5NV4

UDP-Glucose Glycoprotein Glucosyltransferase from Chaetomium thermophilum double mutant D611C:G1050C

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Thioredoxin-like	8106395	3000031	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	UNK_F_TYPE	e5nv4A6	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Prealbumin-like	F: UNK_F_TYPE	ECOD (1.6)
A	UDP-g_GGTase	e5nv4A1	A: a+b three layers	X: Thioredoxin-like	H: Thioredoxin-like (From Topology)	T: Thioredoxin-like	F: UDP-g_GGTase	ECOD (1.6)
A	UNK_F_TYPE	e5nv4A2	A: a+b three layers	X: Thioredoxin-like	H: Thioredoxin-like (From Topology)	T: Thioredoxin-like	F: UNK_F_TYPE	ECOD (1.6)
A	Glyco_transf_8	e5nv4A7	A: a/b three-layered sandwiches	X: Nucleotide-diphospho-sugar transferases (From Topology)	H: Nucleotide-diphospho-sugar transferases (From Topology)	T: Nucleotide-diphospho-sugar transferases	F: Glyco_transf_8	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF18400	Thioredoxin-like domain (Thioredoxin_12)	Thioredoxin-like domain	This is one of four TRXL(thioredoxin-like) domains found in UDP-glucose:glycoprotein glucosyltransferase (UGGT)[1].	Domain
A	PF18403	Thioredoxin-like domain (Thioredoxin_15)	Thioredoxin-like domain	This is the fourth TRXL(thioredoxin-like) domain found in UDP-glucose:glycoprotein glucosyltransferase (UGGT)[1].	Domain
A	PF18404	Glucosyltransferase 24 (Glyco_transf_24)	Glucosyltransferase 24	This is the catalytic domain found in UDP-glucose:glycoprotein glucosyltransferase (UGGT). This domain belongs to glucosyltransferase 24 family (GT24) A-type domain. The GT domain displays the expected glycosyltransferase type A (GT-A) fold [1].	Domain
A	PF18402	Thioredoxin-like domain (Thioredoxin_14)	Thioredoxin-like domain	This is the third out of four TRXL(thioredoxin-like) domains found in UDP-glucose:glycoprotein glucosyltransferase (UGGT)[1].	Domain
A	PF06427	UDP-glucose:Glycoprotein Glucosyltransferase (UDP-g_GGTase)	UDP-glucose:Glycoprotein Glucosyltransferase	This domain consists of 7 stranded beta-sandwiches found in UDP-glucose-glycoprotein glucosyltransferase-like proteins [1]. UDP-g_GGTase is an important, central component of the QC system in the ER for checking that glycoproteins are folded correctl ...	This domain consists of 7 stranded beta-sandwiches found in UDP-glucose-glycoprotein glucosyltransferase-like proteins [1]. UDP-g_GGTase is an important, central component of the QC system in the ER for checking that glycoproteins are folded correctly. This QC prevents incorrectly folded glycoproteins from leaving the ER [2,3].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	UDP-glucose-glycoprotein glucosyltransferase-like protein	UDP-glycosyltransferase activity glycosyltransferase activity transferase activity glucosyltransferase activity hexosyltransferase activity catalytic activity UDP-glucose:glycoprotein glucosyltransferase activity UDP-glucosyltransferase activity cation binding ion binding binding metal ion binding small molecule binding	carbohydrate derivative biosynthetic process organonitrogen compound metabolic process cellular biosynthetic process cellular metabolic process organonitrogen compound biosynthetic process glycoprotein biosynthetic process carbohydrate derivative metabolic process primary metabolic process glycoprotein metabolic process protein glycosylation macromolecule biosynthetic process organic substance metabolic process biosynthetic process glycosylation macromolecule modification carbohydrate derivative biosynthetic process organonitrogen compound metabolic process cellular biosynthetic process cellular metabolic process organonitrogen compound biosynthetic process glycoprotein biosynthetic process carbohydrate derivative metabolic process primary metabolic process glycoprotein metabolic process protein glycosylation macromolecule biosynthetic process organic substance metabolic process biosynthetic process glycosylation macromolecule modification macromolecule glycosylation organic substance biosynthetic process metabolic process cellular process protein metabolic process macromolecule metabolic process protein modification process	membrane-bounded organelle intracellular anatomical structure membrane-enclosed lumen cellular anatomical entity intracellular membrane-bounded organelle endomembrane system intracellular organelle lumen endoplasmic reticulum lumen intracellular organelle organelle lumen organelle endoplasmic reticulum cytoplasm

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR040693	UGGT, thioredoxin-like domain 1	Domain
A	IPR040497	Glucosyltransferase 24, catalytic domain	Domain
A	IPR040694	UGGT, thioredoxin-like domain 2	Domain
A	IPR029044	Nucleotide-diphospho-sugar transferases	Homologous Superfamily
A	IPR040692	UGGT, thioredoxin-like domain 3	Domain
A	IPR009448	UDP-glucose:Glycoprotein Glucosyltransferase	Family
A	IPR040525	UDP-glucose:glycoprotein glucosyltransferase, thioredoxin-like domain 4	Domain

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.