5MPB

26S proteasome in presence of AMP-PNP (s3)

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A [auth a]	SCOP2B Superfamily	Class II glutamine amidotransferases	8036842	3000131	SCOP2B (2022-06-29)
O [auth A]	SCOP2B Superfamily	Class II glutamine amidotransferases	8036842	3000131	SCOP2B (2022-06-29)
L [auth l]	SCOP2B Superfamily	Class II glutamine amidotransferases	8079504	3000131	SCOP2B (2022-06-29)
Z [auth 5]	SCOP2B Superfamily	Class II glutamine amidotransferases	8079504	3000131	SCOP2B (2022-06-29)
B [auth b]	SCOP2B Superfamily	Class II glutamine amidotransferases	8064048	3000131	SCOP2B (2022-06-29)
P [auth B]	SCOP2B Superfamily	Class II glutamine amidotransferases	8064048	3000131	SCOP2B (2022-06-29)
JA [auth V]	SCOP2B Superfamily	JAB1/MPN domain-like	8053248	3001105	SCOP2B (2022-06-29)
LA [auth X]	SCOP2B Superfamily	PH domain-like	8093403	3000134	SCOP2B (2022-06-29)
C [auth c]	SCOP2B Superfamily	Class II glutamine amidotransferases	8064020	3000131	SCOP2B (2022-06-29)
Q [auth C]	SCOP2B Superfamily	Class II glutamine amidotransferases	8064020	3000131	SCOP2B (2022-06-29)
SA [auth R]	SCOP2B Superfamily	TPR-like	8057042	3001345	SCOP2B (2022-06-29)
SA [auth R]	SCOP2B Superfamily	Winged helix DNA-binding domain	8057044	3000034	SCOP2B (2022-06-29)
TA [auth U]	SCOP2B Superfamily	EIF3 subunit F C-terminal domain-like	8053273	3002167	SCOP2B (2022-06-29)
TA [auth U]	SCOP2B Superfamily	JAB1/MPN domain-like	8053272	3001105	SCOP2B (2022-06-29)
D [auth d]	SCOP2B Superfamily	Class II glutamine amidotransferases	8064012	3000131	SCOP2B (2022-06-29)
R [auth D]	SCOP2B Superfamily	Class II glutamine amidotransferases	8064012	3000131	SCOP2B (2022-06-29)
E [auth e]	SCOP2B Superfamily	Class II glutamine amidotransferases	8064026	3000131	SCOP2B (2022-06-29)
S [auth E]	SCOP2B Superfamily	Class II glutamine amidotransferases	8064026	3000131	SCOP2B (2022-06-29)
F [auth f]	SCOP2B Superfamily	Class II glutamine amidotransferases	8064066	3000131	SCOP2B (2022-06-29)
T [auth F]	SCOP2B Superfamily	Class II glutamine amidotransferases	8064066	3000131	SCOP2B (2022-06-29)
G [auth g]	SCOP2B Superfamily	Class II glutamine amidotransferases	8079169	3000131	SCOP2B (2022-06-29)
U [auth G]	SCOP2B Superfamily	Class II glutamine amidotransferases	8079169	3000131	SCOP2B (2022-06-29)
H [auth h]	SCOP2B Superfamily	Class II glutamine amidotransferases	8036787	3000131	SCOP2B (2022-06-29)
V [auth 1]	SCOP2B Superfamily	Class II glutamine amidotransferases	8036787	3000131	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
CA [auth H]	PF17862	e5mpbH2	A: alpha arrays	X: Histone-like	H: Histone-related	T: AAA+ ATPase lid domain	F: PF17862	ECOD (1.6)
DA [auth I]	PF16450	e5mpbI1	A: beta barrels	X: OB-fold	H: Nucleic acid-binding proteins (From Topology)	T: Nucleic acid-binding proteins	F: PF16450	ECOD (1.6)
DA [auth I]	PF17862	e5mpbI2	A: alpha arrays	X: Histone-like	H: Histone-related	T: AAA+ ATPase lid domain	F: PF17862	ECOD (1.6)
DA [auth I]	PF00004	e5mpbI3	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: PF00004	ECOD (1.6)
A [auth a]	PF00227,PF10584	e5mpba1	A: a+b four layers	X: Ntn/PP2C	H: Ntn	T: Proteasome subunits	F: PF00227,PF10584	ECOD (1.6)
O [auth A]	PF00227,PF10584	e5mpbA1	A: a+b four layers	X: Ntn/PP2C	H: Ntn	T: Proteasome subunits	F: PF00227,PF10584	ECOD (1.6)
J [auth j]	PF00227	e5mpbj1	A: a+b four layers	X: Ntn/PP2C	H: Ntn	T: Proteasome subunits	F: PF00227	ECOD (1.6)
X [auth 3]	PF00227	e5mpb31	A: a+b four layers	X: Ntn/PP2C	H: Ntn	T: Proteasome subunits	F: PF00227	ECOD (1.6)
K [auth k]	PF00227	e5mpbk1	A: a+b four layers	X: Ntn/PP2C	H: Ntn	T: Proteasome subunits	F: PF00227	ECOD (1.6)
Y [auth 4]	PF00227	e5mpb41	A: a+b four layers	X: Ntn/PP2C	H: Ntn	T: Proteasome subunits	F: PF00227	ECOD (1.6)
L [auth l]	PF00227	e5mpbl1	A: a+b four layers	X: Ntn/PP2C	H: Ntn	T: Proteasome subunits	F: PF00227	ECOD (1.6)
Z [auth 5]	PF00227	e5mpb51	A: a+b four layers	X: Ntn/PP2C	H: Ntn	T: Proteasome subunits	F: PF00227	ECOD (1.6)
AA [auth 6]	PF00227	e5mpb61	A: a+b four layers	X: Ntn/PP2C	H: Ntn	T: Proteasome subunits	F: PF00227	ECOD (1.6)
M [auth m]	PF00227	e5mpbm1	A: a+b four layers	X: Ntn/PP2C	H: Ntn	T: Proteasome subunits	F: PF00227	ECOD (1.6)
BA [auth 7]	PF00227	e5mpb71	A: a+b four layers	X: Ntn/PP2C	H: Ntn	T: Proteasome subunits	F: PF00227	ECOD (1.6)
N [auth n]	PF00227	e5mpbn1	A: a+b four layers	X: Ntn/PP2C	H: Ntn	T: Proteasome subunits	F: PF00227	ECOD (1.6)
FA [auth L]	PF16450	e5mpbL1	A: beta barrels	X: OB-fold	H: Nucleic acid-binding proteins (From Topology)	T: Nucleic acid-binding proteins	F: PF16450	ECOD (1.6)
FA [auth L]	PF17862	e5mpbL2	A: alpha arrays	X: Histone-like	H: Histone-related	T: AAA+ ATPase lid domain	F: PF17862	ECOD (1.6)
FA [auth L]	PF00004	e5mpbL3	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: PF00004	ECOD (1.6)
GA [auth M]	PF16450	e5mpbM2	A: beta barrels	X: OB-fold	H: Nucleic acid-binding proteins (From Topology)	T: Nucleic acid-binding proteins	F: PF16450	ECOD (1.6)
GA [auth M]	PF17862	e5mpbM1	A: alpha arrays	X: Histone-like	H: Histone-related	T: AAA+ ATPase lid domain	F: PF17862	ECOD (1.6)
GA [auth M]	PF00004	e5mpbM3	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: PF00004	ECOD (1.6)
B [auth b]	PF00227,PF10584	e5mpbb1	A: a+b four layers	X: Ntn/PP2C	H: Ntn	T: Proteasome subunits	F: PF00227,PF10584	ECOD (1.6)
P [auth B]	PF00227,PF10584	e5mpbB1	A: a+b four layers	X: Ntn/PP2C	H: Ntn	T: Proteasome subunits	F: PF00227,PF10584	ECOD (1.6)
IA [auth W]	PF13519	e5mpbW1	A: a/b three-layered sandwiches	X: HAD domain-like	H: HAD domain-related	T: vWA-like	F: PF13519	ECOD (1.6)
JA [auth V]	PF01398	e5mpbV1	A: a+b three layers	X: Cytidine deaminase-like (From Topology)	H: Cytidine deaminase-like (From Topology)	T: Cytidine deaminase-like	F: PF01398	ECOD (1.6)
JA [auth V]	F_UNCLASSIFIED	e5mpbV2	A: extended segments	X: 26S proteasome regulatory subunit RPN8/RPN11 C-terminal domain (From Topology)	H: 26S proteasome regulatory subunit RPN8/RPN11 C-terminal domain (From Topology)	T: 26S proteasome regulatory subunit RPN8/RPN11 C-terminal domain	F: F_UNCLASSIFIED	ECOD (1.6)
KA [auth T]	PF10075	e5mpbT1	A: alpha arrays	X: HTH	H: HTH	T: winged	F: PF10075	ECOD (1.6)
KA [auth T]	PF10075	e5mpbT2	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: PF10075	ECOD (1.6)
LA [auth X]	PF04683	e5mpbX1	A: beta barrels	X: PH domain-like	H: PH domain-like (From Topology)	T: PH domain-like	F: PF04683	ECOD (1.6)
NA [auth Z]	PF17781	e5mpbZ2	A: alpha superhelices	X: Repetitive alpha hairpins	H: 26S proteasome subunit Rpn2 N-terminal domain (From Topology)	T: 26S proteasome subunit Rpn2 N-terminal domain	F: PF17781	ECOD (1.6)
NA [auth Z]	PF01851,PF18051	e5mpbZ1	A: alpha superhelices	X: Repetitive alpha hairpins	H: Proteasome/cyclosome (PC) repeat (From Topology)	T: Proteasome/cyclosome (PC) repeat	F: PF01851,PF18051	ECOD (1.6)
OA [auth N]	PF18004	e5mpbN1	A: beta sandwiches	X: 26S proteasome subunit Rpn2 C-terminal domain (From Topology)	H: 26S proteasome subunit Rpn2 C-terminal domain (From Topology)	T: 26S proteasome subunit Rpn2 C-terminal domain	F: PF18004	ECOD (1.6)
OA [auth N]	PF21505	e5mpbN2	A: alpha superhelices	X: Repetitive alpha hairpins	H: 26S proteasome subunit Rpn2 N-terminal domain (From Topology)	T: 26S proteasome subunit Rpn2 N-terminal domain	F: PF21505	ECOD (1.6)
OA [auth N]	PF01851	e5mpbN3	A: alpha superhelices	X: Repetitive alpha hairpins	H: Proteasome/cyclosome (PC) repeat (From Topology)	T: Proteasome/cyclosome (PC) repeat	F: PF01851	ECOD (1.6)
PA [auth S]	PF01399	e5mpbS1	A: alpha arrays	X: HTH	H: HTH	T: winged	F: PF01399	ECOD (1.6)
PA [auth S]	F_UNCLASSIFIED	e5mpbS2	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: F_UNCLASSIFIED	ECOD (1.6)
PA [auth S]	PF08375	e5mpbS3	A: extended segments	X: 26S proteasome regulatory subunits C-terminal helices	H: 26S proteasome regulatory subunit RPN3 C-terminal helix (From Topology)	T: 26S proteasome regulatory subunit RPN3 C-terminal helix	F: PF08375	ECOD (1.6)
QA [auth P]	PF01399	e5mpbP1	A: alpha arrays	X: HTH	H: HTH	T: winged	F: PF01399	ECOD (1.6)
QA [auth P]	PF22241	e5mpbP2	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: PF22241	ECOD (1.6)
QA [auth P]	PF18098	e5mpbP3	A: extended segments	X: 26S proteasome regulatory subunits C-terminal helices	H: 26S proteasome regulatory subunit RPN5 C-terminal helix (From Topology)	T: 26S proteasome regulatory subunit RPN5 C-terminal helix	F: PF18098	ECOD (1.6)
C [auth c]	PF00227,PF10584	e5mpbc1	A: a+b four layers	X: Ntn/PP2C	H: Ntn	T: Proteasome subunits	F: PF00227,PF10584	ECOD (1.6)
Q [auth C]	PF00227,PF10584	e5mpbC1	A: a+b four layers	X: Ntn/PP2C	H: Ntn	T: Proteasome subunits	F: PF00227,PF10584	ECOD (1.6)
RA [auth Q]	PF01399	e5mpbQ3	A: alpha arrays	X: HTH	H: HTH	T: winged	F: PF01399	ECOD (1.6)
RA [auth Q]	PF18055	e5mpbQ2	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: PF18055	ECOD (1.6)
RA [auth Q]	PF18503	e5mpbQ1	A: extended segments	X: 26S proteasome regulatory subunits C-terminal helices	H: 26S proteasome regulatory subunit RPN6 C-termial helix (From Topology)	T: 26S proteasome regulatory subunit RPN6 C-termial helix	F: PF18503	ECOD (1.6)
SA [auth R]	PF01399	e5mpbR3	A: alpha arrays	X: HTH	H: HTH	T: winged	F: PF01399	ECOD (1.6)
SA [auth R]	PF10602	e5mpbR2	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: PF10602	ECOD (1.6)
SA [auth R]	PF21154	e5mpbR1	A: extended segments	X: 26S proteasome regulatory subunits C-terminal helices	H: 26S proteasome regulatory subunit RPN7 C-terminal helix (From Topology)	T: 26S proteasome regulatory subunit RPN7 C-terminal helix	F: PF21154	ECOD (1.6)
TA [auth U]	PF01398	e5mpbU1	A: a+b three layers	X: Cytidine deaminase-like (From Topology)	H: Cytidine deaminase-like (From Topology)	T: Cytidine deaminase-like	F: PF01398	ECOD (1.6)
TA [auth U]	PF13012	e5mpbU2	A: extended segments	X: 26S proteasome regulatory subunit RPN8/RPN11 C-terminal domain (From Topology)	H: 26S proteasome regulatory subunit RPN8/RPN11 C-terminal domain (From Topology)	T: 26S proteasome regulatory subunit RPN8/RPN11 C-terminal domain	F: PF13012	ECOD (1.6)
UA [auth O]	PF01399	e5mpbO1	A: alpha arrays	X: HTH	H: HTH	T: winged	F: PF01399	ECOD (1.6)
UA [auth O]	PF22037	e5mpbO3	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: PF22037	ECOD (1.6)
UA [auth O]	PF18261	e5mpbO2	A: extended segments	X: 26S proteasome regulatory subunits C-terminal helices	H: 26S proteasome regulatory subunit RPN9 C-terminal helix (From Topology)	T: 26S proteasome regulatory subunit RPN9 C-terminal helix	F: PF18261	ECOD (1.6)
D [auth d]	PF00227,PF10584	e5mpbd1	A: a+b four layers	X: Ntn/PP2C	H: Ntn	T: Proteasome subunits	F: PF00227,PF10584	ECOD (1.6)
R [auth D]	PF00227,PF10584	e5mpbD1	A: a+b four layers	X: Ntn/PP2C	H: Ntn	T: Proteasome subunits	F: PF00227,PF10584	ECOD (1.6)
E [auth e]	PF00227,PF10584	e5mpbe1	A: a+b four layers	X: Ntn/PP2C	H: Ntn	T: Proteasome subunits	F: PF00227,PF10584	ECOD (1.6)
S [auth E]	PF00227,PF10584	e5mpbE1	A: a+b four layers	X: Ntn/PP2C	H: Ntn	T: Proteasome subunits	F: PF00227,PF10584	ECOD (1.6)
F [auth f]	PF00227,PF10584	e5mpbf1	A: a+b four layers	X: Ntn/PP2C	H: Ntn	T: Proteasome subunits	F: PF00227,PF10584	ECOD (1.6)
T [auth F]	PF00227,PF10584	e5mpbF1	A: a+b four layers	X: Ntn/PP2C	H: Ntn	T: Proteasome subunits	F: PF00227,PF10584	ECOD (1.6)
G [auth g]	PF00227,PF10584	e5mpbg1	A: a+b four layers	X: Ntn/PP2C	H: Ntn	T: Proteasome subunits	F: PF00227,PF10584	ECOD (1.6)
U [auth G]	PF00227,PF10584	e5mpbG1	A: a+b four layers	X: Ntn/PP2C	H: Ntn	T: Proteasome subunits	F: PF00227,PF10584	ECOD (1.6)
H [auth h]	PF00227	e5mpbh1	A: a+b four layers	X: Ntn/PP2C	H: Ntn	T: Proteasome subunits	F: PF00227	ECOD (1.6)
V [auth 1]	PF00227	e5mpb11	A: a+b four layers	X: Ntn/PP2C	H: Ntn	T: Proteasome subunits	F: PF00227	ECOD (1.6)
I [auth i]	PF00227,PF12465	e5mpbi1	A: a+b four layers	X: Ntn/PP2C	H: Ntn	T: Proteasome subunits	F: PF00227,PF12465	ECOD (1.6)
W [auth 2]	PF00227,PF12465	e5mpb21	A: a+b four layers	X: Ntn/PP2C	H: Ntn	T: Proteasome subunits	F: PF00227,PF12465	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
CA [auth H]	PF17862	AAA+ lid domain (AAA_lid_3)	AAA+ lid domain	This entry represents the alpha helical AAA+ lid domain that is found to the C-terminus of AAA domains.	Domain
CA [auth H]	PF00004	ATPase family associated with various cellular activities (AAA) (AAA)	ATPase family associated with various cellular activities (AAA)	AAA family proteins often perform chaperone-like functions that assist in the assembly, operation, or disassembly of protein complexes [2].	Domain
DA [auth I]	PF16450	Proteasomal ATPase OB C-terminal domain (Prot_ATP_ID_OB_C)	Proteasomal ATPase OB C-terminal domain	This is the C-terminal interdomain (ID) or oligonucleotide binding (OB) domain of proteasomal ATPase [1-2]	Domain
DA [auth I]	PF17862	AAA+ lid domain (AAA_lid_3)	AAA+ lid domain	This entry represents the alpha helical AAA+ lid domain that is found to the C-terminus of AAA domains.	Domain
DA [auth I]	PF00004	ATPase family associated with various cellular activities (AAA) (AAA)	ATPase family associated with various cellular activities (AAA)	AAA family proteins often perform chaperone-like functions that assist in the assembly, operation, or disassembly of protein complexes [2].	Domain
A [auth a], O [auth A]	PF00227	Proteasome subunit (Proteasome)	Proteasome subunit	The proteasome is a multisubunit structure that degrades proteins. Protein degradation is an essential component of regulation because proteins can become misfolded, damaged, or unnecessary. Proteasomes and their homologues vary greatly in complexity ...	The proteasome is a multisubunit structure that degrades proteins. Protein degradation is an essential component of regulation because proteins can become misfolded, damaged, or unnecessary. Proteasomes and their homologues vary greatly in complexity: from HslV (heat shock locus v), which is encoded by 1 gene in bacteria, to the eukaryotic 20S proteasome, which is encoded by more than 14 genes [1]. Recently evidence of two novel groups of bacterial proteasomes was proposed. The first is Anbu, which is sparsely distributed among cyanobacteria and proteobacteria [1]. The second is call beta-proteobacteria proteasome homologue (BPH) [1].	Domain
A [auth a], O [auth A]	PF10584	Proteasome subunit A N-terminal signature (Proteasome_A_N)	Proteasome subunit A N-terminal signature	-	Family
J [auth j], X [auth 3]	PF00227	Proteasome subunit (Proteasome)	Proteasome subunit	The proteasome is a multisubunit structure that degrades proteins. Protein degradation is an essential component of regulation because proteins can become misfolded, damaged, or unnecessary. Proteasomes and their homologues vary greatly in complexity ...	The proteasome is a multisubunit structure that degrades proteins. Protein degradation is an essential component of regulation because proteins can become misfolded, damaged, or unnecessary. Proteasomes and their homologues vary greatly in complexity: from HslV (heat shock locus v), which is encoded by 1 gene in bacteria, to the eukaryotic 20S proteasome, which is encoded by more than 14 genes [1]. Recently evidence of two novel groups of bacterial proteasomes was proposed. The first is Anbu, which is sparsely distributed among cyanobacteria and proteobacteria [1]. The second is call beta-proteobacteria proteasome homologue (BPH) [1].	Domain
K [auth k], Y [auth 4]	PF00227	Proteasome subunit (Proteasome)	Proteasome subunit	The proteasome is a multisubunit structure that degrades proteins. Protein degradation is an essential component of regulation because proteins can become misfolded, damaged, or unnecessary. Proteasomes and their homologues vary greatly in complexity ...	The proteasome is a multisubunit structure that degrades proteins. Protein degradation is an essential component of regulation because proteins can become misfolded, damaged, or unnecessary. Proteasomes and their homologues vary greatly in complexity: from HslV (heat shock locus v), which is encoded by 1 gene in bacteria, to the eukaryotic 20S proteasome, which is encoded by more than 14 genes [1]. Recently evidence of two novel groups of bacterial proteasomes was proposed. The first is Anbu, which is sparsely distributed among cyanobacteria and proteobacteria [1]. The second is call beta-proteobacteria proteasome homologue (BPH) [1].	Domain
L [auth l], Z [auth 5]	PF00227	Proteasome subunit (Proteasome)	Proteasome subunit	The proteasome is a multisubunit structure that degrades proteins. Protein degradation is an essential component of regulation because proteins can become misfolded, damaged, or unnecessary. Proteasomes and their homologues vary greatly in complexity ...	The proteasome is a multisubunit structure that degrades proteins. Protein degradation is an essential component of regulation because proteins can become misfolded, damaged, or unnecessary. Proteasomes and their homologues vary greatly in complexity: from HslV (heat shock locus v), which is encoded by 1 gene in bacteria, to the eukaryotic 20S proteasome, which is encoded by more than 14 genes [1]. Recently evidence of two novel groups of bacterial proteasomes was proposed. The first is Anbu, which is sparsely distributed among cyanobacteria and proteobacteria [1]. The second is call beta-proteobacteria proteasome homologue (BPH) [1].	Domain
AA [auth 6], M [auth m]	PF00227	Proteasome subunit (Proteasome)	Proteasome subunit	The proteasome is a multisubunit structure that degrades proteins. Protein degradation is an essential component of regulation because proteins can become misfolded, damaged, or unnecessary. Proteasomes and their homologues vary greatly in complexity ...	The proteasome is a multisubunit structure that degrades proteins. Protein degradation is an essential component of regulation because proteins can become misfolded, damaged, or unnecessary. Proteasomes and their homologues vary greatly in complexity: from HslV (heat shock locus v), which is encoded by 1 gene in bacteria, to the eukaryotic 20S proteasome, which is encoded by more than 14 genes [1]. Recently evidence of two novel groups of bacterial proteasomes was proposed. The first is Anbu, which is sparsely distributed among cyanobacteria and proteobacteria [1]. The second is call beta-proteobacteria proteasome homologue (BPH) [1].	Domain
BA [auth 7], N [auth n]	PF00227	Proteasome subunit (Proteasome)	Proteasome subunit	The proteasome is a multisubunit structure that degrades proteins. Protein degradation is an essential component of regulation because proteins can become misfolded, damaged, or unnecessary. Proteasomes and their homologues vary greatly in complexity ...	The proteasome is a multisubunit structure that degrades proteins. Protein degradation is an essential component of regulation because proteins can become misfolded, damaged, or unnecessary. Proteasomes and their homologues vary greatly in complexity: from HslV (heat shock locus v), which is encoded by 1 gene in bacteria, to the eukaryotic 20S proteasome, which is encoded by more than 14 genes [1]. Recently evidence of two novel groups of bacterial proteasomes was proposed. The first is Anbu, which is sparsely distributed among cyanobacteria and proteobacteria [1]. The second is call beta-proteobacteria proteasome homologue (BPH) [1].	Domain
EA [auth K]	PF16450	Proteasomal ATPase OB C-terminal domain (Prot_ATP_ID_OB_C)	Proteasomal ATPase OB C-terminal domain	This is the C-terminal interdomain (ID) or oligonucleotide binding (OB) domain of proteasomal ATPase [1-2]	Domain
EA [auth K]	PF00004	ATPase family associated with various cellular activities (AAA) (AAA)	ATPase family associated with various cellular activities (AAA)	AAA family proteins often perform chaperone-like functions that assist in the assembly, operation, or disassembly of protein complexes [2].	Domain
FA [auth L]	PF16450	Proteasomal ATPase OB C-terminal domain (Prot_ATP_ID_OB_C)	Proteasomal ATPase OB C-terminal domain	This is the C-terminal interdomain (ID) or oligonucleotide binding (OB) domain of proteasomal ATPase [1-2]	Domain
FA [auth L]	PF17862	AAA+ lid domain (AAA_lid_3)	AAA+ lid domain	This entry represents the alpha helical AAA+ lid domain that is found to the C-terminus of AAA domains.	Domain
FA [auth L]	PF00004	ATPase family associated with various cellular activities (AAA) (AAA)	ATPase family associated with various cellular activities (AAA)	AAA family proteins often perform chaperone-like functions that assist in the assembly, operation, or disassembly of protein complexes [2].	Domain
GA [auth M]	PF16450	Proteasomal ATPase OB C-terminal domain (Prot_ATP_ID_OB_C)	Proteasomal ATPase OB C-terminal domain	This is the C-terminal interdomain (ID) or oligonucleotide binding (OB) domain of proteasomal ATPase [1-2]	Domain
GA [auth M]	PF17862	AAA+ lid domain (AAA_lid_3)	AAA+ lid domain	This entry represents the alpha helical AAA+ lid domain that is found to the C-terminus of AAA domains.	Domain
GA [auth M]	PF00004	ATPase family associated with various cellular activities (AAA) (AAA)	ATPase family associated with various cellular activities (AAA)	AAA family proteins often perform chaperone-like functions that assist in the assembly, operation, or disassembly of protein complexes [2].	Domain
B [auth b], P [auth B]	PF00227	Proteasome subunit (Proteasome)	Proteasome subunit	The proteasome is a multisubunit structure that degrades proteins. Protein degradation is an essential component of regulation because proteins can become misfolded, damaged, or unnecessary. Proteasomes and their homologues vary greatly in complexity ...	The proteasome is a multisubunit structure that degrades proteins. Protein degradation is an essential component of regulation because proteins can become misfolded, damaged, or unnecessary. Proteasomes and their homologues vary greatly in complexity: from HslV (heat shock locus v), which is encoded by 1 gene in bacteria, to the eukaryotic 20S proteasome, which is encoded by more than 14 genes [1]. Recently evidence of two novel groups of bacterial proteasomes was proposed. The first is Anbu, which is sparsely distributed among cyanobacteria and proteobacteria [1]. The second is call beta-proteobacteria proteasome homologue (BPH) [1].	Domain
B [auth b], P [auth B]	PF10584	Proteasome subunit A N-terminal signature (Proteasome_A_N)	Proteasome subunit A N-terminal signature	-	Family
HA [auth J]	PF16450	Proteasomal ATPase OB C-terminal domain (Prot_ATP_ID_OB_C)	Proteasomal ATPase OB C-terminal domain	This is the C-terminal interdomain (ID) or oligonucleotide binding (OB) domain of proteasomal ATPase [1-2]	Domain
HA [auth J]	PF17862	AAA+ lid domain (AAA_lid_3)	AAA+ lid domain	This entry represents the alpha helical AAA+ lid domain that is found to the C-terminus of AAA domains.	Domain
HA [auth J]	PF00004	ATPase family associated with various cellular activities (AAA) (AAA)	ATPase family associated with various cellular activities (AAA)	AAA family proteins often perform chaperone-like functions that assist in the assembly, operation, or disassembly of protein complexes [2].	Domain
IA [auth W]	PF13519	von Willebrand factor type A domain (VWA_2)	von Willebrand factor type A domain	-	Domain
JA [auth V]	PF01398	JAB1/Mov34/MPN/PAD-1 ubiquitin protease (JAB)	JAB1/Mov34/MPN/PAD-1 ubiquitin protease	-	Family
KA [auth T]	PF10075	CSN8/PSMD8/EIF3K family (CSN8_PSD8_EIF3K)	CSN8/PSMD8/EIF3K family	-	Family
LA [auth X]	PF04683	Proteasome complex subunit Rpn13, Pru domain (Rpn13_ADRM1_Pru)	Proteasome complex subunit Rpn13, Pru domain	This family was thought originally to be involved in cell-adhesion [1,2], but the members are now known to be proteasome subunit Rpn13, a novel ubiquitin receptor. The 26S proteasome is a huge macromolecular protein-degradation machine consisting of ...	This family was thought originally to be involved in cell-adhesion [1,2], but the members are now known to be proteasome subunit Rpn13, a novel ubiquitin receptor. The 26S proteasome is a huge macromolecular protein-degradation machine consisting of a proteolytically active 20S core, in the form of four disc-like proteins, and one or two 19S regulatory particles. The regulatory particle(s) sit on the top and or bottom of the core, de-ubiquitinate the substrate peptides, unfold them and guide them into the narrow channel through the centre of the core. Rpn13 and its homologues dock onto the regulatory particle through the N-terminal region which binds Rpn2. The C-terminal part of the domain binds de-ubiquitinating enzyme Uch37/UCHL5 and enhances its isopeptidase activity. Rpn13 binds ubiquitin via a conserved amino-terminal region called the pleckstrin-like receptor for ubiquitin, termed Pru, domain [4]. The domain forms two contiguous anti-parallel beta-sheets with a configuration similar to the pleckstrin-homology domain (PHD) fold [5]. Rpn13's ability to bind ubiquitin and the proteasome subunit Rpn2/S1 simultaneously supports evidence of its role as a ubiquitin receptor. Finally, when complexed to di-ubiquitin, via the Pru, and Uch37 via the C-terminal part, it frees up the distal ubiquitin for de-ubiquitination by the Uch37 [5].	Domain
MA [auth Y]	PF05160	DSS1/SEM1 family (DSS1_SEM1)	DSS1/SEM1 family	-	Family
NA [auth Z]	PF17781	RPN1 N-terminal domain (RPN1_RPN2_N)	RPN1 N-terminal domain	This domain is found at the N-terminus of the 26S proteasome regulatory subunits RPN1 (also known as 26S proteasome non-ATPase regulatory subunit 2 (PMSD2)[1]. The domain is formed by an array of alpha helices [2].	Domain
NA [auth Z]	PF01851	Proteasome/cyclosome repeat (PC_rep)	Proteasome/cyclosome repeat	-	Repeat
NA [auth Z]	PF18051	26S proteasome non-ATPase regulatory subunit RPN1 C-terminal (RPN1_C)	26S proteasome non-ATPase regulatory subunit RPN1 C-terminal	This is the C-terminal domain found in RPN1 proteins (26S proteasome non-ATPase regulatory subunit 2). The 26S proteasome holocomplex consists of a 28-subunit barrel-shaped core particle (CP) in the center capped at the top and bottom by 19-subunit ...	This is the C-terminal domain found in RPN1 proteins (26S proteasome non-ATPase regulatory subunit 2). The 26S proteasome holocomplex consists of a 28-subunit barrel-shaped core particle (CP) in the center capped at the top and bottom by 19-subunit regulatory particles (RPs). The CP forms the catalytic chamber and the RP is formed from two subcomplexes known as the lid and the base [1]. The lid comprises nine Rpn subunits in yeast (Rpn3/5/6/7/8/9/11/12/15) and the base comprises three Rpn subunits (Rpn1/2/13) and six ATPases (Rpt1-6) [2].	Domain
OA [auth N]	PF13646	HEAT repeats (HEAT_2)	HEAT repeats	-	Repeat
OA [auth N]	PF18004	26S proteasome regulatory subunit RPN2 C-terminal domain (RPN2_C)	26S proteasome regulatory subunit RPN2 C-terminal domain	This is the C-terminal domain found in S. cerevisiae Rpn2 (26S proteasome regulatory subunit RPN2) as well as other eukaryotic species. A study revealed that the C-terminal 52 residues of the Rpn2 C-terminal domain are responsible for mediating inter ...	This is the C-terminal domain found in S. cerevisiae Rpn2 (26S proteasome regulatory subunit RPN2) as well as other eukaryotic species. A study revealed that the C-terminal 52 residues of the Rpn2 C-terminal domain are responsible for mediating interactions with the ubiquitin-binding subunit Rpn13. Futhermore, the extreme C-terminal 20 or 21 residues of Rpn2 (926-945 or 925-945) of S. cerevisiae, were shown to be equally effective at binding Rpn13. Multiple sequence alignments indicate that Rpn2 orthologs are highly conserved in this C-terminal region and share characteristic acidic, aromatic, and proline residues, suggesting a common function. In the structure of Rpn2 from S. cerevisiae , this region is exposed and disordered, and is thus accessible for associating with Rpn13. The Rpn2 binding surface of human Rpn13 has been mapped by nuclear magnetic resonance titration to one surface of its Pru domain [1].	Domain
OA [auth N]	PF21505	26S proteasome subunit RPN2, N-terminal domain (RPN2_N)	26S proteasome subunit RPN2, N-terminal domain	This entry represents the N-terminal helical domain of 26S proteasome regulatory subunit RPN2 and 26S proteasome non-ATPase regulatory subunit 1 (PSMD1). It adopts a rod-like structure [1-5].	Domain
OA [auth N]	PF01851	Proteasome/cyclosome repeat (PC_rep)	Proteasome/cyclosome repeat	-	Repeat
PA [auth S]	PF08375	Proteasome regulatory subunit C-terminal (Rpn3_C)	Proteasome regulatory subunit C-terminal	-	Family
PA [auth S]	PF01399	PCI domain (PCI)	PCI domain	This domain has also been called the PINT motif (Proteasome, Int-6, Nip-1 and TRIP-15) [1].	Domain
QA [auth P]	PF18098	26S proteasome regulatory subunit RPN5 C-terminal domain (RPN5_C)	26S proteasome regulatory subunit RPN5 C-terminal domain	This is the C-terminal domain of the 26S proteasome regulatory subunit RPN5 proteins.This helical domain can be found adjacent to Pfam:PF01399. The 26S proteasome is the major ATP-dependent protease in eukaryotes. Three subcomplexes form this degrada ...	This is the C-terminal domain of the 26S proteasome regulatory subunit RPN5 proteins.This helical domain can be found adjacent to Pfam:PF01399. The 26S proteasome is the major ATP-dependent protease in eukaryotes. Three subcomplexes form this degradation machine: the lid, the base, and the core. The helices found at the C terminus of each lid subunit form a helical bundle that directs the ordered self-assembly of the lid subcomplex. This domain which comprises the tail of RPN5 along with the tail of Rpn9, are important for Rpn12 binding to the lid [1].	Domain
QA [auth P]	PF01399	PCI domain (PCI)	PCI domain	This domain has also been called the PINT motif (Proteasome, Int-6, Nip-1 and TRIP-15) [1].	Domain
C [auth c], Q [auth C]	PF00227	Proteasome subunit (Proteasome)	Proteasome subunit	The proteasome is a multisubunit structure that degrades proteins. Protein degradation is an essential component of regulation because proteins can become misfolded, damaged, or unnecessary. Proteasomes and their homologues vary greatly in complexity ...	The proteasome is a multisubunit structure that degrades proteins. Protein degradation is an essential component of regulation because proteins can become misfolded, damaged, or unnecessary. Proteasomes and their homologues vary greatly in complexity: from HslV (heat shock locus v), which is encoded by 1 gene in bacteria, to the eukaryotic 20S proteasome, which is encoded by more than 14 genes [1]. Recently evidence of two novel groups of bacterial proteasomes was proposed. The first is Anbu, which is sparsely distributed among cyanobacteria and proteobacteria [1]. The second is call beta-proteobacteria proteasome homologue (BPH) [1].	Domain
C [auth c], Q [auth C]	PF10584	Proteasome subunit A N-terminal signature (Proteasome_A_N)	Proteasome subunit A N-terminal signature	-	Family
RA [auth Q]	PF18055	26S proteasome regulatory subunit RPN6 N-terminal domain (RPN6_N)	26S proteasome regulatory subunit RPN6 N-terminal domain	-	Repeat
RA [auth Q]	PF18503	26S proteasome subunit RPN6 C-terminal helix domain (RPN6_C_helix)	26S proteasome subunit RPN6 C-terminal helix domain	This is the C-terminal helix domain found in RPN6, a component of the 26S proteasome. The C-terminal helices are essential for lid assembly [1, 2].	Domain
RA [auth Q]	PF01399	PCI domain (PCI)	PCI domain	This domain has also been called the PINT motif (Proteasome, Int-6, Nip-1 and TRIP-15) [1].	Domain
SA [auth R]	PF21154	26S proteasome regulatory subunit RPN7/PSMD6 C-terminal helix (RPN7_PSMD6_C)	26S proteasome regulatory subunit RPN7/PSMD6 C-terminal helix	RPN7/PSDM6 are regulatory subunits from the 26S proteasome. This entry represents the C-terminal helix.	Domain
SA [auth R]	PF01399	PCI domain (PCI)	PCI domain	This domain has also been called the PINT motif (Proteasome, Int-6, Nip-1 and TRIP-15) [1].	Domain
SA [auth R]	PF10602	26S proteasome subunit RPN7 (RPN7)	26S proteasome subunit RPN7	-	Repeat
TA [auth U]	PF13012	Maintenance of mitochondrial structure and function (MitMem_reg)	Maintenance of mitochondrial structure and function	-	Family
TA [auth U]	PF01398	JAB1/Mov34/MPN/PAD-1 ubiquitin protease (JAB)	JAB1/Mov34/MPN/PAD-1 ubiquitin protease	-	Family
UA [auth O]	PF18261	Rpn9 C-terminal helix (Rpn9_C)	Rpn9 C-terminal helix	-	Family
UA [auth O]	PF01399	PCI domain (PCI)	PCI domain	This domain has also been called the PINT motif (Proteasome, Int-6, Nip-1 and TRIP-15) [1].	Domain
D [auth d], R [auth D]	PF00227	Proteasome subunit (Proteasome)	Proteasome subunit	The proteasome is a multisubunit structure that degrades proteins. Protein degradation is an essential component of regulation because proteins can become misfolded, damaged, or unnecessary. Proteasomes and their homologues vary greatly in complexity ...	The proteasome is a multisubunit structure that degrades proteins. Protein degradation is an essential component of regulation because proteins can become misfolded, damaged, or unnecessary. Proteasomes and their homologues vary greatly in complexity: from HslV (heat shock locus v), which is encoded by 1 gene in bacteria, to the eukaryotic 20S proteasome, which is encoded by more than 14 genes [1]. Recently evidence of two novel groups of bacterial proteasomes was proposed. The first is Anbu, which is sparsely distributed among cyanobacteria and proteobacteria [1]. The second is call beta-proteobacteria proteasome homologue (BPH) [1].	Domain
D [auth d], R [auth D]	PF10584	Proteasome subunit A N-terminal signature (Proteasome_A_N)	Proteasome subunit A N-terminal signature	-	Family
E [auth e], S [auth E]	PF00227	Proteasome subunit (Proteasome)	Proteasome subunit	The proteasome is a multisubunit structure that degrades proteins. Protein degradation is an essential component of regulation because proteins can become misfolded, damaged, or unnecessary. Proteasomes and their homologues vary greatly in complexity ...	The proteasome is a multisubunit structure that degrades proteins. Protein degradation is an essential component of regulation because proteins can become misfolded, damaged, or unnecessary. Proteasomes and their homologues vary greatly in complexity: from HslV (heat shock locus v), which is encoded by 1 gene in bacteria, to the eukaryotic 20S proteasome, which is encoded by more than 14 genes [1]. Recently evidence of two novel groups of bacterial proteasomes was proposed. The first is Anbu, which is sparsely distributed among cyanobacteria and proteobacteria [1]. The second is call beta-proteobacteria proteasome homologue (BPH) [1].	Domain
E [auth e], S [auth E]	PF10584	Proteasome subunit A N-terminal signature (Proteasome_A_N)	Proteasome subunit A N-terminal signature	-	Family
F [auth f], T [auth F]	PF00227	Proteasome subunit (Proteasome)	Proteasome subunit	The proteasome is a multisubunit structure that degrades proteins. Protein degradation is an essential component of regulation because proteins can become misfolded, damaged, or unnecessary. Proteasomes and their homologues vary greatly in complexity ...	The proteasome is a multisubunit structure that degrades proteins. Protein degradation is an essential component of regulation because proteins can become misfolded, damaged, or unnecessary. Proteasomes and their homologues vary greatly in complexity: from HslV (heat shock locus v), which is encoded by 1 gene in bacteria, to the eukaryotic 20S proteasome, which is encoded by more than 14 genes [1]. Recently evidence of two novel groups of bacterial proteasomes was proposed. The first is Anbu, which is sparsely distributed among cyanobacteria and proteobacteria [1]. The second is call beta-proteobacteria proteasome homologue (BPH) [1].	Domain
F [auth f], T [auth F]	PF10584	Proteasome subunit A N-terminal signature (Proteasome_A_N)	Proteasome subunit A N-terminal signature	-	Family
G [auth g], U [auth G]	PF00227	Proteasome subunit (Proteasome)	Proteasome subunit	The proteasome is a multisubunit structure that degrades proteins. Protein degradation is an essential component of regulation because proteins can become misfolded, damaged, or unnecessary. Proteasomes and their homologues vary greatly in complexity ...	The proteasome is a multisubunit structure that degrades proteins. Protein degradation is an essential component of regulation because proteins can become misfolded, damaged, or unnecessary. Proteasomes and their homologues vary greatly in complexity: from HslV (heat shock locus v), which is encoded by 1 gene in bacteria, to the eukaryotic 20S proteasome, which is encoded by more than 14 genes [1]. Recently evidence of two novel groups of bacterial proteasomes was proposed. The first is Anbu, which is sparsely distributed among cyanobacteria and proteobacteria [1]. The second is call beta-proteobacteria proteasome homologue (BPH) [1].	Domain
G [auth g], U [auth G]	PF10584	Proteasome subunit A N-terminal signature (Proteasome_A_N)	Proteasome subunit A N-terminal signature	-	Family
H [auth h], V [auth 1]	PF00227	Proteasome subunit (Proteasome)	Proteasome subunit	The proteasome is a multisubunit structure that degrades proteins. Protein degradation is an essential component of regulation because proteins can become misfolded, damaged, or unnecessary. Proteasomes and their homologues vary greatly in complexity ...	The proteasome is a multisubunit structure that degrades proteins. Protein degradation is an essential component of regulation because proteins can become misfolded, damaged, or unnecessary. Proteasomes and their homologues vary greatly in complexity: from HslV (heat shock locus v), which is encoded by 1 gene in bacteria, to the eukaryotic 20S proteasome, which is encoded by more than 14 genes [1]. Recently evidence of two novel groups of bacterial proteasomes was proposed. The first is Anbu, which is sparsely distributed among cyanobacteria and proteobacteria [1]. The second is call beta-proteobacteria proteasome homologue (BPH) [1].	Domain
I [auth i], W [auth 2]	PF00227	Proteasome subunit (Proteasome)	Proteasome subunit	The proteasome is a multisubunit structure that degrades proteins. Protein degradation is an essential component of regulation because proteins can become misfolded, damaged, or unnecessary. Proteasomes and their homologues vary greatly in complexity ...	The proteasome is a multisubunit structure that degrades proteins. Protein degradation is an essential component of regulation because proteins can become misfolded, damaged, or unnecessary. Proteasomes and their homologues vary greatly in complexity: from HslV (heat shock locus v), which is encoded by 1 gene in bacteria, to the eukaryotic 20S proteasome, which is encoded by more than 14 genes [1]. Recently evidence of two novel groups of bacterial proteasomes was proposed. The first is Anbu, which is sparsely distributed among cyanobacteria and proteobacteria [1]. The second is call beta-proteobacteria proteasome homologue (BPH) [1].	Domain
I [auth i], W [auth 2]	PF12465	Proteasome beta subunits C terminal (Pr_beta_C)	Proteasome beta subunits C terminal	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
CA [auth H]	26S protease regulatory subunit 7 homolog	binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding pyrophosphatase activity ATP hydrolysis activity ribonucleoside triphosphate phosphatase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity hydrolase activity, acting on acid anhydrides catalytic activity ATP-dependent activity ubiquitin protein ligase binding protein binding ubiquitin-like protein ligase binding enzyme binding proteasome-activating activity	organonitrogen compound catabolic process organonitrogen compound metabolic process catabolic process proteolysis involved in protein catabolic process primary metabolic process protein catabolic process macromolecule catabolic process organic substance metabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis ubiquitin-dependent protein catabolic process metabolic process protein metabolic process organonitrogen compound catabolic process organonitrogen compound metabolic process catabolic process proteolysis involved in protein catabolic process primary metabolic process protein catabolic process macromolecule catabolic process organic substance metabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis ubiquitin-dependent protein catabolic process metabolic process protein metabolic process macromolecule metabolic process organic substance catabolic process regulation of cellular process transcription preinitiation complex assembly positive regulation of macromolecule biosynthetic process regulation of primary metabolic process cellular component biogenesis nucleobase-containing compound metabolic process DNA-templated transcription positive regulation of metabolic process regulation of DNA-templated transcription initiation regulation of RNA metabolic process cellular component assembly transcription by RNA polymerase II organic substance biosynthetic process positive regulation of macromolecule metabolic process regulation of nucleobase-containing compound metabolic process transcription initiation at RNA polymerase II promoter regulation of transcription by RNA polymerase II regulation of biological process positive regulation of nucleobase-containing compound metabolic process cellular metabolic process regulation of cellular metabolic process positive regulation of transcription by RNA polymerase II positive regulation of DNA-templated transcription initiation positive regulation of RNA metabolic process organic cyclic compound metabolic process regulation of gene expression biosynthetic process organic cyclic compound biosynthetic process RNA polymerase II preinitiation complex assembly regulation of macromolecule biosynthetic process regulation of DNA-templated transcription regulation of metabolic process regulation of RNA polymerase II transcription preinitiation complex assembly regulation of cellular component organization positive regulation of cellular component organization cellular biosynthetic process positive regulation of DNA-templated transcription positive regulation of biological process RNA metabolic process positive regulation of cellular metabolic process cellular component organization protein-DNA complex organization RNA biosynthetic process nucleic acid biosynthetic process regulation of protein-containing complex assembly positive regulation of protein-containing complex assembly positive regulation of biosynthetic process protein-containing complex assembly cellular component organization or biogenesis positive regulation of cellular process regulation of RNA biosynthetic process regulation of biosynthetic process positive regulation of RNA polymerase II transcription preinitiation complex assembly protein-containing complex organization positive regulation of cellular component biogenesis positive regulation of transcription initiation by RNA polymerase II biological regulation protein-DNA complex assembly regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process gene expression regulation of cellular component biogenesis macromolecule biosynthetic process DNA-templated transcription initiation nucleic acid metabolic process regulation of cellular biosynthetic process positive regulation of RNA biosynthetic process cellular process regulation of transcription initiation by RNA polymerase II positive regulation of cellular biosynthetic process positive regulation of protein metabolic process regulation of protein metabolic process regulation of catabolic process positive regulation of protein catabolic process positive regulation of catabolic process regulation of protein catabolic process proteasome assembly proteasome regulatory particle assembly proteasomal protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process	protein-containing complex catalytic complex peptidase complex proteasome complex endopeptidase complex intracellular protein-containing complex intracellular anatomical structure proteasome regulatory particle cellular anatomical entity proteasome accessory complex proteasome regulatory particle, base subcomplex cytoplasm membrane-bounded organelle intracellular organelle protein-containing complex catalytic complex peptidase complex proteasome complex endopeptidase complex intracellular protein-containing complex intracellular anatomical structure proteasome regulatory particle cellular anatomical entity proteasome accessory complex proteasome regulatory particle, base subcomplex cytoplasm membrane-bounded organelle intracellular organelle organelle nucleus intracellular membrane-bounded organelle
DA [auth I]	26S protease regulatory subunit 4 homolog	binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding pyrophosphatase activity ATP hydrolysis activity ribonucleoside triphosphate phosphatase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity hydrolase activity, acting on acid anhydrides catalytic activity ATP-dependent activity proteasome-activating activity	organonitrogen compound catabolic process organonitrogen compound metabolic process catabolic process proteolysis involved in protein catabolic process primary metabolic process protein catabolic process macromolecule catabolic process organic substance metabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis ubiquitin-dependent protein catabolic process metabolic process protein metabolic process organonitrogen compound catabolic process organonitrogen compound metabolic process catabolic process proteolysis involved in protein catabolic process primary metabolic process protein catabolic process macromolecule catabolic process organic substance metabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis ubiquitin-dependent protein catabolic process metabolic process protein metabolic process macromolecule metabolic process organic substance catabolic process cellular catabolic process cellular metabolic process cellular process peptide metabolic process peptide catabolic process nonfunctional rRNA decay RNA metabolic process rRNA catabolic process nucleic acid metabolic process organic cyclic compound catabolic process nucleobase-containing compound catabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process ncRNA metabolic process nucleic acid catabolic process rRNA metabolic process RNA catabolic process positive regulation of protein metabolic process positive regulation of biological process regulation of primary metabolic process positive regulation of metabolic process positive regulation of macromolecule metabolic process regulation of biological process regulation of protein metabolic process biological regulation regulation of macromolecule metabolic process regulation of catabolic process positive regulation of protein catabolic process positive regulation of catabolic process regulation of metabolic process regulation of protein catabolic process localization protein-containing complex localization cellular component organization cellular component biogenesis proteasome assembly cellular component assembly protein-containing complex organization protein-containing complex assembly cellular component organization or biogenesis proteasome regulatory particle assembly proteasomal protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process	protein-containing complex catalytic complex peptidase complex proteasome complex endopeptidase complex intracellular protein-containing complex intracellular anatomical structure proteasome regulatory particle cellular anatomical entity proteasome accessory complex proteasome regulatory particle, base subcomplex cytoplasm membrane-bounded organelle intracellular organelle protein-containing complex catalytic complex peptidase complex proteasome complex endopeptidase complex intracellular protein-containing complex intracellular anatomical structure proteasome regulatory particle cellular anatomical entity proteasome accessory complex proteasome regulatory particle, base subcomplex cytoplasm membrane-bounded organelle intracellular organelle organelle nucleus intracellular membrane-bounded organelle
A [auth a], O [auth A]	Proteasome subunit alpha type-1	-	organonitrogen compound catabolic process organonitrogen compound metabolic process catabolic process proteolysis involved in protein catabolic process proteasomal protein catabolic process primary metabolic process protein catabolic process proteasomal ubiquitin-independent protein catabolic process macromolecule catabolic process organic substance metabolic process proteolysis metabolic process protein metabolic process macromolecule metabolic process organonitrogen compound catabolic process organonitrogen compound metabolic process catabolic process proteolysis involved in protein catabolic process proteasomal protein catabolic process primary metabolic process protein catabolic process proteasomal ubiquitin-independent protein catabolic process macromolecule catabolic process organic substance metabolic process proteolysis metabolic process protein metabolic process macromolecule metabolic process organic substance catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process ubiquitin-dependent protein catabolic process	membrane-bounded organelle intracellular organelle intracellular anatomical structure mitochondrion organelle cytoplasm cellular anatomical entity intracellular membrane-bounded organelle protein-containing complex catalytic complex peptidase complex proteasome complex endopeptidase complex intracellular protein-containing complex membrane-bounded organelle intracellular organelle intracellular anatomical structure mitochondrion organelle cytoplasm cellular anatomical entity intracellular membrane-bounded organelle protein-containing complex catalytic complex peptidase complex proteasome complex endopeptidase complex intracellular protein-containing complex proteasome core complex, alpha-subunit complex proteasome core complex nucleus
J [auth j], X [auth 3]	Proteasome subunit beta type-3	endopeptidase activator activity enzyme regulator activity enzyme activator activity peptidase regulator activity molecular function activator activity molecular function regulator activity peptidase activator activity endopeptidase regulator activity	organonitrogen compound catabolic process organonitrogen compound metabolic process catabolic process proteolysis involved in protein catabolic process proteasomal protein catabolic process primary metabolic process protein catabolic process macromolecule catabolic process organic substance metabolic process proteolysis metabolic process protein metabolic process macromolecule metabolic process organic substance catabolic process organonitrogen compound catabolic process organonitrogen compound metabolic process catabolic process proteolysis involved in protein catabolic process proteasomal protein catabolic process primary metabolic process protein catabolic process macromolecule catabolic process organic substance metabolic process proteolysis metabolic process protein metabolic process macromolecule metabolic process organic substance catabolic process proteasomal ubiquitin-independent protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process ubiquitin-dependent protein catabolic process	protein-containing complex catalytic complex peptidase complex proteasome complex endopeptidase complex intracellular protein-containing complex intracellular anatomical structure proteasome core complex cellular anatomical entity proteasome core complex, beta-subunit complex cytoplasm membrane-bounded organelle intracellular organelle organelle protein-containing complex catalytic complex peptidase complex proteasome complex endopeptidase complex intracellular protein-containing complex intracellular anatomical structure proteasome core complex cellular anatomical entity proteasome core complex, beta-subunit complex cytoplasm membrane-bounded organelle intracellular organelle organelle nucleus intracellular membrane-bounded organelle
K [auth k], Y [auth 4]	Proteasome subunit beta type-4	endopeptidase activator activity enzyme regulator activity enzyme activator activity peptidase regulator activity molecular function activator activity molecular function regulator activity peptidase activator activity endopeptidase regulator activity	organonitrogen compound catabolic process organonitrogen compound metabolic process catabolic process proteolysis involved in protein catabolic process proteasomal protein catabolic process primary metabolic process protein catabolic process macromolecule catabolic process organic substance metabolic process proteolysis metabolic process protein metabolic process macromolecule metabolic process organic substance catabolic process organonitrogen compound catabolic process organonitrogen compound metabolic process catabolic process proteolysis involved in protein catabolic process proteasomal protein catabolic process primary metabolic process protein catabolic process macromolecule catabolic process organic substance metabolic process proteolysis metabolic process protein metabolic process macromolecule metabolic process organic substance catabolic process proteasomal ubiquitin-independent protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process ubiquitin-dependent protein catabolic process	protein-containing complex catalytic complex peptidase complex proteasome complex endopeptidase complex intracellular protein-containing complex intracellular anatomical structure proteasome core complex cellular anatomical entity proteasome core complex, beta-subunit complex membrane-bounded organelle intracellular organelle organelle nucleus protein-containing complex catalytic complex peptidase complex proteasome complex endopeptidase complex intracellular protein-containing complex intracellular anatomical structure proteasome core complex cellular anatomical entity proteasome core complex, beta-subunit complex membrane-bounded organelle intracellular organelle organelle nucleus intracellular membrane-bounded organelle organelle subcompartment membrane endomembrane system endoplasmic reticulum subcompartment nuclear outer membrane-endoplasmic reticulum membrane network endoplasmic reticulum cytoplasm organelle membrane endoplasmic reticulum membrane
L [auth l], Z [auth 5]	Proteasome subunit beta type-5	peptidase activity catalytic activity, acting on a protein threonine-type peptidase activity hydrolase activity catalytic activity endopeptidase activity threonine-type endopeptidase activity	organonitrogen compound catabolic process organonitrogen compound metabolic process catabolic process proteolysis involved in protein catabolic process proteasomal protein catabolic process primary metabolic process protein catabolic process macromolecule catabolic process organic substance metabolic process proteolysis metabolic process protein metabolic process macromolecule metabolic process organic substance catabolic process organonitrogen compound catabolic process organonitrogen compound metabolic process catabolic process proteolysis involved in protein catabolic process proteasomal protein catabolic process primary metabolic process protein catabolic process macromolecule catabolic process organic substance metabolic process proteolysis metabolic process protein metabolic process macromolecule metabolic process organic substance catabolic process cellular component organization cellular component biogenesis proteasome assembly proteasome core complex assembly cellular component assembly protein-containing complex organization protein-containing complex assembly cellular process cellular component organization or biogenesis proteasomal ubiquitin-independent protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process ubiquitin-dependent protein catabolic process	protein-containing complex catalytic complex peptidase complex proteasome complex endopeptidase complex intracellular protein-containing complex intracellular anatomical structure cytoplasm cellular anatomical entity cytosol proteasome core complex proteasome core complex, beta-subunit complex membrane-bounded organelle intracellular organelle protein-containing complex catalytic complex peptidase complex proteasome complex endopeptidase complex intracellular protein-containing complex intracellular anatomical structure cytoplasm cellular anatomical entity cytosol proteasome core complex proteasome core complex, beta-subunit complex membrane-bounded organelle intracellular organelle organelle nucleus intracellular membrane-bounded organelle
AA [auth 6], M [auth m]	Proteasome subunit beta type-6	-	organonitrogen compound catabolic process organonitrogen compound metabolic process catabolic process proteolysis involved in protein catabolic process proteasomal protein catabolic process primary metabolic process protein catabolic process proteasomal ubiquitin-independent protein catabolic process macromolecule catabolic process organic substance metabolic process proteolysis metabolic process protein metabolic process macromolecule metabolic process organonitrogen compound catabolic process organonitrogen compound metabolic process catabolic process proteolysis involved in protein catabolic process proteasomal protein catabolic process primary metabolic process protein catabolic process proteasomal ubiquitin-independent protein catabolic process macromolecule catabolic process organic substance metabolic process proteolysis metabolic process protein metabolic process macromolecule metabolic process organic substance catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process ubiquitin-dependent protein catabolic process	intracellular anatomical structure cytoplasm cellular anatomical entity cytosol protein-containing complex catalytic complex peptidase complex proteasome complex endopeptidase complex intracellular protein-containing complex proteasome core complex proteasome core complex, beta-subunit complex membrane-bounded organelle intracellular organelle intracellular anatomical structure cytoplasm cellular anatomical entity cytosol protein-containing complex catalytic complex peptidase complex proteasome complex endopeptidase complex intracellular protein-containing complex proteasome core complex proteasome core complex, beta-subunit complex membrane-bounded organelle intracellular organelle organelle nucleus intracellular membrane-bounded organelle
BA [auth 7], N [auth n]	Proteasome subunit beta type-7	-	organonitrogen compound catabolic process organonitrogen compound metabolic process catabolic process proteolysis involved in protein catabolic process proteasomal protein catabolic process primary metabolic process protein catabolic process macromolecule catabolic process organic substance metabolic process proteolysis metabolic process protein metabolic process macromolecule metabolic process organic substance catabolic process organonitrogen compound catabolic process organonitrogen compound metabolic process catabolic process proteolysis involved in protein catabolic process proteasomal protein catabolic process primary metabolic process protein catabolic process macromolecule catabolic process organic substance metabolic process proteolysis metabolic process protein metabolic process macromolecule metabolic process organic substance catabolic process cellular component organization cellular component biogenesis proteasome assembly cellular component assembly protein-containing complex organization protein-containing complex assembly cellular process cellular component organization or biogenesis proteasomal ubiquitin-independent protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process ubiquitin-dependent protein catabolic process	protein-containing complex catalytic complex peptidase complex proteasome complex endopeptidase complex intracellular protein-containing complex intracellular anatomical structure proteasome core complex cellular anatomical entity proteasome core complex, beta-subunit complex intracellular organelle organelle intracellular non-membrane-bounded organelle cytoplasm protein-containing complex catalytic complex peptidase complex proteasome complex endopeptidase complex intracellular protein-containing complex intracellular anatomical structure proteasome core complex cellular anatomical entity proteasome core complex, beta-subunit complex intracellular organelle organelle intracellular non-membrane-bounded organelle cytoplasm proteasome storage granule non-membrane-bounded organelle membrane-bounded organelle nucleus intracellular membrane-bounded organelle
EA [auth K]	26S protease regulatory subunit 6B homolog	binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding pyrophosphatase activity ATP hydrolysis activity ribonucleoside triphosphate phosphatase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity hydrolase activity, acting on acid anhydrides catalytic activity ATP-dependent activity identical protein binding protein binding proteasome-activating activity	organonitrogen compound catabolic process organonitrogen compound metabolic process catabolic process proteolysis involved in protein catabolic process primary metabolic process protein catabolic process macromolecule catabolic process organic substance metabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis ubiquitin-dependent protein catabolic process metabolic process protein metabolic process organonitrogen compound catabolic process organonitrogen compound metabolic process catabolic process proteolysis involved in protein catabolic process primary metabolic process protein catabolic process macromolecule catabolic process organic substance metabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis ubiquitin-dependent protein catabolic process metabolic process protein metabolic process macromolecule metabolic process organic substance catabolic process regulation of cellular process transcription preinitiation complex assembly positive regulation of macromolecule biosynthetic process regulation of primary metabolic process cellular component biogenesis nucleobase-containing compound metabolic process DNA-templated transcription positive regulation of metabolic process regulation of DNA-templated transcription initiation regulation of RNA metabolic process cellular component assembly transcription by RNA polymerase II organic substance biosynthetic process positive regulation of macromolecule metabolic process regulation of nucleobase-containing compound metabolic process transcription initiation at RNA polymerase II promoter regulation of transcription by RNA polymerase II regulation of biological process positive regulation of nucleobase-containing compound metabolic process cellular metabolic process regulation of cellular metabolic process positive regulation of transcription by RNA polymerase II positive regulation of DNA-templated transcription initiation positive regulation of RNA metabolic process organic cyclic compound metabolic process regulation of gene expression biosynthetic process organic cyclic compound biosynthetic process RNA polymerase II preinitiation complex assembly regulation of macromolecule biosynthetic process regulation of DNA-templated transcription regulation of metabolic process regulation of RNA polymerase II transcription preinitiation complex assembly regulation of cellular component organization positive regulation of cellular component organization cellular biosynthetic process positive regulation of DNA-templated transcription positive regulation of biological process RNA metabolic process positive regulation of cellular metabolic process cellular component organization protein-DNA complex organization RNA biosynthetic process nucleic acid biosynthetic process regulation of protein-containing complex assembly positive regulation of protein-containing complex assembly positive regulation of biosynthetic process protein-containing complex assembly cellular component organization or biogenesis positive regulation of cellular process regulation of RNA biosynthetic process regulation of biosynthetic process positive regulation of RNA polymerase II transcription preinitiation complex assembly protein-containing complex organization positive regulation of cellular component biogenesis positive regulation of transcription initiation by RNA polymerase II biological regulation protein-DNA complex assembly regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process gene expression regulation of cellular component biogenesis macromolecule biosynthetic process DNA-templated transcription initiation nucleic acid metabolic process regulation of cellular biosynthetic process positive regulation of RNA biosynthetic process cellular process regulation of transcription initiation by RNA polymerase II positive regulation of cellular biosynthetic process proteasome assembly proteasome regulatory particle assembly proteasomal protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process	protein-containing complex catalytic complex peptidase complex proteasome complex endopeptidase complex intracellular protein-containing complex intracellular anatomical structure proteasome regulatory particle cellular anatomical entity proteasome accessory complex proteasome regulatory particle, base subcomplex cytoplasm membrane-bounded organelle intracellular organelle protein-containing complex catalytic complex peptidase complex proteasome complex endopeptidase complex intracellular protein-containing complex intracellular anatomical structure proteasome regulatory particle cellular anatomical entity proteasome accessory complex proteasome regulatory particle, base subcomplex cytoplasm membrane-bounded organelle intracellular organelle organelle nucleus intracellular membrane-bounded organelle
FA [auth L]	26S protease subunit RPT4	binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding protein binding protein domain specific binding pyrophosphatase activity ATP hydrolysis activity ribonucleoside triphosphate phosphatase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity hydrolase activity, acting on acid anhydrides catalytic activity ATP-dependent activity ubiquitin protein ligase binding ubiquitin-like protein ligase binding enzyme binding proteasome-activating activity	cellular response to stimulus response to stimulus primary metabolic process DNA metabolic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process cellular response to stress nucleotide-excision repair DNA damage response response to stress metabolic process cellular process cellular response to stimulus response to stimulus primary metabolic process DNA metabolic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process cellular response to stress nucleotide-excision repair DNA damage response response to stress metabolic process cellular process macromolecule metabolic process DNA repair regulation of cellular process transcription preinitiation complex assembly positive regulation of macromolecule biosynthetic process regulation of primary metabolic process cellular component biogenesis DNA-templated transcription positive regulation of metabolic process regulation of DNA-templated transcription initiation regulation of RNA metabolic process cellular component assembly transcription by RNA polymerase II organic substance biosynthetic process positive regulation of macromolecule metabolic process regulation of nucleobase-containing compound metabolic process transcription initiation at RNA polymerase II promoter regulation of transcription by RNA polymerase II regulation of biological process positive regulation of nucleobase-containing compound metabolic process cellular metabolic process regulation of cellular metabolic process positive regulation of transcription by RNA polymerase II positive regulation of DNA-templated transcription initiation positive regulation of RNA metabolic process regulation of gene expression biosynthetic process organic cyclic compound biosynthetic process RNA polymerase II preinitiation complex assembly regulation of macromolecule biosynthetic process regulation of DNA-templated transcription regulation of metabolic process regulation of RNA polymerase II transcription preinitiation complex assembly regulation of cellular component organization positive regulation of cellular component organization cellular biosynthetic process positive regulation of DNA-templated transcription positive regulation of biological process RNA metabolic process positive regulation of cellular metabolic process cellular component organization protein-DNA complex organization RNA biosynthetic process nucleic acid biosynthetic process regulation of protein-containing complex assembly positive regulation of protein-containing complex assembly positive regulation of biosynthetic process protein-containing complex assembly cellular component organization or biogenesis positive regulation of cellular process regulation of RNA biosynthetic process regulation of biosynthetic process positive regulation of RNA polymerase II transcription preinitiation complex assembly protein-containing complex organization positive regulation of cellular component biogenesis positive regulation of transcription initiation by RNA polymerase II biological regulation protein-DNA complex assembly regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process gene expression regulation of cellular component biogenesis macromolecule biosynthetic process DNA-templated transcription initiation regulation of cellular biosynthetic process positive regulation of RNA biosynthetic process regulation of transcription initiation by RNA polymerase II positive regulation of cellular biosynthetic process regulation of DNA-templated transcription elongation regulation of transcription elongation by RNA polymerase II transcription elongation by RNA polymerase II positive regulation of transcription elongation by RNA polymerase II positive regulation of DNA-templated transcription, elongation DNA-templated transcription elongation proteasome assembly proteasome regulatory particle assembly organonitrogen compound catabolic process organonitrogen compound metabolic process catabolic process proteolysis involved in protein catabolic process proteasomal protein catabolic process protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process macromolecule catabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis ubiquitin-dependent protein catabolic process protein metabolic process organic substance catabolic process	protein-containing complex catalytic complex peptidase complex proteasome complex endopeptidase complex intracellular protein-containing complex intracellular anatomical structure proteasome regulatory particle cellular anatomical entity proteasome accessory complex proteasome regulatory particle, base subcomplex cytosolic proteasome complex cytoplasm cytosol protein-containing complex catalytic complex peptidase complex proteasome complex endopeptidase complex intracellular protein-containing complex intracellular anatomical structure proteasome regulatory particle cellular anatomical entity proteasome accessory complex proteasome regulatory particle, base subcomplex cytosolic proteasome complex cytoplasm cytosol membrane-bounded organelle intracellular organelle organelle nucleus intracellular membrane-bounded organelle
GA [auth M]	26S protease regulatory subunit 6A	binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding pyrophosphatase activity ATP hydrolysis activity ribonucleoside triphosphate phosphatase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity hydrolase activity, acting on acid anhydrides catalytic activity ATP-dependent activity proteasome-activating activity	organonitrogen compound catabolic process organonitrogen compound metabolic process catabolic process proteolysis involved in protein catabolic process primary metabolic process protein catabolic process macromolecule catabolic process organic substance metabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis ubiquitin-dependent protein catabolic process metabolic process protein metabolic process organonitrogen compound catabolic process organonitrogen compound metabolic process catabolic process proteolysis involved in protein catabolic process primary metabolic process protein catabolic process macromolecule catabolic process organic substance metabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis ubiquitin-dependent protein catabolic process metabolic process protein metabolic process macromolecule metabolic process organic substance catabolic process regulation of cellular process transcription preinitiation complex assembly positive regulation of macromolecule biosynthetic process regulation of primary metabolic process cellular component biogenesis nucleobase-containing compound metabolic process DNA-templated transcription positive regulation of metabolic process regulation of DNA-templated transcription initiation regulation of RNA metabolic process cellular component assembly transcription by RNA polymerase II organic substance biosynthetic process positive regulation of macromolecule metabolic process regulation of nucleobase-containing compound metabolic process transcription initiation at RNA polymerase II promoter regulation of transcription by RNA polymerase II regulation of biological process positive regulation of nucleobase-containing compound metabolic process cellular metabolic process regulation of cellular metabolic process positive regulation of transcription by RNA polymerase II positive regulation of DNA-templated transcription initiation positive regulation of RNA metabolic process organic cyclic compound metabolic process regulation of gene expression biosynthetic process organic cyclic compound biosynthetic process RNA polymerase II preinitiation complex assembly regulation of macromolecule biosynthetic process regulation of DNA-templated transcription regulation of metabolic process regulation of RNA polymerase II transcription preinitiation complex assembly regulation of cellular component organization positive regulation of cellular component organization cellular biosynthetic process positive regulation of DNA-templated transcription positive regulation of biological process RNA metabolic process positive regulation of cellular metabolic process cellular component organization protein-DNA complex organization RNA biosynthetic process nucleic acid biosynthetic process regulation of protein-containing complex assembly positive regulation of protein-containing complex assembly positive regulation of biosynthetic process protein-containing complex assembly cellular component organization or biogenesis positive regulation of cellular process regulation of RNA biosynthetic process regulation of biosynthetic process positive regulation of RNA polymerase II transcription preinitiation complex assembly protein-containing complex organization positive regulation of cellular component biogenesis positive regulation of transcription initiation by RNA polymerase II biological regulation protein-DNA complex assembly regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process gene expression regulation of cellular component biogenesis macromolecule biosynthetic process DNA-templated transcription initiation nucleic acid metabolic process regulation of cellular biosynthetic process positive regulation of RNA biosynthetic process cellular process regulation of transcription initiation by RNA polymerase II positive regulation of cellular biosynthetic process proteasome assembly proteasome regulatory particle assembly proteasomal protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process	protein-containing complex catalytic complex peptidase complex proteasome complex endopeptidase complex intracellular protein-containing complex intracellular anatomical structure proteasome regulatory particle cellular anatomical entity proteasome accessory complex proteasome regulatory particle, base subcomplex cytoplasm membrane-bounded organelle intracellular organelle protein-containing complex catalytic complex peptidase complex proteasome complex endopeptidase complex intracellular protein-containing complex intracellular anatomical structure proteasome regulatory particle cellular anatomical entity proteasome accessory complex proteasome regulatory particle, base subcomplex cytoplasm membrane-bounded organelle intracellular organelle organelle nucleus intracellular membrane-bounded organelle
B [auth b], P [auth B]	Proteasome subunit alpha type-2	-	organonitrogen compound catabolic process organonitrogen compound metabolic process catabolic process proteolysis involved in protein catabolic process proteasomal protein catabolic process primary metabolic process protein catabolic process proteasomal ubiquitin-independent protein catabolic process macromolecule catabolic process organic substance metabolic process proteolysis metabolic process protein metabolic process macromolecule metabolic process organonitrogen compound catabolic process organonitrogen compound metabolic process catabolic process proteolysis involved in protein catabolic process proteasomal protein catabolic process primary metabolic process protein catabolic process proteasomal ubiquitin-independent protein catabolic process macromolecule catabolic process organic substance metabolic process proteolysis metabolic process protein metabolic process macromolecule metabolic process organic substance catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process ubiquitin-dependent protein catabolic process	protein-containing complex catalytic complex peptidase complex proteasome complex endopeptidase complex intracellular protein-containing complex intracellular anatomical structure proteasome core complex, alpha-subunit complex proteasome core complex cellular anatomical entity intracellular organelle organelle intracellular non-membrane-bounded organelle cytoplasm protein-containing complex catalytic complex peptidase complex proteasome complex endopeptidase complex intracellular protein-containing complex intracellular anatomical structure proteasome core complex, alpha-subunit complex proteasome core complex cellular anatomical entity intracellular organelle organelle intracellular non-membrane-bounded organelle cytoplasm proteasome storage granule non-membrane-bounded organelle membrane-bounded organelle nucleus intracellular membrane-bounded organelle
HA [auth J]	26S protease regulatory subunit 8 homolog	binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding protein binding protein domain specific binding pyrophosphatase activity ATP hydrolysis activity ribonucleoside triphosphate phosphatase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity hydrolase activity, acting on acid anhydrides catalytic activity ATP-dependent activity ubiquitin protein ligase binding ubiquitin-like protein ligase binding enzyme binding proteasome-activating activity	nonfunctional rRNA decay catabolic process RNA metabolic process primary metabolic process rRNA catabolic process nucleic acid metabolic process macromolecule catabolic process organic cyclic compound catabolic process nucleobase-containing compound catabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process ncRNA metabolic process nucleic acid catabolic process nonfunctional rRNA decay catabolic process RNA metabolic process primary metabolic process rRNA catabolic process nucleic acid metabolic process macromolecule catabolic process organic cyclic compound catabolic process nucleobase-containing compound catabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process ncRNA metabolic process nucleic acid catabolic process metabolic process macromolecule metabolic process rRNA metabolic process organic substance catabolic process RNA catabolic process cellular response to stimulus response to stimulus DNA metabolic process cellular response to stress nucleotide-excision repair DNA damage response response to stress cellular process DNA repair regulation of cellular process transcription preinitiation complex assembly positive regulation of macromolecule biosynthetic process regulation of primary metabolic process cellular component biogenesis DNA-templated transcription positive regulation of metabolic process regulation of DNA-templated transcription initiation regulation of RNA metabolic process cellular component assembly transcription by RNA polymerase II organic substance biosynthetic process positive regulation of macromolecule metabolic process regulation of nucleobase-containing compound metabolic process transcription initiation at RNA polymerase II promoter regulation of transcription by RNA polymerase II regulation of biological process positive regulation of nucleobase-containing compound metabolic process cellular metabolic process regulation of cellular metabolic process positive regulation of transcription by RNA polymerase II positive regulation of DNA-templated transcription initiation positive regulation of RNA metabolic process regulation of gene expression biosynthetic process organic cyclic compound biosynthetic process RNA polymerase II preinitiation complex assembly regulation of macromolecule biosynthetic process regulation of DNA-templated transcription regulation of metabolic process regulation of RNA polymerase II transcription preinitiation complex assembly regulation of cellular component organization positive regulation of cellular component organization cellular biosynthetic process positive regulation of DNA-templated transcription positive regulation of biological process positive regulation of cellular metabolic process cellular component organization protein-DNA complex organization RNA biosynthetic process nucleic acid biosynthetic process regulation of protein-containing complex assembly positive regulation of protein-containing complex assembly positive regulation of biosynthetic process protein-containing complex assembly cellular component organization or biogenesis positive regulation of cellular process regulation of RNA biosynthetic process regulation of biosynthetic process positive regulation of RNA polymerase II transcription preinitiation complex assembly protein-containing complex organization positive regulation of cellular component biogenesis positive regulation of transcription initiation by RNA polymerase II biological regulation protein-DNA complex assembly regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process gene expression regulation of cellular component biogenesis macromolecule biosynthetic process DNA-templated transcription initiation regulation of cellular biosynthetic process positive regulation of RNA biosynthetic process regulation of transcription initiation by RNA polymerase II positive regulation of cellular biosynthetic process regulation of DNA-templated transcription elongation regulation of transcription elongation by RNA polymerase II transcription elongation by RNA polymerase II positive regulation of transcription elongation by RNA polymerase II positive regulation of DNA-templated transcription, elongation DNA-templated transcription elongation proteasome assembly proteasome regulatory particle assembly organonitrogen compound catabolic process organonitrogen compound metabolic process proteolysis involved in protein catabolic process proteasomal protein catabolic process protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis ubiquitin-dependent protein catabolic process protein metabolic process chromatin organization chromatin remodeling	protein-containing complex catalytic complex peptidase complex proteasome complex endopeptidase complex intracellular protein-containing complex intracellular anatomical structure proteasome regulatory particle cellular anatomical entity proteasome accessory complex proteasome regulatory particle, base subcomplex intracellular organelle organelle intracellular non-membrane-bounded organelle protein-containing complex catalytic complex peptidase complex proteasome complex endopeptidase complex intracellular protein-containing complex intracellular anatomical structure proteasome regulatory particle cellular anatomical entity proteasome accessory complex proteasome regulatory particle, base subcomplex intracellular organelle organelle intracellular non-membrane-bounded organelle cytoplasm proteasome storage granule non-membrane-bounded organelle membrane-bounded organelle nucleus intracellular membrane-bounded organelle
IA [auth W]	26S proteasome regulatory subunit RPN10	polyubiquitin modification-dependent protein binding protein binding binding K48-linked polyubiquitin modification-dependent protein binding modification-dependent protein binding	organonitrogen compound catabolic process organonitrogen compound metabolic process catabolic process proteolysis involved in protein catabolic process primary metabolic process protein catabolic process macromolecule catabolic process organic substance metabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis ubiquitin-dependent protein catabolic process metabolic process protein metabolic process organonitrogen compound catabolic process organonitrogen compound metabolic process catabolic process proteolysis involved in protein catabolic process primary metabolic process protein catabolic process macromolecule catabolic process organic substance metabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis ubiquitin-dependent protein catabolic process metabolic process protein metabolic process macromolecule metabolic process organic substance catabolic process proteasomal protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process cellular component organization cellular component biogenesis proteasome assembly cellular component assembly protein-containing complex organization protein-containing complex assembly cellular process cellular component organization or biogenesis	intracellular anatomical structure cytoplasm cellular anatomical entity cytosol protein-containing complex catalytic complex peptidase complex proteasome complex endopeptidase complex intracellular protein-containing complex proteasome regulatory particle proteasome accessory complex proteasome regulatory particle, base subcomplex membrane-bounded organelle intracellular anatomical structure cytoplasm cellular anatomical entity cytosol protein-containing complex catalytic complex peptidase complex proteasome complex endopeptidase complex intracellular protein-containing complex proteasome regulatory particle proteasome accessory complex proteasome regulatory particle, base subcomplex membrane-bounded organelle intracellular organelle organelle nucleus intracellular membrane-bounded organelle
JA [auth V]	Ubiquitin carboxyl-terminal hydrolase RPN11	peptidase activity catalytic activity, acting on a protein metallopeptidase activity hydrolase activity catalytic activity cysteine-type peptidase activity ubiquitin-like protein peptidase activity cysteine-type deubiquitinase activity deubiquitinase activity protein-containing complex binding binding proteasome binding cation binding ion binding peptidase activity catalytic activity, acting on a protein metallopeptidase activity hydrolase activity catalytic activity cysteine-type peptidase activity ubiquitin-like protein peptidase activity cysteine-type deubiquitinase activity deubiquitinase activity protein-containing complex binding binding proteasome binding cation binding ion binding metal ion binding small molecule binding	cellular component organization cellular component biogenesis proteasome assembly cellular component assembly protein-containing complex organization protein-containing complex assembly cellular process cellular component organization or biogenesis protein deubiquitination organonitrogen compound metabolic process primary metabolic process organic substance metabolic process protein modification by small protein removal macromolecule modification cellular component organization cellular component biogenesis proteasome assembly cellular component assembly protein-containing complex organization protein-containing complex assembly cellular process cellular component organization or biogenesis protein deubiquitination organonitrogen compound metabolic process primary metabolic process organic substance metabolic process protein modification by small protein removal macromolecule modification metabolic process protein metabolic process macromolecule metabolic process post-translational protein modification protein modification process protein modification by small protein conjugation or removal peroxisome organization organelle organization peroxisome fission organelle fission mitochondrial fission mitochondrion organization organonitrogen compound catabolic process catabolic process proteolysis involved in protein catabolic process proteasomal protein catabolic process protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process macromolecule catabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis ubiquitin-dependent protein catabolic process organic substance catabolic process organelle assembly non-membrane-bounded organelle assembly proteasome storage granule assembly	membrane-bounded organelle intracellular organelle intracellular anatomical structure mitochondrion organelle cytoplasm cellular anatomical entity intracellular membrane-bounded organelle protein-containing complex catalytic complex peptidase complex proteasome complex endopeptidase complex intracellular protein-containing complex membrane-bounded organelle intracellular organelle intracellular anatomical structure mitochondrion organelle cytoplasm cellular anatomical entity intracellular membrane-bounded organelle protein-containing complex catalytic complex peptidase complex proteasome complex endopeptidase complex intracellular protein-containing complex cytosol proteasome regulatory particle proteasome regulatory particle, lid subcomplex proteasome accessory complex intracellular non-membrane-bounded organelle proteasome storage granule non-membrane-bounded organelle nucleus
KA [auth T]	26S proteasome regulatory subunit RPN12	-	organonitrogen compound catabolic process organonitrogen compound metabolic process catabolic process proteolysis involved in protein catabolic process primary metabolic process protein catabolic process macromolecule catabolic process organic substance metabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis ubiquitin-dependent protein catabolic process metabolic process protein metabolic process organonitrogen compound catabolic process organonitrogen compound metabolic process catabolic process proteolysis involved in protein catabolic process primary metabolic process protein catabolic process macromolecule catabolic process organic substance metabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis ubiquitin-dependent protein catabolic process metabolic process protein metabolic process macromolecule metabolic process organic substance catabolic process proteasomal protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process	protein-containing complex catalytic complex peptidase complex proteasome complex endopeptidase complex intracellular protein-containing complex intracellular anatomical structure proteasome regulatory particle proteasome regulatory particle, lid subcomplex cellular anatomical entity proteasome accessory complex intracellular organelle organelle intracellular non-membrane-bounded organelle protein-containing complex catalytic complex peptidase complex proteasome complex endopeptidase complex intracellular protein-containing complex intracellular anatomical structure proteasome regulatory particle proteasome regulatory particle, lid subcomplex cellular anatomical entity proteasome accessory complex intracellular organelle organelle intracellular non-membrane-bounded organelle cytoplasm proteasome storage granule non-membrane-bounded organelle membrane-bounded organelle nucleus intracellular membrane-bounded organelle
LA [auth X]	26S proteasome regulatory subunit RPN13	protein binding binding ubiquitin binding ubiquitin-like protein binding	organonitrogen compound catabolic process organonitrogen compound metabolic process catabolic process proteolysis involved in protein catabolic process primary metabolic process protein catabolic process macromolecule catabolic process organic substance metabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis ubiquitin-dependent protein catabolic process metabolic process protein metabolic process organonitrogen compound catabolic process organonitrogen compound metabolic process catabolic process proteolysis involved in protein catabolic process primary metabolic process protein catabolic process macromolecule catabolic process organic substance metabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis ubiquitin-dependent protein catabolic process metabolic process protein metabolic process macromolecule metabolic process organic substance catabolic process proteasomal protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process	protein-containing complex catalytic complex peptidase complex proteasome complex endopeptidase complex intracellular protein-containing complex intracellular anatomical structure proteasome regulatory particle proteasome regulatory particle, lid subcomplex cellular anatomical entity proteasome accessory complex intracellular organelle organelle intracellular non-membrane-bounded organelle protein-containing complex catalytic complex peptidase complex proteasome complex endopeptidase complex intracellular protein-containing complex intracellular anatomical structure proteasome regulatory particle proteasome regulatory particle, lid subcomplex cellular anatomical entity proteasome accessory complex intracellular organelle organelle intracellular non-membrane-bounded organelle cytoplasm proteasome storage granule non-membrane-bounded organelle membrane-bounded organelle nucleus intracellular membrane-bounded organelle
MA [auth Y]	26S proteasome complex subunit SEM1	molecular adaptor activity protein folding chaperone	organonitrogen compound catabolic process organonitrogen compound metabolic process catabolic process proteolysis involved in protein catabolic process primary metabolic process protein catabolic process macromolecule catabolic process organic substance metabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis ubiquitin-dependent protein catabolic process metabolic process protein metabolic process organonitrogen compound catabolic process organonitrogen compound metabolic process catabolic process proteolysis involved in protein catabolic process primary metabolic process protein catabolic process macromolecule catabolic process organic substance metabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis ubiquitin-dependent protein catabolic process metabolic process protein metabolic process macromolecule metabolic process organic substance catabolic process chromosome organization DNA metabolic process maintenance of DNA repeat elements nucleic acid metabolic process cellular component organization nucleobase-containing compound metabolic process organic cyclic compound metabolic process organelle organization cellular process cellular component organization or biogenesis maintenance of DNA trinucleotide repeats cellular response to stimulus double-strand break repair response to stimulus DNA recombination cellular response to stress DNA damage response response to stress recombinational repair double-strand break repair via homologous recombination DNA repair growth filamentous growth SAGA complex localization to transcription regulatory region localization protein-containing complex localization cellular localization nitrogen compound transport nucleocytoplasmic transport transport cellular biosynthetic process nuclear transport mRNA transport mRNA export from nucleus establishment of localization in cell organic substance biosynthetic process RNA localization nuclear export nucleobase-containing compound transport RNA transport organic substance transport cellular metabolic process nucleic acid transport intracellular transport gene expression establishment of localization macromolecule biosynthetic process RNA export from nucleus establishment of RNA localization biosynthetic process macromolecule localization cellular component biogenesis proteasome assembly cellular component assembly protein-containing complex organization protein-containing complex assembly regulation of biological process regulation of cellular process biological regulation cell cycle regulation of cell cycle positive regulation of macromolecule biosynthetic process regulation of primary metabolic process positive regulation of metabolic process DNA-templated transcription regulation of RNA metabolic process transcription by RNA polymerase II positive regulation of macromolecule metabolic process regulation of nucleobase-containing compound metabolic process regulation of transcription by RNA polymerase II positive regulation of nucleobase-containing compound metabolic process regulation of cellular metabolic process positive regulation of transcription by RNA polymerase II positive regulation of RNA metabolic process regulation of gene expression organic cyclic compound biosynthetic process regulation of macromolecule biosynthetic process regulation of DNA-templated transcription regulation of metabolic process positive regulation of DNA-templated transcription positive regulation of biological process RNA metabolic process positive regulation of cellular metabolic process RNA biosynthetic process nucleic acid biosynthetic process positive regulation of biosynthetic process positive regulation of cellular process regulation of RNA biosynthetic process regulation of biosynthetic process regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process regulation of cellular biosynthetic process positive regulation of RNA biosynthetic process positive regulation of cellular biosynthetic process proteasomal protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process	protein-containing complex catalytic complex peptidase complex proteasome complex endopeptidase complex intracellular protein-containing complex intracellular anatomical structure cytoplasm cellular anatomical entity cytosol membrane-bounded organelle intracellular organelle organelle nucleus protein-containing complex catalytic complex peptidase complex proteasome complex endopeptidase complex intracellular protein-containing complex intracellular anatomical structure cytoplasm cellular anatomical entity cytosol membrane-bounded organelle intracellular organelle organelle nucleus nuclear protein-containing complex intracellular membrane-bounded organelle transcription export complex 2 proteasome regulatory particle proteasome regulatory particle, lid subcomplex proteasome accessory complex intracellular non-membrane-bounded organelle proteasome storage granule non-membrane-bounded organelle
NA [auth Z]	26S proteasome regulatory subunit RPN1	enzyme regulator activity molecular function regulator activity protein-macromolecule adaptor activity molecular adaptor activity	organonitrogen compound catabolic process organonitrogen compound metabolic process catabolic process proteolysis involved in protein catabolic process primary metabolic process protein catabolic process macromolecule catabolic process organic substance metabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis ubiquitin-dependent protein catabolic process metabolic process protein metabolic process organonitrogen compound catabolic process organonitrogen compound metabolic process catabolic process proteolysis involved in protein catabolic process primary metabolic process protein catabolic process macromolecule catabolic process organic substance metabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis ubiquitin-dependent protein catabolic process metabolic process protein metabolic process macromolecule metabolic process organic substance catabolic process regulation of biological process regulation of protein metabolic process biological regulation regulation of macromolecule metabolic process regulation of catabolic process regulation of primary metabolic process regulation of metabolic process regulation of protein catabolic process proteasomal protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process	protein-containing complex catalytic complex peptidase complex proteasome complex endopeptidase complex intracellular protein-containing complex intracellular anatomical structure proteasome regulatory particle cellular anatomical entity proteasome accessory complex proteasome regulatory particle, base subcomplex cytoplasm intracellular organelle organelle protein-containing complex catalytic complex peptidase complex proteasome complex endopeptidase complex intracellular protein-containing complex intracellular anatomical structure proteasome regulatory particle cellular anatomical entity proteasome accessory complex proteasome regulatory particle, base subcomplex cytoplasm intracellular organelle organelle intracellular non-membrane-bounded organelle proteasome storage granule non-membrane-bounded organelle membrane-bounded organelle nucleus intracellular membrane-bounded organelle endoplasmic reticulum endomembrane system
OA [auth N]	26S proteasome regulatory subunit RPN2	ubiquitin protein ligase binding protein binding binding ubiquitin-like protein ligase binding enzyme binding enzyme regulator activity molecular function regulator activity	organonitrogen compound catabolic process organonitrogen compound metabolic process catabolic process proteolysis involved in protein catabolic process primary metabolic process protein catabolic process macromolecule catabolic process organic substance metabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis ubiquitin-dependent protein catabolic process metabolic process protein metabolic process organonitrogen compound catabolic process organonitrogen compound metabolic process catabolic process proteolysis involved in protein catabolic process primary metabolic process protein catabolic process macromolecule catabolic process organic substance metabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis ubiquitin-dependent protein catabolic process metabolic process protein metabolic process macromolecule metabolic process organic substance catabolic process regulation of biological process regulation of protein metabolic process biological regulation regulation of macromolecule metabolic process regulation of catabolic process regulation of primary metabolic process regulation of metabolic process regulation of protein catabolic process cellular component organization cellular component biogenesis proteasome assembly cellular component assembly protein-containing complex organization protein-containing complex assembly cellular process cellular component organization or biogenesis proteasomal protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process	protein-containing complex catalytic complex peptidase complex proteasome complex endopeptidase complex intracellular protein-containing complex intracellular anatomical structure proteasome regulatory particle cellular anatomical entity proteasome accessory complex proteasome regulatory particle, base subcomplex intracellular organelle organelle intracellular non-membrane-bounded organelle protein-containing complex catalytic complex peptidase complex proteasome complex endopeptidase complex intracellular protein-containing complex intracellular anatomical structure proteasome regulatory particle cellular anatomical entity proteasome accessory complex proteasome regulatory particle, base subcomplex intracellular organelle organelle intracellular non-membrane-bounded organelle cytoplasm proteasome storage granule non-membrane-bounded organelle membrane-bounded organelle nucleus intracellular membrane-bounded organelle
PA [auth S]	26S proteasome regulatory subunit RPN3	enzyme regulator activity molecular function regulator activity	organonitrogen compound catabolic process organonitrogen compound metabolic process catabolic process proteolysis involved in protein catabolic process primary metabolic process protein catabolic process macromolecule catabolic process organic substance metabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis ubiquitin-dependent protein catabolic process metabolic process protein metabolic process organonitrogen compound catabolic process organonitrogen compound metabolic process catabolic process proteolysis involved in protein catabolic process primary metabolic process protein catabolic process macromolecule catabolic process organic substance metabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis ubiquitin-dependent protein catabolic process metabolic process protein metabolic process macromolecule metabolic process organic substance catabolic process regulation of biological process regulation of protein metabolic process biological regulation regulation of macromolecule metabolic process regulation of catabolic process regulation of primary metabolic process regulation of metabolic process regulation of protein catabolic process proteasomal protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process	protein-containing complex catalytic complex peptidase complex proteasome complex endopeptidase complex intracellular protein-containing complex intracellular anatomical structure proteasome regulatory particle proteasome regulatory particle, lid subcomplex cellular anatomical entity proteasome accessory complex
QA [auth P]	26S proteasome regulatory subunit RPN5	-	organonitrogen compound metabolic process primary metabolic process protein deneddylation organic substance metabolic process protein modification by small protein removal macromolecule modification metabolic process protein metabolic process macromolecule metabolic process post-translational protein modification protein modification process protein modification by small protein conjugation or removal organonitrogen compound catabolic process catabolic process organonitrogen compound metabolic process primary metabolic process protein deneddylation organic substance metabolic process protein modification by small protein removal macromolecule modification metabolic process protein metabolic process macromolecule metabolic process post-translational protein modification protein modification process protein modification by small protein conjugation or removal organonitrogen compound catabolic process catabolic process proteolysis involved in protein catabolic process proteasomal protein catabolic process protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process macromolecule catabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis ubiquitin-dependent protein catabolic process organic substance catabolic process	protein-containing complex catalytic complex peptidase complex proteasome complex endopeptidase complex intracellular protein-containing complex membrane-bounded organelle intracellular organelle intracellular anatomical structure organelle nucleus nuclear protein-containing complex COP9 signalosome intracellular membrane-bounded organelle protein-containing complex catalytic complex peptidase complex proteasome complex endopeptidase complex intracellular protein-containing complex membrane-bounded organelle intracellular organelle intracellular anatomical structure organelle nucleus nuclear protein-containing complex COP9 signalosome intracellular membrane-bounded organelle cellular anatomical entity cytoplasm proteasome regulatory particle proteasome regulatory particle, lid subcomplex proteasome accessory complex intracellular non-membrane-bounded organelle proteasome storage granule non-membrane-bounded organelle
C [auth c], Q [auth C]	Proteasome subunit alpha type-3	-	organonitrogen compound catabolic process organonitrogen compound metabolic process catabolic process proteolysis involved in protein catabolic process proteasomal protein catabolic process primary metabolic process protein catabolic process macromolecule catabolic process organic substance metabolic process proteolysis metabolic process protein metabolic process macromolecule metabolic process organic substance catabolic process organonitrogen compound catabolic process organonitrogen compound metabolic process catabolic process proteolysis involved in protein catabolic process proteasomal protein catabolic process primary metabolic process protein catabolic process macromolecule catabolic process organic substance metabolic process proteolysis metabolic process protein metabolic process macromolecule metabolic process organic substance catabolic process cellular component organization cellular component biogenesis proteasome assembly proteasome core complex assembly cellular component assembly protein-containing complex organization protein-containing complex assembly cellular process cellular component organization or biogenesis proteasomal ubiquitin-independent protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process ubiquitin-dependent protein catabolic process	protein-containing complex catalytic complex peptidase complex proteasome complex endopeptidase complex intracellular protein-containing complex intracellular anatomical structure proteasome core complex, alpha-subunit complex proteasome core complex cellular anatomical entity cytoplasm cytosol intracellular organelle organelle protein-containing complex catalytic complex peptidase complex proteasome complex endopeptidase complex intracellular protein-containing complex intracellular anatomical structure proteasome core complex, alpha-subunit complex proteasome core complex cellular anatomical entity cytoplasm cytosol intracellular organelle organelle intracellular non-membrane-bounded organelle proteasome storage granule non-membrane-bounded organelle membrane-bounded organelle nucleus intracellular membrane-bounded organelle
RA [auth Q]	26S proteasome regulatory subunit RPN6	structural molecule activity	organonitrogen compound catabolic process organonitrogen compound metabolic process catabolic process proteolysis involved in protein catabolic process primary metabolic process protein catabolic process macromolecule catabolic process organic substance metabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis ubiquitin-dependent protein catabolic process metabolic process protein metabolic process organonitrogen compound catabolic process organonitrogen compound metabolic process catabolic process proteolysis involved in protein catabolic process primary metabolic process protein catabolic process macromolecule catabolic process organic substance metabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis ubiquitin-dependent protein catabolic process metabolic process protein metabolic process macromolecule metabolic process organic substance catabolic process proteasomal protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process cellular component organization cellular component biogenesis proteasome assembly cellular component assembly protein-containing complex organization protein-containing complex assembly cellular process cellular component organization or biogenesis	protein-containing complex catalytic complex peptidase complex proteasome complex endopeptidase complex intracellular protein-containing complex intracellular anatomical structure proteasome regulatory particle proteasome regulatory particle, lid subcomplex cellular anatomical entity proteasome accessory complex intracellular organelle organelle intracellular non-membrane-bounded organelle protein-containing complex catalytic complex peptidase complex proteasome complex endopeptidase complex intracellular protein-containing complex intracellular anatomical structure proteasome regulatory particle proteasome regulatory particle, lid subcomplex cellular anatomical entity proteasome accessory complex intracellular organelle organelle intracellular non-membrane-bounded organelle cytoplasm proteasome storage granule non-membrane-bounded organelle
SA [auth R]	26S proteasome regulatory subunit RPN7	structural molecule activity	organonitrogen compound catabolic process organonitrogen compound metabolic process catabolic process proteolysis involved in protein catabolic process primary metabolic process protein catabolic process macromolecule catabolic process organic substance metabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis ubiquitin-dependent protein catabolic process metabolic process protein metabolic process organonitrogen compound catabolic process organonitrogen compound metabolic process catabolic process proteolysis involved in protein catabolic process primary metabolic process protein catabolic process macromolecule catabolic process organic substance metabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis ubiquitin-dependent protein catabolic process metabolic process protein metabolic process macromolecule metabolic process organic substance catabolic process proteasomal protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process	protein-containing complex catalytic complex peptidase complex proteasome complex endopeptidase complex intracellular protein-containing complex proteasome accessory complex intracellular anatomical structure proteasome regulatory particle cellular anatomical entity proteasome regulatory particle, lid subcomplex membrane-bounded organelle intracellular organelle organelle protein-containing complex catalytic complex peptidase complex proteasome complex endopeptidase complex intracellular protein-containing complex proteasome accessory complex intracellular anatomical structure proteasome regulatory particle cellular anatomical entity proteasome regulatory particle, lid subcomplex membrane-bounded organelle intracellular organelle organelle nucleus intracellular membrane-bounded organelle
TA [auth U]	26S proteasome regulatory subunit RPN8	peptidase activity catalytic activity, acting on a protein metallopeptidase activity hydrolase activity catalytic activity	organonitrogen compound catabolic process organonitrogen compound metabolic process catabolic process proteolysis involved in protein catabolic process primary metabolic process protein catabolic process macromolecule catabolic process organic substance metabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis ubiquitin-dependent protein catabolic process metabolic process protein metabolic process organonitrogen compound catabolic process organonitrogen compound metabolic process catabolic process proteolysis involved in protein catabolic process primary metabolic process protein catabolic process macromolecule catabolic process organic substance metabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis ubiquitin-dependent protein catabolic process metabolic process protein metabolic process macromolecule metabolic process organic substance catabolic process proteasomal protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process	protein-containing complex catalytic complex peptidase complex proteasome complex endopeptidase complex intracellular protein-containing complex intracellular anatomical structure proteasome regulatory particle proteasome regulatory particle, lid subcomplex cellular anatomical entity proteasome accessory complex intracellular organelle organelle intracellular non-membrane-bounded organelle protein-containing complex catalytic complex peptidase complex proteasome complex endopeptidase complex intracellular protein-containing complex intracellular anatomical structure proteasome regulatory particle proteasome regulatory particle, lid subcomplex cellular anatomical entity proteasome accessory complex intracellular organelle organelle intracellular non-membrane-bounded organelle cytoplasm proteasome storage granule non-membrane-bounded organelle
UA [auth O]	26S proteasome regulatory subunit RPN9	structural molecule activity	organonitrogen compound catabolic process organonitrogen compound metabolic process catabolic process proteolysis involved in protein catabolic process primary metabolic process protein catabolic process macromolecule catabolic process organic substance metabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis ubiquitin-dependent protein catabolic process metabolic process protein metabolic process organonitrogen compound catabolic process organonitrogen compound metabolic process catabolic process proteolysis involved in protein catabolic process primary metabolic process protein catabolic process macromolecule catabolic process organic substance metabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis ubiquitin-dependent protein catabolic process metabolic process protein metabolic process macromolecule metabolic process organic substance catabolic process cellular component organization cellular component biogenesis proteasome assembly cellular component assembly protein-containing complex organization protein-containing complex assembly cellular process cellular component organization or biogenesis proteasomal protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process	protein-containing complex catalytic complex peptidase complex proteasome complex endopeptidase complex intracellular protein-containing complex intracellular anatomical structure cytoplasm cellular anatomical entity cytosol proteasome regulatory particle proteasome regulatory particle, lid subcomplex proteasome accessory complex intracellular organelle protein-containing complex catalytic complex peptidase complex proteasome complex endopeptidase complex intracellular protein-containing complex intracellular anatomical structure cytoplasm cellular anatomical entity cytosol proteasome regulatory particle proteasome regulatory particle, lid subcomplex proteasome accessory complex intracellular organelle organelle intracellular non-membrane-bounded organelle proteasome storage granule non-membrane-bounded organelle membrane-bounded organelle nucleus intracellular membrane-bounded organelle
D [auth d], R [auth D]	Proteasome subunit alpha type-4	-	organonitrogen compound catabolic process organonitrogen compound metabolic process catabolic process proteolysis involved in protein catabolic process proteasomal protein catabolic process primary metabolic process protein catabolic process macromolecule catabolic process organic substance metabolic process proteolysis metabolic process protein metabolic process macromolecule metabolic process organic substance catabolic process organonitrogen compound catabolic process organonitrogen compound metabolic process catabolic process proteolysis involved in protein catabolic process proteasomal protein catabolic process primary metabolic process protein catabolic process macromolecule catabolic process organic substance metabolic process proteolysis metabolic process protein metabolic process macromolecule metabolic process organic substance catabolic process proteasomal ubiquitin-independent protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process ubiquitin-dependent protein catabolic process	membrane-bounded organelle intracellular organelle intracellular anatomical structure mitochondrion organelle cytoplasm cellular anatomical entity intracellular membrane-bounded organelle protein-containing complex catalytic complex peptidase complex proteasome complex endopeptidase complex intracellular protein-containing complex membrane-bounded organelle intracellular organelle intracellular anatomical structure mitochondrion organelle cytoplasm cellular anatomical entity intracellular membrane-bounded organelle protein-containing complex catalytic complex peptidase complex proteasome complex endopeptidase complex intracellular protein-containing complex proteasome core complex, alpha-subunit complex proteasome core complex nuclear outer membrane-endoplasmic reticulum membrane network membrane endomembrane system intracellular non-membrane-bounded organelle proteasome storage granule non-membrane-bounded organelle nucleus
E [auth e], S [auth E]	Proteasome subunit alpha type-5	-	organonitrogen compound catabolic process organonitrogen compound metabolic process catabolic process proteolysis involved in protein catabolic process proteasomal protein catabolic process primary metabolic process protein catabolic process proteasomal ubiquitin-independent protein catabolic process macromolecule catabolic process organic substance metabolic process proteolysis metabolic process protein metabolic process macromolecule metabolic process organonitrogen compound catabolic process organonitrogen compound metabolic process catabolic process proteolysis involved in protein catabolic process proteasomal protein catabolic process primary metabolic process protein catabolic process proteasomal ubiquitin-independent protein catabolic process macromolecule catabolic process organic substance metabolic process proteolysis metabolic process protein metabolic process macromolecule metabolic process organic substance catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process ubiquitin-dependent protein catabolic process	protein-containing complex catalytic complex peptidase complex proteasome complex endopeptidase complex intracellular protein-containing complex intracellular anatomical structure proteasome core complex, alpha-subunit complex proteasome core complex cellular anatomical entity intracellular organelle organelle intracellular non-membrane-bounded organelle cytoplasm protein-containing complex catalytic complex peptidase complex proteasome complex endopeptidase complex intracellular protein-containing complex intracellular anatomical structure proteasome core complex, alpha-subunit complex proteasome core complex cellular anatomical entity intracellular organelle organelle intracellular non-membrane-bounded organelle cytoplasm proteasome storage granule non-membrane-bounded organelle membrane-bounded organelle nucleus intracellular membrane-bounded organelle
F [auth f], T [auth F]	Proteasome subunit alpha type-6	-	organonitrogen compound catabolic process organonitrogen compound metabolic process catabolic process proteolysis involved in protein catabolic process proteasomal protein catabolic process primary metabolic process protein catabolic process proteasomal ubiquitin-independent protein catabolic process macromolecule catabolic process organic substance metabolic process proteolysis metabolic process protein metabolic process macromolecule metabolic process organonitrogen compound catabolic process organonitrogen compound metabolic process catabolic process proteolysis involved in protein catabolic process proteasomal protein catabolic process primary metabolic process protein catabolic process proteasomal ubiquitin-independent protein catabolic process macromolecule catabolic process organic substance metabolic process proteolysis metabolic process protein metabolic process macromolecule metabolic process organic substance catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process ubiquitin-dependent protein catabolic process	protein-containing complex catalytic complex peptidase complex proteasome complex endopeptidase complex intracellular protein-containing complex intracellular anatomical structure proteasome core complex, alpha-subunit complex proteasome core complex cellular anatomical entity intracellular organelle organelle intracellular non-membrane-bounded organelle cytoplasm protein-containing complex catalytic complex peptidase complex proteasome complex endopeptidase complex intracellular protein-containing complex intracellular anatomical structure proteasome core complex, alpha-subunit complex proteasome core complex cellular anatomical entity intracellular organelle organelle intracellular non-membrane-bounded organelle cytoplasm proteasome storage granule non-membrane-bounded organelle membrane-bounded organelle nucleus intracellular membrane-bounded organelle
G [auth g], U [auth G]	Probable proteasome subunit alpha type-7	RNA binding binding organic cyclic compound binding nucleic acid binding mRNA binding	organonitrogen compound catabolic process organonitrogen compound metabolic process catabolic process proteolysis involved in protein catabolic process proteasomal protein catabolic process primary metabolic process protein catabolic process proteasomal ubiquitin-independent protein catabolic process macromolecule catabolic process organic substance metabolic process proteolysis metabolic process protein metabolic process macromolecule metabolic process organonitrogen compound catabolic process organonitrogen compound metabolic process catabolic process proteolysis involved in protein catabolic process proteasomal protein catabolic process primary metabolic process protein catabolic process proteasomal ubiquitin-independent protein catabolic process macromolecule catabolic process organic substance metabolic process proteolysis metabolic process protein metabolic process macromolecule metabolic process organic substance catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process ubiquitin-dependent protein catabolic process	protein-containing complex catalytic complex peptidase complex proteasome complex endopeptidase complex intracellular protein-containing complex intracellular anatomical structure proteasome core complex, alpha-subunit complex proteasome core complex cellular anatomical entity intracellular organelle organelle intracellular non-membrane-bounded organelle cytoplasm protein-containing complex catalytic complex peptidase complex proteasome complex endopeptidase complex intracellular protein-containing complex intracellular anatomical structure proteasome core complex, alpha-subunit complex proteasome core complex cellular anatomical entity intracellular organelle organelle intracellular non-membrane-bounded organelle cytoplasm proteasome storage granule non-membrane-bounded organelle membrane-bounded organelle nucleus intracellular membrane-bounded organelle
H [auth h], V [auth 1]	Proteasome subunit beta type-1	peptidase activity catalytic activity, acting on a protein threonine-type peptidase activity hydrolase activity catalytic activity endopeptidase activity threonine-type endopeptidase activity	organonitrogen compound catabolic process organonitrogen compound metabolic process catabolic process proteolysis involved in protein catabolic process proteasomal protein catabolic process primary metabolic process protein catabolic process macromolecule catabolic process organic substance metabolic process proteolysis metabolic process protein metabolic process macromolecule metabolic process organic substance catabolic process organonitrogen compound catabolic process organonitrogen compound metabolic process catabolic process proteolysis involved in protein catabolic process proteasomal protein catabolic process primary metabolic process protein catabolic process macromolecule catabolic process organic substance metabolic process proteolysis metabolic process protein metabolic process macromolecule metabolic process organic substance catabolic process proteasomal ubiquitin-independent protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process ubiquitin-dependent protein catabolic process	protein-containing complex catalytic complex peptidase complex proteasome complex endopeptidase complex intracellular protein-containing complex intracellular anatomical structure proteasome core complex cellular anatomical entity proteasome core complex, beta-subunit complex intracellular organelle organelle intracellular non-membrane-bounded organelle cytoplasm protein-containing complex catalytic complex peptidase complex proteasome complex endopeptidase complex intracellular protein-containing complex intracellular anatomical structure proteasome core complex cellular anatomical entity proteasome core complex, beta-subunit complex intracellular organelle organelle intracellular non-membrane-bounded organelle cytoplasm proteasome storage granule non-membrane-bounded organelle membrane-bounded organelle nucleus intracellular membrane-bounded organelle
I [auth i], W [auth 2]	Proteasome subunit beta type-2	peptidase activity catalytic activity, acting on a protein threonine-type peptidase activity hydrolase activity catalytic activity endopeptidase activity threonine-type endopeptidase activity	organonitrogen compound catabolic process organonitrogen compound metabolic process catabolic process proteolysis involved in protein catabolic process proteasomal protein catabolic process primary metabolic process protein catabolic process macromolecule catabolic process organic substance metabolic process proteolysis metabolic process protein metabolic process macromolecule metabolic process organic substance catabolic process organonitrogen compound catabolic process organonitrogen compound metabolic process catabolic process proteolysis involved in protein catabolic process proteasomal protein catabolic process primary metabolic process protein catabolic process macromolecule catabolic process organic substance metabolic process proteolysis metabolic process protein metabolic process macromolecule metabolic process organic substance catabolic process proteasomal ubiquitin-independent protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process ubiquitin-dependent protein catabolic process	protein-containing complex catalytic complex peptidase complex proteasome complex endopeptidase complex intracellular protein-containing complex intracellular anatomical structure cytoplasm cellular anatomical entity cytosol proteasome core complex proteasome core complex, beta-subunit complex intracellular organelle organelle protein-containing complex catalytic complex peptidase complex proteasome complex endopeptidase complex intracellular protein-containing complex intracellular anatomical structure cytoplasm cellular anatomical entity cytosol proteasome core complex proteasome core complex, beta-subunit complex intracellular organelle organelle intracellular non-membrane-bounded organelle proteasome storage granule non-membrane-bounded organelle membrane-bounded organelle nucleus intracellular membrane-bounded organelle

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
CA [auth H]	IPR048723	26S proteasome regulatory subunit 7-like, OB domain	Domain
CA [auth H]	IPR041569	AAA ATPase, AAA+ lid domain	Domain
CA [auth H]	IPR003960	ATPase, AAA-type, conserved site	Conserved Site
CA [auth H]	IPR003593	AAA+ ATPase domain	Domain
CA [auth H]	IPR003959	ATPase, AAA-type, core	Domain
CA [auth H]	IPR012340	Nucleic acid-binding, OB-fold	Homologous Superfamily
CA [auth H]	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily
DA [auth I]	IPR041569	AAA ATPase, AAA+ lid domain	Domain
DA [auth I]	IPR032501	Proteasomal ATPase, second OB domain	Domain
DA [auth I]	IPR003960	ATPase, AAA-type, conserved site	Conserved Site
DA [auth I]	IPR003593	AAA+ ATPase domain	Domain
DA [auth I]	IPR003959	ATPase, AAA-type, core	Domain
DA [auth I]	IPR012340	Nucleic acid-binding, OB-fold	Homologous Superfamily
DA [auth I]	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily
A [auth a], O [auth A]	IPR000426	Proteasome alpha-subunit, N-terminal domain	Domain
A [auth a], O [auth A]	IPR029055	Nucleophile aminohydrolases, N-terminal	Homologous Superfamily
A [auth a], O [auth A]	IPR023332	Proteasome alpha-type subunit	Family
A [auth a], O [auth A]	IPR001353	Proteasome, subunit alpha/beta	Family
A [auth a], O [auth A]	IPR034642	Proteasome subunit alpha6	Family
J [auth j], X [auth 3]	IPR016050	Proteasome beta-type subunit, conserved site	Conserved Site
J [auth j], X [auth 3]	IPR029055	Nucleophile aminohydrolases, N-terminal	Homologous Superfamily
J [auth j], X [auth 3]	IPR023333	Proteasome B-type subunit	Family
J [auth j], X [auth 3]	IPR001353	Proteasome, subunit alpha/beta	Family
J [auth j], X [auth 3]	IPR033811	Proteasome beta 3 subunit	Family
K [auth k], Y [auth 4]	IPR016050	Proteasome beta-type subunit, conserved site	Conserved Site
K [auth k], Y [auth 4]	IPR029055	Nucleophile aminohydrolases, N-terminal	Homologous Superfamily
K [auth k], Y [auth 4]	IPR023333	Proteasome B-type subunit	Family
K [auth k], Y [auth 4]	IPR001353	Proteasome, subunit alpha/beta	Family
K [auth k], Y [auth 4]	IPR035206	Proteasome subunit beta 2	Family
L [auth l], Z [auth 5]	IPR016050	Proteasome beta-type subunit, conserved site	Conserved Site
L [auth l], Z [auth 5]	IPR029055	Nucleophile aminohydrolases, N-terminal	Homologous Superfamily
L [auth l], Z [auth 5]	IPR023333	Proteasome B-type subunit	Family
L [auth l], Z [auth 5]	IPR001353	Proteasome, subunit alpha/beta	Family
L [auth l], Z [auth 5]	IPR000243	Peptidase T1A, proteasome beta-subunit	Family
AA [auth 6], M [auth m]	IPR016050	Proteasome beta-type subunit, conserved site	Conserved Site
AA [auth 6], M [auth m]	IPR023333	Proteasome B-type subunit	Family
AA [auth 6], M [auth m]	IPR029055	Nucleophile aminohydrolases, N-terminal	Homologous Superfamily
AA [auth 6], M [auth m]	IPR001353	Proteasome, subunit alpha/beta	Family
BA [auth 7], N [auth n]	IPR016050	Proteasome beta-type subunit, conserved site	Conserved Site
BA [auth 7], N [auth n]	IPR029055	Nucleophile aminohydrolases, N-terminal	Homologous Superfamily
BA [auth 7], N [auth n]	IPR023333	Proteasome B-type subunit	Family
BA [auth 7], N [auth n]	IPR016295	Proteasome subunit beta 4	Family
BA [auth 7], N [auth n]	IPR001353	Proteasome, subunit alpha/beta	Family
EA [auth K]	IPR032501	Proteasomal ATPase, second OB domain	Domain
EA [auth K]	IPR003960	ATPase, AAA-type, conserved site	Conserved Site
EA [auth K]	IPR003593	AAA+ ATPase domain	Domain
EA [auth K]	IPR003959	ATPase, AAA-type, core	Domain
EA [auth K]	IPR012340	Nucleic acid-binding, OB-fold	Homologous Superfamily
EA [auth K]	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily
FA [auth L]	IPR041569	AAA ATPase, AAA+ lid domain	Domain
FA [auth L]	IPR032501	Proteasomal ATPase, second OB domain	Domain
FA [auth L]	IPR003960	ATPase, AAA-type, conserved site	Conserved Site
FA [auth L]	IPR003593	AAA+ ATPase domain	Domain
FA [auth L]	IPR003959	ATPase, AAA-type, core	Domain
FA [auth L]	IPR012340	Nucleic acid-binding, OB-fold	Homologous Superfamily
FA [auth L]	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily
GA [auth M]	IPR041569	AAA ATPase, AAA+ lid domain	Domain
GA [auth M]	IPR032501	Proteasomal ATPase, second OB domain	Domain
GA [auth M]	IPR003960	ATPase, AAA-type, conserved site	Conserved Site
GA [auth M]	IPR003593	AAA+ ATPase domain	Domain
GA [auth M]	IPR003959	ATPase, AAA-type, core	Domain
GA [auth M]	IPR012340	Nucleic acid-binding, OB-fold	Homologous Superfamily
GA [auth M]	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily
B [auth b], P [auth B]	IPR000426	Proteasome alpha-subunit, N-terminal domain	Domain
B [auth b], P [auth B]	IPR029055	Nucleophile aminohydrolases, N-terminal	Homologous Superfamily
B [auth b], P [auth B]	IPR023332	Proteasome alpha-type subunit	Family
B [auth b], P [auth B]	IPR001353	Proteasome, subunit alpha/beta	Family
HA [auth J]	IPR041569	AAA ATPase, AAA+ lid domain	Domain
HA [auth J]	IPR032501	Proteasomal ATPase, second OB domain	Domain
HA [auth J]	IPR003960	ATPase, AAA-type, conserved site	Conserved Site
HA [auth J]	IPR003593	AAA+ ATPase domain	Domain
HA [auth J]	IPR003959	ATPase, AAA-type, core	Domain
HA [auth J]	IPR012340	Nucleic acid-binding, OB-fold	Homologous Superfamily
HA [auth J]	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily
IA [auth W]	IPR002035	von Willebrand factor, type A	Domain
IA [auth W]	IPR003903	Ubiquitin interacting motif	Conserved Site
IA [auth W]	IPR036465	von Willebrand factor A-like domain superfamily	Homologous Superfamily
JA [auth V]	IPR037518	MPN domain	Domain
JA [auth V]	IPR000555	JAB1/MPN/MOV34 metalloenzyme domain	Domain
KA [auth T]	IPR000717	Proteasome component (PCI) domain	Domain
KA [auth T]	IPR006746	26S proteasome non-ATPase regulatory subunit Rpn12	Family
KA [auth T]	IPR033464	CSN8/PSMD8/EIF3K	Domain
LA [auth X]	IPR044868	Rpn13/ADRM1, Pru domain	Domain
LA [auth X]	IPR006773	Proteasomal ubiquitin receptor Rpn13/ADRM1	Family
LA [auth X]	IPR038633	Proteasomal ubiquitin receptor Rpn13/ADRM1, Pru domain superfamily	Homologous Superfamily
MA [auth Y]	IPR007834	DSS1/SEM1	Family
NA [auth Z]	IPR041433	26S proteasome non-ATPase regulatory subunit RPN1, C-terminal	Domain
NA [auth Z]	IPR016024	Armadillo-type fold	Homologous Superfamily
NA [auth Z]	IPR002015	Proteasome/cyclosome repeat	Repeat
NA [auth Z]	IPR016643	26S proteasome regulatory complex, non-ATPase subcomplex, Rpn1 subunit	Family
NA [auth Z]	IPR011989	Armadillo-like helical	Homologous Superfamily
NA [auth Z]	IPR040892	RPN1, N-terminal	Domain
OA [auth N]	IPR040623	26S proteasome regulatory subunit RPN2, C-terminal	Domain
OA [auth N]	IPR016024	Armadillo-type fold	Homologous Superfamily
OA [auth N]	IPR002015	Proteasome/cyclosome repeat	Repeat
OA [auth N]	IPR011989	Armadillo-like helical	Homologous Superfamily
OA [auth N]	IPR048570	26S proteasome non-ATPase regulatory subunit 1/RPN2, N-terminal domain	Domain
OA [auth N]	IPR016642	26S proteasome regulatory complex, non-ATPase subcomplex, Rpn2/Psmd1 subunit	Family
PA [auth S]	IPR000717	Proteasome component (PCI) domain	Domain
PA [auth S]	IPR013586	26S proteasome regulatory subunit, C-terminal	Domain
PA [auth S]	IPR036390	Winged helix DNA-binding domain superfamily	Homologous Superfamily
QA [auth P]	IPR000717	Proteasome component (PCI) domain	Domain
QA [auth P]	IPR040896	26S proteasome regulatory subunit RPN5, C-terminal domain	Domain
QA [auth P]	IPR040134	26S Proteasome non-ATPase regulatory subunit 12/COP9 signalosome complex subunit 4	Family
QA [auth P]	IPR036388	Winged helix-like DNA-binding domain superfamily	Homologous Superfamily
QA [auth P]	IPR036390	Winged helix DNA-binding domain superfamily	Homologous Superfamily
C [auth c], Q [auth C]	IPR016050	Proteasome beta-type subunit, conserved site	Conserved Site
C [auth c], Q [auth C]	IPR029055	Nucleophile aminohydrolases, N-terminal	Homologous Superfamily
C [auth c], Q [auth C]	IPR000426	Proteasome alpha-subunit, N-terminal domain	Domain
C [auth c], Q [auth C]	IPR023332	Proteasome alpha-type subunit	Family
C [auth c], Q [auth C]	IPR001353	Proteasome, subunit alpha/beta	Family
RA [auth Q]	IPR040773	26S proteasome regulatory subunit Rpn6, N-terminal	Domain
RA [auth Q]	IPR000717	Proteasome component (PCI) domain	Domain
RA [auth Q]	IPR040780	6S proteasome subunit Rpn6, C-terminal helix domain	Domain
RA [auth Q]	IPR011990	Tetratricopeptide-like helical domain superfamily	Homologous Superfamily
RA [auth Q]	IPR036390	Winged helix DNA-binding domain superfamily	Homologous Superfamily
SA [auth R]	IPR011990	Tetratricopeptide-like helical domain superfamily	Homologous Superfamily
SA [auth R]	IPR019585	26S proteasome regulatory subunit Rpn7/COP9 signalosome complex subunit 1	Family
SA [auth R]	IPR036390	Winged helix DNA-binding domain superfamily	Homologous Superfamily
SA [auth R]	IPR049549	26S proteasome regulatory subunit RPN7/PSMD6, C-terminal helix	Domain
SA [auth R]	IPR000717	Proteasome component (PCI) domain	Domain
SA [auth R]	IPR045135	26S proteasome regulatory subunit Rpn7, N-terminal	Domain
SA [auth R]	IPR019734	Tetratricopeptide repeat	Repeat
TA [auth U]	IPR024969	EIF3F/CSN6-like, C-terminal	Domain
TA [auth U]	IPR037518	MPN domain	Domain
TA [auth U]	IPR033858	26S Proteasome non-ATPase regulatory subunit 7/8	Family
TA [auth U]	IPR000555	JAB1/MPN/MOV34 metalloenzyme domain	Domain
UA [auth O]	IPR036390	Winged helix DNA-binding domain superfamily	Homologous Superfamily
UA [auth O]	IPR035298	26S Proteasome non-ATPase regulatory subunit 13	Family
UA [auth O]	IPR000717	Proteasome component (PCI) domain	Domain
UA [auth O]	IPR040798	Rpn9, C-terminal helix	Domain
D [auth d], R [auth D]	IPR016050	Proteasome beta-type subunit, conserved site	Conserved Site
D [auth d], R [auth D]	IPR029055	Nucleophile aminohydrolases, N-terminal	Homologous Superfamily
D [auth d], R [auth D]	IPR000426	Proteasome alpha-subunit, N-terminal domain	Domain
D [auth d], R [auth D]	IPR023332	Proteasome alpha-type subunit	Family
D [auth d], R [auth D]	IPR001353	Proteasome, subunit alpha/beta	Family
E [auth e], S [auth E]	IPR033812	Proteasome subunit alpha5	Family
E [auth e], S [auth E]	IPR000426	Proteasome alpha-subunit, N-terminal domain	Domain
E [auth e], S [auth E]	IPR029055	Nucleophile aminohydrolases, N-terminal	Homologous Superfamily
E [auth e], S [auth E]	IPR023332	Proteasome alpha-type subunit	Family
E [auth e], S [auth E]	IPR001353	Proteasome, subunit alpha/beta	Family
F [auth f], T [auth F]	IPR000426	Proteasome alpha-subunit, N-terminal domain	Domain
F [auth f], T [auth F]	IPR029055	Nucleophile aminohydrolases, N-terminal	Homologous Superfamily
F [auth f], T [auth F]	IPR023332	Proteasome alpha-type subunit	Family
F [auth f], T [auth F]	IPR001353	Proteasome, subunit alpha/beta	Family
G [auth g], U [auth G]	IPR000426	Proteasome alpha-subunit, N-terminal domain	Domain
G [auth g], U [auth G]	IPR029055	Nucleophile aminohydrolases, N-terminal	Homologous Superfamily
G [auth g], U [auth G]	IPR023332	Proteasome alpha-type subunit	Family
G [auth g], U [auth G]	IPR001353	Proteasome, subunit alpha/beta	Family
H [auth h], V [auth 1]	IPR016050	Proteasome beta-type subunit, conserved site	Conserved Site
H [auth h], V [auth 1]	IPR029055	Nucleophile aminohydrolases, N-terminal	Homologous Superfamily
H [auth h], V [auth 1]	IPR023333	Proteasome B-type subunit	Family
H [auth h], V [auth 1]	IPR001353	Proteasome, subunit alpha/beta	Family
H [auth h], V [auth 1]	IPR000243	Peptidase T1A, proteasome beta-subunit	Family
I [auth i], W [auth 2]	IPR016050	Proteasome beta-type subunit, conserved site	Conserved Site
I [auth i], W [auth 2]	IPR029055	Nucleophile aminohydrolases, N-terminal	Homologous Superfamily
I [auth i], W [auth 2]	IPR024689	Proteasome beta subunit, C-terminal	Domain
I [auth i], W [auth 2]	IPR023333	Proteasome B-type subunit	Family
I [auth i], W [auth 2]	IPR001353	Proteasome, subunit alpha/beta	Family
I [auth i], W [auth 2]	IPR000243	Peptidase T1A, proteasome beta-subunit	Family