5MV3

ACC1 Fab fragment in complex with CII583-591 (CG10)

External Resource: Annotation

Domain Annotation: ECOD Classification
Domain Annotation: CATH
IMGT Antibody Annotation
SAbDab Antibody Annotation
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Protein Modification Annotation

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	C1-set_1	e5mv3A2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: C1-set_1	ECOD (1.6)
A	V-set_12	e5mv3A1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: V-set_12	ECOD (1.6)
D [auth C]	C1-set_1	e5mv3C2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: C1-set_1	ECOD (1.6)
D [auth C]	V-set_12	e5mv3C1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: V-set_12	ECOD (1.6)
G [auth F]	C1-set_1	e5mv3F1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: C1-set_1	ECOD (1.6)
G [auth F]	V-set_12	e5mv3F2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: V-set_12	ECOD (1.6)
J [auth I]	C1-set_1	e5mv3I2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: C1-set_1	ECOD (1.6)
J [auth I]	V-set_12	e5mv3I1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: V-set_12	ECOD (1.6)
P [auth O]	C1-set_1	e5mv3O1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: C1-set_1	ECOD (1.6)
P [auth O]	V-set_12	e5mv3O2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: V-set_12	ECOD (1.6)
S [auth R]	C1-set_1	e5mv3R1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: C1-set_1	ECOD (1.6)
S [auth R]	V-set_12	e5mv3R2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: V-set_12	ECOD (1.6)
V [auth U]	C1-set_1	e5mv3U2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: C1-set_1	ECOD (1.6)
V [auth U]	V-set_12	e5mv3U1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: V-set_12	ECOD (1.6)
B	C1-set_4	e5mv3B1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: C1-set_4	ECOD (1.6)
B	V-set	e5mv3B2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: V-set	ECOD (1.6)
E [auth D]	C1-set_4	e5mv3D2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: C1-set_4	ECOD (1.6)
E [auth D]	V-set	e5mv3D1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: V-set	ECOD (1.6)
H [auth G]	C1-set_4	e5mv3G2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: C1-set_4	ECOD (1.6)
H [auth G]	V-set	e5mv3G1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: V-set	ECOD (1.6)
K [auth J]	C1-set_4	e5mv3J1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: C1-set_4	ECOD (1.6)
K [auth J]	V-set	e5mv3J2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: V-set	ECOD (1.6)
N [auth M]	C1-set_4	e5mv3M2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: C1-set_4	ECOD (1.6)
N [auth M]	V-set	e5mv3M1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: V-set	ECOD (1.6)
Q [auth P]	C1-set_4	e5mv3P1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: C1-set_4	ECOD (1.6)
Q [auth P]	V-set	e5mv3P2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: V-set	ECOD (1.6)
T [auth S]	C1-set_4	e5mv3S1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: C1-set_4	ECOD (1.6)
T [auth S]	V-set	e5mv3S2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: V-set	ECOD (1.6)
W [auth V]	C1-set_4	e5mv3V1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: C1-set_4	ECOD (1.6)
W [auth V]	V-set	e5mv3V2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: V-set	ECOD (1.6)
M [auth L]	C1-set_1	e5mv3L2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: C1-set_1	ECOD (1.6)
M [auth L]	V-set_12	e5mv3L1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: V-set_12	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (4.3.0)
D [auth C]	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (4.3.0)
G [auth F]	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (4.3.0)
J [auth I]	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (4.3.0)
P [auth O]	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (4.3.0)
S [auth R]	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (4.3.0)
V [auth U]	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (4.3.0)
B	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (4.3.0)
E [auth D]	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (4.3.0)
H [auth G]	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (4.3.0)
K [auth J]	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (4.3.0)
N [auth M]	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (4.3.0)
Q [auth P]	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (4.3.0)
T [auth S]	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (4.3.0)
W [auth V]	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (4.3.0)
M [auth L]	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (4.3.0)

IMGT Antibody Annotation IMGT Database Homepage

Chain	Protein Name	Description	Organism Name	Gene Allele Name(s)	Domain Name(s)	Receptor Type	Receptor Description	Provenance Source
A, D [auth C], G [auth F], J [auth I], P [auth O], A, D [auth C], G [auth F], J [auth I], P [auth O], S [auth R], V [auth U]	ACC1 Fab	VH-CH1	Mus musculus (house mouse)	IGHV6-601, IGHJ201, IGHG2C01, IGHG2C02, IGHG2C*03	V-DOMAIN VH, C-DOMAIN CH1	IG	FAB-GAMMA-2C_KAPPA	IMGT (202415-0)
B, E [auth D], H [auth G], K [auth J], N [auth M], B, E [auth D], H [auth G], K [auth J], N [auth M], Q [auth P], T [auth S], W [auth V]	ACC1 Fab	L-KAPPA	Mus musculus (house mouse)	IGKV3-201, IGKJ201, IGKC01, IGKC02	V-DOMAIN V-KAPPA, C-DOMAIN C-KAPPA	IG	FAB-GAMMA-2C_KAPPA	IMGT (202415-0)
M [auth L]	ACC1 Fab	VH-CH1	Mus musculus (house mouse)	IGHV6-601, IGHJ201, IGHG2C01, IGHG2C02, IGHG2C*03	V-DOMAIN VH, C-DOMAIN CH1	IG	FAB-GAMMA-2C_KAPPA	IMGT (202415-0)

SAbDab Antibody Annotation SAbDab Database Homepage

Chain	Chain Class	Chain Subclass	Chain Type	Antigen Name(s)	Provenance Source
A, D [auth C], G [auth F], J [auth I], P [auth O], A, D [auth C], G [auth F], J [auth I], P [auth O], S [auth R], V [auth U]	Heavy Chain	IGHV6	-	synthetic peptide containing the cii583-591 epitope ofcollagen type ii,collagen alpha-1(ii) chain,synthetic peptide containing the cii583-591 epitope of collagen type ii,	SAbDab (2024-04-19)
B, E [auth D], H [auth G], K [auth J], N [auth M], B, E [auth D], H [auth G], K [auth J], N [auth M], Q [auth P], T [auth S], W [auth V]	Light Chain	IGKV3	Kappa	synthetic peptide containing the cii583-591 epitope ofcollagen type ii,collagen alpha-1(ii) chain,synthetic peptide containing the cii583-591 epitope of collagen type ii,	SAbDab (2024-04-19)
M [auth L]	Heavy Chain	IGHV6	-	synthetic peptide containing the cii583-591 epitope ofcollagen type ii,collagen alpha-1(ii) chain,synthetic peptide containing the cii583-591 epitope of collagen type ii,	SAbDab (2024-04-19)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
C [auth X], F [auth E], I [auth H], L [auth K], O [auth N], C [auth X], F [auth E], I [auth H], L [auth K], O [auth N], R [auth Q], U [auth T], X [auth W]	PF01391	Collagen triple helix repeat (20 copies) (Collagen)	Collagen triple helix repeat (20 copies)	-	Repeat

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, D [auth C], G [auth F], J [auth I], P [auth O], A, D [auth C], G [auth F], J [auth I], P [auth O], S [auth R], V [auth U]	heavy chain of ACC1 Fab fragment	-	-	-
B, E [auth D], H [auth G], K [auth J], N [auth M], B, E [auth D], H [auth G], K [auth J], N [auth M], Q [auth P], T [auth S], W [auth V]	light chain of ACC1 Fab fragment	-	-	-
C [auth X], F [auth E], I [auth H], L [auth K], O [auth N], C [auth X], F [auth E], I [auth H], L [auth K], O [auth N], R [auth Q], U [auth T], X [auth W]	synthetic peptide containing the CII583-591 epitope of collagen type II,Collagen alpha-1(II) chain,synthetic peptide containing the CII583-591 epitope of collagen type II,	protein binding binding signaling receptor binding MHC class II protein binding MHC protein binding structural molecule activity extracellular matrix structural constituent extracellular matrix structural constituent conferring tensile strength identical protein binding protein homodimerization activity protein dimerization activity platelet-derived growth factor binding growth factor binding proteoglycan binding protein binding binding signaling receptor binding MHC class II protein binding MHC protein binding structural molecule activity extracellular matrix structural constituent extracellular matrix structural constituent conferring tensile strength identical protein binding protein homodimerization activity protein dimerization activity platelet-derived growth factor binding growth factor binding proteoglycan binding carbohydrate derivative binding cation binding ion binding metal ion binding small molecule binding	developmental process multicellular organism development multicellular organismal process skeletal system development connective tissue development anatomical structure development animal organ development tissue development cartilage development system development organic substance metabolic process organonitrogen compound metabolic process carbohydrate derivative metabolic process metabolic process developmental process multicellular organism development multicellular organismal process skeletal system development connective tissue development anatomical structure development animal organ development tissue development cartilage development system development organic substance metabolic process organonitrogen compound metabolic process carbohydrate derivative metabolic process metabolic process primary metabolic process protein metabolic process macromolecule metabolic process proteoglycan metabolic process glycoprotein metabolic process limb development appendage development limb bud formation anatomical structure morphogenesis appendage morphogenesis anatomical structure formation involved in morphogenesis limb morphogenesis cellular response to stimulus negative regulation of extrinsic apoptotic signaling pathway in absence of ligand regulation of cellular process response to stimulus signal transduction in absence of ligand negative regulation of signaling signaling negative regulation of biological process regulation of signal transduction regulation of programmed cell death negative regulation of cell communication extrinsic apoptotic signaling pathway negative regulation of signal transduction in absence of ligand cell communication negative regulation of extrinsic apoptotic signaling pathway negative regulation of apoptotic signaling pathway negative regulation of cellular process extrinsic apoptotic signaling pathway in absence of ligand signal transduction regulation of signaling regulation of biological process cell surface receptor signaling pathway negative regulation of response to stimulus negative regulation of programmed cell death regulation of apoptotic process biological regulation cell death negative regulation of signal transduction regulation of extrinsic apoptotic signaling pathway apoptotic signaling pathway negative regulation of apoptotic process regulation of response to stimulus regulation of extrinsic apoptotic signaling pathway in absence of ligand regulation of cell communication cellular process apoptotic process programmed cell death regulation of apoptotic signaling pathway central nervous system development nervous system development epithelium development otic vesicle development ear development sensory organ development tube development inner ear development embryonic skeletal joint development embryonic organ morphogenesis chordate embryonic development embryonic morphogenesis embryo development embryonic skeletal joint morphogenesis embryo development ending in birth or egg hatching embryonic skeletal system development animal organ morphogenesis skeletal system morphogenesis embryonic organ development embryonic skeletal system morphogenesis ear morphogenesis sensory organ morphogenesis inner ear morphogenesis regulation of biosynthetic process cellular biosynthetic process cellular metabolic process regulation of cellular metabolic process regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process regulation of cellular biosynthetic process regulation of gene expression biosynthetic process organic substance biosynthetic process regulation of macromolecule biosynthetic process regulation of metabolic process bone development endochondral ossification replacement ossification endochondral bone morphogenesis ossification bone morphogenesis cell aggregation cartilage condensation cellular component organization collagen fibril organization extracellular matrix organization cellular component organization or biogenesis supramolecular fiber organization extracellular structure organization external encapsulating structure organization heart development heart morphogenesis circulatory system development notochord development system process sensory perception nervous system process sensory perception of sound sensory perception of mechanical stimulus sensory perception of light stimulus visual perception multicellular organismal-level homeostasis homeostatic process anatomical structure homeostasis tissue homeostasis cartilage development involved in endochondral bone morphogenesis cellular developmental process cell differentiation chondrocyte differentiation roof of mouth development anterior head development head development cellular response to BMP stimulus cellular response to endogenous stimulus response to BMP cellular response to growth factor stimulus response to endogenous stimulus response to growth factor	protein-containing complex collagen trimer basement membrane cell periphery extracellular matrix external encapsulating structure collagen-containing extracellular matrix cellular anatomical entity banded collagen fibril fibrillar collagen trimer complex of collagen trimers collagen type XI trimer supramolecular fiber supramolecular polymer protein-containing complex collagen trimer basement membrane cell periphery extracellular matrix external encapsulating structure collagen-containing extracellular matrix cellular anatomical entity banded collagen fibril fibrillar collagen trimer complex of collagen trimers collagen type XI trimer supramolecular fiber supramolecular polymer supramolecular complex collagen type II trimer intracellular anatomical structure cytoplasm extracellular region extracellular space
M [auth L]	heavy chain of ACC1 Fab fragment	-	-	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
C [auth X], F [auth E], I [auth H], L [auth K], O [auth N], C [auth X], F [auth E], I [auth H], L [auth K], O [auth N], R [auth Q], U [auth T], X [auth W]	IPR008160	Collagen triple helix repeat	Repeat
C [auth X], F [auth E], I [auth H], L [auth K], O [auth N], C [auth X], F [auth E], I [auth H], L [auth K], O [auth N], R [auth Q], U [auth T], X [auth W]	IPR000885	Fibrillar collagen, C-terminal	Domain
C [auth X], F [auth E], I [auth H], L [auth K], O [auth N], C [auth X], F [auth E], I [auth H], L [auth K], O [auth N], R [auth Q], U [auth T], X [auth W]	IPR001007	VWFC domain	Domain

Protein Modification Annotation

Modified Residue(s)
Chain	Residue(s)	Description
C [auth X], F [auth E], I [auth H], L [auth K], O [auth N], C [auth X], F [auth E], I [auth H], L [auth K], O [auth N], R [auth Q], U [auth T], X [auth W]	HYP	Parent Component: PRO RESID: AA0030 PSI-MOD : 4-hydroxy-L-proline MOD:00039