Annotations: 5NKK

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF10220	e5nkkA2	A: alpha bundles	X: Interferon-induced guanylate-binding protein 1 (GBP1), C-terminal domain (From Topology)	H: Interferon-induced guanylate-binding protein 1 (GBP1), C-terminal domain (From Topology)	T: Interferon-induced guanylate-binding protein 1 (GBP1), C-terminal domain	F: PF10220	ECOD (1.6)
A	PF10220	e5nkkA1	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: PF10220	ECOD (1.6)
C	F_UNCLASSIFIED	e5nkkC1	A: alpha bundles	X: Interferon-induced guanylate-binding protein 1 (GBP1), C-terminal domain (From Topology)	H: Interferon-induced guanylate-binding protein 1 (GBP1), C-terminal domain (From Topology)	T: Interferon-induced guanylate-binding protein 1 (GBP1), C-terminal domain	F: F_UNCLASSIFIED	ECOD (1.6)
C	PF10220	e5nkkC2	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: PF10220	ECOD (1.6)
E	PF10220	e5nkkE2	A: alpha bundles	X: Interferon-induced guanylate-binding protein 1 (GBP1), C-terminal domain (From Topology)	H: Interferon-induced guanylate-binding protein 1 (GBP1), C-terminal domain (From Topology)	T: Interferon-induced guanylate-binding protein 1 (GBP1), C-terminal domain	F: PF10220	ECOD (1.6)
E	PF10220	e5nkkE1	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: PF10220	ECOD (1.6)
B	F_UNCLASSIFIED	e5nkkB1	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: F_UNCLASSIFIED	ECOD (1.6)
D	F_UNCLASSIFIED	e5nkkD1	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: F_UNCLASSIFIED	ECOD (1.6)
F	F_UNCLASSIFIED	e5nkkF1	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: F_UNCLASSIFIED	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, C, E	PF10220	Smg8_Smg9 (Smg8_Smg9)	Smg8_Smg9	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, C, E	Protein smg-8	-	regulation of cellular process catabolic process nuclear-transcribed mRNA catabolic process, nonsense-mediated decay cellular biosynthetic process negative regulation of biological process RNA metabolic process negative regulation of cellular metabolic process macromolecule catabolic process nucleobase-containing compound metabolic process organic substance metabolic process organic substance biosynthetic process negative regulation of cellular process RNA catabolic process negative regulation of macromolecule metabolic process regulation of cellular process catabolic process nuclear-transcribed mRNA catabolic process, nonsense-mediated decay cellular biosynthetic process negative regulation of biological process RNA metabolic process negative regulation of cellular metabolic process macromolecule catabolic process nucleobase-containing compound metabolic process organic substance metabolic process organic substance biosynthetic process negative regulation of cellular process RNA catabolic process negative regulation of macromolecule metabolic process regulation of biosynthetic process mRNA catabolic process nuclear-transcribed mRNA catabolic process regulation of biological process cellular metabolic process negative regulation of metabolic process biological regulation regulation of cellular metabolic process primary metabolic process regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process mRNA metabolic process negative regulation of cellular biosynthetic process nucleic acid metabolic process organic cyclic compound catabolic process nucleobase-containing compound catabolic process regulation of cellular biosynthetic process regulation of gene expression organic cyclic compound metabolic process negative regulation of gene expression biosynthetic process negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process nucleic acid catabolic process regulation of macromolecule biosynthetic process metabolic process cellular process macromolecule metabolic process regulation of metabolic process organic substance catabolic process	intracellular anatomical structure cellular anatomical entity intracellular organelle organelle intracellular non-membrane-bounded organelle contractile muscle fiber cytoplasm supramolecular fiber supramolecular polymer supramolecular complex striated muscle dense body non-membrane-bounded organelle
B, D, F	Protein smg-9	molecular sequestering activity	regulation of cellular process catabolic process nuclear-transcribed mRNA catabolic process, nonsense-mediated decay cellular biosynthetic process negative regulation of biological process RNA metabolic process negative regulation of cellular metabolic process macromolecule catabolic process nucleobase-containing compound metabolic process organic substance metabolic process organic substance biosynthetic process negative regulation of cellular process RNA catabolic process negative regulation of macromolecule metabolic process regulation of cellular process catabolic process nuclear-transcribed mRNA catabolic process, nonsense-mediated decay cellular biosynthetic process negative regulation of biological process RNA metabolic process negative regulation of cellular metabolic process macromolecule catabolic process nucleobase-containing compound metabolic process organic substance metabolic process organic substance biosynthetic process negative regulation of cellular process RNA catabolic process negative regulation of macromolecule metabolic process regulation of biosynthetic process mRNA catabolic process nuclear-transcribed mRNA catabolic process regulation of biological process cellular metabolic process negative regulation of metabolic process biological regulation regulation of cellular metabolic process primary metabolic process regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process mRNA metabolic process negative regulation of cellular biosynthetic process nucleic acid metabolic process organic cyclic compound catabolic process nucleobase-containing compound catabolic process regulation of cellular biosynthetic process regulation of gene expression organic cyclic compound metabolic process negative regulation of gene expression biosynthetic process negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process nucleic acid catabolic process regulation of macromolecule biosynthetic process metabolic process cellular process macromolecule metabolic process regulation of metabolic process organic substance catabolic process	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, C, E	IPR019354	Nonsense-mediated mRNA decay factor SMG8-like	Family
B, D, F	IPR039177	Nonsense-mediated mRNA decay factor SMG9	Family
B, D, F	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.