5MGX

The structure of FKBP38 in complex with the MEEVD tetratricopeptide binding-motif of Hsp90

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
E	SCOP2B Superfamily	Rotamase-like	8065278	3000622	SCOP2B (2022-06-29)
F	SCOP2B Superfamily	Rotamase-like	8065278	3000622	SCOP2B (2022-06-29)
G	SCOP2B Superfamily	Rotamase-like	8065278	3000622	SCOP2B (2022-06-29)
H	SCOP2B Superfamily	Rotamase-like	8065278	3000622	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
E	TPR_11_8	e5mgxE1	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: TPR_11_8	ECOD (1.6)
E	FKBP_C	e5mgxE2	A: a+b two layers	X: FKBP-like	H: FKBP-like	T: FKBP-like	F: FKBP_C	ECOD (1.6)
F	TPR_11_8	e5mgxF1	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: TPR_11_8	ECOD (1.6)
F	FKBP_C	e5mgxF2	A: a+b two layers	X: FKBP-like	H: FKBP-like	T: FKBP-like	F: FKBP_C	ECOD (1.6)
G	TPR_11_8	e5mgxG2	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: TPR_11_8	ECOD (1.6)
G	FKBP_C	e5mgxG1	A: a+b two layers	X: FKBP-like	H: FKBP-like	T: FKBP-like	F: FKBP_C	ECOD (1.6)
H	TPR_11_8	e5mgxH2	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: TPR_11_8	ECOD (1.6)
H	FKBP_C	e5mgxH1	A: a+b two layers	X: FKBP-like	H: FKBP-like	T: FKBP-like	F: FKBP_C	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D	PF00183	Hsp90 protein (HSP90)	Hsp90 protein	-	Family
E, F, G, H	PF00254	FKBP-type peptidyl-prolyl cis-trans isomerase (FKBP_C)	FKBP-type peptidyl-prolyl cis-trans isomerase	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D	yeast HSP90 C-terminus	ATP-dependent protein folding chaperone protein folding chaperone ATP-dependent activity binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP-dependent protein folding chaperone protein folding chaperone ATP-dependent activity binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding unfolded protein binding protein binding pyrophosphatase activity ATP hydrolysis activity ribonucleoside triphosphate phosphatase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity hydrolase activity, acting on acid anhydrides catalytic activity identical protein binding	protein refolding organonitrogen compound metabolic process cellular biosynthetic process cellular metabolic process primary metabolic process gene expression macromolecule biosynthetic process protein maturation organic substance metabolic process protein folding biosynthetic process organic substance biosynthetic process metabolic process cellular process protein refolding organonitrogen compound metabolic process cellular biosynthetic process cellular metabolic process primary metabolic process gene expression macromolecule biosynthetic process protein maturation organic substance metabolic process protein folding biosynthetic process organic substance biosynthetic process metabolic process cellular process protein metabolic process macromolecule metabolic process protein localization establishment of protein localization cellular localization protein targeting establishment of localization localization establishment of protein localization to organelle cellular macromolecule localization macromolecule localization protein localization to organelle protein localization to mitochondrion protein targeting to mitochondrion establishment of protein localization to mitochondrion regulation of protein stability biological regulation regulation of biological quality protein stabilization cellular response to stimulus cellular response to heat response to stimulus cellular response to stress response to stress response to heat response to abiotic stimulus response to temperature stimulus cellular component organization cellular component biogenesis proteasome assembly cellular component assembly protein-containing complex organization protein-containing complex assembly cellular component organization or biogenesis response to oxygen levels regulation of telomere maintenance regulation of cellular component organization regulation of cellular process telomere organization regulation of primary metabolic process nucleobase-containing compound metabolic process regulation of nucleobase-containing compound metabolic process regulation of biological process chromosome organization regulation of chromosome organization regulation of macromolecule metabolic process DNA metabolic process regulation of organelle organization nucleic acid metabolic process telomere maintenance organic cyclic compound metabolic process organelle organization regulation of metabolic process regulation of DNA metabolic process ribonucleoprotein complex biogenesis small nucleolar ribonucleoprotein complex assembly protein-RNA complex assembly protein-RNA complex organization box C/D snoRNP assembly positive regulation of organelle organization regulation of DNA biosynthetic process positive regulation of macromolecule biosynthetic process RNA-templated DNA biosynthetic process telomere maintenance via telomere lengthening positive regulation of metabolic process positive regulation of telomere maintenance via telomere lengthening positive regulation of macromolecule metabolic process positive regulation of telomere maintenance positive regulation of nucleobase-containing compound metabolic process regulation of cellular metabolic process regulation of telomere maintenance via telomere lengthening positive regulation of chromosome organization positive regulation of DNA metabolic process positive regulation of telomere maintenance via telomerase organic cyclic compound biosynthetic process regulation of macromolecule biosynthetic process DNA biosynthetic process positive regulation of cellular component organization positive regulation of biological process positive regulation of cellular metabolic process nucleic acid biosynthetic process positive regulation of biosynthetic process positive regulation of cellular process regulation of biosynthetic process telomere maintenance via telomerase positive regulation of DNA biosynthetic process nucleobase-containing compound biosynthetic process regulation of telomere maintenance via telomerase regulation of cellular biosynthetic process positive regulation of cellular biosynthetic process 'de novo' protein folding response to osmotic stress	intracellular anatomical structure cytoplasm cellular anatomical entity cytosol cell periphery plasma membrane membrane protein-containing complex perinuclear region of cytoplasm membrane-bounded organelle intracellular organelle organelle nucleus intracellular membrane-bounded organelle
E, F, G, H	Peptidyl-prolyl cis-trans isomerase FKBP8	isomerase activity catalytic activity, acting on a protein peptidyl-prolyl cis-trans isomerase activity catalytic activity cis-trans isomerase activity protein binding binding calmodulin binding protein folding chaperone cation binding ion binding metal ion binding small molecule binding disordered domain specific binding isomerase activity catalytic activity, acting on a protein peptidyl-prolyl cis-trans isomerase activity catalytic activity cis-trans isomerase activity protein binding binding calmodulin binding protein folding chaperone cation binding ion binding metal ion binding small molecule binding disordered domain specific binding protein domain specific binding identical protein binding	catabolic process regulation of cellular process regulation of cellular component organization autophagy regulation of autophagy cellular catabolic process cellular component organization organelle disassembly regulation of autophagy of mitochondrion cellular component organization or biogenesis process utilizing autophagic mechanism mitochondrion organization cellular component disassembly regulation of biological process catabolic process regulation of cellular process regulation of cellular component organization autophagy regulation of autophagy cellular catabolic process cellular component organization organelle disassembly regulation of autophagy of mitochondrion cellular component organization or biogenesis process utilizing autophagic mechanism mitochondrion organization cellular component disassembly regulation of biological process cellular metabolic process biological regulation regulation of cellular metabolic process regulation of catabolic process regulation of organelle organization organelle organization regulation of cellular catabolic process regulation of mitochondrion organization metabolic process cellular process regulation of metabolic process autophagy of mitochondrion developmental process multicellular organismal process cellular developmental process neuron fate commitment nervous system development cell fate specification generation of neurons neurogenesis multicellular organism development neuron differentiation cell differentiation anatomical structure development neuron fate specification cell fate commitment system development cellular response to stimulus cell surface receptor signaling pathway response to stimulus signaling smoothened signaling pathway cell communication signal transduction cellular response to BMP stimulus cell surface receptor protein serine/threonine kinase signaling pathway cellular response to growth factor stimulus response to endogenous stimulus cellular response to endogenous stimulus response to BMP transforming growth factor beta receptor superfamily signaling pathway response to growth factor BMP signaling pathway enzyme-linked receptor protein signaling pathway organonitrogen compound metabolic process cellular biosynthetic process primary metabolic process gene expression macromolecule biosynthetic process protein maturation organic substance metabolic process protein folding biosynthetic process organic substance biosynthetic process protein metabolic process macromolecule metabolic process sensory organ development eye development animal organ development visual system development camera-type eye development sensory system development negative regulation of programmed cell death regulation of apoptotic process negative regulation of biological process regulation of programmed cell death cell death negative regulation of apoptotic process negative regulation of cellular process apoptotic process programmed cell death regulation of biosynthetic process regulation of macromolecule metabolic process regulation of cellular biosynthetic process regulation of gene expression regulation of macromolecule biosynthetic process regulation of protein modification process regulation of protein phosphorylation negative regulation of phosphate metabolic process negative regulation of cellular metabolic process regulation of primary metabolic process regulation of phosphate metabolic process phosphate-containing compound metabolic process negative regulation of protein modification process protein modification process phosphorus metabolic process negative regulation of protein metabolic process negative regulation of macromolecule metabolic process protein phosphorylation phosphorylation regulation of protein metabolic process negative regulation of metabolic process negative regulation of protein phosphorylation macromolecule modification negative regulation of phosphorus metabolic process regulation of phosphorylation regulation of phosphorus metabolic process negative regulation of phosphorylation positive regulation of cell communication positive regulation of signal transduction regulation of transmembrane receptor protein serine/threonine kinase signaling pathway positive regulation of biological process regulation of signal transduction positive regulation of BMP signaling pathway positive regulation of response to stimulus positive regulation of cellular process regulation of signaling regulation of BMP signaling pathway regulation of cellular response to growth factor stimulus positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway regulation of response to stimulus regulation of cell communication positive regulation of signaling protein localization localization cellular localization protein localization to organelle cellular macromolecule localization macromolecule localization protein localization to mitochondrion epithelium development neural tube development tube development chordate embryonic development pattern specification process embryo development tissue development regionalization dorsal/ventral pattern formation embryo development ending in birth or egg hatching dorsal/ventral neural tube patterning neural tube patterning intracellular signal transduction multicellular organism growth developmental growth growth	cellular anatomical entity endomembrane system membrane-bounded organelle intracellular organelle intracellular anatomical structure mitochondrion organelle cytoplasm intracellular membrane-bounded organelle membrane mitochondrial membrane organelle envelope mitochondrial envelope organelle membrane cellular anatomical entity endomembrane system membrane-bounded organelle intracellular organelle intracellular anatomical structure mitochondrion organelle cytoplasm intracellular membrane-bounded organelle membrane mitochondrial membrane organelle envelope mitochondrial envelope organelle membrane cytosol protein-containing complex organelle subcompartment endoplasmic reticulum subcompartment nuclear outer membrane-endoplasmic reticulum membrane network endoplasmic reticulum endoplasmic reticulum membrane

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D	IPR003594	Histidine kinase/HSP90-like ATPase	Domain
A, B, C, D	IPR020575	Heat shock protein Hsp90, N-terminal	Domain
A, B, C, D	IPR036890	Histidine kinase/HSP90-like ATPase superfamily	Homologous Superfamily
A, B, C, D	IPR037196	HSP90, C-terminal domain	Homologous Superfamily
A, B, C, D	IPR020568	Ribosomal protein uS5 domain 2-type superfamily	Homologous Superfamily
A, B, C, D	IPR001404	Heat shock protein Hsp90 family	Family
A, B, C, D	IPR019805	Heat shock protein Hsp90, conserved site	Conserved Site
E, F, G, H	IPR046357	Peptidyl-prolyl cis-trans isomerase domain superfamily	Homologous Superfamily
E, F, G, H	IPR011990	Tetratricopeptide-like helical domain superfamily	Homologous Superfamily
E, F, G, H	IPR019734	Tetratricopeptide repeat	Repeat
E, F, G, H	IPR001179	FKBP-type peptidyl-prolyl cis-trans isomerase domain	Domain
E, F, G, H	IPR013105	Tetratricopeptide repeat 2	Repeat

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
E, F, G, H	Pharos: Q14318	attention deficit hyperactivity disorder, inattentive type heart disease psoriasis breast carcinoma medulloblastoma rheumatoid arthritis dental caries osteosarcoma Sjogren syndrome

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.