5M73

Structure of the human SRP S domain with SRP72 RNA-binding domain

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
B	SCOP2B Superfamily	SRP19	8037027	3000831	SCOP2B (2022-06-29)
F	SCOP2B Superfamily	SRP19	8037027	3000831	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	TPR-like	8053751	3001345	SCOP2B (2022-06-29)
G	SCOP2B Superfamily	TPR-like	8053751	3001345	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
B	PF01922	e5m73B1	A: alpha arrays	X: HTH	H: HTH	T: Putative DNA-binding domain	F: PF01922	ECOD (1.6)
F	PF01922	e5m73F1	A: alpha arrays	X: HTH	H: HTH	T: Putative DNA-binding domain	F: PF01922	ECOD (1.6)
C	PF16969	e5m73C1	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: PF16969	ECOD (1.6)
G	PF16969	e5m73G1	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: PF16969	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
B	3.30.56.30	Alpha Beta	2-Layer Sandwich	Phenylalanyl-tRNA Synthetase	Chain B, domain 1	CATH (4.3.0)
F	3.30.56.30	Alpha Beta	2-Layer Sandwich	Phenylalanyl-tRNA Synthetase	Chain B, domain 1	CATH (4.3.0)
C	1.10.3450.40	Mainly Alpha	Orthogonal Bundle	Hyaluronidase domain-like	Signal recognition particle, SRP68 subunit, RNA-binding domain	CATH (4.3.0)
G	1.10.3450.40	Mainly Alpha	Orthogonal Bundle	Hyaluronidase domain-like	Signal recognition particle, SRP68 subunit, RNA-binding domain	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
B, F	PF01922	SRP19 protein (SRP19)	SRP19 protein	-	Family
C, G	PF16969	RNA-binding signal recognition particle 68 (SRP68)	RNA-binding signal recognition particle 68	-	Family
D, H	PF08492	SRP72 RNA-binding domain (SRP72)	SRP72 RNA-binding domain	This region has been identified as the binding site of the SRP72 protein to SRP RNA [1].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, E	Human gene for small cytoplasmic 7SL RNA (7L30.1)	-	-	-
B, F	Signal recognition particle 19 kDa protein	RNA binding 7S RNA binding binding organic cyclic compound binding nucleic acid binding	protein localization establishment of protein localization cellular localization establishment of protein localization to membrane protein targeting localization within membrane protein localization to membrane establishment of localization protein targeting to membrane localization cellular macromolecule localization macromolecule localization cotranslational protein targeting to membrane cellular process protein localization establishment of protein localization cellular localization establishment of protein localization to membrane protein targeting localization within membrane protein localization to membrane establishment of localization protein targeting to membrane localization cellular macromolecule localization macromolecule localization cotranslational protein targeting to membrane cellular process cellular component organization cellular component biogenesis cellular component assembly SRP-dependent cotranslational protein targeting to membrane protein-containing complex assembly cellular component organization or biogenesis establishment of protein localization to endoplasmic reticulum protein localization to endoplasmic reticulum SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition protein-containing complex organization establishment of protein localization to organelle protein localization to organelle protein targeting to ER	intracellular anatomical structure cytoplasm cellular anatomical entity cytosol signal recognition particle protein-containing complex ribonucleoprotein complex membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membrane-bounded organelle nucleolus intracellular organelle lumen intracellular organelle intracellular anatomical structure cytoplasm cellular anatomical entity cytosol signal recognition particle protein-containing complex ribonucleoprotein complex membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membrane-bounded organelle nucleolus intracellular organelle lumen intracellular organelle organelle lumen organelle intracellular non-membrane-bounded organelle nuclear lumen non-membrane-bounded organelle signal recognition particle, endoplasmic reticulum targeting nuclear body nucleoplasm
C, G	Signal recognition particle subunit SRP68	endoplasmic reticulum signal peptide binding signal sequence binding binding peptide binding protein binding protein domain specific binding ribonucleoprotein complex binding protein-containing complex binding signal recognition particle binding RNA binding 7S RNA binding organic cyclic compound binding nucleic acid binding	response to stimulus response to chemical response to xenobiotic stimulus protein localization establishment of protein localization cellular localization establishment of protein localization to membrane protein targeting localization within membrane protein localization to membrane establishment of localization protein targeting to membrane localization SRP-dependent cotranslational protein targeting to membrane response to stimulus response to chemical response to xenobiotic stimulus protein localization establishment of protein localization cellular localization establishment of protein localization to membrane protein targeting localization within membrane protein localization to membrane establishment of localization protein targeting to membrane localization SRP-dependent cotranslational protein targeting to membrane establishment of protein localization to organelle cellular macromolecule localization macromolecule localization protein localization to organelle cotranslational protein targeting to membrane cellular process establishment of protein localization to endoplasmic reticulum protein localization to endoplasmic reticulum protein targeting to ER	anchoring junction cell junction cellular anatomical entity focal adhesion cell-substrate junction membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle nucleolus intracellular organelle lumen intracellular organelle organelle lumen anchoring junction cell junction cellular anatomical entity focal adhesion cell-substrate junction membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle nucleolus intracellular organelle lumen intracellular organelle organelle lumen organelle intracellular non-membrane-bounded organelle nuclear lumen non-membrane-bounded organelle cytoplasm cytosol signal recognition particle protein-containing complex ribonucleoprotein complex signal recognition particle, endoplasmic reticulum targeting ribosome endoplasmic reticulum endomembrane system
D, H	Signal recognition particle subunit SRP72	ribonucleoprotein complex binding protein-containing complex binding binding signal recognition particle binding RNA binding 7S RNA binding organic cyclic compound binding nucleic acid binding TPR domain binding protein binding protein domain specific binding	protein localization establishment of protein localization cellular localization establishment of protein localization to membrane protein targeting localization within membrane protein localization to membrane establishment of localization protein targeting to membrane localization SRP-dependent cotranslational protein targeting to membrane establishment of protein localization to organelle cellular macromolecule localization macromolecule localization protein localization to organelle protein localization establishment of protein localization cellular localization establishment of protein localization to membrane protein targeting localization within membrane protein localization to membrane establishment of localization protein targeting to membrane localization SRP-dependent cotranslational protein targeting to membrane establishment of protein localization to organelle cellular macromolecule localization macromolecule localization protein localization to organelle cotranslational protein targeting to membrane cellular process establishment of protein localization to endoplasmic reticulum protein localization to endoplasmic reticulum protein targeting to ER	intracellular anatomical structure cytoplasm cellular anatomical entity cytosol signal recognition particle protein-containing complex ribonucleoprotein complex signal recognition particle, endoplasmic reticulum targeting membrane-bounded organelle intracellular organelle organelle endoplasmic reticulum intracellular membrane-bounded organelle endomembrane system

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
B, F	IPR002778	Signal recognition particle, SRP19 subunit	Family
B, F	IPR036521	Signal recognition particle, subunit SRP19-like superfamily	Homologous Superfamily
C, G	IPR038253	SRP68, N-terminal domain superfamily	Homologous Superfamily
C, G	IPR034652	Signal recognition particle subunit SRP68, RNA-binding domain	Domain
C, G	IPR026258	Signal recognition particle subunit SRP68	Family
D, H	IPR013699	Signal recognition particle, SRP72 subunit, RNA-binding	Domain
D, H	IPR011990	Tetratricopeptide-like helical domain superfamily	Homologous Superfamily
D, H	IPR031545	Signal recognition particle subunit SRP72, TPR-like repeat	Repeat
D, H	IPR026270	Signal recognition particle, SRP72 subunit	Family
D, H	IPR019734	Tetratricopeptide repeat	Repeat

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
B, F	Pharos: P09132	colorectal adenoma colorectal cancer
C, G	Pharos: Q9UHB9	Craniofacial Abnormalities ovarian cancer skin disease
D, H	Pharos: O76094	autosomal dominant aplasia and myelodysplasia bone marrow failure syndrome cholestasis plasma cell myeloma ulcerative colitis Chemically-Induced Liver Toxicity drug-induced liver injury juvenile dermatomyositis lung cancer ovarian cancer psoriasis large cell medulloblastoma myopathy pancytopenia-developmental delay syndrome rheumatoid arthritis autosomal dominant aplasia and myelodysplasia bone marrow failure syndrome cholestasis plasma cell myeloma ulcerative colitis Chemically-Induced Liver Toxicity drug-induced liver injury juvenile dermatomyositis lung cancer ovarian cancer psoriasis large cell medulloblastoma myopathy pancytopenia-developmental delay syndrome rheumatoid arthritis congenital anemia lung adenocarcinoma osteosarcoma

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.