5ODS

Structure of a phosphoprotein-protein complex

External Resource: Annotation

Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations
Protein Modification Annotation

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF01394	e5odsA1	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 7-bladed	F: PF01394	ECOD (1.6)
A	PF09268,PF13838	e5odsA2	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: PF09268,PF13838	ECOD (1.6)
B	PF01394	e5odsB2	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 7-bladed	F: PF01394	ECOD (1.6)
B	PF09268,PF13838	e5odsB1	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: PF09268,PF13838	ECOD (1.6)
C	PF01394	e5odsC1	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 7-bladed	F: PF01394	ECOD (1.6)
C	PF09268,PF13838	e5odsC2	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: PF09268,PF13838	ECOD (1.6)
D	PF01394	e5odsD1	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 7-bladed	F: PF01394	ECOD (1.6)
D	PF09268,PF13838	e5odsD2	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: PF09268,PF13838	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
D	2.130.10.110	Mainly Beta	7 Propeller	Methylamine Dehydrogenase	Chain H	CATH (utative)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D	PF09268	Clathrin, heavy-chain linker (Clathrin-link)	Clathrin, heavy-chain linker	-	Repeat
A, B, C, D	PF00637	Region in Clathrin and VPS (Clathrin)	Region in Clathrin and VPS	-	Repeat
A, B, C, D	PF13838	Clathrin-H-link (Clathrin_H_link)	Clathrin-H-link	-	Repeat
A, B, C, D	PF01394	Clathrin propeller repeat (Clathrin_propel)	Clathrin propeller repeat	-	Repeat

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D	Clathrin heavy chain 1	clathrin binding protein binding binding clathrin light chain binding RNA binding double-stranded RNA binding organic cyclic compound binding nucleic acid binding cytoskeletal protein binding ankyrin binding heat shock protein binding ubiquitin-specific protease binding enzyme binding protease binding clathrin binding protein binding binding clathrin light chain binding RNA binding double-stranded RNA binding organic cyclic compound binding nucleic acid binding cytoskeletal protein binding ankyrin binding heat shock protein binding ubiquitin-specific protease binding enzyme binding protease binding protein serine/threonine kinase binding kinase binding protein kinase binding low-density lipoprotein particle receptor binding signaling receptor binding lipoprotein particle receptor binding peptide binding structural molecule activity disordered domain specific binding protein domain specific binding	localization import into cell receptor internalization transport cellular process receptor-mediated endocytosis endocytosis establishment of localization vesicle-mediated transport cell division cellular catabolic process catabolic process cellular metabolic process autophagy localization import into cell receptor internalization transport cellular process receptor-mediated endocytosis endocytosis establishment of localization vesicle-mediated transport cell division cellular catabolic process catabolic process cellular metabolic process autophagy metabolic process process utilizing autophagic mechanism cellular component disassembly clathrin coat disassembly protein-containing complex organization protein-containing complex disassembly vesicle uncoating cellular component organization cellular component organization or biogenesis protein depolymerization cellular localization intracellular transport endosomal transport cytosolic transport retrograde transport, endosome to Golgi establishment of localization in cell protein localization establishment of protein localization nitrogen compound transport organic substance transport iron ion transport metal ion transport protein transport cellular macromolecule localization macromolecule localization transferrin transport transition metal ion transport monoatomic ion transport monoatomic cation transport cell cycle mitotic cell cycle synaptic vesicle endocytosis synaptic vesicle cycle presynaptic endocytosis vesicle-mediated transport in synapse synaptic vesicle recycling regulation of localization regulation of cellular process regulation of protein localization negative regulation of biological process negative regulation of protein localization to plasma membrane negative regulation of cellular process regulation of protein localization to membrane negative regulation of protein localization regulation of biological process protein localization to cell periphery protein localization to plasma membrane biological regulation localization within membrane regulation of protein localization to cell periphery protein localization to membrane negative regulation of protein localization to membrane regulation of cellular localization negative regulation of protein localization to cell periphery regulation of protein localization to plasma membrane clathrin-dependent endocytosis regulation of cytoskeleton organization regulation of cellular component organization microtubule cytoskeleton organization regulation of mitotic spindle organization regulation of cell cycle microtubule cytoskeleton organization involved in mitosis spindle organization cell cycle process regulation of cell cycle process regulation of microtubule-based process regulation of spindle organization regulation of organelle organization mitotic spindle organization organelle organization mitotic cell cycle process microtubule-based process cytoskeleton organization regulation of microtubule cytoskeleton organization intracellular protein transport clathrin coat assembly cellular component biogenesis cellular component assembly protein-containing complex assembly non-membrane-bounded organelle assembly mitotic sister chromatid segregation chromosome segregation mitotic nuclear division organelle assembly organelle fission chromosome organization sister chromatid segregation spindle assembly mitotic spindle assembly nuclear division nuclear chromosome segregation multicellular organismal process amyloid-beta clearance amyloid-beta clearance by transcytosis transcytosis organonitrogen compound biosynthetic process carbohydrate derivative metabolic process negative regulation of cellular metabolic process regulation of primary metabolic process organic substance biosynthetic process glycosaminoglycan biosynthetic process negative regulation of carbohydrate metabolic process negative regulation of metabolic process carbohydrate biosynthetic process regulation of cellular metabolic process primary metabolic process negative regulation of cellular biosynthetic process hyaluronan biosynthetic process biosynthetic process negative regulation of macromolecule biosynthetic process regulation of macromolecule biosynthetic process macromolecule metabolic process regulation of metabolic process mucopolysaccharide metabolic process cellular biosynthetic process glycosaminoglycan metabolic process regulation of hyaluronan biosynthetic process regulation of polysaccharide metabolic process negative regulation of hyaluronan biosynthetic process organic substance metabolic process hyaluronan metabolic process polysaccharide metabolic process regulation of carbohydrate metabolic process negative regulation of macromolecule metabolic process regulation of biosynthetic process carbohydrate derivative biosynthetic process carbohydrate metabolic process organonitrogen compound metabolic process polysaccharide biosynthetic process regulation of macromolecule metabolic process macromolecule biosynthetic process regulation of cellular biosynthetic process negative regulation of biosynthetic process regulation of polysaccharide biosynthetic process aminoglycan metabolic process aminoglycan biosynthetic process regulation of carbohydrate biosynthetic process Golgi organization endomembrane system organization	cell periphery sarcolemma plasma membrane membrane T-tubule cellular anatomical entity clathrin-coated pit endomembrane system presynaptic endocytic zone synapse presynaptic membrane synaptic membrane presynapse presynaptic endocytic zone membrane cell periphery sarcolemma plasma membrane membrane T-tubule cellular anatomical entity clathrin-coated pit endomembrane system presynaptic endocytic zone synapse presynaptic membrane synaptic membrane presynapse presynaptic endocytic zone membrane cell junction plasma membrane region intracellular anatomical structure cytoplasm cytosol intracellular organelle cytoskeleton spindle organelle intracellular non-membrane-bounded organelle microtubule cytoskeleton non-membrane-bounded organelle membrane coat protein-containing complex membrane protein complex coated membrane polymeric cytoskeletal fiber mitotic spindle spindle microtubule mitotic spindle microtubule supramolecular fiber microtubule supramolecular polymer supramolecular complex membrane-bounded organelle mitochondrion intracellular membrane-bounded organelle plasma membrane protein complex clathrin coat clathrin coat of coated pit myelin sheath pigment granule intracellular vesicle melanosome cytoplasmic vesicle vesicle clathrin-coated vesicle coated vesicle extrinsic component of synaptic vesicle membrane transport vesicle membrane extrinsic component of organelle membrane bounding membrane of organelle vesicle membrane synaptic vesicle synaptic vesicle membrane transport vesicle exocytic vesicle membrane cytoplasmic vesicle membrane secretory vesicle organelle membrane extrinsic component of membrane exocytic vesicle lytic vacuole vacuole lysosome nucleus nuclear protein-containing complex Myb complex clathrin complex photoreceptor ribbon synapse ribbon synapse endosome clathrin-coated endocytic vesicle endocytic vesicle vesicle coat clathrin coat of trans-Golgi network vesicle trans-Golgi network transport vesicle membrane trans-Golgi network transport vesicle clathrin vesicle coat Golgi-associated vesicle clathrin-coated vesicle membrane Golgi apparatus coated vesicle membrane Golgi-associated vesicle membrane
E, F, G, H	LYS-GLU-SER-ALA-LEU-ARG-LYS-GLN-SEP-LEU-TYR-LEU-LYS-PHE-ASP-PRO-LEU-LEU	-	regulation of cytoskeleton organization regulation of cellular component organization regulation of cellular process microtubule cytoskeleton organization regulation of mitotic spindle organization mitotic cell cycle cellular component organization cell cycle cellular component organization or biogenesis regulation of cell cycle microtubule cytoskeleton organization involved in mitosis spindle organization cell cycle process regulation of biological process regulation of cytoskeleton organization regulation of cellular component organization regulation of cellular process microtubule cytoskeleton organization regulation of mitotic spindle organization mitotic cell cycle cellular component organization cell cycle cellular component organization or biogenesis regulation of cell cycle microtubule cytoskeleton organization involved in mitosis spindle organization cell cycle process regulation of biological process regulation of cell cycle process biological regulation regulation of microtubule-based process regulation of spindle organization regulation of organelle organization mitotic spindle organization organelle organization mitotic cell cycle process cellular process microtubule-based process cytoskeleton organization regulation of microtubule cytoskeleton organization developmental process multicellular organismal process head development forebrain development animal organ development brain development nervous system development pallium development cerebral cortex development multicellular organism development central nervous system development anatomical structure development telencephalon development system development regulation of chromosome segregation cell cycle phase transition chromosome segregation chromosome organization sister chromatid segregation regulation of chromosome organization regulation of sister chromatid segregation nuclear chromosome segregation metaphase/anaphase transition of mitotic cell cycle metaphase/anaphase transition of cell cycle mitotic cell cycle phase transition cell division cell population proliferation	intracellular organelle intracellular anatomical structure cytoskeleton spindle organelle intracellular non-membrane-bounded organelle spindle pole cellular anatomical entity microtubule cytoskeleton non-membrane-bounded organelle centrosome microtubule organizing center centriolar satellite cytoplasm intracellular organelle intracellular anatomical structure cytoskeleton spindle organelle intracellular non-membrane-bounded organelle spindle pole cellular anatomical entity microtubule cytoskeleton non-membrane-bounded organelle centrosome microtubule organizing center centriolar satellite cytoplasm cytosol membrane-bounded organelle intracellular membrane-bounded organelle mitotic spindle

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D	IPR016341	Clathrin, heavy chain	Family
A, B, C, D	IPR015348	Clathrin, heavy chain, linker, core motif	Domain
A, B, C, D	IPR016024	Armadillo-type fold	Homologous Superfamily
A, B, C, D	IPR016025	Clathrin heavy chain, N-terminal	Homologous Superfamily
A, B, C, D	IPR000547	Clathrin, heavy chain/VPS, 7-fold repeat	Repeat
A, B, C, D	IPR022365	Clathrin, heavy chain, propeller repeat	Repeat
A, B, C, D	IPR011990	Tetratricopeptide-like helical domain superfamily	Homologous Superfamily
E, F, G, H	IPR039915	TACC family	Family
E, F, G, H	IPR007707	Transforming acidic coiled-coil-containing protein, C-terminal	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
E, F, G, H	Pharos: Q9Y6A5	transitional cell carcinoma gliosarcoma giant cell glioblastoma urinary bladder cancer ovarian cancer primitive neuroectodermal tumor adrenal cortex carcinoma breast cancer glioblastoma interstitial cystitis lung cancer malignant mesothelioma osteoarthritis pancreatic intraductal papillary-mucinous carcinoma psoriasis transitional cell carcinoma gliosarcoma giant cell glioblastoma urinary bladder cancer ovarian cancer primitive neuroectodermal tumor adrenal cortex carcinoma breast cancer glioblastoma interstitial cystitis lung cancer malignant mesothelioma osteoarthritis pancreatic intraductal papillary-mucinous carcinoma psoriasis urinary bladder neoplasm atopic eczema endometriosis invasive ductal breast carcinoma malignant colon neoplasm medulloblastoma osteosarcoma pancreatic intraductal papillary-mucinous neoplasm atypical teratoid rhabdoid tumor hepatocellular carcinoma large cell medulloblastoma malignant glioma non-small cell lung carcinoma

Protein Modification Annotation

Modified Residue(s)
Chain	Residue(s)	Description
E, F, G, H	SEP	Parent Component: SER RESID: AA0037 PSI-MOD : O-phospho-L-serine MOD:00046

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.