5LX9

CRYSTAL STRUCTURE OF HUMAN ADIPONECTIN RECEPTOR 2 IN COMPLEX WITH A C18 FREE FATTY ACID AT 2.4 ANGSTROM RESOLUTION

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations
Membrane Protein Annotation: PDBTM
Membrane Protein Annotation: MemProtMD
Membrane Protein Annotation: mpstruc

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
B [auth H]	d5lx9h1	All beta proteins	Immunoglobulin-like beta-sandwich	Immunoglobulin	automated matches	automated matches	HOUSE MOUSE (Mus musculus ) [TaxId: 10090 ],	SCOPe (2.08)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF03006	e5lx9A1	A: alpha bundles	X: Family A G protein-coupled receptor-like (From Topology)	H: Family A G protein-coupled receptor-like (From Topology)	T: Family A G protein-coupled receptor-like	F: PF03006	ECOD (1.6)
B [auth H]	PF07686	e5lx9H1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF07686	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
B [auth H]	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (utative)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF03006	Haemolysin-III related (HlyIII)	Haemolysin-III related	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	HUMAN ADIPONECTIN RECEPTOR 2	molecular transducer activity signaling receptor activity protein-hormone receptor activity adipokinetic hormone receptor activity protein binding binding adiponectin binding hormone binding cation binding ion binding metal ion binding small molecule binding identical protein binding	cellular response to stimulus response to organic substance regulation of cellular process response to stimulus signaling response to cytokine hormone-mediated signaling pathway cytokine-mediated signaling pathway cell communication cellular response to endogenous stimulus response to hormone cellular response to cytokine stimulus cellular response to organic substance signal transduction cellular response to stimulus response to organic substance regulation of cellular process response to stimulus signaling response to cytokine hormone-mediated signaling pathway cytokine-mediated signaling pathway cell communication cellular response to endogenous stimulus response to hormone cellular response to cytokine stimulus cellular response to organic substance signal transduction cellular response to hormone stimulus regulation of biological process cell surface receptor signaling pathway response to endogenous stimulus biological regulation adiponectin-activated signaling pathway cellular response to chemical stimulus response to chemical cellular process multicellular organismal process homeostatic process positive regulation of biological process adaptive thermogenesis positive regulation of metabolic process multicellular organismal-level homeostasis regulation of cold-induced thermogenesis cold-induced thermogenesis temperature homeostasis positive regulation of cold-induced thermogenesis positive regulation of multicellular organismal process metabolic process regulation of multicellular organismal process regulation of metabolic process fatty acid metabolic process oxoacid metabolic process cellular metabolic process carboxylic acid metabolic process lipid modification primary metabolic process organic acid metabolic process fatty acid oxidation organic substance metabolic process cellular lipid metabolic process small molecule metabolic process lipid oxidation monocarboxylic acid metabolic process lipid metabolic process developmental process wound healing blood vessel morphogenesis tube development angiogenesis involved in wound healing angiogenesis vasculature development circulatory system development multicellular organism development anatomical structure morphogenesis tube morphogenesis vascular wound healing response to stress anatomical structure development anatomical structure formation involved in morphogenesis response to wounding blood vessel development system development chemical homeostasis glucose homeostasis carbohydrate homeostasis	cell periphery plasma membrane membrane cellular anatomical entity
B [auth H]	single-chain variable fragment	-	-	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR004254	AdipoR/Haemolysin-III-related	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: Q86V24	female infertility DOID:0081062 malignant mesothelioma spina bifida Down syndrome obesity disorder ductal breast carcinoma in situ inborn carbohydrate metabolic disorder ovarian cancer type 2 diabetes mellitus

Membrane Protein Annotation: PDBTM PDBTM Database Homepage

Chains	External Link	Comment
A	PDBTM	Annotated as membrane protein by PDBTM

Membrane Protein Annotation: MemProtMD MemProtMD Database Homepage

Chains	External Link	Comment
A	MemProtMD	Annotated as membrane protein by MemProtMD

Membrane Protein Annotation: mpstruc mpstruc Database Homepage

Chains	Resource Link	Group	Subgroup	Protein
A	mpstruc	TRANSMEMBRANE PROTEINS: ALPHA-HELICAL	Adiponectin Receptors	AdipoR1 adiponectin 1 receptor in complex with an Fv fragment

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.