5O1N

Crystal structure of human aminoadipate semialdehyde synthase, saccharopine dehydrogenase domain with N-[(2S)-2-Pyrrolidinylmethyl]-trifluoromethanesulfonamide bound

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	Saccharopine reductase-like	8089055	4000094	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	GAPDH-like	8089056	3000043	SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Sacchrp_dh_C	e5o1nA1	A: a+b two layers	X: FwdE/GAPDH domain-like	H: Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain (From Topology)	T: Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain	F: Sacchrp_dh_C	ECOD (1.6)
A	Sacchrp_dh_NADP	e5o1nA2	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: NAD(P)-binding Rossmann-fold domains	F: Sacchrp_dh_NADP	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.40.50.720	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	NAD(P)-binding Rossmann-like Domain	CATH (4.3.0)
A	3.30.360.10	Alpha Beta	2-Layer Sandwich	Dihydrodipicolinate Reductase	domain 2	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF16653	Saccharopine dehydrogenase C-terminal domain (Sacchrp_dh_C)	Saccharopine dehydrogenase C-terminal domain	This family comprises the C-terminal domain of saccharopine dehydrogenase. In some organisms this enzyme is found as a bifunctional polypeptide with lysine ketoglutarate reductase. The saccharopine dehydrogenase can also function as a saccharopine re ...	This family comprises the C-terminal domain of saccharopine dehydrogenase. In some organisms this enzyme is found as a bifunctional polypeptide with lysine ketoglutarate reductase. The saccharopine dehydrogenase can also function as a saccharopine reductase.	Domain
A	PF03435	Saccharopine dehydrogenase NADP binding domain (Sacchrp_dh_NADP)	Saccharopine dehydrogenase NADP binding domain	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Alpha-aminoadipic semialdehyde synthase, mitochondrial	transcription corepressor activity transcription regulator activity transcription coregulator activity protein-macromolecule adaptor activity molecular adaptor activity protein binding binding histone binding saccharopine dehydrogenase activity oxidoreductase activity oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor oxidoreductase activity, acting on the CH-NH group of donors catalytic activity saccharopine dehydrogenase (NADP+, L-lysine-forming) activity transcription corepressor activity transcription regulator activity transcription coregulator activity protein-macromolecule adaptor activity molecular adaptor activity protein binding binding histone binding saccharopine dehydrogenase activity oxidoreductase activity oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor oxidoreductase activity, acting on the CH-NH group of donors catalytic activity saccharopine dehydrogenase (NADP+, L-lysine-forming) activity saccharopine dehydrogenase (NAD+, L-lysine-forming) activity saccharopine dehydrogenase (NAD+, L-glutamate-forming) activity	nucleoside bisphosphate metabolic process oxoacid metabolic process aspartate family amino acid metabolic process carbohydrate derivative metabolic process amino acid metabolic process acetyl-CoA metabolic process organic acid catabolic process organic acid metabolic process nucleobase-containing compound metabolic process cellular catabolic process carboxylic acid catabolic process L-lysine metabolic process amide catabolic process phosphate-containing compound metabolic process nucleoside bisphosphate metabolic process oxoacid metabolic process aspartate family amino acid metabolic process carbohydrate derivative metabolic process amino acid metabolic process acetyl-CoA metabolic process organic acid catabolic process organic acid metabolic process nucleobase-containing compound metabolic process cellular catabolic process carboxylic acid catabolic process L-lysine metabolic process amide catabolic process phosphate-containing compound metabolic process small molecule metabolic process sulfur compound metabolic process thioester metabolic process phosphorus metabolic process amino acid catabolic process nucleoside phosphate metabolic process organonitrogen compound catabolic process cellular metabolic process primary metabolic process nucleotide metabolic process L-amino acid metabolic process organic cyclic compound metabolic process alpha-amino acid catabolic process metabolic process purine ribonucleotide metabolic process small molecule catabolic process ribose phosphate metabolic process purine nucleoside bisphosphate metabolic process ribonucleoside bisphosphate metabolic process lysine metabolic process catabolic process L-lysine catabolic process alpha-amino acid metabolic process purine nucleotide metabolic process organic substance metabolic process acyl-CoA metabolic process ribonucleotide metabolic process nucleobase-containing small molecule metabolic process amide metabolic process aspartate family amino acid catabolic process organonitrogen compound metabolic process L-lysine catabolic process to acetyl-CoA via saccharopine lysine catabolic process L-amino acid catabolic process carboxylic acid metabolic process purine-containing compound metabolic process proteinogenic amino acid metabolic process proteinogenic amino acid catabolic process L-lysine catabolic process to acetyl-CoA organophosphate metabolic process cellular process organic substance catabolic process regulation of cellular process negative regulation of biological process negative regulation of cellular metabolic process regulation of primary metabolic process negative regulation of RNA biosynthetic process DNA-templated transcription regulation of RNA metabolic process transcription by RNA polymerase II organic substance biosynthetic process negative regulation of nucleobase-containing compound metabolic process regulation of nucleobase-containing compound metabolic process regulation of transcription by RNA polymerase II negative regulation of DNA-templated transcription regulation of biological process negative regulation of transcription by RNA polymerase II negative regulation of metabolic process regulation of cellular metabolic process negative regulation of cellular biosynthetic process regulation of gene expression biosynthetic process negative regulation of macromolecule biosynthetic process organic cyclic compound biosynthetic process regulation of macromolecule biosynthetic process macromolecule metabolic process regulation of DNA-templated transcription regulation of metabolic process negative regulation of RNA metabolic process cellular biosynthetic process RNA metabolic process RNA biosynthetic process nucleic acid biosynthetic process negative regulation of cellular process regulation of RNA biosynthetic process negative regulation of macromolecule metabolic process regulation of biosynthetic process biological regulation regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process regulation of cellular biosynthetic process negative regulation of biosynthetic process lysine biosynthetic process via aminoadipic acid aspartate family amino acid biosynthetic process organonitrogen compound biosynthetic process organic acid biosynthetic process carboxylic acid biosynthetic process lysine biosynthetic process small molecule biosynthetic process L-amino acid biosynthetic process amino acid biosynthetic process proteinogenic amino acid biosynthetic process alpha-amino acid biosynthetic process	membrane-bounded organelle intracellular organelle intracellular anatomical structure mitochondrion organelle cytoplasm cellular anatomical entity intracellular membrane-bounded organelle cytosol membrane-enclosed lumen mitochondrial matrix intracellular organelle lumen organelle lumen nucleus

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR007886	Alanine dehydrogenase/pyridine nucleotide transhydrogenase, N-terminal	Domain
A	IPR005097	Saccharopine dehydrogenase, NADP binding domain	Domain
A	IPR036291	NAD(P)-binding domain superfamily	Homologous Superfamily
A	IPR032095	Saccharopine dehydrogenase-like, C-terminal	Domain
A	IPR007698	Alanine dehydrogenase/pyridine nucleotide transhydrogenase, NAD(H)-binding domain	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: Q9UDR5	hyperlysinemia saccharopinuria pancreatic intraductal papillary-mucinous neoplasm progressive encephalopathy with leukodystrophy due to DECR deficiency acute myeloid leukemia breast cancer glioblastoma inborn errors of metabolism lung cancer malignant mesothelioma ovarian carcinoma pilocytic astrocytoma psoriasis Alpha-Aminoadipic Semialdehyde Deficiency Disease drug-induced liver injury hyperlysinemia saccharopinuria pancreatic intraductal papillary-mucinous neoplasm progressive encephalopathy with leukodystrophy due to DECR deficiency acute myeloid leukemia breast cancer glioblastoma inborn errors of metabolism lung cancer malignant mesothelioma ovarian carcinoma pilocytic astrocytoma psoriasis Alpha-Aminoadipic Semialdehyde Deficiency Disease drug-induced liver injury intellectual disability oligodendroglioma pancreatic intraductal papillary-mucinous carcinoma primitive neuroectodermal tumor astrocytic tumor ductal breast carcinoma in situ hyperlysinuria with hyperammonemia invasive ductal breast carcinoma malignant ependymoma ovarian cancer

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.