Annotations: 5MSM

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Dcc1_1st	e5msmA1	A: beta complex topology	X: triple barrel (From Homology)	H: triple barrel	T: Rap30/74 interaction domains-like	F: Dcc1_1st	ECOD (1.6)
A	Dcc1_3rd	e5msmA3	A: alpha arrays	X: HTH	H: HTH	T: winged	F: Dcc1_3rd	ECOD (1.6)
A	Dcc1_4th	e5msmA4	A: alpha arrays	X: HTH	H: HTH	T: winged	F: Dcc1_4th	ECOD (1.6)
A	Dcc1_2nd	e5msmA2	A: alpha arrays	X: HTH	H: HTH	T: winged	F: Dcc1_2nd	ECOD (1.6)
A	Dcc1_5th	e5msmA5	A: alpha arrays	X: HTH	H: HTH	T: winged	F: Dcc1_5th	ECOD (1.6)
D	Dcc1_1st	e5msmD2	A: beta complex topology	X: triple barrel (From Homology)	H: triple barrel	T: Rap30/74 interaction domains-like	F: Dcc1_1st	ECOD (1.6)
D	Dcc1_3rd	e5msmD5	A: alpha arrays	X: HTH	H: HTH	T: winged	F: Dcc1_3rd	ECOD (1.6)
D	Dcc1_4th	e5msmD3	A: alpha arrays	X: HTH	H: HTH	T: winged	F: Dcc1_4th	ECOD (1.6)
D	Dcc1_2nd	e5msmD4	A: alpha arrays	X: HTH	H: HTH	T: winged	F: Dcc1_2nd	ECOD (1.6)
D	Dcc1_5th	e5msmD1	A: alpha arrays	X: HTH	H: HTH	T: winged	F: Dcc1_5th	ECOD (1.6)
E	Dcc1_1st	e5msmE1	A: beta complex topology	X: triple barrel (From Homology)	H: triple barrel	T: Rap30/74 interaction domains-like	F: Dcc1_1st	ECOD (1.6)
B	Dcc1_1st	e5msmB1	A: beta complex topology	X: triple barrel (From Homology)	H: triple barrel	T: Rap30/74 interaction domains-like	F: Dcc1_1st	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, D	PF09724	Sister chromatid cohesion protein Dcc1 (Dcc1)	Sister chromatid cohesion protein Dcc1	-	Family
B, E	PF09696	Ctf8 (Ctf8)	Ctf8	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, D	Sister chromatid cohesion protein DCC1	-	nucleobase-containing compound metabolic process organic cyclic compound metabolic process DNA replication organic substance metabolic process metabolic process primary metabolic process DNA metabolic process macromolecule metabolic process nucleic acid metabolic process chromosome organization maintenance of DNA repeat elements cellular component organization organelle organization cellular process nucleobase-containing compound metabolic process organic cyclic compound metabolic process DNA replication organic substance metabolic process metabolic process primary metabolic process DNA metabolic process macromolecule metabolic process nucleic acid metabolic process chromosome organization maintenance of DNA repeat elements cellular component organization organelle organization cellular process cellular component organization or biogenesis maintenance of DNA trinucleotide repeats mitotic sister chromatid cohesion sister chromatid cohesion maintenance of sister chromatid cohesion maintenance of mitotic sister chromatid cohesion cell cycle cell cycle process	membrane-bounded organelle protein-containing complex Ctf18 RFC-like complex intracellular anatomical structure nucleus nuclear protein-containing complex chromosome intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle organelle intracellular non-membrane-bounded organelle non-membrane-bounded organelle chromosome, centromeric region membrane-bounded organelle protein-containing complex Ctf18 RFC-like complex intracellular anatomical structure nucleus nuclear protein-containing complex chromosome intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle organelle intracellular non-membrane-bounded organelle non-membrane-bounded organelle chromosome, centromeric region chromosomal region protein-DNA complex chromatin
B, E	Chromosome transmission fidelity protein 8	DNA binding binding organic cyclic compound binding nucleic acid binding	nucleobase-containing compound metabolic process organic cyclic compound metabolic process DNA replication organic substance metabolic process metabolic process primary metabolic process DNA metabolic process macromolecule metabolic process nucleic acid metabolic process chromosome organization maintenance of DNA repeat elements cellular component organization organelle organization cellular process nucleobase-containing compound metabolic process organic cyclic compound metabolic process DNA replication organic substance metabolic process metabolic process primary metabolic process DNA metabolic process macromolecule metabolic process nucleic acid metabolic process chromosome organization maintenance of DNA repeat elements cellular component organization organelle organization cellular process cellular component organization or biogenesis maintenance of DNA trinucleotide repeats mitotic sister chromatid cohesion sister chromatid cohesion cell cycle cell cycle process	membrane-bounded organelle protein-containing complex Ctf18 RFC-like complex intracellular anatomical structure nucleus nuclear protein-containing complex chromosome intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle organelle intracellular non-membrane-bounded organelle non-membrane-bounded organelle
C, F	Chromosome transmission fidelity protein 18	binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding DNA binding nucleic acid binding pyrophosphatase activity ATP hydrolysis activity ribonucleoside triphosphate phosphatase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity hydrolase activity, acting on acid anhydrides catalytic activity ATP-dependent activity	DNA-templated DNA replication DNA replication initiation primary metabolic process DNA metabolic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process DNA replication organic substance metabolic process metabolic process macromolecule metabolic process chromosome organization maintenance of DNA repeat elements cellular component organization DNA-templated DNA replication DNA replication initiation primary metabolic process DNA metabolic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process DNA replication organic substance metabolic process metabolic process macromolecule metabolic process chromosome organization maintenance of DNA repeat elements cellular component organization organelle organization cellular process cellular component organization or biogenesis maintenance of DNA trinucleotide repeats cellular response to stimulus double-strand break repair response to stimulus DNA recombination cellular response to stress DNA damage response response to stress recombinational repair double-strand break repair via homologous recombination DNA repair mitotic sister chromatid cohesion sister chromatid cohesion cell cycle cell cycle process	membrane-bounded organelle intracellular organelle intracellular anatomical structure mitochondrion organelle cytoplasm cellular anatomical entity intracellular membrane-bounded organelle protein-containing complex Ctf18 RFC-like complex nucleus nuclear protein-containing complex chromosome intracellular non-membrane-bounded organelle membrane-bounded organelle intracellular organelle intracellular anatomical structure mitochondrion organelle cytoplasm cellular anatomical entity intracellular membrane-bounded organelle protein-containing complex Ctf18 RFC-like complex nucleus nuclear protein-containing complex chromosome intracellular non-membrane-bounded organelle non-membrane-bounded organelle membrane-enclosed lumen nuclear replication fork nuclear chromosome intracellular organelle lumen organelle lumen replication fork nuclear lumen

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, D	IPR019128	Sister chromatid cohesion protein Dcc1	Family
B, E	IPR018607	Chromosome transmission fidelity protein 8	Family
C, F	IPR047854	Replication factor C, lid domain	Domain
C, F	IPR003593	AAA+ ATPase domain	Domain
C, F	IPR003959	ATPase, AAA-type, core	Domain
C, F	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.