5M1G

Structure of a Spumaretrovirus Gag central domain reveals an ancient retroviral capsid

External Resource: Annotation

Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Gag_spuma_3rd	e5m1gA1	A: alpha bundles	X: Retrovirus capsid protein	H: Retrovirus capsid protein-C (From Topology)	T: Retrovirus capsid protein-C	F: Gag_spuma_3rd	ECOD (1.6)
B	Gag_spuma_3rd	e5m1gB1	A: alpha bundles	X: Retrovirus capsid protein	H: Retrovirus capsid protein-C (From Topology)	T: Retrovirus capsid protein-C	F: Gag_spuma_3rd	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF20672	Spumavirus Gag polyprotein, conserved central domain (Gag_FV_central)	Spumavirus Gag polyprotein, conserved central domain	This is the conserved central domain of the Gag polyprotein from Foamyviruses (FVs) or Spuma-retroviruses. Gag is the major structural protein required for genome packaging virion assembly, trafficking and egress. This domain has an all alpha-helical ...	This is the conserved central domain of the Gag polyprotein from Foamyviruses (FVs) or Spuma-retroviruses. Gag is the major structural protein required for genome packaging virion assembly, trafficking and egress. This domain has an all alpha-helical fold and contains the highly conserved PGQA and YxxLGL sequences [1].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	Gag protein	DNA binding binding organic cyclic compound binding nucleic acid binding RNA binding	exit from host cell biological process involved in interspecies interaction between organisms viral process viral release from host cell viral life cycle biological process involved in interaction with host biological process involved in symbiotic interaction microtubule-dependent intracellular transport of viral material microtubule-dependent intracellular transport of viral material towards nucleus intracellular transport of virus transport of virus transport of viral material towards nucleus symbiont entry into host cell symbiont entry into host exit from host cell biological process involved in interspecies interaction between organisms viral process viral release from host cell viral life cycle biological process involved in interaction with host biological process involved in symbiotic interaction microtubule-dependent intracellular transport of viral material microtubule-dependent intracellular transport of viral material towards nucleus intracellular transport of virus transport of virus transport of viral material towards nucleus symbiont entry into host cell symbiont entry into host virion assembly viral budding viral budding via host ESCRT complex	host cellular component host intracellular part host cytoskeleton host cell part host intracellular region cellular anatomical entity host intracellular organelle host intracellular membrane-bounded organelle host cell nucleus viral nucleocapsid viral capsid virion component host cell cytoplasm

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR004957	Gag polyprotein, N-terminal domain	Domain
A, B	IPR049099	Gag polyprotein, C-terminal	Domain
A, B	IPR049101	Gag polyprotein, conserved central domain	Domain

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.