5LPV

Crystal structure of the BRI1 kinase domain (865-1160) in complex with AMPPNP and Mn from Arabidopsis thaliana

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Protein Modification Annotation

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d5lpva_	Alpha and beta proteins (a+b)	Protein kinase-like (PK-like)	Protein kinase-like (PK-like)	automated matches	automated matches	Mouse-ear cress (Arabidopsis thaliana ) [TaxId: 3702 ],	SCOPe (2.08)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Pkinase_Tyr	e5lpvA1	A: a+b complex topology	X: Protein kinase/SAICAR synthase/ATP-grasp (From Homology)	H: Protein kinase/SAICAR synthase/ATP-grasp	T: Protein kinase	F: Pkinase_Tyr	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.10.510.10	Mainly Alpha	Orthogonal Bundle	Transferase(Phosphotransferase)	domain 1	CATH (utative)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF00069	Protein kinase domain (Pkinase)	Protein kinase domain	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Protein BRASSINOSTEROID INSENSITIVE 1	protein heterodimerization activity protein binding binding protein dimerization activity molecular transducer activity catalytic activity, acting on a protein kinase activity protein kinase activity signaling receptor activity transferase activity phosphotransferase activity, alcohol group as acceptor transferase activity, transferring phosphorus-containing groups protein tyrosine kinase activity transmembrane receptor protein tyrosine kinase activity protein heterodimerization activity protein binding binding protein dimerization activity molecular transducer activity catalytic activity, acting on a protein kinase activity protein kinase activity signaling receptor activity transferase activity phosphotransferase activity, alcohol group as acceptor transferase activity, transferring phosphorus-containing groups protein tyrosine kinase activity transmembrane receptor protein tyrosine kinase activity transmembrane receptor protein kinase activity transmembrane signaling receptor activity catalytic activity protein serine kinase activity adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding identical protein binding protein homodimerization activity protein serine/threonine kinase activity steroid binding lipid binding	chemical homeostasis homeostatic process brassinosteroid homeostasis lipid homeostasis cellular component organization microtubule bundle formation organelle organization microtubule cytoskeleton organization cellular process microtubule-based process cellular component organization or biogenesis cytoskeleton organization cellular response to stimulus response to organic substance chemical homeostasis homeostatic process brassinosteroid homeostasis lipid homeostasis cellular component organization microtubule bundle formation organelle organization microtubule cytoskeleton organization cellular process microtubule-based process cellular component organization or biogenesis cytoskeleton organization cellular response to stimulus response to organic substance regulation of cellular process response to stimulus response to lipid signaling hormone-mediated signaling pathway cell communication brassinosteroid mediated signaling pathway cellular response to endogenous stimulus response to hormone response to steroid hormone cellular response to organic substance signal transduction response to organic cyclic compound cellular response to steroid hormone stimulus cellular response to hormone stimulus regulation of biological process response to endogenous stimulus cellular response to brassinosteroid stimulus cellular response to organic cyclic compound biological regulation response to oxygen-containing compound cellular response to oxygen-containing compound cellular response to chemical stimulus steroid hormone mediated signaling pathway response to chemical response to brassinosteroid cellular response to lipid response to light stimulus response to radiation response to abiotic stimulus response to UV response to UV-B developmental process multicellular organismal process cellular component assembly involved in morphogenesis cellular component biogenesis anatomical structure morphogenesis multicellular organism development cellular anatomical entity morphogenesis cellular component assembly gametophyte development pollen wall assembly pollen exine formation anatomical structure formation involved in morphogenesis anatomical structure development pollen development external encapsulating structure organization cellular developmental process anther morphogenesis reproductive process stamen morphogenesis anther wall tapetum cell differentiation developmental process involved in reproduction floral organ formation reproductive shoot system development cell differentiation anther development reproductive structure development post-embryonic development phyllome development system development androecium development plant organ development anther wall tapetum morphogenesis reproductive system development floral whorl development stamen development flower development post-embryonic plant organ morphogenesis post-embryonic plant morphogenesis plant organ morphogenesis anther wall tapetum development anther wall tapetum formation stamen formation post-embryonic plant organ development shoot system development plant organ formation floral organ morphogenesis floral organ development regulation of developmental process regulation of reproductive process positive regulation of biological process positive regulation of developmental process regulation of multicellular organismal process regulation of flower development positive regulation of reproductive process positive regulation of flower development regulation of multicellular organismal development regulation of shoot system development regulation of post-embryonic development positive regulation of multicellular organismal process positive regulation of post-embryonic development response to light intensity response to absence of light skotomorphogenesis leaf development phosphorylation cellular metabolic process phosphate-containing compound metabolic process metabolic process phosphorus metabolic process detection of hormone stimulus detection of brassinosteroid stimulus detection of stimulus detection of chemical stimulus detection of endogenous stimulus seedling development	cell periphery plasma membrane membrane cellular anatomical entity protein-containing complex membrane-bounded organelle intracellular anatomical structure endosome intracellular vesicle intracellular membrane-bounded organelle endomembrane system intracellular organelle cytoplasmic vesicle organelle cell periphery plasma membrane membrane cellular anatomical entity protein-containing complex membrane-bounded organelle intracellular anatomical structure endosome intracellular vesicle intracellular membrane-bounded organelle endomembrane system intracellular organelle cytoplasmic vesicle organelle cytoplasm vesicle endosome membrane cytoplasmic vesicle membrane bounding membrane of organelle vesicle membrane organelle membrane

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR017441	Protein kinase, ATP binding site	Binding Site
A	IPR013210	Leucine-rich repeat-containing N-terminal, plant-type	Domain
A	IPR003591	Leucine-rich repeat, typical subtype	Repeat
A	IPR000719	Protein kinase domain	Domain
A	IPR045381	Brassinosteroid receptor BRI1, island domain	Domain
A	IPR001611	Leucine-rich repeat	Repeat
A	IPR011009	Protein kinase-like domain superfamily	Homologous Superfamily
A	IPR032675	Leucine-rich repeat domain superfamily	Homologous Superfamily
A	IPR008271	Serine/threonine-protein kinase, active site	Active Site

Protein Modification Annotation

Modified Residue(s)
Chain	Residue(s)	Description
A	SEP	Parent Component: SER RESID: AA0037 PSI-MOD : O-phospho-L-serine MOD:00046
A	TPO	Parent Component: THR RESID: AA0037 , AA0038 PSI-MOD : O-phospho-L-serine MOD:00046 , O-phospho-L-threonine MOD:00047

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.