5LXQ
Structure of PRL-1 in complex with the Bateman domain of CNNM2
Domain Annotation: SCOP2 Classification SCOP2 Database Homepage
Chains | Type | Family Name | Domain Identifier | Family Identifier | Provenance Source (Version) |
---|---|---|---|---|---|
A [auth B] | SCOP2 Family | Dual specificity phosphatase-like | 8067103 | 4000437 | SCOP2 (2022-06-29) |
A [auth B] | SCOP2 Superfamily | (Phosphotyrosine protein) phosphatases II | 8067104 | 3000304 | SCOP2 (2022-06-29) |
C | SCOP2B Superfamily | (Phosphotyrosine protein) phosphatases II | 8067104 | 3000304 | SCOP2B (2022-06-29) |
Domain Annotation: ECOD Classification ECOD Database Homepage
Chains | Family Name | Domain Identifier | Architecture | Possible Homology | Homology | Topology | Family | Provenance Source (Version) |
---|---|---|---|---|---|---|---|---|
A [auth B] | PF00102 | e5lxqB1 | A: a/b three-layered sandwiches | X: Flavodoxin-like | H: Flavoproteins/Phosphotyrosine protein phosphatases-like | T: (Phosphotyrosine protein) phosphatases II | F: PF00102 | ECOD (1.6) |
C | PF00102 | e5lxqC1 | A: a/b three-layered sandwiches | X: Flavodoxin-like | H: Flavoproteins/Phosphotyrosine protein phosphatases-like | T: (Phosphotyrosine protein) phosphatases II | F: PF00102 | ECOD (1.6) |
B [auth A] | PF00571 | e5lxqA1 | A: a+b duplicates or obligate multimers | X: CBS-domain (From Topology) | H: CBS-domain (From Topology) | T: CBS-domain | F: PF00571 | ECOD (1.6) |
D [auth H] | PF00571 | e5lxqH1 | A: a+b duplicates or obligate multimers | X: CBS-domain (From Topology) | H: CBS-domain (From Topology) | T: CBS-domain | F: PF00571 | ECOD (1.6) |
Domain Annotation: CATH CATH Database Homepage
Chain | Domain | Class | Architecture | Topology | Homology | Provenance Source (Version) |
---|---|---|---|---|---|---|
A [auth B] | 3.90.190.10 | Alpha Beta | Alpha-Beta Complex | Protein-Tyrosine Phosphatase | Chain A | CATH (4.3.0) |
C | 3.90.190.10 | Alpha Beta | Alpha-Beta Complex | Protein-Tyrosine Phosphatase | Chain A | CATH (4.3.0) |
B [auth A] | 3.10.580.10 | Alpha Beta | Roll | CBS-domain | CBS-domain | CATH (4.3.0) |
D [auth H] | 3.10.580.10 | Alpha Beta | Roll | CBS-domain | CBS-domain | CATH (4.3.0) |
Protein Family Annotation Pfam Database Homepage
Chains | Accession | Name | Description | Comments | Source |
---|---|---|---|---|---|
A [auth B], C | PF00782 | Dual specificity phosphatase, catalytic domain (DSPc) | Dual specificity phosphatase, catalytic domain | Ser/Thr and Tyr protein phosphatases. The enzyme's tertiary fold is highly similar to that of tyrosine-specific phosphatases, except for a "recognition" region [2]. | Domain |
B [auth A], D [auth H] | PF00571 | CBS domain (CBS) | CBS domain | CBS domains are small intracellular modules that pair together to form a stable globular domain [2]. This family represents a single CBS domain. Pairs of these domains have been termed a Bateman domain [6]. CBS domains have been shown to bind ligands ... | Domain |
B [auth A], D [auth H] | PF01595 | Cyclin M transmembrane N-terminal domain (CNNM) | Cyclin M transmembrane N-terminal domain | This transmembrane domain is found in metal transporter proteins such as cyclin M 1/2 (CNNM). CNNMs are integral membrane proteins that are conserved from bacteria to humans. CNNM family members influence metal ion homeostasis through mechanisms that ... | Domain |
Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage
InterPro: Protein Family Classification InterPro Database Homepage
Chains | Accession | Name | Type |
---|---|---|---|
A [auth B], C | IPR029021 | Protein-tyrosine phosphatase-like | Homologous Superfamily |
A [auth B], C | IPR003595 | Protein-tyrosine phosphatase, catalytic | Domain |
A [auth B], C | IPR000387 | Tyrosine-specific protein phosphatases domain | Domain |
A [auth B], C | IPR020422 | Dual specificity protein phosphatase domain | Domain |
A [auth B], C | IPR000340 | Dual specificity phosphatase, catalytic domain | Domain |
B [auth A], D [auth H] | IPR046342 | CBS domain superfamily | Homologous Superfamily |
B [auth A], D [auth H] | IPR044751 | Ion transporter-like, CBS domain | Domain |
B [auth A], D [auth H] | IPR045095 | Ancient conserved domain protein family | Family |
B [auth A], D [auth H] | IPR000644 | CBS domain | Domain |
B [auth A], D [auth H] | IPR002550 | CNNM, transmembrane domain | Domain |
B [auth A], D [auth H] | IPR014710 | RmlC-like jelly roll fold | Homologous Superfamily |