5NFJ

Crystal structure of the methyltransferase subunit of human mitochondrial Ribonuclease P (MRPP1) bound to S-adenosyl-methionine (SAM)

External Resource: Annotation

Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	UNK_F_TYPE	e5nfjA1	A: a/b three-layered sandwiches	X: alpha/beta knot (From Topology)	H: alpha/beta knot (From Topology)	T: alpha/beta knot	F: UNK_F_TYPE	ECOD (1.6)
B	UNK_F_TYPE	e5nfjB1	A: a/b three-layered sandwiches	X: alpha/beta knot (From Topology)	H: alpha/beta knot (From Topology)	T: alpha/beta knot	F: UNK_F_TYPE	ECOD (1.6)
C	UNK_F_TYPE	e5nfjC1	A: a/b three-layered sandwiches	X: alpha/beta knot (From Topology)	H: alpha/beta knot (From Topology)	T: alpha/beta knot	F: UNK_F_TYPE	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C	PF01746	tRNA (Guanine-1)-methyltransferase (tRNA_m1G_MT)	tRNA (Guanine-1)-methyltransferase	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C	Mitochondrial ribonuclease P protein 1	tRNA methyltransferase activity RNA methyltransferase activity catalytic activity, acting on RNA transferase activity, transferring one-carbon groups catalytic activity, acting on a nucleic acid catalytic activity, acting on a tRNA transferase activity S-adenosylmethionine-dependent methyltransferase activity tRNA (adenine) methyltransferase activity tRNA (adenine(9)-N1)-methyltransferase activity methyltransferase activity catalytic activity RNA binding binding tRNA methyltransferase activity RNA methyltransferase activity catalytic activity, acting on RNA transferase activity, transferring one-carbon groups catalytic activity, acting on a nucleic acid catalytic activity, acting on a tRNA transferase activity S-adenosylmethionine-dependent methyltransferase activity tRNA (adenine) methyltransferase activity tRNA (adenine(9)-N1)-methyltransferase activity methyltransferase activity catalytic activity RNA binding binding organic cyclic compound binding nucleic acid binding tRNA binding tRNA (guanine) methyltransferase activity tRNA (guanosine(9)-N1)-methyltransferase activity identical protein binding protein binding	cellular biosynthetic process RNA metabolic process mitochondrial gene expression nucleobase-containing compound metabolic process mitochondrial RNA processing organic substance metabolic process tRNA processing organic substance biosynthetic process RNA processing mitochondrial tRNA processing cellular metabolic process primary metabolic process gene expression macromolecule biosynthetic process cellular biosynthetic process RNA metabolic process mitochondrial gene expression nucleobase-containing compound metabolic process mitochondrial RNA processing organic substance metabolic process tRNA processing organic substance biosynthetic process RNA processing mitochondrial tRNA processing cellular metabolic process primary metabolic process gene expression macromolecule biosynthetic process nucleic acid metabolic process tRNA metabolic process organic cyclic compound metabolic process biosynthetic process ncRNA metabolic process nucleic acid catabolic process metabolic process cellular process macromolecule metabolic process mitochondrial RNA metabolic process mitochondrial tRNA 5'-end processing tRNA 5'-end processing mitochondrial RNA 5'-end processing RNA 5'-end processing regulation of cellular process mitochondrial translation positive regulation of protein metabolic process regulation of mitochondrial gene expression organonitrogen compound biosynthetic process positive regulation of biological process positive regulation of translation positive regulation of cellular metabolic process positive regulation of macromolecule biosynthetic process regulation of primary metabolic process post-transcriptional regulation of gene expression positive regulation of metabolic process positive regulation of biosynthetic process positive regulation of macromolecule metabolic process protein metabolic process positive regulation of cellular process regulation of biosynthetic process regulation of biological process organonitrogen compound metabolic process regulation of protein metabolic process biological regulation regulation of cellular metabolic process regulation of macromolecule metabolic process translation regulation of cellular biosynthetic process regulation of gene expression positive regulation of gene expression regulation of mitochondrial translation regulation of translation regulation of macromolecule biosynthetic process regulation of metabolic process positive regulation of cellular biosynthetic process positive regulation of mitochondrial translation mitochondrial tRNA 3'-end processing RNA 3'-end processing tRNA 3'-end processing mitochondrial RNA 3'-end processing mitochondrial tRNA modification mitochondrial RNA modification tRNA threonylcarbamoyladenosine metabolic process mitochondrial tRNA methylation tRNA modification macromolecule methylation RNA modification methylation macromolecule modification RNA methylation tRNA methylation	membrane-bounded organelle intracellular organelle intracellular anatomical structure mitochondrion organelle cytoplasm cellular anatomical entity intracellular membrane-bounded organelle membrane-enclosed lumen nucleoid mitochondrial matrix intracellular organelle lumen organelle lumen intracellular non-membrane-bounded organelle membrane-bounded organelle intracellular organelle intracellular anatomical structure mitochondrion organelle cytoplasm cellular anatomical entity intracellular membrane-bounded organelle membrane-enclosed lumen nucleoid mitochondrial matrix intracellular organelle lumen organelle lumen intracellular non-membrane-bounded organelle mitochondrial nucleoid non-membrane-bounded organelle protein-containing complex catalytic complex methyltransferase complex transferase complex tRNA methyltransferase complex nucleus nucleoplasm nuclear lumen mitochondrial protein-containing complex ribonuclease P complex endonuclease complex endoribonuclease complex ribonucleoprotein complex mitochondrial ribonuclease P complex intracellular protein-containing complex

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C	IPR007356	tRNA (guanine-N1-)-methyltransferase, eukaryotic	Family
A, B, C	IPR016009	tRNA methyltransferase TRMD/TRM10-type domain	Domain
A, B, C	IPR028564	tRNA methyltransferase TRM10-type domain	Domain
A, B, C	IPR038459	tRNA methyltransferase TRM10-type domain superfamily	Homologous Superfamily
A, B, C	IPR025812	tRNA methyltransferase 10 homolog C, TRM10-type domain	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B, C	Pharos: Q7L0Y3	combined oxidative phosphorylation defect type 30 breast cancer Mitochondrial Diseases

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.