5LTV

LIGAND BINDING DOMAIN OF PSEUDOMONAS AERUGINOSA PAO1 AMINO ACID CHEMORECPETOR PCTC IN COMPLEX WITH GABA

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d5ltva_	Alpha and beta proteins (a+b)	Profilin-like	Sensory domain-like	automated matches	automated matches	(Pseudomonas aeruginosa ) [TaxId: 287 ],	SCOPe (2.08)
B	d5ltvb_	Alpha and beta proteins (a+b)	Profilin-like	Sensory domain-like	automated matches	automated matches	(Pseudomonas aeruginosa ) [TaxId: 287 ],	SCOPe (2.08)
C	d5ltvc_	Alpha and beta proteins (a+b)	Profilin-like	Sensory domain-like	automated matches	automated matches	(Pseudomonas aeruginosa ) [TaxId: 287 ],	SCOPe (2.08)
D	d5ltvd_	Alpha and beta proteins (a+b)	Profilin-like	Sensory domain-like	automated matches	automated matches	(Pseudomonas aeruginosa ) [TaxId: 287 ],	SCOPe (2.08)
E	d5ltve_	Alpha and beta proteins (a+b)	Profilin-like	Sensory domain-like	automated matches	automated matches	(Pseudomonas aeruginosa ) [TaxId: 287 ],	SCOPe (2.08)
F	d5ltvf_	Alpha and beta proteins (a+b)	Profilin-like	Sensory domain-like	automated matches	automated matches	(Pseudomonas aeruginosa ) [TaxId: 287 ],	SCOPe (2.08)
G	d5ltvg_	Alpha and beta proteins (a+b)	Profilin-like	Sensory domain-like	automated matches	automated matches	(Pseudomonas aeruginosa ) [TaxId: 287 ],	SCOPe (2.08)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	F_UNCLASSIFIED	e5ltvA1	A: a+b three layers	X: Profilin-like	H: sensor domains (From Topology)	T: sensor domains	F: F_UNCLASSIFIED	ECOD (1.6)
A	PF02743	e5ltvA2	A: a+b three layers	X: Profilin-like	H: sensor domains (From Topology)	T: sensor domains	F: PF02743	ECOD (1.6)
B	F_UNCLASSIFIED	e5ltvB2	A: a+b three layers	X: Profilin-like	H: sensor domains (From Topology)	T: sensor domains	F: F_UNCLASSIFIED	ECOD (1.6)
B	PF02743	e5ltvB1	A: a+b three layers	X: Profilin-like	H: sensor domains (From Topology)	T: sensor domains	F: PF02743	ECOD (1.6)
C	F_UNCLASSIFIED	e5ltvC2	A: a+b three layers	X: Profilin-like	H: sensor domains (From Topology)	T: sensor domains	F: F_UNCLASSIFIED	ECOD (1.6)
C	PF02743	e5ltvC1	A: a+b three layers	X: Profilin-like	H: sensor domains (From Topology)	T: sensor domains	F: PF02743	ECOD (1.6)
D	F_UNCLASSIFIED	e5ltvD1	A: a+b three layers	X: Profilin-like	H: sensor domains (From Topology)	T: sensor domains	F: F_UNCLASSIFIED	ECOD (1.6)
D	PF02743	e5ltvD2	A: a+b three layers	X: Profilin-like	H: sensor domains (From Topology)	T: sensor domains	F: PF02743	ECOD (1.6)
E	F_UNCLASSIFIED	e5ltvE2	A: a+b three layers	X: Profilin-like	H: sensor domains (From Topology)	T: sensor domains	F: F_UNCLASSIFIED	ECOD (1.6)
E	PF02743	e5ltvE1	A: a+b three layers	X: Profilin-like	H: sensor domains (From Topology)	T: sensor domains	F: PF02743	ECOD (1.6)
F	F_UNCLASSIFIED	e5ltvF1	A: a+b three layers	X: Profilin-like	H: sensor domains (From Topology)	T: sensor domains	F: F_UNCLASSIFIED	ECOD (1.6)
F	PF02743	e5ltvF2	A: a+b three layers	X: Profilin-like	H: sensor domains (From Topology)	T: sensor domains	F: PF02743	ECOD (1.6)
G	F_UNCLASSIFIED	e5ltvG1	A: a+b three layers	X: Profilin-like	H: sensor domains (From Topology)	T: sensor domains	F: F_UNCLASSIFIED	ECOD (1.6)
G	PF02743	e5ltvG2	A: a+b three layers	X: Profilin-like	H: sensor domains (From Topology)	T: sensor domains	F: PF02743	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D, E A, B, C, D, E, F, G	PF02743	Cache domain (dCache_1)	Cache domain	Double cache domain 1 covers the last three strands from the membrane distal PAS-like domain, the first two strands of the membrane proximal domain, and the connecting elements between the two domains [2]. This domain when present in chemoreceptor ...	Double cache domain 1 covers the last three strands from the membrane distal PAS-like domain, the first two strands of the membrane proximal domain, and the connecting elements between the two domains [2]. This domain when present in chemoreceptors recognise several signals such as proteinogenic amino acids, GABA, Histamine and polyamines, decanoic acid, Autoinducer-2, purine derivatives, quaternary amines, citrate and taurine, among others. When associated with histidine kinases, it recognises C3/C4-dicarboxylic acids, Spermine, guanosine and Autoinducer-2 (Mantilla et al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1 https://doi.org/10.1093/femsre/fuab043).	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D, E A, B, C, D, E, F, G	Chemotactic transducer PctC	binding amino acid binding	response to acid chemical response to organic substance response to stimulus response to chemical response to amino acid chemotaxis taxis response to external stimulus locomotion cellular response to stimulus regulation of biological process regulation of cellular process signaling biological regulation response to acid chemical response to organic substance response to stimulus response to chemical response to amino acid chemotaxis taxis response to external stimulus locomotion cellular response to stimulus regulation of biological process regulation of cellular process signaling biological regulation cellular process signal transduction cell communication	cell periphery plasma membrane membrane cellular anatomical entity

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D, E A, B, C, D, E, F, G	IPR000727	Target SNARE coiled-coil homology domain	Domain
A, B, C, D, E A, B, C, D, E, F, G	IPR033479	Double Cache domain 1	Domain
A, B, C, D, E A, B, C, D, E, F, G	IPR003660	HAMP domain	Domain
A, B, C, D, E A, B, C, D, E, F, G	IPR029151	Periplasmic sensor-like domain superfamily	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F, G	IPR004089	Methyl-accepting chemotaxis protein (MCP) signalling domain	Domain

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.