5NAF

Co-crystal structure of an MeCP2 peptide with TBLR1 WD40 domain

External Resource: Annotation

Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF00400	e5nafA1	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 8-bladed	F: PF00400	ECOD (1.6)
B	PF00400	e5nafB1	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 8-bladed	F: PF00400	ECOD (1.6)
C	PF00400	e5nafC1	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 8-bladed	F: PF00400	ECOD (1.6)
D	PF00400	e5nafD1	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 8-bladed	F: PF00400	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	2.130.10.10	Mainly Beta	7 Propeller	Methylamine Dehydrogenase	Chain H	CATH (4.3.0)
B	2.130.10.10	Mainly Beta	7 Propeller	Methylamine Dehydrogenase	Chain H	CATH (4.3.0)
C	2.130.10.10	Mainly Beta	7 Propeller	Methylamine Dehydrogenase	Chain H	CATH (4.3.0)
D	2.130.10.10	Mainly Beta	7 Propeller	Methylamine Dehydrogenase	Chain H	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D	PF00400	WD domain, G-beta repeat (WD40)	WD domain, G-beta repeat	-	Repeat

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D	F-box-like/WD repeat-containing protein TBL1XR1	protein binding binding histone binding DNA binding sequence-specific DNA binding sequence-specific double-stranded DNA binding transcription cis-regulatory region binding double-stranded DNA binding organic cyclic compound binding nucleic acid binding transcription regulatory region nucleic acid binding transcription corepressor activity transcription regulator activity transcription coregulator activity protein binding binding histone binding DNA binding sequence-specific DNA binding sequence-specific double-stranded DNA binding transcription cis-regulatory region binding double-stranded DNA binding organic cyclic compound binding nucleic acid binding transcription regulatory region nucleic acid binding transcription corepressor activity transcription regulator activity transcription coregulator activity protein-macromolecule adaptor activity molecular adaptor activity beta-catenin binding	regulation of cellular process negative regulation of biological process negative regulation of cellular metabolic process regulation of primary metabolic process negative regulation of RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription regulation of RNA metabolic process organic substance biosynthetic process negative regulation of nucleobase-containing compound metabolic process regulation of nucleobase-containing compound metabolic process negative regulation of DNA-templated transcription regulation of biological process cellular metabolic process regulation of cellular process negative regulation of biological process negative regulation of cellular metabolic process regulation of primary metabolic process negative regulation of RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription regulation of RNA metabolic process organic substance biosynthetic process negative regulation of nucleobase-containing compound metabolic process regulation of nucleobase-containing compound metabolic process negative regulation of DNA-templated transcription regulation of biological process cellular metabolic process negative regulation of metabolic process primary metabolic process regulation of cellular metabolic process negative regulation of cellular biosynthetic process organic cyclic compound metabolic process regulation of gene expression biosynthetic process negative regulation of macromolecule biosynthetic process organic cyclic compound biosynthetic process metabolic process regulation of macromolecule biosynthetic process macromolecule metabolic process regulation of DNA-templated transcription regulation of metabolic process negative regulation of RNA metabolic process cellular biosynthetic process RNA metabolic process RNA biosynthetic process nucleic acid biosynthetic process organic substance metabolic process negative regulation of cellular process regulation of RNA biosynthetic process negative regulation of macromolecule metabolic process regulation of biosynthetic process biological regulation regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process regulation of cellular biosynthetic process negative regulation of biosynthetic process cellular process developmental process connective tissue development adipose tissue development animal organ development anatomical structure development tissue development neutral lipid metabolic process regulation of triglyceride metabolic process regulation of lipid metabolic process triglyceride metabolic process cellular lipid metabolic process glycerolipid metabolic process acylglycerol metabolic process lipid metabolic process multicellular organismal process chordate embryonic development embryo development in utero embryonic development multicellular organism development hatching embryo development ending in birth or egg hatching blastocyst hatching organism emergence from protective structure blastocyst development organonitrogen compound catabolic process organonitrogen compound metabolic process catabolic process proteolysis involved in protein catabolic process proteasomal protein catabolic process protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process macromolecule catabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis ubiquitin-dependent protein catabolic process protein metabolic process organic substance catabolic process lipid catabolic process positive regulation of macromolecule biosynthetic process positive regulation of metabolic process positive regulation of macromolecule metabolic process positive regulation of nucleobase-containing compound metabolic process positive regulation of RNA metabolic process positive regulation of DNA-templated transcription positive regulation of biological process positive regulation of cellular metabolic process positive regulation of biosynthetic process positive regulation of cellular process positive regulation of RNA biosynthetic process positive regulation of cellular biosynthetic process transcription by RNA polymerase II regulation of transcription by RNA polymerase II cellular response to stimulus positive regulation of cell communication positive regulation of signal transduction response to stimulus signaling regulation of canonical Wnt signaling pathway canonical Wnt signaling pathway regulation of signal transduction cell communication positive regulation of response to stimulus positive regulation of Wnt signaling pathway signal transduction Wnt signaling pathway positive regulation of canonical Wnt signaling pathway regulation of signaling cell surface receptor signaling pathway regulation of Wnt signaling pathway regulation of response to stimulus regulation of cell communication positive regulation of signaling negative regulation of transcription by RNA polymerase II multicellular organism growth developmental growth growth positive regulation of transcription by RNA polymerase II fat pad development protein-DNA complex organization cellular component organization protein-containing complex organization chromatin organization cellular component organization or biogenesis response to nutrient levels multicellular organismal-level homeostasis response to dietary excess homeostatic process energy homeostasis fat cell differentiation cellular developmental process cell differentiation white fat cell differentiation	intracellular organelle intracellular anatomical structure mitotic spindle cytoskeleton spindle organelle intracellular non-membrane-bounded organelle cellular anatomical entity microtubule cytoskeleton non-membrane-bounded organelle membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle intracellular anatomical structure mitotic spindle cytoskeleton spindle organelle intracellular non-membrane-bounded organelle cellular anatomical entity microtubule cytoskeleton non-membrane-bounded organelle membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen protein-containing complex catalytic complex nuclear protein-containing complex histone deacetylase complex transcription regulator complex transcription repressor complex
E, F	Methyl-CpG-binding protein 2	binding organic cyclic compound binding nucleic acid binding histone deacetylase binding protein binding enzyme binding sequence-specific DNA binding DNA binding unmethylated CpG binding protein-containing complex binding chromatin binding promoter-specific chromatin binding histone reader activity chromatin-protein adaptor activity binding organic cyclic compound binding nucleic acid binding histone deacetylase binding protein binding enzyme binding sequence-specific DNA binding DNA binding unmethylated CpG binding protein-containing complex binding chromatin binding promoter-specific chromatin binding histone reader activity chromatin-protein adaptor activity protein-macromolecule adaptor activity molecular adaptor activity DNA secondary structure binding four-way junction DNA binding protein domain specific binding regulatory RNA binding RNA binding siRNA binding transcription corepressor activity transcription regulator activity transcription coregulator activity chromatin DNA binding mRNA binding nucleoside phosphate binding nucleotide binding heterocyclic compound binding methyl-CpG binding small molecule binding identical protein binding double-stranded DNA binding double-stranded methylated DNA binding molecular condensate scaffold activity	developmental process heart development multicellular organism development multicellular organismal process anatomical structure development animal organ development circulatory system development system development protein localization localization cellular localization cellular macromolecule localization macromolecule localization cellular process developmental process heart development multicellular organism development multicellular organismal process anatomical structure development animal organ development circulatory system development system development protein localization localization cellular localization cellular macromolecule localization macromolecule localization cellular process system process nervous system process sensory perception neuromuscular process proprioception neuromuscular process controlling posture regulation of morphogenesis of a branching structure regulation of biological process regulation of developmental process biological regulation positive regulation of biological process positive regulation of branching morphogenesis of a nerve nervous system development regulation of branching morphogenesis of a nerve positive regulation of developmental process anatomical structure morphogenesis morphogenesis of a branching structure positive regulation of multicellular organismal process regulation of multicellular organismal process branching morphogenesis of a nerve regulation of anatomical structure morphogenesis respiratory gaseous exchange by respiratory system biological process involved in interspecies interaction between organisms response to stimulus response to other organism response to external stimulus response to external biotic stimulus response to biotic stimulus organonitrogen compound metabolic process cellular metabolic process glycerophospholipid metabolic process primary metabolic process phospholipid metabolic process organic substance metabolic process organophosphate metabolic process cellular lipid metabolic process phosphate-containing compound metabolic process phosphatidylcholine metabolic process metabolic process glycerolipid metabolic process phosphorus metabolic process lipid metabolic process behavior learning or memory cognition memory regulation of synaptic plasticity trans-synaptic signaling regulation of signaling regulation of cellular process modulation of chemical synaptic transmission signaling cell-cell signaling chemical synaptic transmission cell communication positive regulation of synaptic plasticity synaptic signaling regulation of trans-synaptic signaling anterograde trans-synaptic signaling regulation of cell communication regulation of biological quality head development brain development cerebellum development central nervous system development metencephalon development hindbrain development startle response glutamine metabolic process oxoacid metabolic process carboxylic acid metabolic process amino acid metabolic process organic acid metabolic process alpha-amino acid metabolic process L-amino acid metabolic process glutamine family amino acid metabolic process proteinogenic amino acid metabolic process small molecule metabolic process negative regulation of biological process negative regulation of cellular metabolic process regulation of primary metabolic process negative regulation of RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription regulation of RNA metabolic process transcription by RNA polymerase II organic substance biosynthetic process negative regulation of nucleobase-containing compound metabolic process regulation of nucleobase-containing compound metabolic process regulation of transcription by RNA polymerase II negative regulation of DNA-templated transcription negative regulation of transcription by RNA polymerase II negative regulation of metabolic process regulation of cellular metabolic process negative regulation of cellular biosynthetic process organic cyclic compound metabolic process regulation of gene expression biosynthetic process negative regulation of macromolecule biosynthetic process organic cyclic compound biosynthetic process regulation of macromolecule biosynthetic process macromolecule metabolic process regulation of DNA-templated transcription regulation of metabolic process negative regulation of RNA metabolic process cellular biosynthetic process RNA metabolic process RNA biosynthetic process nucleic acid biosynthetic process negative regulation of cellular process regulation of RNA biosynthetic process negative regulation of macromolecule metabolic process regulation of biosynthetic process regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process regulation of cellular biosynthetic process negative regulation of biosynthetic process establishment of organelle localization vesicle cytoskeletal trafficking regulation of retrograde axon cargo transport regulation of localization organelle transport along microtubule dense core granule cytoskeletal transport vesicle transport along microtubule establishment of localization in cell secretory granule localization transport along microtubule regulation of dense core granule transport regulation of intracellular transport dense core granule transport intracellular transport regulation of microtubule-based movement axonal transport establishment of localization axo-dendritic transport cytosolic transport cytoskeleton-dependent intracellular transport microtubule-based movement microtubule-based process transport positive regulation of dense core granule transport positive regulation of retrograde dense core granule transport retrograde neuronal dense core vesicle transport positive regulation of retrograde axon cargo transport dense core granule localization organelle localization positive regulation of intracellular transport positive regulation of vesicle transport along microtubule positive regulation of cellular process vesicle localization regulation of transport establishment of vesicle localization regulation of microtubule-based process retrograde axonal transport regulation of vesicle transport along microtubule regulation of retrograde dense core granule transport regulation of organelle transport along microtubule positive regulation of transport regulation of cellular localization microtubule-based transport cellular response to stimulus cell surface receptor signaling pathway Notch signaling pathway signal transduction regulation of growth developmental growth cell projection organization neuron projection development regulation of cell morphogenesis cell projection morphogenesis neuron differentiation negative regulation of growth negative regulation of dendrite extension neuron projection morphogenesis cell differentiation negative regulation of cell growth developmental growth involved in morphogenesis generation of neurons negative regulation of developmental growth regulation of cellular component organization cellular developmental process plasma membrane bounded cell projection morphogenesis cell development cell growth cell morphogenesis cellular component organization neurogenesis cellular component organization or biogenesis dendrite extension neuron projection extension regulation of developmental growth plasma membrane bounded cell projection organization developmental cell growth negative regulation of developmental process growth regulation of dendrite extension regulation of cell growth neuron development monoamine transport nitrogen compound transport secretion organic substance transport export from cell organic hydroxy compound transport catecholamine secretion secretion by cell catecholamine transport positive regulation of developmental growth positive regulation of dendrite extension positive regulation of cell growth positive regulation of growth polyol metabolic process inositol metabolic process organic hydroxy compound metabolic process alcohol metabolic process astrocyte differentiation regulation of cell differentiation regulation of neurogenesis regulation of astrocyte differentiation regulation of gliogenesis regulation of cell development regulation of nervous system development negative regulation of neurogenesis gliogenesis negative regulation of nervous system development negative regulation of cell differentiation regulation of multicellular organismal development regulation of glial cell differentiation negative regulation of astrocyte differentiation negative regulation of gliogenesis negative regulation of cell development negative regulation of glial cell differentiation glial cell differentiation negative regulation of multicellular organismal process spinal cord development phosphatidylglycerol metabolic process cardiolipin metabolic process glucocorticoid metabolic process steroid metabolic process regulation of synapse organization cell junction organization regulation of synapse structure or activity synapse organization forebrain development diencephalon development thalamus development regulation of postsynaptic membrane potential chemical synaptic transmission, postsynaptic excitatory postsynaptic potential regulation of membrane potential response to metal ion response to chemical response to lead ion response to inorganic substance protein-DNA complex organization chromatin organization chromatin remodeling heterochromatin formation protein-containing complex organization epigenetic regulation of gene expression negative regulation of gene expression negative regulation of gene expression, epigenetic biological process involved in intraspecies interaction between organisms social behavior learning associative learning regulation of action potential regulation of action potential firing threshold action potential sensory perception of pain angiogenesis regulation of vasculature development tube morphogenesis blood vessel development blood vessel morphogenesis tube development negative regulation of blood vessel morphogenesis negative regulation of angiogenesis vasculature development negative regulation of vasculature development regulation of angiogenesis anatomical structure formation involved in morphogenesis sexual reproduction reproductive process cellular process involved in reproduction in multicellular organism developmental process involved in reproduction gamete generation epigenetic programming of gene expression multicellular organismal reproductive process genomic imprinting germ cell development positive regulation of nervous system development positive regulation of cell population proliferation positive regulation of glial cell proliferation positive regulation of gliogenesis regulation of glial cell proliferation positive regulation of cell differentiation positive regulation of neurogenesis cell population proliferation positive regulation of cell development regulation of cell population proliferation glial cell proliferation respiratory tube development lung development respiratory system development lung alveolus development response to organic substance response to lipid response to estradiol response to oxygen-containing compound response to organic cyclic compound negative regulation of behavior negative regulation of locomotion locomotion involved in locomotory behavior regulation of behavior negative regulation of locomotion involved in locomotory behavior locomotory behavior regulation of locomotion regulation of locomotion involved in locomotory behavior locomotion positive regulation of cellular metabolic process positive regulation of macromolecule biosynthetic process positive regulation of metabolic process positive regulation of biosynthetic process positive regulation of macromolecule metabolic process positive regulation of gene expression positive regulation of cellular biosynthetic process cellular response to inorganic substance cellular response to metal ion response to potassium ion cellular response to chemical stimulus cellular response to potassium ion positive regulation of dendritic spine development regulation of dendritic spine development dendrite development dendritic spine development response to stress multicellular organismal response to stress smooth muscle cell differentiation regulation of smooth muscle cell differentiation negative regulation of muscle cell differentiation muscle cell differentiation muscle structure development negative regulation of smooth muscle cell differentiation regulation of muscle cell differentiation response to ionizing radiation response to radiation response to abiotic stimulus pallium development cerebral cortex development telencephalon development regulation of cell motility regulation of blood vessel endothelial cell migration endothelial cell migration negative regulation of endothelial cell migration negative regulation of blood vessel endothelial cell migration tissue migration negative regulation of epithelial cell migration ameboidal-type cell migration regulation of cell migration blood vessel endothelial cell migration regulation of endothelial cell migration epithelial cell migration cell migration cell motility regulation of epithelial cell migration negative regulation of cell migration epithelium migration negative regulation of cell motility response to decreased oxygen levels response to hypoxia response to oxygen levels striatum development subpallium development amine metabolic process biogenic amine metabolic process regulation of systemic arterial blood pressure circulatory system process regulation of blood pressure nervous system process involved in regulation of systemic arterial blood pressure blood circulation anterograde axonal transport positive regulation of anterograde dense core granule transport regulation of anterograde dense core granule transport anterograde neuronal dense core vesicle transport cellular component biogenesis cellular component assembly cell junction assembly synapse assembly ventricular system development positive regulation of nucleobase-containing compound metabolic process positive regulation of transcription by RNA polymerase II positive regulation of RNA metabolic process positive regulation of DNA-templated transcription positive regulation of RNA biosynthetic process olfactory lobe development olfactory bulb development negative regulation of dendritic spine development hippocampus development limbic system development adult locomotory behavior adult behavior post-transcriptional regulation of gene expression RNA processing regulation of miRNA processing primary miRNA processing miRNA-mediated post-transcriptional gene silencing negative regulation of miRNA-mediated gene silencing post-transcriptional gene silencing miRNA processing negative regulation of post-transcriptional gene silencing negative regulation of primary miRNA processing regulation of miRNA-mediated gene silencing negative regulation of post-transcriptional gene silencing by regulatory ncRNA regulation of regulatory ncRNA processing regulation of gene silencing by regulatory ncRNA regulation of post-transcriptional gene silencing by regulatory ncRNA negative regulation of miRNA processing regulation of primary miRNA processing negative regulation of gene silencing by regulatory ncRNA regulatory ncRNA-mediated post-transcriptional gene silencing regulatory ncRNA processing regulatory ncRNA-mediated gene silencing regulation of post-transcriptional gene silencing developmental maturation anatomical structure maturation neuron maturation cell maturation regulation of system process respiratory system process regulation of respiratory gaseous exchange regulation of respiratory system process regulation of respiratory gaseous exchange by nervous system process positive regulation of organelle organization regulation of cytoskeleton organization regulation of microtubule polymerization or depolymerization positive regulation of cellular component organization microtubule cytoskeleton organization regulation of protein-containing complex assembly positive regulation of protein-containing complex assembly microtubule polymerization or depolymerization positive regulation of protein polymerization protein-containing complex assembly protein polymerization positive regulation of microtubule nucleation positive regulation of microtubule polymerization or depolymerization positive regulation of cellular component biogenesis positive regulation of cytoskeleton organization microtubule polymerization regulation of cellular component biogenesis positive regulation of supramolecular fiber organization regulation of microtubule nucleation regulation of organelle organization organelle organization microtubule nucleation regulation of microtubule polymerization regulation of protein polymerization positive regulation of microtubule polymerization regulation of supramolecular fiber organization supramolecular fiber organization cytoskeleton organization regulation of microtubule cytoskeleton organization principal sensory nucleus of trigeminal nerve development trigeminal sensory nucleus development neural nucleus development negative regulation of respiratory gaseous exchange response to light stimulus visual learning visual behavior neuron apoptotic process negative regulation of neuron apoptotic process negative regulation of programmed cell death regulation of apoptotic process regulation of programmed cell death cell death negative regulation of apoptotic process apoptotic process programmed cell death regulation of neuron apoptotic process long-term memory cellular response to nitrogen compound response to isoquinoline alkaloid response to organonitrogen compound response to endogenous stimulus cellular response to organic cyclic compound cellular response to isoquinoline alkaloid response to nitrogen compound response to alkaloid cellular response to endogenous stimulus cellular response to organonitrogen compound cellular response to organic substance cellular response to alkaloid oligodendrocyte development glial cell development oligodendrocyte differentiation trans-synaptic signaling by BDNF behavioral defense response fear response behavioral fear response defense response positive regulation of cell communication long-term synaptic potentiation positive regulation of synaptic transmission positive regulation of signaling post-embryonic development response to cocaine	intracellular anatomical structure cytoplasm cellular anatomical entity cytosol protein-containing complex intracellular organelle protein-DNA complex organelle intracellular non-membrane-bounded organelle chromatin chromosome non-membrane-bounded organelle synapse cell junction intracellular anatomical structure cytoplasm cellular anatomical entity cytosol protein-containing complex intracellular organelle protein-DNA complex organelle intracellular non-membrane-bounded organelle chromatin chromosome non-membrane-bounded organelle synapse cell junction glutamatergic synapse heterochromatin postsynapse centrosome microtubule organizing center cytoskeleton microtubule cytoskeleton membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D	IPR019775	WD40 repeat, conserved site	Conserved Site
A, B, C, D	IPR006594	LIS1 homology motif	Conserved Site
A, B, C, D	IPR015943	WD40/YVTN repeat-like-containing domain superfamily	Homologous Superfamily
A, B, C, D	IPR045183	F-box-like/WD repeat-containing protein Ebi-like	Family
A, B, C, D	IPR036322	WD40-repeat-containing domain superfamily	Homologous Superfamily
A, B, C, D	IPR001680	WD40 repeat	Repeat
A, B, C, D	IPR020472	G-protein beta WD-40 repeat	Repeat
E, F	IPR016177	DNA-binding domain superfamily	Homologous Superfamily
E, F	IPR017353	Methyl-CpG binding protein MeCP2	Family
E, F	IPR045138	Methyl-CpG binding protein MeCP2/MBD4	Family
E, F	IPR001739	Methyl-CpG DNA binding	Domain

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.