5NGV
CRYSTAL STRUCTURE OF THE Activin receptor type-2B LIGAND BINDING DOMAIN IN COMPLEX WITH BIMAGRUMAB FV, ORTHORHOMBIC CRYSTAL FORM
External Resource: Annotation
- Domain Annotation: SCOP/SCOPe Classification
- Domain Annotation: SCOP2 Classification
- Domain Annotation: ECOD Classification
- Domain Annotation: CATH
- IMGT Antibody Annotation
- SAbDab Antibody Annotation
- Thera-SAbDab Antibody Annotation
- Protein Family Annotation
- Gene Ontology: Gene Product Annotation
- InterPro: Protein Family Classification
- Pharos: Disease Associations
- Protein Modification Annotation
Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage
Chains | Domain Info | Class | Fold | Superfamily | Family | Domain | Species | Provenance Source (Version) |
---|---|---|---|---|---|---|---|---|
A | d5ngva_ | Small proteins | Snake toxin-like | Snake toxin-like | Extracellular domain of cell surface receptors | Type II activin receptor | Human (Homo sapiens ) [TaxId: 9606 ], | SCOPe (2.08) |
B [auth H] | d5ngvh1 | All beta proteins | Immunoglobulin-like beta-sandwich | Immunoglobulin | automated matches | automated matches | Human (Homo sapiens ) [TaxId: 9606 ], | SCOPe (2.08) |
B [auth H] | d5ngvh2 | Artifacts | Tags | Tags | Tags | C-terminal Tags | Human (Homo sapiens ) [TaxId: 9606 ], | SCOPe (2.08) |
C [auth L] | d5ngvl1 | All beta proteins | Immunoglobulin-like beta-sandwich | Immunoglobulin | automated matches | automated matches | Human (Homo sapiens ) [TaxId: 9606 ], | SCOPe (2.08) |
C [auth L] | d5ngvl2 | Artifacts | Tags | Tags | Tags | C-terminal Tags | Human (Homo sapiens ) [TaxId: 9606 ], | SCOPe (2.08) |
Domain Annotation: SCOP2 Classification SCOP2 Database Homepage
Chains | Type | Family Name | Domain Identifier | Family Identifier | Provenance Source (Version) |
---|---|---|---|---|---|
A | SCOP2B Superfamily | Snake toxin-like | 8042166 | 3000545 | SCOP2B (2022-06-29) |
Domain Annotation: ECOD Classification ECOD Database Homepage
Chains | Family Name | Domain Identifier | Architecture | Possible Homology | Homology | Topology | Family | Provenance Source (Version) |
---|---|---|---|---|---|---|---|---|
A | PF01064 | e5ngvA1 | A: few secondary structure elements | X: Snake toxin-like (From Topology) | H: Snake toxin-like (From Topology) | T: Snake toxin-like | F: PF01064 | ECOD (1.6) |
B [auth H] | PF07686 | e5ngvH1 | A: beta sandwiches | X: Immunoglobulin-like beta-sandwich | H: Immunoglobulin-related | T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like | F: PF07686 | ECOD (1.6) |
C [auth L] | PF07686 | e5ngvL1 | A: beta sandwiches | X: Immunoglobulin-like beta-sandwich | H: Immunoglobulin-related | T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like | F: PF07686 | ECOD (1.6) |
Domain Annotation: CATH CATH Database Homepage
Chain | Domain | Class | Architecture | Topology | Homology | Provenance Source (Version) |
---|---|---|---|---|---|---|
A | 2.10.60.10 | Mainly Beta | Ribbon | CD59 | CD59 | CATH (4.3.0) |
C [auth L] | 2.60.40.10 | Mainly Beta | Sandwich | Immunoglobulin-like | Immunoglobulins | CATH (utative) |
IMGT Antibody Annotation IMGT Database Homepage
Chain | Protein Name | Description | Organism Name | Gene Allele Name(s) | Domain Name(s) | Receptor Type | Receptor Description | Provenance Source |
---|---|---|---|---|---|---|---|---|
ActRIIB receptor | ACVR2B | Homo sapiens (human) | ACVR2B*01 | R-LIKE-DOMAIN ACVR2B (Pr20-134) | IG | ACVR2B | IMGT (202418-0) | |
B [auth H] | Anti-human ActRIIB mAb BYM338 | VH | Homo sapiens (human) | IGHV1-2*02, IGHJ4*01, IGHJ5*01, IGHJ5*02, IGHJ4*02, IGHJ4*03 | V-DOMAIN VH | IG | VH_V-LAMBDA | IMGT (202418-0) |
C [auth L] | Anti-human ActRIIB mAb BYM338 | V-LAMBDA | Homo sapiens (human) | IGLV2-23*01, IGLJ2*01, IGLJ3*02, IGLJ3*01 | V-DOMAIN V-LAMBDA | IG | VH_V-LAMBDA | IMGT (202418-0) |
SAbDab Antibody Annotation SAbDab Database Homepage
Chain | Chain Class | Chain Subclass | Chain Type | Antigen Name(s) | Provenance Source |
---|---|---|---|---|---|
B [auth H] | Heavy Chain | IGHV1 | - | activin receptor type-2b | SAbDab (2024-05-10) |
C [auth L] | Light Chain | IGLV2 | Lambda | activin receptor type-2b | SAbDab (2024-05-10) |
Thera-SAbDab Antibody Annotation Thera-SAbDab Database Homepage
Chain | Name | Target | Provenance Source |
---|---|---|---|
B [auth H] | Bimagrumab | ACVR2B | Therapeutic SAbDab (2024-05-10) |
C [auth L] | Bimagrumab | ACVR2B | Therapeutic SAbDab (2024-05-10) |
Protein Family Annotation Pfam Database Homepage
Chains | Accession | Name | Description | Comments | Source |
---|---|---|---|---|---|
PF01064 | Activin types I and II receptor domain (Activin_recp) | Activin types I and II receptor domain | This Pfam entry consists of both TGF-beta receptor types. This is an alignment of the hydrophilic cysteine-rich ligand-binding domains, Both receptor types, (type I and II) posses a 9 amino acid cysteine box, with the the consensus CCX{4-5}CN. The t ... | Domain | |
Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage
InterPro: Protein Family Classification InterPro Database Homepage
Chains | Accession | Name | Type |
---|---|---|---|
IPR000472 | Activin types I and II receptor domain | Domain | |
IPR000719 | Protein kinase domain | Domain | |
IPR000333 | Ser/Thr protein kinase, TGFB receptor | Family | |
IPR045860 | Snake toxin-like superfamily | Homologous Superfamily | |
IPR011009 | Protein kinase-like domain superfamily | Homologous Superfamily | |
IPR008271 | Serine/threonine-protein kinase, active site | Active Site |
Pharos: Disease Associations Pharos Homepage Annotation
Protein Modification Annotation
Modified Residue(s) | ||
---|---|---|
Chain | Residue(s) | Description |
B [auth H] | PCA | Parent Component: GLN :  AA0031 :  2-pyrrolidone-5-carboxylic acid (Gln) MOD:00040 , 2-pyrrolidone-5-carboxylic acid (Glu) MOD:00420 |
C [auth L] | PCA | Parent Component: GLN :  AA0031 , AA0031 :  2-pyrrolidone-5-carboxylic acid (Gln) MOD:00040 , 2-pyrrolidone-5-carboxylic acid (Glu) MOD:00420 , 2-pyrrolidone-5-carboxylic acid (Gln) MOD:00040 , 2-pyrrolidone-5-carboxylic acid (Glu) MOD:00420 |