5MSU

Structure of the R domain of carboxylic acid reductase (CAR) from Mycobacterium marinum in complex with NADP, P21 form

External Resource: Annotation

Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A [auth C]	PF07993	e5msuC1	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: NAD(P)-binding Rossmann-fold domains	F: PF07993	ECOD (1.6)
B [auth A]	PF07993	e5msuA1	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: NAD(P)-binding Rossmann-fold domains	F: PF07993	ECOD (1.6)
C [auth B]	PF07993	e5msuB1	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: NAD(P)-binding Rossmann-fold domains	F: PF07993	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A [auth C], B [auth A], C [auth B]	PF07993	Male sterility protein (NAD_binding_4)	Male sterility protein	-	Family
A [auth C], B [auth A], C [auth B]	PF00550	Phosphopantetheine attachment site (PP-binding)	Phosphopantetheine attachment site	A 4'-phosphopantetheine prosthetic group is attached through a serine. This prosthetic group acts as a a 'swinging arm' for the attachment of activated fatty acid and amino-acid groups. This domain forms a four helix bundle. This family includes memb ...	A 4'-phosphopantetheine prosthetic group is attached through a serine. This prosthetic group acts as a a 'swinging arm' for the attachment of activated fatty acid and amino-acid groups. This domain forms a four helix bundle. This family includes members not included in Prosite. The inclusion of these members is supported by sequence analysis and functional evidence. The related domain of Swiss:P19828 has the attachment serine replaced by an alanine.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A [auth C], B [auth A], C [auth B]	Carboxylic acid reductase	binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding oxidoreductase activity oxidoreductase activity, acting on the aldehyde or oxo group of donors catalytic activity oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor NADP binding vitamin binding amide binding modified amino acid binding phosphopantetheine binding	fatty acid metabolic process oxoacid metabolic process cellular metabolic process carboxylic acid metabolic process primary metabolic process organic acid metabolic process organic substance metabolic process cellular lipid metabolic process metabolic process cellular process small molecule metabolic process monocarboxylic acid metabolic process lipid metabolic process organonitrogen compound metabolic process fatty acid metabolic process oxoacid metabolic process cellular metabolic process carboxylic acid metabolic process primary metabolic process organic acid metabolic process organic substance metabolic process cellular lipid metabolic process metabolic process cellular process small molecule metabolic process monocarboxylic acid metabolic process lipid metabolic process organonitrogen compound metabolic process biosynthetic process organonitrogen compound biosynthetic process organic substance biosynthetic process	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A [auth C], B [auth A], C [auth B]	IPR009081	Phosphopantetheine binding ACP domain	Domain
A [auth C], B [auth A], C [auth B]	IPR046407	Carboxylic acid reductase	Family
A [auth C], B [auth A], C [auth B]	IPR013120	Fatty acyl-coenzyme A reductase, NAD-binding domain	Domain
A [auth C], B [auth A], C [auth B]	IPR020845	AMP-binding, conserved site	Conserved Site
A [auth C], B [auth A], C [auth B]	IPR042099	ANL, N-terminal domain	Homologous Superfamily
A [auth C], B [auth A], C [auth B]	IPR036291	NAD(P)-binding domain superfamily	Homologous Superfamily
A [auth C], B [auth A], C [auth B]	IPR020806	Polyketide synthase, phosphopantetheine-binding domain	Domain
A [auth C], B [auth A], C [auth B]	IPR036736	ACP-like superfamily	Homologous Superfamily
A [auth C], B [auth A], C [auth B]	IPR000873	AMP-dependent synthetase/ligase domain	Domain
A [auth C], B [auth A], C [auth B]	IPR010080	Thioester reductase-like domain	Domain

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.