5NUO

Structural basis for maintenance of bacterial outer membrane lipid asymmetry

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Membrane Protein Annotation: OPM
Membrane Protein Annotation: PDBTM
Membrane Protein Annotation: MemProtMD
Membrane Protein Annotation: mpstruc

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
E	SCOP2B Superfamily	Porins	8033399	3000224	SCOP2B (2022-06-29)
A [auth C]	SCOP2B Superfamily	Porins	8033399	3000224	SCOP2B (2022-06-29)
C [auth A]	SCOP2B Superfamily	Porins	8033399	3000224	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
E	PF00267	e5nuoE1	A: beta barrels	X: Outer membrane meander beta-barrels	H: Porins	T: Porin	F: PF00267	ECOD (1.6)
A [auth C]	PF00267	e5nuoC1	A: beta barrels	X: Outer membrane meander beta-barrels	H: Porins	T: Porin	F: PF00267	ECOD (1.6)
C [auth A]	PF00267	e5nuoA1	A: beta barrels	X: Outer membrane meander beta-barrels	H: Porins	T: Porin	F: PF00267	ECOD (1.6)
B [auth D]	PF04333	e5nuoD1	A: alpha arrays	X: Phospholipid translocation channel MlaA (From Topology)	H: Phospholipid translocation channel MlaA (From Topology)	T: Phospholipid translocation channel MlaA	F: PF04333	ECOD (1.6)
D [auth B]	PF04333	e5nuoB1	A: alpha arrays	X: Phospholipid translocation channel MlaA (From Topology)	H: Phospholipid translocation channel MlaA (From Topology)	T: Phospholipid translocation channel MlaA	F: PF04333	ECOD (1.6)
F	PF04333	e5nuoF1	A: alpha arrays	X: Phospholipid translocation channel MlaA (From Topology)	H: Phospholipid translocation channel MlaA (From Topology)	T: Phospholipid translocation channel MlaA	F: PF04333	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
E	2.40.160.10	Mainly Beta	Beta Barrel	Porin	Porin	CATH (4.3.0)
A [auth C]	2.40.160.10	Mainly Beta	Beta Barrel	Porin	Porin	CATH (4.3.0)
C [auth A]	2.40.160.10	Mainly Beta	Beta Barrel	Porin	Porin	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A [auth C], C [auth A], E	PF00267	Gram-negative porin (Porin_1)	Gram-negative porin	-	Domain
B [auth D], D [auth B], F	PF04333	MlaA lipoprotein (MlaA)	MlaA lipoprotein	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A [auth C], C [auth A], E	Outer membrane protein F	wide pore channel activity passive transmembrane transporter activity channel activity porin activity transporter activity transmembrane transporter activity binding lipid binding lipopolysaccharide binding carbohydrate derivative binding monoatomic ion channel activity monoatomic ion transmembrane transporter activity xenobiotic transmembrane transporter activity amide transmembrane transporter activity wide pore channel activity passive transmembrane transporter activity channel activity porin activity transporter activity transmembrane transporter activity binding lipid binding lipopolysaccharide binding carbohydrate derivative binding monoatomic ion channel activity monoatomic ion transmembrane transporter activity xenobiotic transmembrane transporter activity amide transmembrane transporter activity colicin transmembrane transporter activity bacteriocin transmembrane transporter activity disordered domain specific binding protein binding protein domain specific binding identical protein binding	transmembrane transport localization transport monoatomic ion transmembrane transport monoatomic ion transport cellular process establishment of localization protein-containing complex organization protein trimerization cellular component organization cellular component biogenesis cellular component assembly protein homotrimerization protein complex oligomerization transmembrane transport localization transport monoatomic ion transmembrane transport monoatomic ion transport cellular process establishment of localization protein-containing complex organization protein trimerization cellular component organization cellular component biogenesis cellular component assembly protein homotrimerization protein complex oligomerization protein-containing complex assembly protein homooligomerization cellular component organization or biogenesis	membrane cellular anatomical entity protein-containing complex transmembrane transporter complex membrane protein complex transporter complex monoatomic ion channel complex pore complex cell periphery cell outer membrane external encapsulating structure cell envelope outer membrane
B [auth D], D [auth B], F	ABC transporter permease	-	-	membrane cellular anatomical entity

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A [auth C], C [auth A], E	IPR001897	Porin, gammaproteobacterial	Family
A [auth C], C [auth A], E	IPR033900	Porin domain, Gram-negative type	Domain
A [auth C], C [auth A], E	IPR023614	Porin domain superfamily	Homologous Superfamily
A [auth C], C [auth A], E	IPR001702	Porin, Gram-negative type	Family
A [auth C], C [auth A], E	IPR013793	Porin, Gram-negative type, conserved site	Conserved Site
B [auth D], D [auth B], F	IPR007428	MlaA lipoprotein	Family

Membrane Protein Annotation: OPM OPM Database Homepage

Chains	External Link	Type	Class	Superfamily	Family
A [auth C], C [auth A], E	OPM	Transmembrane	Beta-barrel transmembrane	Trimeric porins (n=16,S=20)	General Bacterial Porin (GBP)

Membrane Protein Annotation: PDBTM PDBTM Database Homepage

Chains	External Link	Comment
A [auth C], C [auth A], E	PDBTM	Annotated as membrane protein by PDBTM

Membrane Protein Annotation: MemProtMD MemProtMD Database Homepage

Chains	External Link	Comment
A [auth C], C [auth A], E	MemProtMD	Annotated as membrane protein by MemProtMD

Membrane Protein Annotation: mpstruc mpstruc Database Homepage

Chains	Resource Link	Group	Subgroup	Protein
A [auth C], C [auth A], E	mpstruc	TRANSMEMBRANE PROTEINS: ALPHA-HELICAL	Outer Membrane Proteins	MlaA lipid transport protein in complex with OmpF

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.