This is the N-terminal domain of transactive response DNA-binding protein 43 kDa (TDP-43), an RNA transporting and processing protein whose aberrant aggregates are implicated in neurodegenerative diseases. TDP-43 N-terminal domain has been shown to p ...
This is the N-terminal domain of transactive response DNA-binding protein 43 kDa (TDP-43), an RNA transporting and processing protein whose aberrant aggregates are implicated in neurodegenerative diseases. TDP-43 N-terminal domain has been shown to play an important role in the aggregation of TDP-43 monomers and its loss of function affects the RNA metabolic levels. Secondary structure of the N-terminal domain consists of six beta-strands and it resembles axin 1 [1-3]. This domain is known to mediate TDP-43 dimerization. This region is followed by a nuclear localization sequence (NLS) which links the N-terminal domain with the RNA recognition motif 1 (RRM1).
