Annotations: 5ME3

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF12765,PF12830	e5me3A1	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: PF12765,PF12830	ECOD (1.6)
B	PF12765,PF12830	e5me3B1	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: PF12765,PF12830	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF12765	HEAT repeat associated with sister chromatid cohesion (Cohesin_HEAT)	HEAT repeat associated with sister chromatid cohesion	-	Repeat
A, B	PF12830	Sister chromatid cohesion C-terminus (Nipped-B_C)	Sister chromatid cohesion C-terminus	-	Repeat

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	Sister chromatid cohesion protein 2	protein-containing complex binding chromatin binding binding sequence-specific DNA binding DNA binding organic cyclic compound binding nucleic acid binding kinetochore binding	cellular response to stimulus double-strand break repair response to stimulus DNA recombination primary metabolic process DNA metabolic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process replication-born double-strand break repair via sister chromatid exchange cellular response to stress DNA damage response response to stress cellular response to stimulus double-strand break repair response to stimulus DNA recombination primary metabolic process DNA metabolic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process replication-born double-strand break repair via sister chromatid exchange cellular response to stress DNA damage response response to stress recombinational repair metabolic process cellular process macromolecule metabolic process double-strand break repair via homologous recombination DNA repair cellular component organization organelle organization chromosome organization cellular component organization or biogenesis transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery regulation of biosynthetic process regulation of biological process regulation of cellular process cellular biosynthetic process cellular metabolic process biological regulation regulation of cellular metabolic process regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process regulation of cellular biosynthetic process regulation of gene expression biosynthetic process organic substance biosynthetic process regulation of macromolecule biosynthetic process regulation of metabolic process mitotic nuclear division mitotic chromosome condensation organelle fission sister chromatid segregation mitotic cell cycle nuclear division mitotic cell cycle process chromosome condensation mitotic sister chromatid segregation nuclear chromosome segregation cell cycle chromosome segregation cell cycle process rDNA chromatin condensation protein-containing complex organization nucleolar chromatin organization protein-DNA complex organization nucleus organization nucleolus organization chromatin organization tRNA gene clustering mitotic sister chromatid cohesion establishment of mitotic sister chromatid cohesion sister chromatid cohesion establishment of sister chromatid cohesion protein localization establishment of protein localization cellular localization protein localization to chromatin establishment of protein localization to chromatin establishment of localization localization establishment of protein localization to organelle protein localization to chromosome cellular macromolecule localization macromolecule localization protein localization to organelle establishment of protein localization to chromosome cohesin loading mitotic cohesin loading	membrane-bounded organelle protein-containing complex intracellular anatomical structure nucleus nuclear protein-containing complex intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle SMC loading complex Scc2-Scc4 cohesin loading complex organelle cytoplasm cytosol 2-micrometer circle DNA membrane-bounded organelle protein-containing complex intracellular anatomical structure nucleus nuclear protein-containing complex intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle SMC loading complex Scc2-Scc4 cohesin loading complex organelle cytoplasm cytosol 2-micrometer circle DNA extrachromosomal circular DNA extrachromosomal DNA protein-DNA complex intracellular non-membrane-bounded organelle chromatin chromosome non-membrane-bounded organelle
C [auth X]	unassigned sequence of Scc2	-	-	-
D [auth Y]	Scc2 unassigned sequence	-	-	-
E [auth Z], F [auth W]	Scc2 unassigned sequence	-	-	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR033031	Scc2/Nipped-B family	Family
A, B	IPR016024	Armadillo-type fold	Homologous Superfamily
A, B	IPR024986	Sister chromatid cohesion C-terminal domain	Domain
A, B	IPR026003	HEAT repeat associated with sister chromatid cohesion protein	Repeat

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.