5MTW

Mycobacterium tuberculosis Rv1957 SecB-like chaperone in complex with a ChAD peptide from Rv1956 HigA1 antitoxin

External Resource: Annotation

Domain Annotation: ECOD Classification
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A [auth C]	F_UNCLASSIFIED	e5mtwC2	A: a+b two layers	X: Bacterial protein-export protein SecB (From Topology)	H: Bacterial protein-export protein SecB (From Topology)	T: Bacterial protein-export protein SecB	F: F_UNCLASSIFIED	ECOD (1.6)
B [auth D]	F_UNCLASSIFIED	e5mtwD2	A: a+b two layers	X: Bacterial protein-export protein SecB (From Topology)	H: Bacterial protein-export protein SecB (From Topology)	T: Bacterial protein-export protein SecB	F: F_UNCLASSIFIED	ECOD (1.6)
C [auth A]	F_UNCLASSIFIED	e5mtwA2	A: a+b two layers	X: Bacterial protein-export protein SecB (From Topology)	H: Bacterial protein-export protein SecB (From Topology)	T: Bacterial protein-export protein SecB	F: F_UNCLASSIFIED	ECOD (1.6)
D [auth B]	F_UNCLASSIFIED	e5mtwB1	A: a+b two layers	X: Bacterial protein-export protein SecB (From Topology)	H: Bacterial protein-export protein SecB (From Topology)	T: Bacterial protein-export protein SecB	F: F_UNCLASSIFIED	ECOD (1.6)

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A [auth C], B [auth D], C [auth A], D [auth B]	SecB-like chaperone Rv1957	-	-	cell periphery external encapsulating structure cell wall cellular anatomical entity peptidoglycan-based cell wall
E, F, G	Antitoxin HigA1	DNA binding binding organic cyclic compound binding nucleic acid binding molecular sequestering activity toxin sequestering activity	regulation of cellular process negative regulation of biological process negative regulation of cellular metabolic process regulation of primary metabolic process negative regulation of RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription regulation of RNA metabolic process organic substance biosynthetic process negative regulation of nucleobase-containing compound metabolic process regulation of nucleobase-containing compound metabolic process negative regulation of DNA-templated transcription regulation of biological process cellular metabolic process regulation of cellular process negative regulation of biological process negative regulation of cellular metabolic process regulation of primary metabolic process negative regulation of RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription regulation of RNA metabolic process organic substance biosynthetic process negative regulation of nucleobase-containing compound metabolic process regulation of nucleobase-containing compound metabolic process negative regulation of DNA-templated transcription regulation of biological process cellular metabolic process negative regulation of metabolic process primary metabolic process regulation of cellular metabolic process negative regulation of cellular biosynthetic process organic cyclic compound metabolic process regulation of gene expression biosynthetic process negative regulation of macromolecule biosynthetic process organic cyclic compound biosynthetic process metabolic process regulation of macromolecule biosynthetic process macromolecule metabolic process regulation of DNA-templated transcription regulation of metabolic process negative regulation of RNA metabolic process cellular biosynthetic process RNA metabolic process RNA biosynthetic process nucleic acid biosynthetic process organic substance metabolic process negative regulation of cellular process regulation of RNA biosynthetic process negative regulation of macromolecule metabolic process regulation of biosynthetic process biological regulation regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process regulation of cellular biosynthetic process negative regulation of biosynthetic process cellular process positive regulation of growth regulation of growth positive regulation of biological process growth biological process involved in interspecies interaction between organisms modulation by symbiont of host process modulation of process of another organism biological process involved in interaction with host biological process involved in symbiotic interaction response to decreased oxygen levels response to stimulus response to hypoxia response to stress response to oxygen levels response to abiotic stimulus	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A [auth C], B [auth D], C [auth A], D [auth B]	IPR035958	SecB-like superfamily	Homologous Superfamily
E, F, G	IPR001387	Cro/C1-type helix-turn-helix domain	Domain
E, F, G	IPR010982	Lambda repressor-like, DNA-binding domain superfamily	Homologous Superfamily

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.