyte development homeostatic process erythrocyte maturation erythrocyte differentiation multicellular organismal-level homeostasis myeloid cell differentiation immune system process myeloid cell development homeostasis of number of cells myeloid cell homeostasis cell maturation erythrocyte homeostasis	intracellular anatomical structure cytoplasm cellular anatomical entity cytosol RNA polymerase II transcription regulator complex membrane-bounded organelle protein-containing complex transcription factor TFIIH core complex nucleus nuclear protein-containing complex transcription regulator complex intracellular membrane-bounded organelle intracellular organelle organelle intracellular anatomical structure cytoplasm cellular anatomical entity cytosol RNA polymerase II transcription regulator complex membrane-bounded organelle protein-containing complex transcription factor TFIIH core complex nucleus nuclear protein-containing complex transcription regulator complex intracellular membrane-bounded organelle intracellular organelle organelle RNA polymerase II, holoenzyme membrane-enclosed lumen transferase complex intracellular organelle lumen nucleoplasm catalytic complex transferase complex, transferring phosphorus-containing groups nuclear DNA-directed RNA polymerase complex organelle lumen RNA polymerase complex transcription factor TFIID complex DNA-directed RNA polymerase complex intracellular protein-containing complex nuclear lumen cytoskeleton spindle intracellular non-membrane-bounded organelle microtubule cytoskeleton non-membrane-bounded organelle CAK-ERCC2 complex protein kinase complex transcription factor TFIIH holo complex carboxy-terminal domain protein kinase complex serine/threonine protein kinase complex MMXD complex
C [auth D]	General transcription factor IIH subunit 4,p52,General transcription factor IIH subunit 4	DNA binding double-stranded DNA binding binding organic cyclic compound binding nucleic acid binding ATPase activator activity molecular function activator activity molecular function regulator activity ATPase regulator activity general transcription initiation factor activity RNA polymerase II general transcription initiation factor activity	cellular response to stimulus response to stimulus primary metabolic process DNA metabolic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process cellular response to stress DNA damage response response to stress metabolic process cellular process macromolecule metabolic process cellular response to stimulus response to stimulus primary metabolic process DNA metabolic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process cellular response to stress DNA damage response response to stress metabolic process cellular process macromolecule metabolic process DNA repair cellular biosynthetic process cellular metabolic process RNA metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process RNA biosynthetic process DNA-templated transcription nucleic acid biosynthetic process transcription by RNA polymerase II biosynthetic process organic cyclic compound biosynthetic process organic substance biosynthetic process nucleotide-excision repair	membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen cellular anatomical entity intracellular membrane-bounded organelle intracellular organelle lumen nuclear speck nuclear body intracellular organelle nucleoplasm organelle lumen organelle nuclear lumen membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen cellular anatomical entity intracellular membrane-bounded organelle intracellular organelle lumen nuclear speck nuclear body intracellular organelle nucleoplasm organelle lumen organelle nuclear lumen RNA polymerase II transcription regulator complex protein-containing complex transcription factor TFIIH core complex nuclear protein-containing complex transcription regulator complex RNA polymerase II, holoenzyme transferase complex catalytic complex transferase complex, transferring phosphorus-containing groups nuclear DNA-directed RNA polymerase complex RNA polymerase complex transcription factor TFIID complex DNA-directed RNA polymerase complex intracellular protein-containing complex protein kinase complex core TFIIH complex portion of holo TFIIH complex transcription factor TFIIH holo complex carboxy-terminal domain protein kinase complex serine/threonine protein kinase complex
D [auth E]	General transcription factor IIH subunit 2	general transcription initiation factor activity RNA polymerase II general transcription initiation factor activity cation binding transition metal ion binding zinc ion binding ion binding binding metal ion binding small molecule binding	cellular biosynthetic process RNA metabolic process RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription nucleic acid biosynthetic process transcription by RNA polymerase II organic substance metabolic process organic substance biosynthetic process transcription initiation at RNA polymerase II promoter cellular metabolic process primary metabolic process nucleobase-containing compound biosynthetic process gene expression cellular biosynthetic process RNA metabolic process RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription nucleic acid biosynthetic process transcription by RNA polymerase II organic substance metabolic process organic substance biosynthetic process transcription initiation at RNA polymerase II promoter cellular metabolic process primary metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process DNA-templated transcription initiation organic cyclic compound metabolic process biosynthetic process organic cyclic compound biosynthetic process metabolic process cellular process macromolecule metabolic process response to light stimulus response to stimulus response to radiation response to abiotic stimulus response to UV cellular response to stimulus DNA metabolic process cellular response to stress nucleotide-excision repair DNA damage response response to stress DNA repair regulation of cellular process regulation of primary metabolic process regulation of RNA metabolic process regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process regulation of transcription by RNA polymerase II regulation of biosynthetic process regulation of biological process biological regulation regulation of cellular metabolic process regulation of macromolecule metabolic process regulation of cellular biosynthetic process regulation of gene expression regulation of macromolecule biosynthetic process regulation of DNA-templated transcription regulation of metabolic process negative adaptation of signaling pathway import into cell receptor internalization negative regulation of signaling signaling transport negative regulation of biological process desensitization of G protein-coupled receptor signaling pathway regulation of signal transduction negative regulation of G protein-coupled receptor signaling pathway negative regulation of cell communication vesicle-mediated transport cell communication localization negative regulation of cellular process signal transduction regulation of G protein-coupled receptor signaling pathway G protein-coupled receptor internalization regulation of signaling negative regulation of response to stimulus negative regulation of signal transduction establishment of localization regulation of response to stimulus adaptation of signaling pathway regulation of cell communication G protein-coupled receptor signaling pathway receptor-mediated endocytosis endocytosis positive regulation of organelle organization regulation of ATP-dependent activity regulation of cellular component organization positive regulation of cellular component organization regulation of catalytic activity positive regulation of helicase activity positive regulation of ATP-dependent activity DNA geometric change positive regulation of biological process DNA conformation change cellular component organization positive regulation of molecular function positive regulation of DNA duplex unwinding cellular component organization or biogenesis positive regulation of cellular process DNA duplex unwinding chromosome organization positive regulation of catalytic activity regulation of chromosome organization regulation of DNA duplex unwinding regulation of organelle organization positive regulation of chromosome organization positive regulation of DNA helicase activity regulation of helicase activity regulation of molecular function organelle organization regulation of DNA helicase activity	membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen cellular anatomical entity intracellular membrane-bounded organelle intracellular organelle lumen nuclear speck nuclear body intracellular organelle nucleoplasm organelle lumen organelle nuclear lumen membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen cellular anatomical entity intracellular membrane-bounded organelle intracellular organelle lumen nuclear speck nuclear body intracellular organelle nucleoplasm organelle lumen organelle nuclear lumen RNA polymerase II transcription regulator complex protein-containing complex transcription factor TFIIH core complex nuclear protein-containing complex transcription regulator complex RNA polymerase II, holoenzyme transferase complex catalytic complex transferase complex, transferring phosphorus-containing groups nuclear DNA-directed RNA polymerase complex RNA polymerase complex transcription factor TFIID complex DNA-directed RNA polymerase complex intracellular protein-containing complex protein kinase complex core TFIIH complex portion of holo TFIIH complex transcription factor TFIIH holo complex carboxy-terminal domain protein kinase complex serine/threonine protein kinase complex
E [auth F]	General transcription factor IIH subunit 3	general transcription initiation factor activity RNA polymerase II general transcription initiation factor activity cation binding ion binding binding metal ion binding small molecule binding	regulation of cellular process cellular biosynthetic process RNA metabolic process regulation of primary metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process nucleic acid biosynthetic process DNA-templated transcription regulation of RNA metabolic process organic substance metabolic process organic substance biosynthetic process regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process regulation of biosynthetic process regulation of cellular process cellular biosynthetic process RNA metabolic process regulation of primary metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process nucleic acid biosynthetic process DNA-templated transcription regulation of RNA metabolic process organic substance metabolic process organic substance biosynthetic process regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process regulation of biosynthetic process regulation of biological process cellular metabolic process biological regulation primary metabolic process regulation of cellular metabolic process regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process regulation of cellular biosynthetic process organic cyclic compound metabolic process regulation of gene expression biosynthetic process organic cyclic compound biosynthetic process metabolic process regulation of macromolecule biosynthetic process cellular process regulation of DNA-templated transcription macromolecule metabolic process regulation of metabolic process cellular response to stimulus response to stimulus DNA metabolic process cellular response to stress DNA damage response response to stress DNA repair transcription by RNA polymerase II nucleotide-excision repair	RNA polymerase II transcription regulator complex membrane-bounded organelle protein-containing complex intracellular anatomical structure transcription factor TFIIH core complex nucleus nuclear protein-containing complex transcription regulator complex intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle organelle transcription preinitiation complex protein-DNA complex RNA polymerase II transcription regulator complex membrane-bounded organelle protein-containing complex intracellular anatomical structure transcription factor TFIIH core complex nucleus nuclear protein-containing complex transcription regulator complex intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle organelle transcription preinitiation complex protein-DNA complex RNA polymerase II, holoenzyme membrane-enclosed lumen transferase complex intracellular organelle lumen nucleoplasm catalytic complex transferase complex, transferring phosphorus-containing groups nuclear DNA-directed RNA polymerase complex organelle lumen RNA polymerase complex transcription factor TFIID complex DNA-directed RNA polymerase complex intracellular protein-containing complex nuclear lumen protein kinase complex core TFIIH complex portion of holo TFIIH complex transcription factor TFIIH holo complex carboxy-terminal domain protein kinase complex serine/threonine protein kinase complex
F [auth G]	General transcription factor IIH subunit 5	-	cellular biosynthetic process RNA metabolic process RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription nucleic acid biosynthetic process transcription by RNA polymerase II organic substance metabolic process organic substance biosynthetic process transcription initiation at RNA polymerase II promoter cellular metabolic process primary metabolic process nucleobase-containing compound biosynthetic process gene expression cellular biosynthetic process RNA metabolic process RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription nucleic acid biosynthetic process transcription by RNA polymerase II organic substance metabolic process organic substance biosynthetic process transcription initiation at RNA polymerase II promoter cellular metabolic process primary metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process DNA-templated transcription initiation organic cyclic compound metabolic process biosynthetic process organic cyclic compound biosynthetic process metabolic process cellular process macromolecule metabolic process ribonucleoprotein complex biogenesis rRNA processing maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) cellular component biogenesis ribosome biogenesis maturation of SSU-rRNA cellular component organization or biogenesis RNA processing rRNA metabolic process ribosomal small subunit biogenesis ncRNA metabolic process nucleic acid catabolic process cellular response to stimulus response to stimulus cellular response to ionizing radiation cellular response to radiation cellular response to environmental stimulus response to ionizing radiation cellular response to gamma radiation response to radiation response to abiotic stimulus cellular response to abiotic stimulus response to gamma radiation DNA metabolic process cellular response to stress nucleotide-excision repair DNA damage response response to stress DNA repair transcription elongation by RNA polymerase I transcription by RNA polymerase I rRNA transcription nucleolar large rRNA transcription by RNA polymerase I DNA-templated transcription elongation cellular component organization protein-DNA complex organization cellular component assembly protein-containing complex assembly protein-containing complex organization nucleotide-excision repair, preincision complex assembly protein-DNA complex assembly	membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle cellular anatomical entity nucleolus intracellular organelle lumen intracellular organelle organelle lumen organelle intracellular non-membrane-bounded organelle nuclear lumen non-membrane-bounded organelle membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle cellular anatomical entity nucleolus intracellular organelle lumen intracellular organelle organelle lumen organelle intracellular non-membrane-bounded organelle nuclear lumen non-membrane-bounded organelle RNA polymerase II transcription regulator complex protein-containing complex transcription factor TFIIH core complex nuclear protein-containing complex transcription regulator complex RNA polymerase II, holoenzyme transferase complex nucleoplasm catalytic complex transferase complex, transferring phosphorus-containing groups nuclear DNA-directed RNA polymerase complex RNA polymerase complex transcription factor TFIID complex DNA-directed RNA polymerase complex intracellular protein-containing complex cytoplasm protein kinase complex transcription factor TFIIH holo complex carboxy-terminal domain protein kinase complex serine/threonine protein kinase complex
G [auth H]	MAT1	-	-	-
H [auth Z]	Unassigned secondary structure elements.	-	-	-
I [auth Y]	Unassigned secondary structure elements (p52 region)	-	-	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR032830	Helicase XPB/Ssl2, N-terminal domain	Domain
A	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily
A	IPR006935	Helicase/UvrB, N-terminal	Domain
A	IPR001650	Helicase, C-terminal domain-like	Domain
A	IPR014001	Helicase superfamily 1/2, ATP-binding domain	Domain
A	IPR032438	ERCC3/RAD25/XPB helicase, C-terminal domain	Domain
A	IPR001161	Helicase XPB/Ssl2	Family
B	IPR001945	RAD3/XPD family	Family
B	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily
B	IPR006554	Helicase-like, DEXD box c2 type	Domain
B	IPR010614	RAD3-like helicase, DEAD	Domain
B	IPR013020	ATP-dependent helicase Rad3/Chl1-like	Family
B	IPR010643	Helical and beta-bridge domain	Domain
B	IPR045028	Helicase superfamily 1/2, DinG/Rad3-like	Family
B	IPR002464	DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site	Conserved Site
B	IPR006555	ATP-dependent helicase, C-terminal	Domain
B	IPR014013	Helicase superfamily 1/2, ATP-binding domain, DinG/Rad3-type	Domain
C [auth D]	IPR040662	Transcription factor Tfb2, C-terminal domain	Domain
C [auth D]	IPR004598	Transcription factor TFIIH subunit p52/Tfb2	Family
D [auth E]	IPR007198	Ssl1-like	Domain
D [auth E]	IPR012170	TFIIH subunit Ssl1/p44	Family
D [auth E]	IPR004595	TFIIH C1-like domain	Domain
D [auth E]	IPR013087	Zinc finger C2H2-type	Domain
D [auth E]	IPR036465	von Willebrand factor A-like domain superfamily	Homologous Superfamily
D [auth E]	IPR013083	Zinc finger, RING/FYVE/PHD-type	Homologous Superfamily
D [auth E]	IPR002035	von Willebrand factor, type A	Domain
D [auth E]	IPR046349	C1-like domain superfamily	Homologous Superfamily
E [auth F]	IPR004600	TFIIH subunit Tfb4/GTF2H3	Family
E [auth F]	IPR036465	von Willebrand factor A-like domain superfamily	Homologous Superfamily
F [auth G]	IPR009400	TFIIH subunit TTDA/Tfb5	Family
F [auth G]	IPR035935	TFB5-like superfamily	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: P19447	xeroderma pigmentosum trichothiodystrophy 2, photosensitive xeroderma pigmentosum group B trichothiodystrophy Cockayne syndrome peripheral nervous system disease peripheral neuropathy Arsenic Poisoning photosensitive trichothiodystrophy squamous cell carcinoma cutaneous melanoma lung cancer Pick disease xeroderma pigmentosum-Cockayne syndrome complex cataract xeroderma pigmentosum trichothiodystrophy 2, photosensitive xeroderma pigmentosum group B trichothiodystrophy Cockayne syndrome peripheral nervous system disease peripheral neuropathy Arsenic Poisoning photosensitive trichothiodystrophy squamous cell carcinoma cutaneous melanoma lung cancer Pick disease xeroderma pigmentosum-Cockayne syndrome complex cataract intellectual disability osteosarcoma skin basal cell carcinoma trichothiodystrophy 1, photosensitive leukodystrophy melanoma ovarian cancer
B	Pharos: P18074	xeroderma pigmentosum photosensitive trichothiodystrophy cerebrooculofacioskeletal syndrome 2 skin neoplasm Cockayne syndrome trichothiodystrophy xeroderma pigmentosum group D squamous cell carcinoma sunburn prostate cancer cataract Occupational Diseases skin cancer trichothiodystrophy 1, photosensitive COFS syndrome xeroderma pigmentosum photosensitive trichothiodystrophy cerebrooculofacioskeletal syndrome 2 skin neoplasm Cockayne syndrome trichothiodystrophy xeroderma pigmentosum group D squamous cell carcinoma sunburn prostate cancer cataract Occupational Diseases skin cancer trichothiodystrophy 1, photosensitive COFS syndrome epidermolytic hyperkeratosis urinary bladder cancer colorectal cancer leukodystrophy peripheral nervous system disease bladder benign neoplasm skin basal cell carcinoma urinary bladder carcinoma colorectal carcinoma gastric neoplasm peripheral neuropathy bladder carcinoma in situ cerebrooculofacioskeletal syndrome 1 urinary bladder neoplasm xeroderma pigmentosum-Cockayne syndrome complex hereditary diffuse gastric adenocarcinoma intellectual disability melanoma skin disease cutaneous melanoma gastric cancer
C [auth D]	Pharos: Q92759	autism spectrum disorder Hashimoto thyroiditis oropharynx cancer swine influenza cutaneous lupus erythematosus lung carcinoma psoriatic arthritis systemic lupus erythematosus endogenous depression membranous glomerulonephritis squamous cell lung carcinoma
E [auth F]	Pharos: Q13889	adenoma malignant ependymoma osteosarcoma pancreatic intraductal papillary-mucinous carcinoma atypical teratoid rhabdoid tumor malignant glioma ovarian cancer Pick disease glioblastoma nasopharyngeal carcinoma pancreatic ductal adenocarcinoma psoriasis
F [auth G]	Pharos: Q6ZYL4	trichothiodystrophy 3, photosensitive trichothiodystrophy photosensitive trichothiodystrophy acute myeloid leukemia glioblastoma leukodystrophy osteosarcoma pilocytic astrocytoma X-linked mixed deafness with perilymphatic gusher atypical teratoid rhabdoid tumor intellectual disability lung cancer ovarian cancer pituitary cancer trichothiodystrophy 1, photosensitive trichothiodystrophy 3, photosensitive trichothiodystrophy photosensitive trichothiodystrophy acute myeloid leukemia glioblastoma leukodystrophy osteosarcoma pilocytic astrocytoma X-linked mixed deafness with perilymphatic gusher atypical teratoid rhabdoid tumor intellectual disability lung cancer ovarian cancer pituitary cancer trichothiodystrophy 1, photosensitive xeroderma pigmentosum Cockayne syndrome large cell medulloblastoma malignant glioma polycystic ovary syndrome