5NNR

Structure of Naa15/Naa10 bound to HypK-THB

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Protein Modification Annotation

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
B	d5nnrb_	Alpha and beta proteins (a+b)	Acyl-CoA N-acyltransferases (Nat)	Acyl-CoA N-acyltransferases (Nat)	automated matches	automated matches	(Thermochaetoides thermophila ) [TaxId: 209285 ],	SCOPe (2.08)
E	d5nnre_	Alpha and beta proteins (a+b)	Acyl-CoA N-acyltransferases (Nat)	Acyl-CoA N-acyltransferases (Nat)	automated matches	automated matches	(Thermochaetoides thermophila ) [TaxId: 209285 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
B	SCOP2B Superfamily	Acyl-CoA N-acyltransferases (Nat)	8097798	3000403	SCOP2B (2022-06-29)
E	SCOP2 Family	N-acetyltransferase NAT	8097797	4001800	SCOP2 (2022-06-29)
E	SCOP2 Superfamily	Acyl-CoA N-acyltransferases (Nat)	8097798	3000403	SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
B	PF00583	e5nnrB1	A: a+b three layers	X: Nat/Ivy	H: Acyl-CoA N-acyltransferases (Nat) (From Topology)	T: Acyl-CoA N-acyltransferases (Nat)	F: PF00583	ECOD (1.6)
E	PF00583	e5nnrE1	A: a+b three layers	X: Nat/Ivy	H: Acyl-CoA N-acyltransferases (Nat) (From Topology)	T: Acyl-CoA N-acyltransferases (Nat)	F: PF00583	ECOD (1.6)
A	PF12569	e5nnrA2	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: PF12569	ECOD (1.6)
D	PF12569	e5nnrD1	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: PF12569	ECOD (1.6)
C	PF19026	e5nnrC1	A: alpha arrays	X: RuvA-C	H: RuvA-C, UBA, CRAL/TRIO-N, HBS1 (From Topology)	T: RuvA-C, UBA, CRAL/TRIO-N, HBS1	F: PF19026	ECOD (1.6)
F	PF19026	e5nnrF1	A: alpha arrays	X: RuvA-C	H: RuvA-C, UBA, CRAL/TRIO-N, HBS1 (From Topology)	T: RuvA-C, UBA, CRAL/TRIO-N, HBS1	F: PF19026	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
B	3.40.630.30	Alpha Beta	3-Layer(aba) Sandwich	Aminopeptidase	Gcn5-related N-acetyltransferase (GNAT)	CATH (4.3.0)
E	3.40.630.30	Alpha Beta	3-Layer(aba) Sandwich	Aminopeptidase	Gcn5-related N-acetyltransferase (GNAT)	CATH (4.3.0)
A	1.25.40.1040	Mainly Alpha	Alpha Horseshoe	Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat		CATH (4.3.0)
D	1.25.40.1040	Mainly Alpha	Alpha Horseshoe	Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat		CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
B, E	PF00583	Acetyltransferase (GNAT) family (Acetyltransf_1)	Acetyltransferase (GNAT) family	-	Family
A, D	PF13181	Tetratricopeptide repeat (TPR_8)	Tetratricopeptide repeat	-	Repeat
A, D	PF12569	N-terminal acetyltransferase A, auxiliary subunit (NatA_aux_su)	N-terminal acetyltransferase A, auxiliary subunit	-	Repeat
C, F	PF19026	HYPK UBA domain (HYPK_UBA)	HYPK UBA domain	This entry represents the UBA domain [1] found at the C-terminus of the HYPK protein and its homologues. This domain in HYPK mediates a protein interaction with the Naa15 C-terminus [1].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
B, E	Naa10	acetyltransferase activity N-acetyltransferase activity acyltransferase activity peptide alpha-N-acetyltransferase activity acyltransferase activity, transferring groups other than amino-acyl groups transferase activity peptide N-acetyltransferase activity catalytic activity N-acyltransferase activity	-	protein-containing complex intracellular anatomical structure NatA complex catalytic complex N-terminal protein acetyltransferase complex cellular anatomical entity transferase complex acetyltransferase complex protein acetyltransferase complex cytoplasm intracellular protein-containing complex
A, D	N-terminal acetyltransferase-like protein	transferase activity catalytic activity	-	intracellular anatomical structure cytoplasm cellular anatomical entity
C, F	HypK	-	-	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
B, E	IPR045047	N-acetyltransferase Ard1-like	Family
B, E	IPR016181	Acyl-CoA N-acyltransferase	Homologous Superfamily
B, E	IPR000182	GNAT domain	Domain
A, D	IPR021183	N-terminal acetyltransferase A, auxiliary subunit	Family
A, D	IPR011990	Tetratricopeptide-like helical domain superfamily	Homologous Superfamily
A, D	IPR019734	Tetratricopeptide repeat	Repeat
C, F	IPR044034	Nascent polypeptide-associated complex subunit alpha-like, UBA domain	Domain
C, F	IPR038922	Huntingtin-interacting protein K, UBA-like domain	Domain

Protein Modification Annotation

Modified Residue(s)
Chain	Residue(s)	Description
B, E	FME	Parent Component: MET RESID: AA0021 , AA0566 PSI-MOD : N-formyl-L-methionine residue MOD:00030 , N-formyl-L-methionine (Met) MOD:00482 , N-[(L-histidin-1'-yl)methyl]-L-methionine (fMet) MOD:01890 , N-[(L-histidin-1'-yl)methyl]-L-methionine (Met) MOD:01891
C, F	MSE	Parent Component: MET RESID: AA0021 , AA0566

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.