Annotations: 5M9E

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	EB1 dimerisation domain-like	8080828	3001381	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	EB1 dimerisation domain-like	8080828	3001381	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	EB1 dimerisation domain-like	8080828	3001381	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	EB1 dimerisation domain-like	8080828	3001381	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF03271	e5m9eA1	A: alpha duplicates or obligate multimers	X: EB1 dimerisation domain-like (From Topology)	H: EB1 dimerisation domain-like (From Topology)	T: EB1 dimerisation domain-like	F: PF03271	ECOD (1.6)
B	PF03271	e5m9eB1	A: alpha duplicates or obligate multimers	X: EB1 dimerisation domain-like (From Topology)	H: EB1 dimerisation domain-like (From Topology)	T: EB1 dimerisation domain-like	F: PF03271	ECOD (1.6)
C	PF03271	e5m9eC1	A: alpha duplicates or obligate multimers	X: EB1 dimerisation domain-like (From Topology)	H: EB1 dimerisation domain-like (From Topology)	T: EB1 dimerisation domain-like	F: PF03271	ECOD (1.6)
D	PF03271	e5m9eD1	A: alpha duplicates or obligate multimers	X: EB1 dimerisation domain-like (From Topology)	H: EB1 dimerisation domain-like (From Topology)	T: EB1 dimerisation domain-like	F: PF03271	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.20.5.1430	Mainly Alpha	Up-down Bundle	Single alpha-helices involved in coiled-coils or other helix-helix interfaces		CATH (utative)
B	1.20.5.1430	Mainly Alpha	Up-down Bundle	Single alpha-helices involved in coiled-coils or other helix-helix interfaces		CATH (utative)
C	1.20.5.1430	Mainly Alpha	Up-down Bundle	Single alpha-helices involved in coiled-coils or other helix-helix interfaces		CATH (utative)
D	1.20.5.1430	Mainly Alpha	Up-down Bundle	Single alpha-helices involved in coiled-coils or other helix-helix interfaces		CATH (utative)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D	PF03271	EB1-like C-terminal motif (EB1)	EB1-like C-terminal motif	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D	Microtubule integrity protein mal3	ATPase activator activity molecular function activator activity molecular function regulator activity ATPase regulator activity cytoskeletal protein binding microtubule binding protein binding binding tubulin binding microtubule lateral binding molecular condensate scaffold activity protein-macromolecule adaptor activity molecular adaptor activity cytoskeletal anchor activity ATPase activator activity molecular function activator activity molecular function regulator activity ATPase regulator activity cytoskeletal protein binding microtubule binding protein binding binding tubulin binding microtubule lateral binding molecular condensate scaffold activity protein-macromolecule adaptor activity molecular adaptor activity cytoskeletal anchor activity microtubule plus-end binding	establishment of organelle localization cellular localization mitotic metaphase chromosome alignment mitotic cell cycle metaphase chromosome alignment cellular component organization localization chromosome localization organelle localization establishment of localization in cell mitotic sister chromatid segregation cell cycle cellular component organization or biogenesis chromosome segregation establishment of organelle localization cellular localization mitotic metaphase chromosome alignment mitotic cell cycle metaphase chromosome alignment cellular component organization localization chromosome localization organelle localization establishment of localization in cell mitotic sister chromatid segregation cell cycle cellular component organization or biogenesis chromosome segregation cell cycle process mitotic nuclear division attachment of spindle microtubules to kinetochore organelle fission attachment of mitotic spindle microtubules to kinetochore chromosome organization sister chromatid segregation establishment of localization organelle organization nuclear division mitotic cell cycle process nuclear chromosome segregation cellular process establishment of chromosome localization cell division sexual reproduction organelle transport along microtubule transport nuclear migration involved in conjugation with cellular fusion reproductive process nucleus localization intracellular transport conjugation with cellular fusion nuclear migration along microtubule microtubule-based transport transport along microtubule cytoskeleton-dependent intracellular transport microtubule-based movement microtubule-based process nuclear migration organelle fusion nucleus organization karyogamy karyogamy involved in conjugation with cellular fusion organelle assembly non-membrane-bounded organelle assembly microtubule cytoskeleton organization spindle assembly cellular component biogenesis cellular component assembly cytoskeleton organization spindle organization regulation of cytoskeleton organization regulation of microtubule polymerization or depolymerization regulation of biological process regulation of cellular component organization regulation of cellular process biological regulation regulation of microtubule-based process regulation of organelle organization microtubule polymerization or depolymerization regulation of microtubule cytoskeleton organization protein localization to microtubule cytoskeleton protein localization protein localization to microtubule protein localization to cytoskeleton protein localization to organelle cellular macromolecule localization macromolecule localization meiotic cell cycle process meiosis I meiotic nuclear division dynein-driven meiotic oscillatory nuclear movement meiotic cell cycle meiosis I cell cycle process	polymeric cytoskeletal fiber intracellular anatomical structure mitotic spindle spindle aster mitotic spindle astral microtubule astral microtubule spindle microtubule cellular anatomical entity cytoplasmic microtubule intracellular organelle cytoskeleton organelle intracellular non-membrane-bounded organelle polymeric cytoskeletal fiber intracellular anatomical structure mitotic spindle spindle aster mitotic spindle astral microtubule astral microtubule spindle microtubule cellular anatomical entity cytoplasmic microtubule intracellular organelle cytoskeleton organelle intracellular non-membrane-bounded organelle supramolecular fiber cytoplasm microtubule supramolecular polymer supramolecular complex microtubule cytoskeleton non-membrane-bounded organelle spindle midzone microtubule end microtubule plus-end cell periphery cell cortex cell tip cell pole cell cortex region cell cortex of cell tip cytoplasmic region post-anaphase array microtubule post-anaphase array microtubule end post-anaphase microtubule array microtubule organizing center spindle pole body mitotic spindle pole body cortical cytoskeleton cortical microtubule cortical microtubule cytoskeleton mitotic spindle midzone membrane-bounded organelle nucleus intracellular membrane-bounded organelle nuclear microtubule
E, F, G, H	Phosphoprotein p93	cytoskeletal protein binding microtubule binding protein binding binding tubulin binding microtubule plus end polymerase catalytic activity, acting on a protein transferase activity catalytic activity microtubule plus-end binding	cellular component organization microtubule bundle formation organelle organization microtubule cytoskeleton organization cellular process microtubule-based process cellular component organization or biogenesis cytoskeleton organization localization chromosome localization organelle localization nuclear chromosome segregation microtubule-based movement cell cycle cellular component organization microtubule bundle formation organelle organization microtubule cytoskeleton organization cellular process microtubule-based process cellular component organization or biogenesis cytoskeleton organization localization chromosome localization organelle localization nuclear chromosome segregation microtubule-based movement cell cycle chromosome movement towards spindle pole chromosome segregation cell cycle process establishment of organelle localization cellular localization mitotic metaphase chromosome alignment mitotic cell cycle metaphase chromosome alignment establishment of localization in cell mitotic sister chromatid segregation mitotic nuclear division attachment of spindle microtubules to kinetochore organelle fission attachment of mitotic spindle microtubules to kinetochore chromosome organization sister chromatid segregation establishment of localization nuclear division mitotic cell cycle process establishment of chromosome localization meiotic chromosome segregation centromere localization sexual reproduction reproductive process meiotic cell cycle process meiotic chromosome movement towards spindle pole meiotic nuclear division meiotic cell cycle protein-containing complex localization chromosome organization involved in meiotic cell cycle meiotic centromere clustering centromere clustering protein polymerization protein-containing complex organization microtubule polymerization cellular component biogenesis microtubule polymerization or depolymerization cellular component assembly protein-containing complex assembly supramolecular fiber organization cellular component disassembly protein-containing complex disassembly microtubule depolymerization protein depolymerization establishment or maintenance of microtubule cytoskeleton polarity establishment or maintenance of cytoskeleton polarity establishment or maintenance of cell polarity mitotic spindle elongation spindle elongation microtubule cytoskeleton organization involved in mitosis spindle organization mitotic spindle organization	intracellular anatomical structure meiotic spindle pole body cellular anatomical entity intracellular organelle microtubule organizing center cytoskeleton organelle intracellular non-membrane-bounded organelle spindle pole body microtubule cytoskeleton non-membrane-bounded organelle spindle spindle pole cytoplasm intracellular anatomical structure meiotic spindle pole body cellular anatomical entity intracellular organelle microtubule organizing center cytoskeleton organelle intracellular non-membrane-bounded organelle spindle pole body microtubule cytoskeleton non-membrane-bounded organelle spindle spindle pole cytoplasm mitotic spindle mitotic spindle pole body chromosome chromosomal region kinetochore chromosome, centromeric region condensed chromosome, centromeric region supramolecular complex condensed chromosome polymeric cytoskeletal fiber mitotic spindle polar microtubule spindle microtubule mitotic spindle microtubule polar microtubule supramolecular fiber microtubule supramolecular polymer microtubule bundle static microtubule bundle mitotic spindle pole cytoplasmic microtubule membrane-bounded organelle nucleus intracellular membrane-bounded organelle

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D	IPR001715	Calponin homology domain	Domain
A, B, C, D	IPR004953	EB1, C-terminal	Domain
A, B, C, D	IPR027328	Microtubule-associated protein RP/EB	Family
A, B, C, D	IPR036133	EB1, C-terminal domain superfamily	Homologous Superfamily
A, B, C, D	IPR036872	CH domain superfamily	Homologous Superfamily
E, F, G, H	IPR016024	Armadillo-type fold	Homologous Superfamily
E, F, G, H	IPR048491	XMAP215/Dis1/CLASP, TOG domain	Domain
E, F, G, H	IPR034085	TOG domain	Domain
E, F, G, H	IPR011989	Armadillo-like helical	Homologous Superfamily
E, F, G, H	IPR045110	XMAP215	Family

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.