5MR1

Crystal structure of the Pleckstrin homology domain of Interactor protein for cytohesin exchange factors 1 (IPCEF1)

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d5mr1a_	All beta proteins	PH domain-like barrel	PH domain-like	automated matches	automated matches	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	Pleckstrin-homology domain (PH domain)	8062596	4002395	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	PH domain-like	8062597	3000134	SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PH	e5mr1A1	A: beta barrels	X: PH domain-like	H: PH domain-like (From Topology)	T: PH domain-like	F: PH	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF00169	PH domain (PH)	PH domain	PH stands for pleckstrin homology.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Interactor protein for cytohesin exchange factors 1	oxygen carrier activity molecular carrier activity peroxidase activity oxidoreductase activity antioxidant activity oxidoreductase activity, acting on peroxide as acceptor catalytic activity	oxygen transport localization transport gas transport establishment of localization response to oxidative stress response to stimulus response to stress	cell periphery plasma membrane membrane cellular anatomical entity intracellular anatomical structure cytoplasm

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR001849	Pleckstrin homology domain	Domain
A	IPR011993	PH-like domain superfamily	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: Q8WWN9	allergic contact dermatitis B-cell chronic lymphocytic leukemia lymphocytic leukemia lymphoid leukemia glioblastoma malignant glioma osteosarcoma primitive neuroectodermal tumor astrocytic tumor cutaneous lupus erythematosus large cell medulloblastoma medulloblastoma pilocytic astrocytoma atypical teratoid rhabdoid tumor Down syndrome allergic contact dermatitis B-cell chronic lymphocytic leukemia lymphocytic leukemia lymphoid leukemia glioblastoma malignant glioma osteosarcoma primitive neuroectodermal tumor astrocytic tumor cutaneous lupus erythematosus large cell medulloblastoma medulloblastoma pilocytic astrocytoma atypical teratoid rhabdoid tumor Down syndrome lung cancer malignant ependymoma oligodendroglioma pituitary cancer

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.