5O7O

The crystal structure of DfoC, the desferrioxamine biosynthetic pathway acetyltransferase/Non-Ribosomal Peptide Synthetase (NRPS)-Independent Siderophore (NIS) from the fire blight disease pathogen Erwinia amylovora

External Resource: Annotation

Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
C	RhbC	e5o7oC2	A: a+b two layers	X: N-terminal domain of alcaligin biosynthesis protein C (From Topology)	H: N-terminal domain of alcaligin biosynthesis protein C (From Topology)	T: N-terminal domain of alcaligin biosynthesis protein C	F: RhbC	ECOD (1.6)
C	IucA_IucC	e5o7oC1	A: a+b complex topology	X: Protein kinase/SAICAR synthase/ATP-grasp (From Homology)	H: Protein kinase/SAICAR synthase/ATP-grasp	T: Protein kinase	F: IucA_IucC	ECOD (1.6)
A	Acetyltransf_8	e5o7oA1	A: a+b three layers	X: Nat/Ivy	H: Acyl-CoA N-acyltransferases (Nat) (From Topology)	T: Acyl-CoA N-acyltransferases (Nat)	F: Acetyltransf_8	ECOD (1.6)
B	Acetyltransf_8	e5o7oB1	A: a+b three layers	X: Nat/Ivy	H: Acyl-CoA N-acyltransferases (Nat) (From Topology)	T: Acyl-CoA N-acyltransferases (Nat)	F: Acetyltransf_8	ECOD (1.6)
D	RhbC	e5o7oD1	A: a+b two layers	X: N-terminal domain of alcaligin biosynthesis protein C (From Topology)	H: N-terminal domain of alcaligin biosynthesis protein C (From Topology)	T: N-terminal domain of alcaligin biosynthesis protein C	F: RhbC	ECOD (1.6)
D	IucA_IucC	e5o7oD2	A: a+b complex topology	X: Protein kinase/SAICAR synthase/ATP-grasp (From Homology)	H: Protein kinase/SAICAR synthase/ATP-grasp	T: Protein kinase	F: IucA_IucC	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
C	3.30.310.280	Alpha Beta	2-Layer Sandwich	TATA-Binding Protein		CATH (4.3.0)
C	6.10.250.3370	Special	Helix non-globular	Single alpha-helices involved in coiled-coils or other helix-helix interfaces		CATH (4.3.0)
C	1.10.510.40	Mainly Alpha	Orthogonal Bundle	Transferase(Phosphotransferase)	domain 1	CATH (4.3.0)
D	3.30.310.280	Alpha Beta	2-Layer Sandwich	TATA-Binding Protein		CATH (4.3.0)
D	6.10.250.3370	Special	Helix non-globular	Single alpha-helices involved in coiled-coils or other helix-helix interfaces		CATH (4.3.0)
D	1.10.510.40	Mainly Alpha	Orthogonal Bundle	Transferase(Phosphotransferase)	domain 1	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D	PF04183	IucA / IucC family (IucA_IucC)	IucA / IucC family	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D	Desferrioxamine siderophore biosynthesis protein dfoC	acid-amino acid ligase activity catalytic activity ligase activity, forming carbon-nitrogen bonds ligase activity acyltransferase activity transferase activity	secondary metabolic process siderophore biosynthetic process organic substance metabolic process peptide biosynthetic process biosynthetic process secondary metabolite biosynthetic process siderophore metabolic process organic substance biosynthetic process metabolic process nonribosomal peptide biosynthetic process peptide metabolic process	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D	IPR022770	Aerobactin siderophore biosynthesis IucA/IucC-like, C-terminal	Domain
A, B, C, D	IPR019432	Acyltransferase MbtK/IucB-like, conserved domain	Domain
A, B, C, D	IPR016181	Acyl-CoA N-acyltransferase	Homologous Superfamily
A, B, C, D	IPR037455	Aerobactin siderophore biosynthesis, IucA/IucC-like	Family
A, B, C, D	IPR007310	Aerobactin siderophore biosynthesis, IucA/IucC, N-terminal	Domain

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.