5MB9

Crystal structure of the eukaryotic ribosome associated complex (RAC), a unique Hsp70/Hsp40 pair

External Resource: Annotation

Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Ssz1_peptide-bd	e5mb9A2	A: beta sandwiches	X: Heat shock protein 70kD (HSP70), peptide-binding domain (From Topology)	H: Heat shock protein 70kD (HSP70), peptide-binding domain (From Topology)	T: Heat shock protein 70kD (HSP70), peptide-binding domain	F: Ssz1_peptide-bd	ECOD (1.6)
A	HSP70_1st	e5mb9A3	A: mixed a+b and a/b	X: Ribonuclease H-like	H: Ribonuclease H-like (From Topology)	T: Ribonuclease H-like	F: HSP70_1st	ECOD (1.6)
A	FtsA	e5mb9A1	A: mixed a+b and a/b	X: Ribonuclease H-like	H: Ribonuclease H-like (From Topology)	T: Ribonuclease H-like	F: FtsA	ECOD (1.6)
B	Ssz1_peptide-bd	e5mb9B3	A: beta sandwiches	X: Heat shock protein 70kD (HSP70), peptide-binding domain (From Topology)	H: Heat shock protein 70kD (HSP70), peptide-binding domain (From Topology)	T: Heat shock protein 70kD (HSP70), peptide-binding domain	F: Ssz1_peptide-bd	ECOD (1.6)
B	HSP70_1st	e5mb9B1	A: mixed a+b and a/b	X: Ribonuclease H-like	H: Ribonuclease H-like (From Topology)	T: Ribonuclease H-like	F: HSP70_1st	ECOD (1.6)
B	FtsA	e5mb9B2	A: mixed a+b and a/b	X: Ribonuclease H-like	H: Ribonuclease H-like (From Topology)	T: Ribonuclease H-like	F: FtsA	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF00012	Hsp70 protein (HSP70)	Hsp70 protein	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	Putative heat shock protein	binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding ATP-dependent protein folding chaperone protein folding chaperone ATP-dependent activity	-	-
C, D	Putative ribosome associated protein	protein binding binding Hsp70 protein binding protein-folding chaperone binding heat shock protein binding ribonucleoprotein complex binding protein-containing complex binding ribosome binding	organonitrogen compound metabolic process cellular biosynthetic process cellular metabolic process primary metabolic process gene expression macromolecule biosynthetic process protein maturation organic substance metabolic process protein folding biosynthetic process 'de novo' cotranslational protein folding organic substance biosynthetic process metabolic process cellular process organonitrogen compound metabolic process cellular biosynthetic process cellular metabolic process primary metabolic process gene expression macromolecule biosynthetic process protein maturation organic substance metabolic process protein folding biosynthetic process 'de novo' cotranslational protein folding organic substance biosynthetic process metabolic process cellular process protein metabolic process macromolecule metabolic process 'de novo' protein folding biological regulation regulation of biological quality regulation of translational fidelity	intracellular anatomical structure cytoplasm cellular anatomical entity

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR013126	Heat shock protein 70 family	Family
A, B	IPR043129	ATPase, nucleotide binding domain	Homologous Superfamily
C, D	IPR001623	DnaJ domain	Domain
C, D	IPR044634	J-protein Zuotin/DnaJC2	Family
C, D	IPR032003	Ribosome-associated complex head domain	Domain
C, D	IPR042569	Ribosome-associated complex head domain superfamily	Homologous Superfamily
C, D	IPR036869	Chaperone J-domain superfamily	Homologous Superfamily

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.