Annotations: 5LZL

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	5-aminolaevulinate dehydratase ALAD (porphobilinogen synthase)	8072520	4003237	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	Aldolase	8072521	3000445	SCOP2 (2022-06-29)
B	SCOP2B Superfamily	Aldolase	8072521	3000445	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	Aldolase	8072521	3000445	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	Aldolase	8072521	3000445	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	Aldolase	8072521	3000445	SCOP2B (2022-06-29)
F	SCOP2B Superfamily	Aldolase	8072521	3000445	SCOP2B (2022-06-29)
G	SCOP2B Superfamily	Aldolase	8072521	3000445	SCOP2B (2022-06-29)
H	SCOP2B Superfamily	Aldolase	8072521	3000445	SCOP2B (2022-06-29)
I	SCOP2B Superfamily	Aldolase	8072521	3000445	SCOP2B (2022-06-29)
J	SCOP2B Superfamily	Aldolase	8072521	3000445	SCOP2B (2022-06-29)
K	SCOP2B Superfamily	Aldolase	8072521	3000445	SCOP2B (2022-06-29)
L	SCOP2B Superfamily	Aldolase	8072521	3000445	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF00490	e5lzlA1	A: a/b barrels	X: TIM beta/alpha-barrel	H: TIM barrels (From Topology)	T: TIM barrels	F: PF00490	ECOD (1.6)
B	PF00490	e5lzlB1	A: a/b barrels	X: TIM beta/alpha-barrel	H: TIM barrels (From Topology)	T: TIM barrels	F: PF00490	ECOD (1.6)
C	PF00490	e5lzlC1	A: a/b barrels	X: TIM beta/alpha-barrel	H: TIM barrels (From Topology)	T: TIM barrels	F: PF00490	ECOD (1.6)
D	PF00490	e5lzlD1	A: a/b barrels	X: TIM beta/alpha-barrel	H: TIM barrels (From Topology)	T: TIM barrels	F: PF00490	ECOD (1.6)
E	PF00490	e5lzlE1	A: a/b barrels	X: TIM beta/alpha-barrel	H: TIM barrels (From Topology)	T: TIM barrels	F: PF00490	ECOD (1.6)
F	PF00490	e5lzlF1	A: a/b barrels	X: TIM beta/alpha-barrel	H: TIM barrels (From Topology)	T: TIM barrels	F: PF00490	ECOD (1.6)
G	PF00490	e5lzlG1	A: a/b barrels	X: TIM beta/alpha-barrel	H: TIM barrels (From Topology)	T: TIM barrels	F: PF00490	ECOD (1.6)
H	PF00490	e5lzlH1	A: a/b barrels	X: TIM beta/alpha-barrel	H: TIM barrels (From Topology)	T: TIM barrels	F: PF00490	ECOD (1.6)
I	PF00490	e5lzlI1	A: a/b barrels	X: TIM beta/alpha-barrel	H: TIM barrels (From Topology)	T: TIM barrels	F: PF00490	ECOD (1.6)
J	PF00490	e5lzlJ1	A: a/b barrels	X: TIM beta/alpha-barrel	H: TIM barrels (From Topology)	T: TIM barrels	F: PF00490	ECOD (1.6)
K	PF00490	e5lzlK1	A: a/b barrels	X: TIM beta/alpha-barrel	H: TIM barrels (From Topology)	T: TIM barrels	F: PF00490	ECOD (1.6)
L	PF00490	e5lzlL1	A: a/b barrels	X: TIM beta/alpha-barrel	H: TIM barrels (From Topology)	T: TIM barrels	F: PF00490	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.20.20.70	Alpha Beta	Alpha-Beta Barrel	TIM Barrel	Aldolase class I	CATH (4.3.0)
B	3.20.20.70	Alpha Beta	Alpha-Beta Barrel	TIM Barrel	Aldolase class I	CATH (4.3.0)
C	3.20.20.70	Alpha Beta	Alpha-Beta Barrel	TIM Barrel	Aldolase class I	CATH (4.3.0)
D	3.20.20.70	Alpha Beta	Alpha-Beta Barrel	TIM Barrel	Aldolase class I	CATH (4.3.0)
E	3.20.20.70	Alpha Beta	Alpha-Beta Barrel	TIM Barrel	Aldolase class I	CATH (4.3.0)
F	3.20.20.70	Alpha Beta	Alpha-Beta Barrel	TIM Barrel	Aldolase class I	CATH (4.3.0)
G	3.20.20.70	Alpha Beta	Alpha-Beta Barrel	TIM Barrel	Aldolase class I	CATH (4.3.0)
H	3.20.20.70	Alpha Beta	Alpha-Beta Barrel	TIM Barrel	Aldolase class I	CATH (4.3.0)
I	3.20.20.70	Alpha Beta	Alpha-Beta Barrel	TIM Barrel	Aldolase class I	CATH (4.3.0)
J	3.20.20.70	Alpha Beta	Alpha-Beta Barrel	TIM Barrel	Aldolase class I	CATH (4.3.0)
K	3.20.20.70	Alpha Beta	Alpha-Beta Barrel	TIM Barrel	Aldolase class I	CATH (4.3.0)
L	3.20.20.70	Alpha Beta	Alpha-Beta Barrel	TIM Barrel	Aldolase class I	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L	PF00490	Delta-aminolevulinic acid dehydratase (ALAD)	Delta-aminolevulinic acid dehydratase	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L	Delta-aminolevulinic acid dehydratase	hydro-lyase activity lyase activity catalytic activity porphobilinogen synthase activity carbon-oxygen lyase activity cation binding ion binding binding metal ion binding small molecule binding	pigment metabolic process heme metabolic process porphyrin-containing compound biosynthetic process organonitrogen compound metabolic process tetrapyrrole metabolic process heme biosynthetic process protoporphyrinogen IX metabolic process organonitrogen compound biosynthetic process pigment biosynthetic process organic cyclic compound metabolic process protoporphyrinogen IX biosynthetic process organic substance metabolic process tetrapyrrole biosynthetic process biosynthetic process organic cyclic compound biosynthetic process pigment metabolic process heme metabolic process porphyrin-containing compound biosynthetic process organonitrogen compound metabolic process tetrapyrrole metabolic process heme biosynthetic process protoporphyrinogen IX metabolic process organonitrogen compound biosynthetic process pigment biosynthetic process organic cyclic compound metabolic process protoporphyrinogen IX biosynthetic process organic substance metabolic process tetrapyrrole biosynthetic process biosynthetic process organic cyclic compound biosynthetic process organic substance biosynthetic process metabolic process porphyrin-containing compound metabolic process	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L	IPR001731	Delta-aminolevulinic acid dehydratase	Family
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L	IPR030656	Delta-aminolevulinic acid dehydratase, active site	Active Site
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L	IPR013785	Aldolase-type TIM barrel	Homologous Superfamily

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.