5LOW

Structure of the Ca2+-bound Rabphilin 3A C2B domain SNAP25 complex (P21 space group)

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d5lowa_	All beta proteins	C2 domain-like	C2 domain (Calcium/lipid-binding domain, CaLB)	Synaptotagmin-like (S variant)	automated matches	Norway Rat (Rattus norvegicus ) [TaxId: 10116 ],	SCOPe (2.08)
B	d5lowb_	All beta proteins	C2 domain-like	C2 domain (Calcium/lipid-binding domain, CaLB)	Synaptotagmin-like (S variant)	automated matches	Norway Rat (Rattus norvegicus ) [TaxId: 10116 ],	SCOPe (2.08)
C	d5lowc_	All beta proteins	C2 domain-like	C2 domain (Calcium/lipid-binding domain, CaLB)	Synaptotagmin-like (S variant)	automated matches	Norway Rat (Rattus norvegicus ) [TaxId: 10116 ],	SCOPe (2.08)
H	d5lowh_	All beta proteins	C2 domain-like	C2 domain (Calcium/lipid-binding domain, CaLB)	Synaptotagmin-like (S variant)	automated matches	Norway Rat (Rattus norvegicus ) [TaxId: 10116 ],	SCOPe (2.08)
I	d5lowi_	All beta proteins	C2 domain-like	C2 domain (Calcium/lipid-binding domain, CaLB)	Synaptotagmin-like (S variant)	automated matches	Norway Rat (Rattus norvegicus ) [TaxId: 10116 ],	SCOPe (2.08)
J	d5lowj_	All beta proteins	C2 domain-like	C2 domain (Calcium/lipid-binding domain, CaLB)	Synaptotagmin-like (S variant)	automated matches	Norway Rat (Rattus norvegicus ) [TaxId: 10116 ],	SCOPe (2.08)
D	d5lowd1	Coiled coil proteins	Parallel coiled-coil	SNARE fusion complex	SNARE fusion complex	Synaptosomal-associated protein SNAP-25	Norway Rat (Rattus norvegicus ) [TaxId: 10116 ],	SCOPe (2.08)
D	d5lowd2	Artifacts	Tags	Tags	Tags	N-terminal Tags	Norway Rat (Rattus norvegicus ) [TaxId: 10116 ],	SCOPe (2.08)
F	d5lowf_	Coiled coil proteins	Parallel coiled-coil	SNARE fusion complex	SNARE fusion complex	Synaptosomal-associated protein SNAP-25	Norway Rat (Rattus norvegicus ) [TaxId: 10116 ],	SCOPe (2.08)
K	d5lowk1	Coiled coil proteins	Parallel coiled-coil	SNARE fusion complex	SNARE fusion complex	Synaptosomal-associated protein SNAP-25	Norway Rat (Rattus norvegicus ) [TaxId: 10116 ],	SCOPe (2.08)
K	d5lowk2	Artifacts	Tags	Tags	Tags	N-terminal Tags	Norway Rat (Rattus norvegicus ) [TaxId: 10116 ],	SCOPe (2.08)
M	d5lowm_	Coiled coil proteins	Parallel coiled-coil	SNARE fusion complex	SNARE fusion complex	Synaptosomal-associated protein SNAP-25	Norway Rat (Rattus norvegicus ) [TaxId: 10116 ],	SCOPe (2.08)
E	d5lowe_	Coiled coil proteins	Parallel coiled-coil	SNARE fusion complex	SNARE fusion complex	Synaptosomal-associated protein SNAP-25	Norway Rat (Rattus norvegicus ) [TaxId: 10116 ],	SCOPe (2.08)
G	d5lowg1	Coiled coil proteins	Parallel coiled-coil	SNARE fusion complex	SNARE fusion complex	Synaptosomal-associated protein SNAP-25	Norway Rat (Rattus norvegicus ) [TaxId: 10116 ],	SCOPe (2.08)
G	d5lowg2	Artifacts	Tags	Tags	Tags	N-terminal Tags	Norway Rat (Rattus norvegicus ) [TaxId: 10116 ],	SCOPe (2.08)
L	d5lowl_	Coiled coil proteins	Parallel coiled-coil	SNARE fusion complex	SNARE fusion complex	Synaptosomal-associated protein SNAP-25	Norway Rat (Rattus norvegicus ) [TaxId: 10116 ],	SCOPe (2.08)
N	d5lown1	Coiled coil proteins	Parallel coiled-coil	SNARE fusion complex	SNARE fusion complex	Synaptosomal-associated protein SNAP-25	Norway Rat (Rattus norvegicus ) [TaxId: 10116 ],	SCOPe (2.08)
N	d5lown2	Artifacts	Tags	Tags	Tags	N-terminal Tags	Norway Rat (Rattus norvegicus ) [TaxId: 10116 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	C2 domain (calcium/lipid-binding domain calb)	8039052	3000965	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	C2 domain (calcium/lipid-binding domain calb)	8039052	3000965	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	C2 domain (calcium/lipid-binding domain calb)	8039052	3000965	SCOP2B (2022-06-29)
H	SCOP2B Superfamily	C2 domain (calcium/lipid-binding domain calb)	8039052	3000965	SCOP2B (2022-06-29)
I	SCOP2B Superfamily	C2 domain (calcium/lipid-binding domain calb)	8039052	3000965	SCOP2B (2022-06-29)
J	SCOP2B Superfamily	C2 domain (calcium/lipid-binding domain calb)	8039052	3000965	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	SNARE fusion complex	8043667	3001549	SCOP2B (2022-06-29)
F	SCOP2B Superfamily	SNARE fusion complex	8043667	3001549	SCOP2B (2022-06-29)
K	SCOP2B Superfamily	SNARE fusion complex	8043667	3001549	SCOP2B (2022-06-29)
M	SCOP2B Superfamily	SNARE fusion complex	8043667	3001549	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF00168	e5lowA1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: C2 domain (From Topology)	T: C2 domain	F: PF00168	ECOD (1.6)
B	PF00168	e5lowB1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: C2 domain (From Topology)	T: C2 domain	F: PF00168	ECOD (1.6)
C	PF00168	e5lowC1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: C2 domain (From Topology)	T: C2 domain	F: PF00168	ECOD (1.6)
H	PF00168	e5lowH1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: C2 domain (From Topology)	T: C2 domain	F: PF00168	ECOD (1.6)
I	PF00168	e5lowI1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: C2 domain (From Topology)	T: C2 domain	F: PF00168	ECOD (1.6)
J	PF00168	e5lowJ1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: C2 domain (From Topology)	T: C2 domain	F: PF00168	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	2.60.40.150	Mainly Beta	Sandwich	Immunoglobulin-like	C2 domain	CATH (4.3.0)
B	2.60.40.150	Mainly Beta	Sandwich	Immunoglobulin-like	C2 domain	CATH (4.3.0)
C	2.60.40.150	Mainly Beta	Sandwich	Immunoglobulin-like	C2 domain	CATH (4.3.0)
H	2.60.40.150	Mainly Beta	Sandwich	Immunoglobulin-like	C2 domain	CATH (4.3.0)
I	2.60.40.150	Mainly Beta	Sandwich	Immunoglobulin-like	C2 domain	CATH (4.3.0)
J	2.60.40.150	Mainly Beta	Sandwich	Immunoglobulin-like	C2 domain	CATH (4.3.0)
F	1.20.5.110	Mainly Alpha	Up-down Bundle	Single alpha-helices involved in coiled-coils or other helix-helix interfaces		CATH (4.3.0)
E	1.20.5.110	Mainly Alpha	Up-down Bundle	Single alpha-helices involved in coiled-coils or other helix-helix interfaces		CATH (4.3.0)
G	1.20.5.110	Mainly Alpha	Up-down Bundle	Single alpha-helices involved in coiled-coils or other helix-helix interfaces		CATH (4.3.0)
L	1.20.5.110	Mainly Alpha	Up-down Bundle	Single alpha-helices involved in coiled-coils or other helix-helix interfaces		CATH (4.3.0)
N	1.20.5.110	Mainly Alpha	Up-down Bundle	Single alpha-helices involved in coiled-coils or other helix-helix interfaces		CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, H, I A, B, C, H, I, J	PF00168	C2 domain (C2)	C2 domain	-	Domain
E, G, L, N	PF00835	SNAP-25 family (SNAP-25)	SNAP-25 family	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, H, I A, B, C, H, I, J	Rabphilin-3A	small GTPase binding protein binding binding enzyme binding GTPase binding cation binding ion binding calcium ion binding metal ion binding small molecule binding phospholipid binding lipid binding phosphatidylinositol-4,5-bisphosphate binding anion binding small GTPase binding protein binding binding enzyme binding GTPase binding cation binding ion binding calcium ion binding metal ion binding small molecule binding phospholipid binding lipid binding phosphatidylinositol-4,5-bisphosphate binding anion binding phosphatidylinositol bisphosphate binding phosphatidylinositol phosphate binding phosphatidylinositol binding calcium-dependent phospholipid binding phosphate ion binding protein-containing complex binding transition metal ion binding zinc ion binding alcohol binding inositol 1,4,5 trisphosphate binding selenium binding	regulation of localization regulated exocytosis regulation of biological process regulation of cellular process regulation of calcium ion-dependent exocytosis transport secretion regulation of transport biological regulation export from cell regulation of vesicle-mediated transport establishment of localization vesicle-mediated transport regulation of secretion regulation of regulated secretory pathway regulation of localization regulated exocytosis regulation of biological process regulation of cellular process regulation of calcium ion-dependent exocytosis transport secretion regulation of transport biological regulation export from cell regulation of vesicle-mediated transport establishment of localization vesicle-mediated transport regulation of secretion regulation of regulated secretory pathway localization secretion by cell regulation of secretion by cell exocytosis regulation of exocytosis cellular process calcium-ion regulated exocytosis cellular response to stimulus response to stimulus signaling regulation of signaling receptor activity regulation of transmembrane transporter activity regulation of signal transduction cell communication regulation of transporter activity signal transduction regulation of NMDA receptor activity regulation of monoatomic ion transmembrane transporter activity regulation of signaling transmembrane transport regulation of molecular function regulation of transmembrane transport regulation of response to stimulus regulation of neurotransmitter receptor activity regulation of cell communication cellular localization synaptic signaling signal release establishment of localization in cell spontaneous synaptic transmission trans-synaptic signaling neurotransmitter secretion cell-cell signaling neurotransmitter transport spontaneous neurotransmitter secretion chemical synaptic transmission signal release from synapse anterograde trans-synaptic signaling protein localization establishment of protein localization nitrogen compound transport organic substance transport intracellular transport protein transport cellular macromolecule localization macromolecule localization intracellular protein transport cellular component organization cell junction organization dendritic spine organization postsynapse organization plasma membrane bounded cell projection organization cell projection organization neuron projection organization synapse organization cellular component organization or biogenesis synaptic vesicle priming synaptic vesicle cycle synaptic vesicle exocytosis vesicle-mediated transport in synapse cellular component biogenesis cellular component assembly protein-containing complex assembly protein-containing complex organization exocytic process	cell periphery postsynapse postsynaptic membrane synapse cell junction membrane plasma membrane plasma membrane region cellular anatomical entity synaptic membrane membrane-bounded organelle intracellular anatomical structure intracellular vesicle intracellular membrane-bounded organelle cell periphery postsynapse postsynaptic membrane synapse cell junction membrane plasma membrane plasma membrane region cellular anatomical entity synaptic membrane membrane-bounded organelle intracellular anatomical structure intracellular vesicle intracellular membrane-bounded organelle endomembrane system intracellular organelle cytoplasmic vesicle organelle secretory granule secretory vesicle cytoplasm vesicle extrinsic component of synaptic vesicle membrane transport vesicle membrane extrinsic component of organelle membrane presynapse bounding membrane of organelle vesicle membrane synaptic vesicle synaptic vesicle membrane transport vesicle exocytic vesicle membrane cytoplasmic vesicle membrane organelle membrane extrinsic component of membrane exocytic vesicle cholinergic synapse protein-containing complex cell projection neuron projection plasma membrane bounded cell projection neuromuscular junction neuron spine dendritic spine somatodendritic compartment dendrite dendritic tree
D, F, K, M	Synaptosomal-associated protein 25	SNAP receptor activity protein-macromolecule adaptor activity molecular adaptor activity monoatomic cation transmembrane transporter activity gated channel activity monoatomic ion channel activity potassium ion transmembrane transporter activity voltage-gated channel activity voltage-gated monoatomic ion channel activity potassium channel activity voltage-gated monoatomic cation channel activity monoatomic cation channel activity passive transmembrane transporter activity voltage-gated potassium channel activity SNAP receptor activity protein-macromolecule adaptor activity molecular adaptor activity monoatomic cation transmembrane transporter activity gated channel activity monoatomic ion channel activity potassium ion transmembrane transporter activity voltage-gated channel activity voltage-gated monoatomic ion channel activity potassium channel activity voltage-gated monoatomic cation channel activity monoatomic cation channel activity passive transmembrane transporter activity voltage-gated potassium channel activity inorganic molecular entity transmembrane transporter activity channel activity inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity transporter activity metal ion transmembrane transporter activity transmembrane transporter activity protein binding binding protein domain specific binding syntaxin-1 binding SNARE binding syntaxin binding transmembrane transporter binding lipid binding cytoskeletal protein binding myosin binding calcium-dependent protein binding	positive regulation of cell communication regulation of localization regulation of cellular process regulation of hormone secretion signaling transport positive regulation of biological process positive regulation of secretion by cell hormone secretion cell communication localization positive regulation of hormone secretion regulation of secretion by cell secretion by cell positive regulation of secretion positive regulation of cell communication regulation of localization regulation of cellular process regulation of hormone secretion signaling transport positive regulation of biological process positive regulation of secretion by cell hormone secretion cell communication localization positive regulation of hormone secretion regulation of secretion by cell secretion by cell positive regulation of secretion signal release regulation of biological quality positive regulation of cellular process regulation of signaling regulation of biological process regulation of transport secretion regulation of hormone levels biological regulation export from cell cell-cell signaling establishment of localization regulation of secretion positive regulation of transport regulation of cell communication hormone transport cellular process positive regulation of signaling protein localization establishment of protein localization cellular localization regulation of protein localization regulation of establishment of protein localization regulation of cellular localization cellular macromolecule localization macromolecule localization membrane organization protein-containing complex organization membrane fusion organelle membrane fusion vesicle-mediated transport cellular component organization cellular component biogenesis vesicle organization organelle fusion organelle organization cellular component assembly protein-containing complex assembly SNARE complex assembly cellular component organization or biogenesis vesicle fusion multicellular organismal process axonogenesis cellular developmental process cell projection organization plasma membrane bounded cell projection morphogenesis cell development neuron projection development cell morphogenesis neurogenesis multicellular organism development cell projection morphogenesis neuron differentiation neuron projection morphogenesis cell differentiation anatomical structure development system development developmental process plasma membrane bounded cell projection organization nervous system development axon development cell morphogenesis involved in neuron differentiation generation of neurons anatomical structure morphogenesis neuron development establishment of localization in cell intracellular transport endosomal transport regulated exocytosis synaptic vesicle cycle synaptic vesicle exocytosis vesicle-mediated transport in synapse synaptic signaling calcium-ion regulated exocytosis calcium ion-regulated exocytosis of neurotransmitter trans-synaptic signaling neurotransmitter secretion neurotransmitter transport chemical synaptic transmission signal release from synapse exocytosis anterograde trans-synaptic signaling regulation of cellular component organization cell junction assembly regulation of synapse structure or activity regulation of synapse assembly synapse organization regulation of cellular component biogenesis regulation of cell junction assembly regulation of synapse organization cell junction organization synapse assembly establishment of organelle localization dense core granule localization organelle localization presynaptic dense core vesicle exocytosis secretory granule localization vesicle localization establishment of vesicle localization neuronal dense core vesicle exocytosis dense core granule exocytosis synaptic vesicle priming exocytic process behavior locomotory behavior system process learning or memory long-term memory nervous system process cognition memory learning associative learning import into cell receptor internalization protein-containing complex localization neurotransmitter receptor internalization receptor-mediated endocytosis endocytosis endomembrane system organization vesicle fusion to plasma membrane synaptic vesicle fusion to presynaptic active zone membrane synaptic vesicle membrane organization nitrogen compound transport positive regulation of establishment of protein localization positive regulation of insulin secretion regulation of peptide hormone secretion organic substance transport positive regulation of peptide hormone secretion establishment of protein localization to extracellular region protein secretion regulation of protein secretion positive regulation of protein localization regulation of peptide secretion protein localization to extracellular region positive regulation of protein transport peptide secretion amide transport positive regulation of peptide secretion regulation of peptide transport regulation of protein transport positive regulation of protein secretion peptide transport protein transport regulation of insulin secretion peptide hormone secretion insulin secretion protein localization to synapse neurotransmitter receptor transport to postsynaptic membrane establishment of protein localization to postsynaptic membrane neurotransmitter receptor transport to plasma membrane protein localization to cell periphery protein localization to postsynaptic membrane neurotransmitter receptor transport establishment of protein localization to membrane localization within membrane protein localization to membrane exocytic insertion of neurotransmitter receptor to postsynaptic membrane vesicle-mediated transport to the plasma membrane regulation of postsynaptic membrane neurotransmitter receptor levels protein localization to postsynapse protein localization to cell junction receptor localization to synapse regulation of neuron projection development regulation of cell projection organization regulation of plasma membrane bounded cell projection organization modulation of chemical synaptic transmission long-term synaptic potentiation regulation of synaptic plasticity positive regulation of synaptic transmission regulation of trans-synaptic signaling	cell projection cell leading edge cellular anatomical entity plasma membrane bounded cell projection lamellipodium membrane photoreceptor inner segment intracellular organelle intracellular anatomical structure cytoskeleton organelle intracellular non-membrane-bounded organelle actin cytoskeleton non-membrane-bounded organelle cell projection cell leading edge cellular anatomical entity plasma membrane bounded cell projection lamellipodium membrane photoreceptor inner segment intracellular organelle intracellular anatomical structure cytoskeleton organelle intracellular non-membrane-bounded organelle actin cytoskeleton non-membrane-bounded organelle cell periphery presynapse synapse cell junction plasma membrane presynaptic membrane plasma membrane region synaptic membrane cytoplasm glutamatergic synapse neuron projection membrane-bounded organelle Golgi apparatus subcompartment Golgi apparatus organelle subcompartment intracellular membrane-bounded organelle endomembrane system trans-Golgi network SNARE complex protein-containing complex synaptobrevin 2-SNAP-25-syntaxin-1a complex membrane protein complex synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex perinuclear region of cytoplasm somatodendritic compartment cell body neuronal cell body axon synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex postsynapse transport vesicle intracellular vesicle cytoplasmic vesicle synaptic vesicle secretory vesicle vesicle exocytic vesicle actin-based cell projection filopodium growth cone distal axon axonal growth cone site of polarized growth cell cortex axon terminus terminal bouton neuron projection terminus ribbon synapse voltage-gated potassium channel complex plasma membrane protein complex potassium channel complex cation channel complex transporter complex transmembrane transporter complex monoatomic ion channel complex presynaptic active zone membrane presynaptic active zone endosome extrinsic component of plasma membrane extrinsic component of synaptic membrane extrinsic component of presynaptic membrane extrinsic component of membrane BLOC complex intracellular protein-containing complex BLOC-1 complex
E, G, L, N	Synaptosomal-associated protein 25	SNAP receptor activity protein-macromolecule adaptor activity molecular adaptor activity monoatomic cation transmembrane transporter activity gated channel activity monoatomic ion channel activity potassium ion transmembrane transporter activity voltage-gated channel activity voltage-gated monoatomic ion channel activity potassium channel activity voltage-gated monoatomic cation channel activity monoatomic cation channel activity passive transmembrane transporter activity voltage-gated potassium channel activity SNAP receptor activity protein-macromolecule adaptor activity molecular adaptor activity monoatomic cation transmembrane transporter activity gated channel activity monoatomic ion channel activity potassium ion transmembrane transporter activity voltage-gated channel activity voltage-gated monoatomic ion channel activity potassium channel activity voltage-gated monoatomic cation channel activity monoatomic cation channel activity passive transmembrane transporter activity voltage-gated potassium channel activity inorganic molecular entity transmembrane transporter activity channel activity inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity transporter activity metal ion transmembrane transporter activity transmembrane transporter activity protein binding binding protein domain specific binding syntaxin-1 binding SNARE binding syntaxin binding transmembrane transporter binding lipid binding cytoskeletal protein binding myosin binding calcium-dependent protein binding	positive regulation of cell communication regulation of localization regulation of cellular process regulation of hormone secretion signaling transport positive regulation of biological process positive regulation of secretion by cell hormone secretion cell communication localization positive regulation of hormone secretion regulation of secretion by cell secretion by cell positive regulation of secretion positive regulation of cell communication regulation of localization regulation of cellular process regulation of hormone secretion signaling transport positive regulation of biological process positive regulation of secretion by cell hormone secretion cell communication localization positive regulation of hormone secretion regulation of secretion by cell secretion by cell positive regulation of secretion signal release regulation of biological quality positive regulation of cellular process regulation of signaling regulation of biological process regulation of transport secretion regulation of hormone levels biological regulation export from cell cell-cell signaling establishment of localization regulation of secretion positive regulation of transport regulation of cell communication hormone transport cellular process positive regulation of signaling protein localization establishment of protein localization cellular localization regulation of protein localization regulation of establishment of protein localization regulation of cellular localization cellular macromolecule localization macromolecule localization membrane organization protein-containing complex organization membrane fusion organelle membrane fusion vesicle-mediated transport cellular component organization cellular component biogenesis vesicle organization organelle fusion organelle organization cellular component assembly protein-containing complex assembly SNARE complex assembly cellular component organization or biogenesis vesicle fusion multicellular organismal process axonogenesis cellular developmental process cell projection organization plasma membrane bounded cell projection morphogenesis cell development neuron projection development cell morphogenesis neurogenesis multicellular organism development cell projection morphogenesis neuron differentiation neuron projection morphogenesis cell differentiation anatomical structure development system development developmental process plasma membrane bounded cell projection organization nervous system development axon development cell morphogenesis involved in neuron differentiation generation of neurons anatomical structure morphogenesis neuron development establishment of localization in cell intracellular transport endosomal transport regulated exocytosis synaptic vesicle cycle synaptic vesicle exocytosis vesicle-mediated transport in synapse synaptic signaling calcium-ion regulated exocytosis calcium ion-regulated exocytosis of neurotransmitter trans-synaptic signaling neurotransmitter secretion neurotransmitter transport chemical synaptic transmission signal release from synapse exocytosis anterograde trans-synaptic signaling regulation of cellular component organization cell junction assembly regulation of synapse structure or activity regulation of synapse assembly synapse organization regulation of cellular component biogenesis regulation of cell junction assembly regulation of synapse organization cell junction organization synapse assembly establishment of organelle localization dense core granule localization organelle localization presynaptic dense core vesicle exocytosis secretory granule localization vesicle localization establishment of vesicle localization neuronal dense core vesicle exocytosis dense core granule exocytosis synaptic vesicle priming exocytic process behavior locomotory behavior system process learning or memory long-term memory nervous system process cognition memory learning associative learning import into cell receptor internalization protein-containing complex localization neurotransmitter receptor internalization receptor-mediated endocytosis endocytosis endomembrane system organization vesicle fusion to plasma membrane synaptic vesicle fusion to presynaptic active zone membrane synaptic vesicle membrane organization nitrogen compound transport positive regulation of establishment of protein localization positive regulation of insulin secretion regulation of peptide hormone secretion organic substance transport positive regulation of peptide hormone secretion establishment of protein localization to extracellular region protein secretion regulation of protein secretion positive regulation of protein localization regulation of peptide secretion protein localization to extracellular region positive regulation of protein transport peptide secretion amide transport positive regulation of peptide secretion regulation of peptide transport regulation of protein transport positive regulation of protein secretion peptide transport protein transport regulation of insulin secretion peptide hormone secretion insulin secretion protein localization to synapse neurotransmitter receptor transport to postsynaptic membrane establishment of protein localization to postsynaptic membrane neurotransmitter receptor transport to plasma membrane protein localization to cell periphery protein localization to postsynaptic membrane neurotransmitter receptor transport establishment of protein localization to membrane localization within membrane protein localization to membrane exocytic insertion of neurotransmitter receptor to postsynaptic membrane vesicle-mediated transport to the plasma membrane regulation of postsynaptic membrane neurotransmitter receptor levels protein localization to postsynapse protein localization to cell junction receptor localization to synapse regulation of neuron projection development regulation of cell projection organization regulation of plasma membrane bounded cell projection organization modulation of chemical synaptic transmission long-term synaptic potentiation regulation of synaptic plasticity positive regulation of synaptic transmission regulation of trans-synaptic signaling	cell projection cell leading edge cellular anatomical entity plasma membrane bounded cell projection lamellipodium membrane photoreceptor inner segment intracellular organelle intracellular anatomical structure cytoskeleton organelle intracellular non-membrane-bounded organelle actin cytoskeleton non-membrane-bounded organelle cell projection cell leading edge cellular anatomical entity plasma membrane bounded cell projection lamellipodium membrane photoreceptor inner segment intracellular organelle intracellular anatomical structure cytoskeleton organelle intracellular non-membrane-bounded organelle actin cytoskeleton non-membrane-bounded organelle cell periphery presynapse synapse cell junction plasma membrane presynaptic membrane plasma membrane region synaptic membrane cytoplasm glutamatergic synapse neuron projection membrane-bounded organelle Golgi apparatus subcompartment Golgi apparatus organelle subcompartment intracellular membrane-bounded organelle endomembrane system trans-Golgi network SNARE complex protein-containing complex synaptobrevin 2-SNAP-25-syntaxin-1a complex membrane protein complex synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex perinuclear region of cytoplasm somatodendritic compartment cell body neuronal cell body axon synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex postsynapse transport vesicle intracellular vesicle cytoplasmic vesicle synaptic vesicle secretory vesicle vesicle exocytic vesicle actin-based cell projection filopodium growth cone distal axon axonal growth cone site of polarized growth cell cortex axon terminus terminal bouton neuron projection terminus ribbon synapse voltage-gated potassium channel complex plasma membrane protein complex potassium channel complex cation channel complex transporter complex transmembrane transporter complex monoatomic ion channel complex presynaptic active zone membrane presynaptic active zone endosome extrinsic component of plasma membrane extrinsic component of synaptic membrane extrinsic component of presynaptic membrane extrinsic component of membrane BLOC complex intracellular protein-containing complex BLOC-1 complex

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, H, I A, B, C, H, I, J	IPR017455	Zinc finger, FYVE-related	Domain
A, B, C, H, I A, B, C, H, I, J	IPR028698	Rabphilin-3A, FYVE domain	Domain
A, B, C, H, I A, B, C, H, I, J	IPR000008	C2 domain	Domain
A, B, C, H, I A, B, C, H, I, J	IPR010911	Rab-binding domain	Domain
A, B, C, H, I A, B, C, H, I, J	IPR011011	Zinc finger, FYVE/PHD-type	Homologous Superfamily
A, B, C, H, I A, B, C, H, I, J	IPR001565	Synaptotagmin	Domain
A, B, C, H, I A, B, C, H, I, J	IPR043566	Rabphilin/Doc2/Noc2	Family
A, B, C, H, I A, B, C, H, I, J	IPR047022	Rabphilin/Doc2, first C2 domain	Domain
A, B, C, H, I A, B, C, H, I, J	IPR013083	Zinc finger, RING/FYVE/PHD-type	Homologous Superfamily
A, B, C, H, I A, B, C, H, I, J	IPR035892	C2 domain superfamily	Homologous Superfamily
A, B, C, H, I A, B, C, H, I, J	IPR041282	FYVE-type zinc finger	Domain
D, F, K, M	IPR000727	Target SNARE coiled-coil homology domain	Domain
D, F, K, M	IPR039077	SNAP25, N-terminal SNARE motif, chordates	Domain
D, F, K, M	IPR000928	SNAP-25 domain	Domain
E, G, L, N	IPR000727	Target SNARE coiled-coil homology domain	Domain
E, G, L, N	IPR039077	SNAP25, N-terminal SNARE motif, chordates	Domain
E, G, L, N	IPR000928	SNAP-25 domain	Domain

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.