Annotations: 5LJ3

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
P [auth N]	d5lj3n1	Alpha and beta proteins (a+b)	Ferredoxin-like	RNA-binding domain, RBD, aka RNA recognition motif (RRM)	Canonical RBD	Pre-mRNA splicing factor Cwf5 / Ecm2 / Stl11, RRM domain	(Saccharomyces cerevisiae ) [TaxId: 4932 ],	SCOPe (2.08)
P [auth N]	d5lj3n2	Small proteins	Pre-mRNA splicing factor Cwf5-like	Pre-mRNA splicing factor Cwf5-like	Pre-mRNA splicing factor Cwf5-like	Pre-mRNA splicing factor Cwf5 / Ecm2 / Stl11, Zn-binding domain	(Saccharomyces cerevisiae ) [TaxId: 4932 ],	SCOPe (2.08)
S [auth R]	d5lj3r_	Peptides	Pre-mRNA splicing factor Cwc21 fragment	Pre-mRNA splicing factor Cwc21 fragment	Pre-mRNA splicing factor Cwc21 fragment	Pre-mRNA splicing factor Cwc21 fragment	(Saccharomyces cerevisiae ) [TaxId: 4932 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
M [auth K]	SCOP2B Superfamily	Pre-mRNA-processing protein 45-like	8092739	3002618	SCOP2B (2022-06-29)
JA [auth q]	SCOP2B Superfamily	Sm-like ribonucleoproteins	8043703	3000419	SCOP2B (2022-06-29)
Y [auth f]	SCOP2B Superfamily	Sm-like ribonucleoproteins	8043703	3000419	SCOP2B (2022-06-29)
O [auth M]	SCOP2B Superfamily	CCCH zinc finger-like	8051791	3001741	SCOP2B (2022-06-29)
O [auth M]	SCOP2B Superfamily	RNA-binding domain RBD	8051796	3000110	SCOP2B (2022-06-29)
EA [auth k]	SCOP2B Superfamily	Sm-like ribonucleoproteins	8077613	3000419	SCOP2B (2022-06-29)
V [auth b]	SCOP2B Superfamily	Sm-like ribonucleoproteins	8077613	3000419	SCOP2B (2022-06-29)
HA [auth n]	SCOP2B Superfamily	Sm-like ribonucleoproteins	8098694	3000419	SCOP2B (2022-06-29)
W [auth d]	SCOP2B Superfamily	Sm-like ribonucleoproteins	8098694	3000419	SCOP2B (2022-06-29)
KA [auth r]	SCOP2B Superfamily	Sm-like ribonucleoproteins	8098668	3000419	SCOP2B (2022-06-29)
Z [auth g]	SCOP2B Superfamily	Sm-like ribonucleoproteins	8098668	3000419	SCOP2B (2022-06-29)
BA [auth j]	SCOP2B Superfamily	Sm-like ribonucleoproteins	8063490	3000419	SCOP2B (2022-06-29)
GA [auth m]	SCOP2B Superfamily	Sm-like ribonucleoproteins	8063490	3000419	SCOP2B (2022-06-29)
DA [auth Y]	SCOP2 Family	Canonical RBD	8073744	4000236	SCOP2 (2022-06-29)
DA [auth Y]	SCOP2 Superfamily	RNA-binding domain RBD	8073745	3000110	SCOP2 (2022-06-29)
F [auth A]	SCOP2B Superfamily	Ribonuclease H-like	8040983	3000143	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
JA [auth q]	LSM	e5lj3q1	A: beta barrels	X: SH3	H: SH3	T: SH3	F: LSM	ECOD (1.6)
Y [auth f]	LSM	e5lj3f1	A: beta barrels	X: SH3	H: SH3	T: SH3	F: LSM	ECOD (1.6)
J [auth G]	Isy1	e5lj3G1	A: alpha bundles	X: Long alpha-hairpin	H: ISY1 N-terminal domain-like (From Topology)	T: ISY1 N-terminal domain-like	F: Isy1	ECOD (1.6)
K [auth H]	MIF4G	e5lj3H1	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: MIF4G	ECOD (1.6)
K [auth H]	MA3	e5lj3H2	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: MA3	ECOD (1.6)
L [auth J]	ANAPC4_WD40_9	e5lj3J1	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 7-bladed	F: ANAPC4_WD40_9	ECOD (1.6)
N [auth L]	G10	e5lj3L1	A: few secondary structure elements	X: Pre-mRNA-splicing factor BUD31 (From Topology)	H: Pre-mRNA-splicing factor BUD31 (From Topology)	T: Pre-mRNA-splicing factor BUD31	F: G10	ECOD (1.6)
O [auth M]	RRM_1_6	e5lj3M2	A: a+b two layers	X: Alpha-beta plaits	H: RNA-binding domain, RBD (From Topology)	T: RNA-binding domain, RBD	F: RRM_1_6	ECOD (1.6)
O [auth M]	Torus	e5lj3M1	A: few secondary structure elements	X: CCCH zinc finger	H: CCCH zinc finger (From Topology)	T: CCCH zinc finger	F: Torus	ECOD (1.6)
P [auth N]	RRM_1_7	e5lj3N1	A: a+b two layers	X: Alpha-beta plaits	H: RNA-binding domain, RBD (From Topology)	T: RNA-binding domain, RBD	F: RRM_1_7	ECOD (1.6)
P [auth N]	KOG0153	e5lj3N2	A: few secondary structure elements	X: RING/U-box-like	H: RING/U-box-like	T: FYVE/PHD zinc finger	F: KOG0153	ECOD (1.6)
Q [auth O]	Myb_DNA-binding_1	e5lj3O1	A: alpha arrays	X: HTH	H: HTH	T: tri-helical	F: Myb_DNA-binding_1	ECOD (1.6)
S [auth R]	cwf21	e5lj3R1	A: alpha duplicates or obligate multimers	X: cwf21 domain (From Topology)	H: cwf21 domain (From Topology)	T: cwf21 domain	F: cwf21	ECOD (1.6)
T [auth S]	TPR_15	e5lj3S1	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: TPR_15	ECOD (1.6)
U [auth T]	Suf	e5lj3T1	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: Suf	ECOD (1.6)
EA [auth k]	LSM	e5lj3k1	A: beta barrels	X: SH3	H: SH3	T: SH3	F: LSM	ECOD (1.6)
V [auth b]	LSM	e5lj3b1	A: beta barrels	X: SH3	H: SH3	T: SH3	F: LSM	ECOD (1.6)
HA [auth n]	LSM	e5lj3n1	A: beta barrels	X: SH3	H: SH3	T: SH3	F: LSM	ECOD (1.6)
W [auth d]	LSM	e5lj3d1	A: beta barrels	X: SH3	H: SH3	T: SH3	F: LSM	ECOD (1.6)
X [auth e]	LSM	e5lj3e1	A: beta barrels	X: SH3	H: SH3	T: SH3	F: LSM	ECOD (1.6)
IA [auth p]	LSM	e5lj3p1	A: beta barrels	X: SH3	H: SH3	T: SH3	F: LSM	ECOD (1.6)
KA [auth r]	LSM	e5lj3r1	A: beta barrels	X: SH3	H: SH3	T: SH3	F: LSM	ECOD (1.6)
Z [auth g]	LSM	e5lj3g1	A: beta barrels	X: SH3	H: SH3	T: SH3	F: LSM	ECOD (1.6)
AA [auth h]	LSM	e5lj3h1	A: beta barrels	X: SH3	H: SH3	T: SH3	F: LSM	ECOD (1.6)
FA [auth l]	LSM	e5lj3l1	A: beta barrels	X: SH3	H: SH3	T: SH3	F: LSM	ECOD (1.6)
BA [auth j]	LSM	e5lj3j1	A: beta barrels	X: SH3	H: SH3	T: SH3	F: LSM	ECOD (1.6)
GA [auth m]	LSM	e5lj3m1	A: beta barrels	X: SH3	H: SH3	T: SH3	F: LSM	ECOD (1.6)
CA [auth W]	LRR_9	e5lj3W1	A: beta duplicates or obligate multimers	X: Single-stranded right-handed beta-helix	H: Leucine-rich repeats (From Topology)	T: Leucine-rich repeats	F: LRR_9	ECOD (1.6)
DA [auth Y]	RRM_1_2	e5lj3Y1	A: a+b two layers	X: Alpha-beta plaits	H: RNA-binding domain, RBD (From Topology)	T: RNA-binding domain, RBD	F: RRM_1_2	ECOD (1.6)
F [auth A]	U5_2-snRNA_bdg	e5lj3A3	A: alpha bundles	X: helical bundle domain in reverse transcriptase-like polymerases (From Topology)	H: helical bundle domain in reverse transcriptase-like polymerases (From Topology)	T: helical bundle domain in reverse transcriptase-like polymerases	F: U5_2-snRNA_bdg	ECOD (1.6)
F [auth A]	PROCN_C,PROCN_N	e5lj3A1	A: alpha complex topology	X: Pre-mRNA-splicing factor 8 N-terminal domain (From Topology)	H: Pre-mRNA-splicing factor 8 N-terminal domain (From Topology)	T: Pre-mRNA-splicing factor 8 N-terminal domain	F: PROCN_C,PROCN_N	ECOD (1.6)
F [auth A]	RRM_4	e5lj3A2	A: a+b two layers	X: Alpha-beta plaits	H: Adenylyl and guanylyl cyclase catalytic domain-like	T: Adenylyl and guanylyl cyclase catalytic domain-like	F: RRM_4	ECOD (1.6)
F [auth A]	U6-snRNA_bdg	e5lj3A5	A: a/b three-layered sandwiches	X: Restriction endonuclease-like	H: Restriction endonuclease-like (From Topology)	T: Restriction endonuclease-like	F: U6-snRNA_bdg	ECOD (1.6)
F [auth A]	PRP8_domainIV	e5lj3A4	A: mixed a+b and a/b	X: Ribonuclease H-like	H: Ribonuclease H-like (From Topology)	T: Ribonuclease H-like	F: PRP8_domainIV	ECOD (1.6)
I [auth C]	GTP_EFTU_D2_2	e5lj3C5	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: Alanine racemase-C	F: GTP_EFTU_D2_2	ECOD (1.6)
I [auth C]	EFG_IV	e5lj3C2	A: a+b two layers	X: Ribosomal protein S5 domain 2-like (From Topology)	H: Ribosomal protein S5 domain 2-like (From Topology)	T: Ribosomal protein S5 domain 2-like	F: EFG_IV	ECOD (1.6)
I [auth C]	EFG_C	e5lj3C4	A: a+b two layers	X: Alpha-beta plaits	H: EF-G C-terminal domain-like (From Topology)	T: EF-G C-terminal domain-like	F: EFG_C	ECOD (1.6)
I [auth C]	EFG_II	e5lj3C3	A: a+b two layers	X: Alpha-beta plaits	H: EF-G C-terminal domain-like (From Topology)	T: EF-G C-terminal domain-like	F: EFG_II	ECOD (1.6)
I [auth C]	MnmE_helical_2nd	e5lj3C1	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: MnmE_helical_2nd	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
JA [auth q]	2.30.30.100	Mainly Beta	Roll	SH3 type barrels.		CATH (4.3.0)
Y [auth f]	2.30.30.100	Mainly Beta	Roll	SH3 type barrels.		CATH (4.3.0)
L [auth J]	2.130.10.10	Mainly Beta	7 Propeller	Methylamine Dehydrogenase	Chain H	CATH (4.3.0)
HA [auth n]	2.30.30.100	Mainly Beta	Roll	SH3 type barrels.		CATH (4.3.0)
W [auth d]	2.30.30.100	Mainly Beta	Roll	SH3 type barrels.		CATH (4.3.0)
X [auth e]	2.30.30.100	Mainly Beta	Roll	SH3 type barrels.		CATH (4.3.0)
IA [auth p]	2.30.30.100	Mainly Beta	Roll	SH3 type barrels.		CATH (4.3.0)
KA [auth r]	2.30.30.100	Mainly Beta	Roll	SH3 type barrels.		CATH (4.3.0)
Z [auth g]	2.30.30.100	Mainly Beta	Roll	SH3 type barrels.		CATH (4.3.0)
AA [auth h]	2.30.30.100	Mainly Beta	Roll	SH3 type barrels.		CATH (4.3.0)
FA [auth l]	2.30.30.100	Mainly Beta	Roll	SH3 type barrels.		CATH (4.3.0)
BA [auth j]	2.30.30.100	Mainly Beta	Roll	SH3 type barrels.		CATH (4.3.0)
GA [auth m]	2.30.30.100	Mainly Beta	Roll	SH3 type barrels.		CATH (4.3.0)
DA [auth Y]	3.30.70.330	Alpha Beta	2-Layer Sandwich	Alpha-Beta Plaits	RRM (RNA recognition motif) domain	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
JA [auth q], Y [auth f]	PF01423	LSM domain (LSM)	LSM domain	The LSM domain contains Sm proteins as well as other related LSM (Like Sm) proteins. The U1, U2, U4/U6, and U5 small nuclear ribonucleoprotein particles (snRNPs) involved in pre-mRNA splicing contain seven Sm proteins (B/B', D1, D2, D3, E, F and G) i ...	The LSM domain contains Sm proteins as well as other related LSM (Like Sm) proteins. The U1, U2, U4/U6, and U5 small nuclear ribonucleoprotein particles (snRNPs) involved in pre-mRNA splicing contain seven Sm proteins (B/B', D1, D2, D3, E, F and G) in common, which assemble around the Sm site present in four of the major spliceosomal small nuclear RNAs. The U6 snRNP binds to the LSM (Like Sm) proteins [3]. Sm proteins are also found in archaebacteria, which do not have any splicing apparatus suggesting a more general role for Sm proteins. All Sm proteins contain a common sequence motif in two segments, Sm1 and Sm2, separated by a short variable linker. This family also includes the bacterial Hfq (host factor Q) proteins. Hfq are also RNA-binding proteins, that form hexameric rings.	Domain
J [auth G]	PF06246	Isy1-like splicing family (Isy1)	Isy1-like splicing family	-	Family
L [auth J]	PF00400	WD domain, G-beta repeat (WD40)	WD domain, G-beta repeat	-	Repeat
N [auth L]	PF01125	Pre-mRNA-splicing factor BUD31 (BUD31)	Pre-mRNA-splicing factor BUD31	This entry includes Pre-mRNA-splicing factor BUD31, also known as G10 protein, and its homologues. BUD31 is involved in the pre-mRNA splicing process [1-3] and it is highly conserved in a wide range of eukaryotic species. Human BUD31 may play a role ...	This entry includes Pre-mRNA-splicing factor BUD31, also known as G10 protein, and its homologues. BUD31 is involved in the pre-mRNA splicing process [1-3] and it is highly conserved in a wide range of eukaryotic species. Human BUD31 may play a role as a regulator of androgen receptor (AR) transcriptional activity, probably increasing the AR transcriptional activity [4].	Domain
O [auth M]	PF16131	Torus domain (Torus)	Torus domain	This domain is found in pre-mRNA-splicing factor CWC2. It includes a CCCH-type zinc finger [1].	Domain
O [auth M]	PF00076	RNA recognition motif (RRM_1)	RNA recognition motif	The RRM motif (a.k.a. RRM, RBD, or RNP domain) is probably diagnostic of an RNA binding protein. RRMs are found in a variety of RNA binding proteins, including various hnRNP proteins, proteins implicated in regulation of alternative splicing, and pro ...	The RRM motif (a.k.a. RRM, RBD, or RNP domain) is probably diagnostic of an RNA binding protein. RRMs are found in a variety of RNA binding proteins, including various hnRNP proteins, proteins implicated in regulation of alternative splicing, and protein components of snRNPs. The motif also appears in a few single stranded DNA binding proteins. The RRM structure consists of four strands and two helices arranged in an alpha/beta sandwich, with a third helix present during RNA binding in some cases The C-terminal beta strand (4th strand) and final helix are hard to align and have been omitted in the SEED alignment The LA proteins (Swiss:P05455) have an N terminal rrm which is included in the seed. There is a second region towards the C terminus that has some features characteristic of a rrm but does not appear to have the important structural core of a rrm. The LA proteins (Swiss:P05455) are one of the main autoantigens in Systemic lupus erythematosus (SLE), an autoimmune disease.	Domain
P [auth N]	PF21369	STL11, N-terminal (STL11_N)	STL11, N-terminal	This entry represents the N-terminal domain of STL11 from yeast and its homologues [1-4], such as RBM22 from human. This domain comprises a zinc finger, FYVE/PHD type. Members of this entry are involved in pre-mRNA splicing.	Domain
Q [auth O]	PF00249	Myb-like DNA-binding domain (Myb_DNA-binding)	Myb-like DNA-binding domain	This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family [1].	Domain
R [auth P]	PF04889	Cwf15/Cwc15 cell cycle control protein (Cwf_Cwc_15)	Cwf15/Cwc15 cell cycle control protein	-	Family
S [auth R]	PF08312	cwf21 domain (cwf21)	cwf21 domain	The cwf21 family is involved in mRNA splicing. It has been isolated as a subcomplex of the splicosome in Schizosaccharomyces pombe [1]. The function of the cwf21 domain is to bind directly to the spliceosomal protein Prp8. Mutations in the cwf21 dom ...	The cwf21 family is involved in mRNA splicing. It has been isolated as a subcomplex of the splicosome in Schizosaccharomyces pombe [1]. The function of the cwf21 domain is to bind directly to the spliceosomal protein Prp8. Mutations in the cwf21 domain prevent Prp8 from binding [2]. The structure of this domain has recently been solved which shows this domain to be composed of two alpha helices.	Domain
T [auth S]	PF02184	HAT (Half-A-TPR) repeat (HAT)	HAT (Half-A-TPR) repeat	-	Repeat
EA [auth k], V [auth b]	PF01423	LSM domain (LSM)	LSM domain	The LSM domain contains Sm proteins as well as other related LSM (Like Sm) proteins. The U1, U2, U4/U6, and U5 small nuclear ribonucleoprotein particles (snRNPs) involved in pre-mRNA splicing contain seven Sm proteins (B/B', D1, D2, D3, E, F and G) i ...	The LSM domain contains Sm proteins as well as other related LSM (Like Sm) proteins. The U1, U2, U4/U6, and U5 small nuclear ribonucleoprotein particles (snRNPs) involved in pre-mRNA splicing contain seven Sm proteins (B/B', D1, D2, D3, E, F and G) in common, which assemble around the Sm site present in four of the major spliceosomal small nuclear RNAs. The U6 snRNP binds to the LSM (Like Sm) proteins [3]. Sm proteins are also found in archaebacteria, which do not have any splicing apparatus suggesting a more general role for Sm proteins. All Sm proteins contain a common sequence motif in two segments, Sm1 and Sm2, separated by a short variable linker. This family also includes the bacterial Hfq (host factor Q) proteins. Hfq are also RNA-binding proteins, that form hexameric rings.	Domain
HA [auth n], W [auth d]	PF01423	LSM domain (LSM)	LSM domain	The LSM domain contains Sm proteins as well as other related LSM (Like Sm) proteins. The U1, U2, U4/U6, and U5 small nuclear ribonucleoprotein particles (snRNPs) involved in pre-mRNA splicing contain seven Sm proteins (B/B', D1, D2, D3, E, F and G) i ...	The LSM domain contains Sm proteins as well as other related LSM (Like Sm) proteins. The U1, U2, U4/U6, and U5 small nuclear ribonucleoprotein particles (snRNPs) involved in pre-mRNA splicing contain seven Sm proteins (B/B', D1, D2, D3, E, F and G) in common, which assemble around the Sm site present in four of the major spliceosomal small nuclear RNAs. The U6 snRNP binds to the LSM (Like Sm) proteins [3]. Sm proteins are also found in archaebacteria, which do not have any splicing apparatus suggesting a more general role for Sm proteins. All Sm proteins contain a common sequence motif in two segments, Sm1 and Sm2, separated by a short variable linker. This family also includes the bacterial Hfq (host factor Q) proteins. Hfq are also RNA-binding proteins, that form hexameric rings.	Domain
IA [auth p], X [auth e]	PF01423	LSM domain (LSM)	LSM domain	The LSM domain contains Sm proteins as well as other related LSM (Like Sm) proteins. The U1, U2, U4/U6, and U5 small nuclear ribonucleoprotein particles (snRNPs) involved in pre-mRNA splicing contain seven Sm proteins (B/B', D1, D2, D3, E, F and G) i ...	The LSM domain contains Sm proteins as well as other related LSM (Like Sm) proteins. The U1, U2, U4/U6, and U5 small nuclear ribonucleoprotein particles (snRNPs) involved in pre-mRNA splicing contain seven Sm proteins (B/B', D1, D2, D3, E, F and G) in common, which assemble around the Sm site present in four of the major spliceosomal small nuclear RNAs. The U6 snRNP binds to the LSM (Like Sm) proteins [3]. Sm proteins are also found in archaebacteria, which do not have any splicing apparatus suggesting a more general role for Sm proteins. All Sm proteins contain a common sequence motif in two segments, Sm1 and Sm2, separated by a short variable linker. This family also includes the bacterial Hfq (host factor Q) proteins. Hfq are also RNA-binding proteins, that form hexameric rings.	Domain
KA [auth r], Z [auth g]	PF01423	LSM domain (LSM)	LSM domain	The LSM domain contains Sm proteins as well as other related LSM (Like Sm) proteins. The U1, U2, U4/U6, and U5 small nuclear ribonucleoprotein particles (snRNPs) involved in pre-mRNA splicing contain seven Sm proteins (B/B', D1, D2, D3, E, F and G) i ...	The LSM domain contains Sm proteins as well as other related LSM (Like Sm) proteins. The U1, U2, U4/U6, and U5 small nuclear ribonucleoprotein particles (snRNPs) involved in pre-mRNA splicing contain seven Sm proteins (B/B', D1, D2, D3, E, F and G) in common, which assemble around the Sm site present in four of the major spliceosomal small nuclear RNAs. The U6 snRNP binds to the LSM (Like Sm) proteins [3]. Sm proteins are also found in archaebacteria, which do not have any splicing apparatus suggesting a more general role for Sm proteins. All Sm proteins contain a common sequence motif in two segments, Sm1 and Sm2, separated by a short variable linker. This family also includes the bacterial Hfq (host factor Q) proteins. Hfq are also RNA-binding proteins, that form hexameric rings.	Domain
AA [auth h], FA [auth l]	PF01423	LSM domain (LSM)	LSM domain	The LSM domain contains Sm proteins as well as other related LSM (Like Sm) proteins. The U1, U2, U4/U6, and U5 small nuclear ribonucleoprotein particles (snRNPs) involved in pre-mRNA splicing contain seven Sm proteins (B/B', D1, D2, D3, E, F and G) i ...	The LSM domain contains Sm proteins as well as other related LSM (Like Sm) proteins. The U1, U2, U4/U6, and U5 small nuclear ribonucleoprotein particles (snRNPs) involved in pre-mRNA splicing contain seven Sm proteins (B/B', D1, D2, D3, E, F and G) in common, which assemble around the Sm site present in four of the major spliceosomal small nuclear RNAs. The U6 snRNP binds to the LSM (Like Sm) proteins [3]. Sm proteins are also found in archaebacteria, which do not have any splicing apparatus suggesting a more general role for Sm proteins. All Sm proteins contain a common sequence motif in two segments, Sm1 and Sm2, separated by a short variable linker. This family also includes the bacterial Hfq (host factor Q) proteins. Hfq are also RNA-binding proteins, that form hexameric rings.	Domain
BA [auth j], GA [auth m]	PF01423	LSM domain (LSM)	LSM domain	The LSM domain contains Sm proteins as well as other related LSM (Like Sm) proteins. The U1, U2, U4/U6, and U5 small nuclear ribonucleoprotein particles (snRNPs) involved in pre-mRNA splicing contain seven Sm proteins (B/B', D1, D2, D3, E, F and G) i ...	The LSM domain contains Sm proteins as well as other related LSM (Like Sm) proteins. The U1, U2, U4/U6, and U5 small nuclear ribonucleoprotein particles (snRNPs) involved in pre-mRNA splicing contain seven Sm proteins (B/B', D1, D2, D3, E, F and G) in common, which assemble around the Sm site present in four of the major spliceosomal small nuclear RNAs. The U6 snRNP binds to the LSM (Like Sm) proteins [3]. Sm proteins are also found in archaebacteria, which do not have any splicing apparatus suggesting a more general role for Sm proteins. All Sm proteins contain a common sequence motif in two segments, Sm1 and Sm2, separated by a short variable linker. This family also includes the bacterial Hfq (host factor Q) proteins. Hfq are also RNA-binding proteins, that form hexameric rings.	Domain
CA [auth W]	PF14580	Leucine-rich repeat (LRR_9)	Leucine-rich repeat	-	Repeat
DA [auth Y]	PF13893	RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) (RRM_5)	RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)	The RRM motif is probably diagnostic of an RNA binding protein. RRMs are found in a variety of RNA binding proteins, including various hnRNP proteins, proteins implicated in regulation of alternative splicing, and protein components of snRNPs. The mo ...	The RRM motif is probably diagnostic of an RNA binding protein. RRMs are found in a variety of RNA binding proteins, including various hnRNP proteins, proteins implicated in regulation of alternative splicing, and protein components of snRNPs. The motif also appears in a few single stranded DNA binding proteins.	Domain
F [auth A]	PF10597	U5-snRNA binding site 2 of PrP8 (U5_2-snRNA_bdg)	U5-snRNA binding site 2 of PrP8	The essential spliceosomal protein Prp8 interacts with U5 and U6 snRNAs and with specific pre-mRNA sequences that participate in catalysis [1]. This close association with crucial RNA sequences, together with extensive genetic evidence, suggests that ...	The essential spliceosomal protein Prp8 interacts with U5 and U6 snRNAs and with specific pre-mRNA sequences that participate in catalysis [1]. This close association with crucial RNA sequences, together with extensive genetic evidence, suggests that Prp8 could directly affect the function of the catalytic core, perhaps acting as a splicing cofactor [2].	Domain
F [auth A]	PF10598	RNA recognition motif of the spliceosomal PrP8 (RRM_4)	RNA recognition motif of the spliceosomal PrP8	The large RNA-protein complex of the spliceosome catalyses pre-mRNA splicing. One of the most conserved core proteins is PrP8 which occupies a central position in the catalytic core of the spliceosome, and has been implicated in several crucial molec ...	The large RNA-protein complex of the spliceosome catalyses pre-mRNA splicing. One of the most conserved core proteins is PrP8 which occupies a central position in the catalytic core of the spliceosome, and has been implicated in several crucial molecular rearrangements that occur there, and has recently come under the spotlight for its role in the inherited human disease, Retinitis Pigmentosa [1]. The RNA-recognition motif of PrP8 is highly conserved and provides a possible RNA binding centre for the 5-prime SS, BP, or 3-prime SS of pre-mRNA which are known to contact with Prp8. The most conserved regions of an RRM are defined as the RNP1 and RNP2 sequences. Recognition of RNA targets can also be modulated by a number of other factors, most notably the two loops beta1-alpha1, beta2-beta3 and the amino acid residues C-terminal to the RNP2 domain [2].	Domain
F [auth A]	PF10596	U6-snRNA interacting domain of PrP8 (U6-snRNA_bdg)	U6-snRNA interacting domain of PrP8	This domain incorporates the interacting site for the U6-snRNA as part of the U4/U6.U5 tri-snRNPs complex of the spliceosome, and is the prime candidate for the role of cofactor for the spliceosome's RNA core. The essential spliceosomal protein Prp8 ...	This domain incorporates the interacting site for the U6-snRNA as part of the U4/U6.U5 tri-snRNPs complex of the spliceosome, and is the prime candidate for the role of cofactor for the spliceosome's RNA core. The essential spliceosomal protein Prp8 interacts with U5 and U6 snRNAs and with specific pre-mRNA sequences that participate in catalysis. This close association with crucial RNA sequences, together with extensive genetic evidence, suggests that Prp8 could directly affect the function of the catalytic core, perhaps acting as a splicing cofactor [1].	Domain
F [auth A]	PF08082	PRO8NT (NUC069), PrP8 N-terminal domain (PRO8NT)	PRO8NT (NUC069), PrP8 N-terminal domain	The PRO8NT domain is found at the N-terminus of pre-mRNA splicing factors of PRO8 family [1]. The NLS or nuclear localisation signal for these spliceosome proteins begins at the start and runs for 60 residues. N-terminal to this domain is a highly va ...	The PRO8NT domain is found at the N-terminus of pre-mRNA splicing factors of PRO8 family [1]. The NLS or nuclear localisation signal for these spliceosome proteins begins at the start and runs for 60 residues. N-terminal to this domain is a highly variable proline-rich region [4].	Domain
F [auth A]	PF08083	PROCN (NUC071) domain (PROCN)	PROCN (NUC071) domain	The PROCN domain is the central domain in pre-mRNA splicing factors of PRO8 family [1].	Domain
G [auth D]	PF04502	Saf4/Yju2 protein (Saf4_Yju2)	Saf4/Yju2 protein	-	Family
H [auth F]	PF10197	N-terminal domain of CBF1 interacting co-repressor CIR (Cir_N)	N-terminal domain of CBF1 interacting co-repressor CIR	This is a 45 residue conserved region at the N-terminal end of a family of proteins referred to as CIRs (CBF1-interacting co-repressors). CBF1 (centromere-binding factor 1) acts as a transcription factor that causes repression by binding specifically ...	This is a 45 residue conserved region at the N-terminal end of a family of proteins referred to as CIRs (CBF1-interacting co-repressors). CBF1 (centromere-binding factor 1) acts as a transcription factor that causes repression by binding specifically to GTGGGAA motifs in responsive promoters, and it requires CIR as a co-repressor. CIR binds to histone deacetylase and to SAP30 and serves as a linker between CBF1 and the histone deacetylase complex [1].	Domain
I [auth C]	PF00679	Elongation factor G C-terminus (EFG_C)	Elongation factor G C-terminus	This domain includes the carboxyl terminal regions of Elongation factor G, elongation factor 2 and some tetracycline resistance proteins and adopt a ferredoxin-like fold.	Domain
I [auth C]	PF00009	Elongation factor Tu GTP binding domain (GTP_EFTU)	Elongation factor Tu GTP binding domain	This domain contains a P-loop motif, also found in several other families such as Pfam:PF00071, Pfam:PF00025 and Pfam:PF00063. Elongation factor Tu consists of three structural domains, this plus two C-terminal beta barrel domains.	Domain
I [auth C]	PF16004	116 kDa U5 small nuclear ribonucleoprotein component N-terminus (EFTUD2)	116 kDa U5 small nuclear ribonucleoprotein component N-terminus	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
M [auth K]	Pre-mRNA-processing protein 45	-	ribonucleoprotein complex biogenesis cellular biosynthetic process RNA metabolic process mRNA processing protein-RNA complex assembly cellular component organization cellular component biogenesis nucleobase-containing compound metabolic process protein-RNA complex organization cellular component assembly organic substance metabolic process protein-containing complex assembly organic substance biosynthetic process cellular component organization or biogenesis ribonucleoprotein complex biogenesis cellular biosynthetic process RNA metabolic process mRNA processing protein-RNA complex assembly cellular component organization cellular component biogenesis nucleobase-containing compound metabolic process protein-RNA complex organization cellular component assembly organic substance metabolic process protein-containing complex assembly organic substance biosynthetic process cellular component organization or biogenesis RNA processing generation of catalytic spliceosome for second transesterification step RNA splicing protein-containing complex organization cellular metabolic process spliceosomal conformational changes to generate catalytic conformation primary metabolic process gene expression mRNA metabolic process macromolecule biosynthetic process nucleic acid metabolic process organic cyclic compound metabolic process biosynthetic process RNA splicing, via transesterification reactions mRNA splicing, via spliceosome cellular process metabolic process RNA splicing, via transesterification reactions with bulged adenosine as nucleophile macromolecule metabolic process	membrane-bounded organelle U2-type spliceosomal complex protein-containing complex intracellular anatomical structure catalytic complex nucleus nuclear protein-containing complex U2-type catalytic step 1 spliceosome intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle spliceosomal complex organelle ribonucleoprotein complex membrane-bounded organelle U2-type spliceosomal complex protein-containing complex intracellular anatomical structure catalytic complex nucleus nuclear protein-containing complex U2-type catalytic step 1 spliceosome intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle spliceosomal complex organelle ribonucleoprotein complex catalytic step 1 spliceosome post-mRNA release spliceosomal complex catalytic step 2 spliceosome U2-type catalytic step 2 spliceosome
JA [auth q], Y [auth f]	Small nuclear ribonucleoprotein F	RNA binding binding organic cyclic compound binding nucleic acid binding splicing factor binding protein binding poly-pyrimidine tract binding poly(U) RNA binding single-stranded RNA binding	ribonucleoprotein complex biogenesis cellular biosynthetic process RNA metabolic process mRNA processing protein-RNA complex assembly cellular component organization cellular component biogenesis nucleobase-containing compound metabolic process spliceosomal complex assembly protein-RNA complex organization cellular component assembly organic substance metabolic process protein-containing complex assembly organic substance biosynthetic process ribonucleoprotein complex biogenesis cellular biosynthetic process RNA metabolic process mRNA processing protein-RNA complex assembly cellular component organization cellular component biogenesis nucleobase-containing compound metabolic process spliceosomal complex assembly protein-RNA complex organization cellular component assembly organic substance metabolic process protein-containing complex assembly organic substance biosynthetic process cellular component organization or biogenesis RNA processing RNA splicing protein-containing complex organization cellular metabolic process primary metabolic process gene expression mRNA metabolic process macromolecule biosynthetic process nucleic acid metabolic process organic cyclic compound metabolic process biosynthetic process RNA splicing, via transesterification reactions U2-type prespliceosome assembly mRNA splicing, via spliceosome cellular process metabolic process RNA splicing, via transesterification reactions with bulged adenosine as nucleophile macromolecule metabolic process spliceosomal snRNP assembly mRNA splice site recognition mRNA 5'-splice site recognition mRNA cis splicing, via spliceosome RNA capping 7-methylguanosine cap hypermethylation macromolecule methylation RNA modification methylation macromolecule modification RNA 5'-end processing RNA methylation	membrane-bounded organelle spliceosomal snRNP complex protein-containing complex intracellular anatomical structure nucleus nuclear protein-containing complex Sm-like protein family complex intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle U4 snRNP small nuclear ribonucleoprotein complex organelle ribonucleoprotein complex membrane-bounded organelle spliceosomal snRNP complex protein-containing complex intracellular anatomical structure nucleus nuclear protein-containing complex Sm-like protein family complex intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle U4 snRNP small nuclear ribonucleoprotein complex organelle ribonucleoprotein complex pICln-Sm protein complex cytoplasm U2 snRNP catalytic step 2 spliceosome catalytic complex spliceosomal complex U4/U6 snRNP U4/U6 x U5 tri-snRNP complex spliceosomal tri-snRNP complex U1 snRNP U5 snRNP U2-type spliceosomal complex commitment complex
A [auth U]	U5 snRNA (small nuclear RNA)	-	-	-
J [auth G]	ISY1	-	ribonucleoprotein complex biogenesis cellular biosynthetic process RNA metabolic process mRNA processing protein-RNA complex assembly cellular component organization cellular component biogenesis nucleobase-containing compound metabolic process protein-RNA complex organization cellular component assembly organic substance metabolic process protein-containing complex assembly organic substance biosynthetic process cellular component organization or biogenesis ribonucleoprotein complex biogenesis cellular biosynthetic process RNA metabolic process mRNA processing protein-RNA complex assembly cellular component organization cellular component biogenesis nucleobase-containing compound metabolic process protein-RNA complex organization cellular component assembly organic substance metabolic process protein-containing complex assembly organic substance biosynthetic process cellular component organization or biogenesis RNA processing generation of catalytic spliceosome for second transesterification step RNA splicing protein-containing complex organization cellular metabolic process spliceosomal conformational changes to generate catalytic conformation primary metabolic process gene expression mRNA metabolic process macromolecule biosynthetic process nucleic acid metabolic process organic cyclic compound metabolic process biosynthetic process RNA splicing, via transesterification reactions mRNA splicing, via spliceosome cellular process metabolic process RNA splicing, via transesterification reactions with bulged adenosine as nucleophile macromolecule metabolic process spliceosomal complex assembly mRNA splice site recognition mRNA 3'-splice site recognition	intracellular anatomical structure cytoplasm cellular anatomical entity membrane-bounded organelle protein-containing complex nucleus post-spliceosomal complex nuclear protein-containing complex intracellular membrane-bounded organelle intracellular organelle spliceosomal complex organelle ribonucleoprotein complex U2-type spliceosomal complex intracellular anatomical structure cytoplasm cellular anatomical entity membrane-bounded organelle protein-containing complex nucleus post-spliceosomal complex nuclear protein-containing complex intracellular membrane-bounded organelle intracellular organelle spliceosomal complex organelle ribonucleoprotein complex U2-type spliceosomal complex catalytic complex U2-type catalytic step 1 spliceosome catalytic step 1 spliceosome catalytic step 2 spliceosome post-mRNA release spliceosomal complex U2-type catalytic step 2 spliceosome Prp19 complex
K [auth H]	CWC22	-	-	-
L [auth J]	PRP46	-	RNA splicing cellular biosynthetic process cellular metabolic process RNA metabolic process primary metabolic process gene expression mRNA processing mRNA metabolic process macromolecule biosynthetic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process biosynthetic process RNA splicing, via transesterification reactions RNA splicing cellular biosynthetic process cellular metabolic process RNA metabolic process primary metabolic process gene expression mRNA processing mRNA metabolic process macromolecule biosynthetic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process biosynthetic process RNA splicing, via transesterification reactions mRNA splicing, via spliceosome organic substance biosynthetic process metabolic process cellular process RNA splicing, via transesterification reactions with bulged adenosine as nucleophile macromolecule metabolic process RNA processing	intracellular anatomical structure cytoplasm cellular anatomical entity membrane-bounded organelle catalytic step 2 spliceosome protein-containing complex catalytic complex nucleus nuclear protein-containing complex intracellular membrane-bounded organelle intracellular organelle spliceosomal complex organelle ribonucleoprotein complex intracellular anatomical structure cytoplasm cellular anatomical entity membrane-bounded organelle catalytic step 2 spliceosome protein-containing complex catalytic complex nucleus nuclear protein-containing complex intracellular membrane-bounded organelle intracellular organelle spliceosomal complex organelle ribonucleoprotein complex Prp19 complex
N [auth L]	Pre-mRNA-splicing factor BUD31	-	RNA splicing cellular biosynthetic process cellular metabolic process RNA metabolic process primary metabolic process gene expression mRNA processing mRNA metabolic process macromolecule biosynthetic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process biosynthetic process RNA splicing, via transesterification reactions RNA splicing cellular biosynthetic process cellular metabolic process RNA metabolic process primary metabolic process gene expression mRNA processing mRNA metabolic process macromolecule biosynthetic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process biosynthetic process RNA splicing, via transesterification reactions mRNA splicing, via spliceosome organic substance biosynthetic process metabolic process cellular process RNA splicing, via transesterification reactions with bulged adenosine as nucleophile macromolecule metabolic process RNA processing cytoskeleton-dependent cytokinesis mitotic cytokinesis cytokinesis establishment or maintenance of cell polarity mitotic cell cycle establishment of cell polarity mitotic cell cycle process cell cycle cell division cellular bud site selection cell cycle process	membrane-bounded organelle spliceosomal snRNP complex protein-containing complex intracellular anatomical structure nucleus nuclear protein-containing complex Sm-like protein family complex intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle small nuclear ribonucleoprotein complex organelle ribonucleoprotein complex U2 snRNP membrane-bounded organelle spliceosomal snRNP complex protein-containing complex intracellular anatomical structure nucleus nuclear protein-containing complex Sm-like protein family complex intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle small nuclear ribonucleoprotein complex organelle ribonucleoprotein complex U2 snRNP spliceosomal complex
O [auth M]	CWC2	pre-mRNA binding RNA binding binding organic cyclic compound binding nucleic acid binding U6 snRNA binding snRNA binding cation binding ion binding metal ion binding small molecule binding	regulation of biological process regulation of cellular process biological regulation positive regulation of biological process cellular process cell cycle regulation of cell cycle positive regulation of cell cycle positive regulation of cellular process cellular biosynthetic process RNA metabolic process positive regulation of cellular metabolic process positive regulation of macromolecule biosynthetic process regulation of primary metabolic process regulation of biological process regulation of cellular process biological regulation positive regulation of biological process cellular process cell cycle regulation of cell cycle positive regulation of cell cycle positive regulation of cellular process cellular biosynthetic process RNA metabolic process positive regulation of cellular metabolic process positive regulation of macromolecule biosynthetic process regulation of primary metabolic process nucleobase-containing compound metabolic process positive regulation of metabolic process regulation of RNA metabolic process organic substance metabolic process positive regulation of biosynthetic process organic substance biosynthetic process positive regulation of macromolecule metabolic process RNA processing regulation of nucleobase-containing compound metabolic process regulation of biosynthetic process RNA splicing positive regulation of nucleobase-containing compound metabolic process cellular metabolic process primary metabolic process regulation of cellular metabolic process regulation of macromolecule metabolic process gene expression regulation of RNA splicing macromolecule biosynthetic process nucleic acid metabolic process positive regulation of RNA metabolic process regulation of cellular biosynthetic process organic cyclic compound metabolic process regulation of gene expression biosynthetic process positive regulation of gene expression metabolic process regulation of macromolecule biosynthetic process macromolecule metabolic process positive regulation of RNA splicing regulation of metabolic process positive regulation of cellular biosynthetic process mRNA processing mRNA metabolic process RNA splicing, via transesterification reactions mRNA cis splicing, via spliceosome mRNA splicing, via spliceosome RNA splicing, via transesterification reactions with bulged adenosine as nucleophile ribonucleoprotein complex biogenesis protein-RNA complex assembly cellular component organization cellular component biogenesis protein-RNA complex organization cellular component assembly protein-containing complex assembly cellular component organization or biogenesis protein-containing complex organization spliceosomal snRNP assembly	membrane-bounded organelle U2-type spliceosomal complex protein-containing complex intracellular anatomical structure catalytic complex nucleus nuclear protein-containing complex U2-type catalytic step 1 spliceosome intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle spliceosomal complex organelle ribonucleoprotein complex membrane-bounded organelle U2-type spliceosomal complex protein-containing complex intracellular anatomical structure catalytic complex nucleus nuclear protein-containing complex U2-type catalytic step 1 spliceosome intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle spliceosomal complex organelle ribonucleoprotein complex catalytic step 1 spliceosome Prp19 complex catalytic step 2 spliceosome U2-type catalytic step 2 spliceosome
P [auth N]	Pre-mRNA-splicing factor SLT11	pre-mRNA binding RNA binding binding organic cyclic compound binding nucleic acid binding U6 snRNA binding snRNA binding	RNA splicing cellular biosynthetic process cellular metabolic process RNA metabolic process primary metabolic process gene expression mRNA processing mRNA metabolic process macromolecule biosynthetic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process biosynthetic process RNA splicing, via transesterification reactions RNA splicing cellular biosynthetic process cellular metabolic process RNA metabolic process primary metabolic process gene expression mRNA processing mRNA metabolic process macromolecule biosynthetic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process biosynthetic process RNA splicing, via transesterification reactions mRNA splicing, via spliceosome organic substance biosynthetic process metabolic process cellular process RNA splicing, via transesterification reactions with bulged adenosine as nucleophile macromolecule metabolic process RNA processing	membrane-bounded organelle U2-type spliceosomal complex protein-containing complex intracellular anatomical structure catalytic complex nucleus nuclear protein-containing complex U2-type catalytic step 1 spliceosome intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle spliceosomal complex organelle ribonucleoprotein complex membrane-bounded organelle U2-type spliceosomal complex protein-containing complex intracellular anatomical structure catalytic complex nucleus nuclear protein-containing complex U2-type catalytic step 1 spliceosome intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle spliceosomal complex organelle ribonucleoprotein complex catalytic step 1 spliceosome catalytic step 2 spliceosome U2-type catalytic step 2 spliceosome Prp19 complex
Q [auth O]	CEF1	DNA binding binding organic cyclic compound binding nucleic acid binding	RNA splicing cellular biosynthetic process cellular metabolic process RNA metabolic process primary metabolic process gene expression mRNA processing mRNA metabolic process macromolecule biosynthetic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process biosynthetic process RNA splicing, via transesterification reactions RNA splicing cellular biosynthetic process cellular metabolic process RNA metabolic process primary metabolic process gene expression mRNA processing mRNA metabolic process macromolecule biosynthetic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process biosynthetic process RNA splicing, via transesterification reactions mRNA splicing, via spliceosome organic substance biosynthetic process metabolic process cellular process RNA splicing, via transesterification reactions with bulged adenosine as nucleophile macromolecule metabolic process RNA processing ribonucleoprotein complex biogenesis protein-RNA complex assembly cellular component organization cellular component biogenesis protein-RNA complex organization cellular component assembly protein-containing complex assembly cellular component organization or biogenesis generation of catalytic spliceosome for second transesterification step protein-containing complex organization spliceosomal conformational changes to generate catalytic conformation	membrane-bounded organelle U2-type spliceosomal complex protein-containing complex intracellular anatomical structure catalytic complex nucleus nuclear protein-containing complex U2-type catalytic step 1 spliceosome intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle spliceosomal complex organelle ribonucleoprotein complex membrane-bounded organelle U2-type spliceosomal complex protein-containing complex intracellular anatomical structure catalytic complex nucleus nuclear protein-containing complex U2-type catalytic step 1 spliceosome intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle spliceosomal complex organelle ribonucleoprotein complex catalytic step 1 spliceosome Prp19 complex cytoplasm
R [auth P]	CWC15	RNA binding binding organic cyclic compound binding nucleic acid binding	cellular biosynthetic process RNA metabolic process mRNA processing nucleobase-containing compound metabolic process organic substance metabolic process organic substance biosynthetic process RNA processing RNA splicing cellular metabolic process primary metabolic process gene expression mRNA metabolic process macromolecule biosynthetic process nucleic acid metabolic process cellular biosynthetic process RNA metabolic process mRNA processing nucleobase-containing compound metabolic process organic substance metabolic process organic substance biosynthetic process RNA processing RNA splicing cellular metabolic process primary metabolic process gene expression mRNA metabolic process macromolecule biosynthetic process nucleic acid metabolic process organic cyclic compound metabolic process biosynthetic process RNA splicing, via transesterification reactions mRNA cis splicing, via spliceosome mRNA splicing, via spliceosome metabolic process cellular process RNA splicing, via transesterification reactions with bulged adenosine as nucleophile macromolecule metabolic process	membrane-bounded organelle U2-type spliceosomal complex protein-containing complex intracellular anatomical structure nucleus nuclear protein-containing complex intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle spliceosomal complex organelle ribonucleoprotein complex catalytic step 2 spliceosome catalytic complex
S [auth R]	Pre-mRNA-splicing factor CWC21	-	RNA splicing cellular biosynthetic process cellular metabolic process RNA metabolic process primary metabolic process gene expression mRNA processing mRNA metabolic process macromolecule biosynthetic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process biosynthetic process RNA splicing, via transesterification reactions RNA splicing cellular biosynthetic process cellular metabolic process RNA metabolic process primary metabolic process gene expression mRNA processing mRNA metabolic process macromolecule biosynthetic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process biosynthetic process RNA splicing, via transesterification reactions mRNA splicing, via spliceosome organic substance biosynthetic process metabolic process cellular process RNA splicing, via transesterification reactions with bulged adenosine as nucleophile macromolecule metabolic process RNA processing	membrane-bounded organelle U2-type spliceosomal complex protein-containing complex intracellular anatomical structure nucleus nuclear protein-containing complex intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle spliceosomal complex organelle ribonucleoprotein complex cytoplasm
B [auth E]	Exon 1 (5' exon) of UBC4 pre-mRNA	-	-	-
T [auth S]	CLF1	DNA binding sequence-specific DNA binding sequence-specific double-stranded DNA binding double-stranded DNA binding binding organic cyclic compound binding nucleic acid binding DNA replication origin binding protein-containing complex binding chromatin binding	ribonucleoprotein complex biogenesis cellular biosynthetic process RNA metabolic process mRNA processing protein-RNA complex assembly nucleobase-containing compound metabolic process cellular component organization cellular component biogenesis spliceosomal complex assembly organic substance metabolic process protein-RNA complex organization cellular component assembly organic substance biosynthetic process protein-containing complex assembly ribonucleoprotein complex biogenesis cellular biosynthetic process RNA metabolic process mRNA processing protein-RNA complex assembly nucleobase-containing compound metabolic process cellular component organization cellular component biogenesis spliceosomal complex assembly organic substance metabolic process protein-RNA complex organization cellular component assembly organic substance biosynthetic process protein-containing complex assembly RNA processing cellular component organization or biogenesis RNA splicing protein-containing complex organization cellular metabolic process primary metabolic process gene expression mRNA metabolic process macromolecule biosynthetic process nucleic acid metabolic process organic cyclic compound metabolic process biosynthetic process RNA splicing, via transesterification reactions mRNA cis splicing, via spliceosome cis assembly of pre-catalytic spliceosome mRNA splicing, via spliceosome metabolic process cellular process RNA splicing, via transesterification reactions with bulged adenosine as nucleophile macromolecule metabolic process DNA-templated DNA replication DNA replication initiation DNA metabolic process DNA replication	membrane-bounded organelle U2-type spliceosomal complex protein-containing complex intracellular anatomical structure catalytic complex nucleus nuclear protein-containing complex U2-type catalytic step 1 spliceosome intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle spliceosomal complex organelle ribonucleoprotein complex membrane-bounded organelle U2-type spliceosomal complex protein-containing complex intracellular anatomical structure catalytic complex nucleus nuclear protein-containing complex U2-type catalytic step 1 spliceosome intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle spliceosomal complex organelle ribonucleoprotein complex catalytic step 1 spliceosome Prp19 complex U2-type post-mRNA release spliceosomal complex post-mRNA release spliceosomal complex prespliceosome U2-type prespliceosome protein-DNA complex intracellular non-membrane-bounded organelle chromatin chromosome non-membrane-bounded organelle catalytic step 2 spliceosome U2-type catalytic step 2 spliceosome
U [auth T]	SYF1	-	ribonucleoprotein complex biogenesis cellular biosynthetic process RNA metabolic process mRNA processing protein-RNA complex assembly cellular component organization cellular component biogenesis nucleobase-containing compound metabolic process protein-RNA complex organization cellular component assembly organic substance metabolic process protein-containing complex assembly organic substance biosynthetic process cellular component organization or biogenesis ribonucleoprotein complex biogenesis cellular biosynthetic process RNA metabolic process mRNA processing protein-RNA complex assembly cellular component organization cellular component biogenesis nucleobase-containing compound metabolic process protein-RNA complex organization cellular component assembly organic substance metabolic process protein-containing complex assembly organic substance biosynthetic process cellular component organization or biogenesis RNA processing RNA splicing generation of catalytic spliceosome for first transesterification step protein-containing complex organization cellular metabolic process spliceosomal conformational changes to generate catalytic conformation primary metabolic process gene expression mRNA metabolic process macromolecule biosynthetic process nucleic acid metabolic process organic cyclic compound metabolic process biosynthetic process RNA splicing, via transesterification reactions mRNA splicing, via spliceosome cellular process metabolic process RNA splicing, via transesterification reactions with bulged adenosine as nucleophile macromolecule metabolic process	membrane-bounded organelle U2-type spliceosomal complex protein-containing complex intracellular anatomical structure catalytic complex nucleus nuclear protein-containing complex U2-type catalytic step 1 spliceosome intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle spliceosomal complex organelle ribonucleoprotein complex membrane-bounded organelle U2-type spliceosomal complex protein-containing complex intracellular anatomical structure catalytic complex nucleus nuclear protein-containing complex U2-type catalytic step 1 spliceosome intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle spliceosomal complex organelle ribonucleoprotein complex catalytic step 1 spliceosome Prp19 complex cytoplasm cytosol U2-type post-mRNA release spliceosomal complex post-mRNA release spliceosomal complex prespliceosome U2-type prespliceosome catalytic step 2 spliceosome U2-type catalytic step 2 spliceosome
EA [auth k], V [auth b]	Small nuclear ribonucleoprotein-associated protein B	RNA binding binding organic cyclic compound binding nucleic acid binding	ribonucleoprotein complex biogenesis cellular biosynthetic process RNA metabolic process mRNA processing protein-RNA complex assembly cellular component organization cellular component biogenesis nucleobase-containing compound metabolic process spliceosomal complex assembly protein-RNA complex organization cellular component assembly organic substance metabolic process protein-containing complex assembly organic substance biosynthetic process ribonucleoprotein complex biogenesis cellular biosynthetic process RNA metabolic process mRNA processing protein-RNA complex assembly cellular component organization cellular component biogenesis nucleobase-containing compound metabolic process spliceosomal complex assembly protein-RNA complex organization cellular component assembly organic substance metabolic process protein-containing complex assembly organic substance biosynthetic process cellular component organization or biogenesis RNA processing RNA splicing protein-containing complex organization cellular metabolic process primary metabolic process gene expression mRNA metabolic process macromolecule biosynthetic process nucleic acid metabolic process organic cyclic compound metabolic process biosynthetic process RNA splicing, via transesterification reactions mRNA splicing, via spliceosome cellular process metabolic process RNA splicing, via transesterification reactions with bulged adenosine as nucleophile macromolecule metabolic process mRNA splice site recognition mRNA 5'-splice site recognition mRNA cis splicing, via spliceosome RNA capping 7-methylguanosine cap hypermethylation macromolecule methylation RNA modification methylation macromolecule modification RNA 5'-end processing RNA methylation U2-type prespliceosome assembly spliceosomal snRNP assembly	membrane-bounded organelle spliceosomal snRNP complex protein-containing complex intracellular anatomical structure nucleus nuclear protein-containing complex Sm-like protein family complex intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle U4 snRNP small nuclear ribonucleoprotein complex organelle ribonucleoprotein complex membrane-bounded organelle spliceosomal snRNP complex protein-containing complex intracellular anatomical structure nucleus nuclear protein-containing complex Sm-like protein family complex intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle U4 snRNP small nuclear ribonucleoprotein complex organelle ribonucleoprotein complex U2 snRNP catalytic step 2 spliceosome catalytic complex spliceosomal complex U4/U6 snRNP U5 snRNP U2-type spliceosomal complex commitment complex cytoplasm U4/U6 x U5 tri-snRNP complex spliceosomal tri-snRNP complex prespliceosome U2-type prespliceosome U1 snRNP
HA [auth n], W [auth d]	Small nuclear ribonucleoprotein Sm D3	RNA binding binding organic cyclic compound binding nucleic acid binding mRNA binding	ribonucleoprotein complex biogenesis cellular biosynthetic process RNA metabolic process mRNA processing protein-RNA complex assembly cellular component organization cellular component biogenesis nucleobase-containing compound metabolic process spliceosomal complex assembly protein-RNA complex organization cellular component assembly organic substance metabolic process protein-containing complex assembly organic substance biosynthetic process ribonucleoprotein complex biogenesis cellular biosynthetic process RNA metabolic process mRNA processing protein-RNA complex assembly cellular component organization cellular component biogenesis nucleobase-containing compound metabolic process spliceosomal complex assembly protein-RNA complex organization cellular component assembly organic substance metabolic process protein-containing complex assembly organic substance biosynthetic process cellular component organization or biogenesis RNA processing RNA splicing protein-containing complex organization cellular metabolic process primary metabolic process gene expression mRNA metabolic process macromolecule biosynthetic process nucleic acid metabolic process organic cyclic compound metabolic process biosynthetic process RNA splicing, via transesterification reactions U2-type prespliceosome assembly mRNA splicing, via spliceosome cellular process metabolic process RNA splicing, via transesterification reactions with bulged adenosine as nucleophile macromolecule metabolic process spliceosomal snRNP assembly mRNA splice site recognition mRNA 5'-splice site recognition mRNA cis splicing, via spliceosome RNA capping 7-methylguanosine cap hypermethylation macromolecule methylation RNA modification methylation macromolecule modification RNA 5'-end processing RNA methylation	membrane-bounded organelle spliceosomal snRNP complex protein-containing complex intracellular anatomical structure nucleus nuclear protein-containing complex Sm-like protein family complex intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle U4 snRNP small nuclear ribonucleoprotein complex organelle ribonucleoprotein complex membrane-bounded organelle spliceosomal snRNP complex protein-containing complex intracellular anatomical structure nucleus nuclear protein-containing complex Sm-like protein family complex intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle U4 snRNP small nuclear ribonucleoprotein complex organelle ribonucleoprotein complex pICln-Sm protein complex cytoplasm spliceosomal complex precatalytic spliceosome U2 snRNP catalytic step 2 spliceosome catalytic complex cytosol U4/U6 snRNP U4/U6 x U5 tri-snRNP complex spliceosomal tri-snRNP complex U1 snRNP SMN-Sm protein complex U5 snRNP U2-type spliceosomal complex commitment complex prespliceosome U2-type prespliceosome
IA [auth p], X [auth e]	Small nuclear ribonucleoprotein E	RNA binding binding organic cyclic compound binding nucleic acid binding splicing factor binding protein binding	ribonucleoprotein complex biogenesis cellular biosynthetic process RNA metabolic process mRNA processing protein-RNA complex assembly cellular component organization cellular component biogenesis nucleobase-containing compound metabolic process spliceosomal complex assembly protein-RNA complex organization cellular component assembly organic substance metabolic process protein-containing complex assembly organic substance biosynthetic process ribonucleoprotein complex biogenesis cellular biosynthetic process RNA metabolic process mRNA processing protein-RNA complex assembly cellular component organization cellular component biogenesis nucleobase-containing compound metabolic process spliceosomal complex assembly protein-RNA complex organization cellular component assembly organic substance metabolic process protein-containing complex assembly organic substance biosynthetic process cellular component organization or biogenesis RNA processing RNA splicing protein-containing complex organization cellular metabolic process primary metabolic process gene expression mRNA metabolic process macromolecule biosynthetic process nucleic acid metabolic process organic cyclic compound metabolic process biosynthetic process RNA splicing, via transesterification reactions U2-type prespliceosome assembly mRNA splicing, via spliceosome cellular process metabolic process RNA splicing, via transesterification reactions with bulged adenosine as nucleophile macromolecule metabolic process spliceosomal snRNP assembly mRNA splice site recognition mRNA 5'-splice site recognition mRNA cis splicing, via spliceosome RNA capping 7-methylguanosine cap hypermethylation macromolecule methylation RNA modification methylation macromolecule modification RNA 5'-end processing RNA methylation	membrane-bounded organelle spliceosomal snRNP complex protein-containing complex intracellular anatomical structure nucleus nuclear protein-containing complex Sm-like protein family complex intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle U4 snRNP small nuclear ribonucleoprotein complex organelle ribonucleoprotein complex membrane-bounded organelle spliceosomal snRNP complex protein-containing complex intracellular anatomical structure nucleus nuclear protein-containing complex Sm-like protein family complex intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle U4 snRNP small nuclear ribonucleoprotein complex organelle ribonucleoprotein complex pICln-Sm protein complex cytoplasm spliceosomal complex precatalytic spliceosome U2 snRNP U4/U6 snRNP U4/U6 x U5 tri-snRNP complex spliceosomal tri-snRNP complex U1 snRNP U5 snRNP U2-type spliceosomal complex commitment complex prespliceosome U2-type prespliceosome
KA [auth r], Z [auth g]	Small nuclear ribonucleoprotein G	RNA binding binding organic cyclic compound binding nucleic acid binding	ribonucleoprotein complex biogenesis cellular biosynthetic process RNA metabolic process mRNA processing protein-RNA complex assembly cellular component organization cellular component biogenesis nucleobase-containing compound metabolic process spliceosomal complex assembly protein-RNA complex organization cellular component assembly organic substance metabolic process protein-containing complex assembly organic substance biosynthetic process ribonucleoprotein complex biogenesis cellular biosynthetic process RNA metabolic process mRNA processing protein-RNA complex assembly cellular component organization cellular component biogenesis nucleobase-containing compound metabolic process spliceosomal complex assembly protein-RNA complex organization cellular component assembly organic substance metabolic process protein-containing complex assembly organic substance biosynthetic process cellular component organization or biogenesis RNA processing RNA splicing protein-containing complex organization cellular metabolic process primary metabolic process gene expression mRNA metabolic process macromolecule biosynthetic process nucleic acid metabolic process organic cyclic compound metabolic process biosynthetic process RNA splicing, via transesterification reactions U2-type prespliceosome assembly mRNA splicing, via spliceosome cellular process metabolic process RNA splicing, via transesterification reactions with bulged adenosine as nucleophile macromolecule metabolic process spliceosomal snRNP assembly mRNA splice site recognition mRNA 5'-splice site recognition mRNA cis splicing, via spliceosome RNA capping 7-methylguanosine cap hypermethylation macromolecule methylation RNA modification methylation macromolecule modification RNA 5'-end processing RNA methylation	membrane-bounded organelle spliceosomal snRNP complex protein-containing complex intracellular anatomical structure nucleus nuclear protein-containing complex Sm-like protein family complex intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle U4 snRNP small nuclear ribonucleoprotein complex organelle ribonucleoprotein complex membrane-bounded organelle spliceosomal snRNP complex protein-containing complex intracellular anatomical structure nucleus nuclear protein-containing complex Sm-like protein family complex intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle U4 snRNP small nuclear ribonucleoprotein complex organelle ribonucleoprotein complex spliceosomal complex precatalytic spliceosome U2 snRNP catalytic step 2 spliceosome catalytic complex U4/U6 snRNP cytoplasm U4/U6 x U5 tri-snRNP complex spliceosomal tri-snRNP complex U1 snRNP SMN-Sm protein complex U5 snRNP U2-type spliceosomal complex commitment complex prespliceosome U2-type prespliceosome
AA [auth h], FA [auth l]	Small nuclear ribonucleoprotein Sm D1	RNA binding binding organic cyclic compound binding nucleic acid binding mRNA binding	ribonucleoprotein complex biogenesis cellular biosynthetic process RNA metabolic process mRNA processing protein-RNA complex assembly cellular component organization cellular component biogenesis nucleobase-containing compound metabolic process spliceosomal complex assembly protein-RNA complex organization cellular component assembly organic substance metabolic process protein-containing complex assembly organic substance biosynthetic process ribonucleoprotein complex biogenesis cellular biosynthetic process RNA metabolic process mRNA processing protein-RNA complex assembly cellular component organization cellular component biogenesis nucleobase-containing compound metabolic process spliceosomal complex assembly protein-RNA complex organization cellular component assembly organic substance metabolic process protein-containing complex assembly organic substance biosynthetic process cellular component organization or biogenesis RNA processing RNA splicing protein-containing complex organization cellular metabolic process primary metabolic process gene expression mRNA metabolic process macromolecule biosynthetic process nucleic acid metabolic process organic cyclic compound metabolic process biosynthetic process RNA splicing, via transesterification reactions U2-type prespliceosome assembly mRNA splicing, via spliceosome cellular process metabolic process RNA splicing, via transesterification reactions with bulged adenosine as nucleophile macromolecule metabolic process spliceosomal snRNP assembly mRNA splice site recognition mRNA 5'-splice site recognition mRNA cis splicing, via spliceosome RNA capping 7-methylguanosine cap hypermethylation macromolecule methylation RNA modification methylation macromolecule modification RNA 5'-end processing RNA methylation	membrane-bounded organelle spliceosomal snRNP complex protein-containing complex intracellular anatomical structure nucleus nuclear protein-containing complex Sm-like protein family complex intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle U4 snRNP small nuclear ribonucleoprotein complex organelle ribonucleoprotein complex membrane-bounded organelle spliceosomal snRNP complex protein-containing complex intracellular anatomical structure nucleus nuclear protein-containing complex Sm-like protein family complex intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle U4 snRNP small nuclear ribonucleoprotein complex organelle ribonucleoprotein complex pICln-Sm protein complex cytoplasm spliceosomal complex precatalytic spliceosome U2 snRNP catalytic step 2 spliceosome catalytic complex cytosol U4/U6 snRNP U4/U6 x U5 tri-snRNP complex spliceosomal tri-snRNP complex U1 snRNP SMN-Sm protein complex U5 snRNP U2-type spliceosomal complex commitment complex prespliceosome U2-type prespliceosome
BA [auth j], GA [auth m]	Small nuclear ribonucleoprotein Sm D2	RNA binding binding organic cyclic compound binding nucleic acid binding	ribonucleoprotein complex biogenesis cellular biosynthetic process RNA metabolic process mRNA processing protein-RNA complex assembly cellular component organization cellular component biogenesis nucleobase-containing compound metabolic process spliceosomal complex assembly protein-RNA complex organization cellular component assembly organic substance metabolic process protein-containing complex assembly organic substance biosynthetic process ribonucleoprotein complex biogenesis cellular biosynthetic process RNA metabolic process mRNA processing protein-RNA complex assembly cellular component organization cellular component biogenesis nucleobase-containing compound metabolic process spliceosomal complex assembly protein-RNA complex organization cellular component assembly organic substance metabolic process protein-containing complex assembly organic substance biosynthetic process cellular component organization or biogenesis RNA processing RNA splicing protein-containing complex organization cellular metabolic process primary metabolic process gene expression mRNA metabolic process macromolecule biosynthetic process nucleic acid metabolic process organic cyclic compound metabolic process biosynthetic process RNA splicing, via transesterification reactions U2-type prespliceosome assembly mRNA splicing, via spliceosome cellular process metabolic process RNA splicing, via transesterification reactions with bulged adenosine as nucleophile macromolecule metabolic process spliceosomal snRNP assembly mRNA splice site recognition mRNA 5'-splice site recognition mRNA cis splicing, via spliceosome RNA capping 7-methylguanosine cap hypermethylation macromolecule methylation RNA modification methylation macromolecule modification RNA 5'-end processing RNA methylation	membrane-bounded organelle spliceosomal snRNP complex protein-containing complex intracellular anatomical structure nucleus nuclear protein-containing complex Sm-like protein family complex intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle U4 snRNP small nuclear ribonucleoprotein complex organelle ribonucleoprotein complex membrane-bounded organelle spliceosomal snRNP complex protein-containing complex intracellular anatomical structure nucleus nuclear protein-containing complex Sm-like protein family complex intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle U4 snRNP small nuclear ribonucleoprotein complex organelle ribonucleoprotein complex pICln-Sm protein complex cytoplasm spliceosomal complex precatalytic spliceosome U2 snRNP catalytic step 2 spliceosome catalytic complex cytosol U4/U6 snRNP U4/U6 x U5 tri-snRNP complex spliceosomal tri-snRNP complex U1 snRNP U5 snRNP U2-type spliceosomal complex commitment complex prespliceosome U2-type prespliceosome
CA [auth W]	U2 small nuclear ribonucleoprotein A'	RNA binding snRNA binding binding organic cyclic compound binding nucleic acid binding U2 snRNA binding	ribonucleoprotein complex biogenesis cellular biosynthetic process RNA metabolic process mRNA processing protein-RNA complex assembly cellular component organization cellular component biogenesis nucleobase-containing compound metabolic process spliceosomal complex assembly protein-RNA complex organization cellular component assembly organic substance metabolic process protein-containing complex assembly organic substance biosynthetic process ribonucleoprotein complex biogenesis cellular biosynthetic process RNA metabolic process mRNA processing protein-RNA complex assembly cellular component organization cellular component biogenesis nucleobase-containing compound metabolic process spliceosomal complex assembly protein-RNA complex organization cellular component assembly organic substance metabolic process protein-containing complex assembly organic substance biosynthetic process cellular component organization or biogenesis RNA processing RNA splicing protein-containing complex organization cellular metabolic process primary metabolic process gene expression mRNA metabolic process macromolecule biosynthetic process nucleic acid metabolic process organic cyclic compound metabolic process biosynthetic process RNA splicing, via transesterification reactions U2-type prespliceosome assembly mRNA splicing, via spliceosome cellular process metabolic process RNA splicing, via transesterification reactions with bulged adenosine as nucleophile macromolecule metabolic process	intracellular anatomical structure cytoplasm cellular anatomical entity membrane-bounded organelle spliceosomal snRNP complex protein-containing complex nucleus nuclear protein-containing complex Sm-like protein family complex intracellular membrane-bounded organelle intracellular organelle small nuclear ribonucleoprotein complex organelle ribonucleoprotein complex intracellular anatomical structure cytoplasm cellular anatomical entity membrane-bounded organelle spliceosomal snRNP complex protein-containing complex nucleus nuclear protein-containing complex Sm-like protein family complex intracellular membrane-bounded organelle intracellular organelle small nuclear ribonucleoprotein complex organelle ribonucleoprotein complex U2 snRNP U2-type spliceosomal complex prespliceosome U2-type prespliceosome spliceosomal complex
C [auth I]	Intron of UBC4 pre-mRNA	-	-	-
DA [auth Y]	U2 small nuclear ribonucleoprotein B''	RNA binding snRNA binding binding organic cyclic compound binding nucleic acid binding U2 snRNA binding	ribonucleoprotein complex biogenesis cellular biosynthetic process RNA metabolic process mRNA processing protein-RNA complex assembly cellular component organization cellular component biogenesis nucleobase-containing compound metabolic process spliceosomal complex assembly protein-RNA complex organization cellular component assembly organic substance metabolic process protein-containing complex assembly organic substance biosynthetic process ribonucleoprotein complex biogenesis cellular biosynthetic process RNA metabolic process mRNA processing protein-RNA complex assembly cellular component organization cellular component biogenesis nucleobase-containing compound metabolic process spliceosomal complex assembly protein-RNA complex organization cellular component assembly organic substance metabolic process protein-containing complex assembly organic substance biosynthetic process cellular component organization or biogenesis RNA processing RNA splicing protein-containing complex organization cellular metabolic process primary metabolic process gene expression mRNA metabolic process macromolecule biosynthetic process nucleic acid metabolic process organic cyclic compound metabolic process biosynthetic process RNA splicing, via transesterification reactions U2-type prespliceosome assembly mRNA splicing, via spliceosome cellular process metabolic process RNA splicing, via transesterification reactions with bulged adenosine as nucleophile macromolecule metabolic process	membrane-bounded organelle spliceosomal snRNP complex protein-containing complex intracellular anatomical structure nucleus nuclear protein-containing complex Sm-like protein family complex intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle small nuclear ribonucleoprotein complex organelle ribonucleoprotein complex U2 snRNP membrane-bounded organelle spliceosomal snRNP complex protein-containing complex intracellular anatomical structure nucleus nuclear protein-containing complex Sm-like protein family complex intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle small nuclear ribonucleoprotein complex organelle ribonucleoprotein complex U2 snRNP U2-type spliceosomal complex prespliceosome U2-type prespliceosome spliceosomal complex
LA [auth x]	unknown	-	-	-
D [auth Z]	U2 snRNA (small nuclear RNA)	-	-	-
E [auth V]	U6 snRNA (small nuclear RNA)	-	-	-
F [auth A]	Pre-mRNA-splicing factor 8	peptidase activity catalytic activity, acting on a protein metallopeptidase activity hydrolase activity catalytic activity RNA binding snRNA binding binding organic cyclic compound binding nucleic acid binding U1 snRNA binding U6 snRNA binding mRNA binding U5 snRNA binding peptidase activity catalytic activity, acting on a protein metallopeptidase activity hydrolase activity catalytic activity RNA binding snRNA binding binding organic cyclic compound binding nucleic acid binding U1 snRNA binding U6 snRNA binding mRNA binding U5 snRNA binding U2 snRNA binding pre-mRNA binding pre-mRNA intronic binding	ribonucleoprotein complex biogenesis cellular biosynthetic process RNA metabolic process mRNA processing spliceosomal tri-snRNP complex assembly protein-RNA complex assembly cellular component organization cellular component biogenesis nucleobase-containing compound metabolic process protein-RNA complex organization cellular component assembly organic substance metabolic process protein-containing complex assembly organic substance biosynthetic process ribonucleoprotein complex biogenesis cellular biosynthetic process RNA metabolic process mRNA processing spliceosomal tri-snRNP complex assembly protein-RNA complex assembly cellular component organization cellular component biogenesis nucleobase-containing compound metabolic process protein-RNA complex organization cellular component assembly organic substance metabolic process protein-containing complex assembly organic substance biosynthetic process cellular component organization or biogenesis RNA processing RNA splicing protein-containing complex organization spliceosomal snRNP assembly cellular metabolic process primary metabolic process gene expression mRNA metabolic process macromolecule biosynthetic process nucleic acid metabolic process organic cyclic compound metabolic process biosynthetic process RNA splicing, via transesterification reactions mRNA splicing, via spliceosome cellular process metabolic process RNA splicing, via transesterification reactions with bulged adenosine as nucleophile macromolecule metabolic process spliceosomal complex assembly mRNA splice site recognition mRNA 3'-splice site recognition mRNA 5'-splice site recognition mRNA cis splicing, via spliceosome generation of catalytic spliceosome for second transesterification step spliceosomal conformational changes to generate catalytic conformation	membrane-bounded organelle catalytic step 2 spliceosome protein-containing complex intracellular anatomical structure catalytic complex nucleus nuclear protein-containing complex intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle spliceosomal complex organelle ribonucleoprotein complex cytoplasm membrane-bounded organelle catalytic step 2 spliceosome protein-containing complex intracellular anatomical structure catalytic complex nucleus nuclear protein-containing complex intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle spliceosomal complex organelle ribonucleoprotein complex cytoplasm spliceosomal snRNP complex Sm-like protein family complex U4/U6 x U5 tri-snRNP complex spliceosomal tri-snRNP complex small nuclear ribonucleoprotein complex U5 snRNP
G [auth D]	Protein CWC16	RNA binding snRNA binding binding organic cyclic compound binding nucleic acid binding U2 snRNA binding cation binding ion binding metal ion binding small molecule binding	RNA splicing cellular biosynthetic process cellular metabolic process RNA metabolic process primary metabolic process gene expression macromolecule biosynthetic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process biosynthetic process organic substance biosynthetic process metabolic process RNA splicing cellular biosynthetic process cellular metabolic process RNA metabolic process primary metabolic process gene expression macromolecule biosynthetic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process biosynthetic process organic substance biosynthetic process metabolic process cellular process RNA processing macromolecule metabolic process ribonucleoprotein complex biogenesis mRNA processing protein-RNA complex assembly cellular component organization cellular component biogenesis protein-RNA complex organization cellular component assembly protein-containing complex assembly cellular component organization or biogenesis generation of catalytic spliceosome for first transesterification step protein-containing complex organization spliceosomal conformational changes to generate catalytic conformation mRNA metabolic process RNA splicing, via transesterification reactions mRNA splicing, via spliceosome RNA splicing, via transesterification reactions with bulged adenosine as nucleophile generation of catalytic spliceosome for second transesterification step	membrane-bounded organelle U2-type spliceosomal complex protein-containing complex intracellular anatomical structure catalytic complex nucleus nuclear protein-containing complex U2-type catalytic step 1 spliceosome intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle spliceosomal complex organelle ribonucleoprotein complex membrane-bounded organelle U2-type spliceosomal complex protein-containing complex intracellular anatomical structure catalytic complex nucleus nuclear protein-containing complex U2-type catalytic step 1 spliceosome intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle spliceosomal complex organelle ribonucleoprotein complex catalytic step 1 spliceosome catalytic step 2 spliceosome U2-type catalytic step 2 spliceosome
H [auth F]	Pre-mRNA-splicing factor CWC25	-	RNA splicing cellular biosynthetic process cellular metabolic process RNA metabolic process primary metabolic process gene expression mRNA processing mRNA metabolic process macromolecule biosynthetic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process biosynthetic process RNA splicing, via transesterification reactions RNA splicing cellular biosynthetic process cellular metabolic process RNA metabolic process primary metabolic process gene expression mRNA processing mRNA metabolic process macromolecule biosynthetic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process biosynthetic process RNA splicing, via transesterification reactions mRNA splicing, via spliceosome organic substance biosynthetic process metabolic process cellular process RNA splicing, via transesterification reactions with bulged adenosine as nucleophile macromolecule metabolic process RNA processing	membrane-bounded organelle U2-type spliceosomal complex protein-containing complex intracellular anatomical structure nucleus nuclear protein-containing complex intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle spliceosomal complex organelle ribonucleoprotein complex
I [auth C]	Pre-mRNA-splicing factor SNU114	binding guanyl nucleotide binding GTP binding nucleotide binding guanyl ribonucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding organic cyclic compound binding purine nucleotide binding anion binding heterocyclic compound binding carbohydrate derivative binding binding guanyl nucleotide binding GTP binding nucleotide binding guanyl ribonucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding organic cyclic compound binding purine nucleotide binding anion binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding RNA binding snRNA binding U5 snRNA binding nucleic acid binding pyrophosphatase activity GTPase activity ribonucleoside triphosphate phosphatase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity hydrolase activity, acting on acid anhydrides catalytic activity	ribonucleoprotein complex biogenesis cellular biosynthetic process RNA metabolic process mRNA processing protein-RNA complex assembly cellular component organization cellular component biogenesis nucleobase-containing compound metabolic process protein-RNA complex organization cellular component assembly organic substance metabolic process protein-containing complex assembly organic substance biosynthetic process cellular component organization or biogenesis ribonucleoprotein complex biogenesis cellular biosynthetic process RNA metabolic process mRNA processing protein-RNA complex assembly cellular component organization cellular component biogenesis nucleobase-containing compound metabolic process protein-RNA complex organization cellular component assembly organic substance metabolic process protein-containing complex assembly organic substance biosynthetic process cellular component organization or biogenesis RNA processing RNA splicing generation of catalytic spliceosome for first transesterification step protein-containing complex organization cellular metabolic process spliceosomal conformational changes to generate catalytic conformation primary metabolic process gene expression mRNA metabolic process macromolecule biosynthetic process nucleic acid metabolic process organic cyclic compound metabolic process biosynthetic process RNA splicing, via transesterification reactions mRNA splicing, via spliceosome cellular process metabolic process RNA splicing, via transesterification reactions with bulged adenosine as nucleophile macromolecule metabolic process spliceosomal tri-snRNP complex assembly spliceosomal snRNP assembly spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)	intracellular anatomical structure cytoplasm cellular anatomical entity cytosol membrane-bounded organelle spliceosomal snRNP complex protein-containing complex nucleus nuclear protein-containing complex Sm-like protein family complex intracellular membrane-bounded organelle intracellular organelle U4/U6 x U5 tri-snRNP complex spliceosomal tri-snRNP complex intracellular anatomical structure cytoplasm cellular anatomical entity cytosol membrane-bounded organelle spliceosomal snRNP complex protein-containing complex nucleus nuclear protein-containing complex Sm-like protein family complex intracellular membrane-bounded organelle intracellular organelle U4/U6 x U5 tri-snRNP complex spliceosomal tri-snRNP complex small nuclear ribonucleoprotein complex organelle ribonucleoprotein complex spliceosomal complex U5 snRNP U2-type spliceosomal complex catalytic step 2 spliceosome catalytic complex U2-type catalytic step 2 spliceosome

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
M [auth K]	IPR017862	SKI-interacting protein, SKIP	Family
M [auth K]	IPR004015	SKI-interacting protein SKIP, SNW domain	Domain
JA [auth q], Y [auth f]	IPR016487	Sm-like protein Lsm6/SmF	Family
JA [auth q], Y [auth f]	IPR034100	Small nuclear ribonucleoprotein F	Family
JA [auth q], Y [auth f]	IPR001163	Sm domain, eukaryotic/archaea-type	Domain
JA [auth q], Y [auth f]	IPR047575	Sm domain	Domain
JA [auth q], Y [auth f]	IPR010920	LSM domain superfamily	Homologous Superfamily
J [auth G]	IPR029012	Helix hairpin bin domain superfamily	Homologous Superfamily
J [auth G]	IPR009360	Pre-mRNA-splicing factor Isy1	Family
J [auth G]	IPR037200	Pre-mRNA-splicing factor Isy1 superfamily	Homologous Superfamily
L [auth J]	IPR045241	WD repeat Prp46/PLRG1-like	Family
L [auth J]	IPR001680	WD40 repeat	Repeat
L [auth J]	IPR019775	WD40 repeat, conserved site	Conserved Site
L [auth J]	IPR020472	G-protein beta WD-40 repeat	Repeat
L [auth J]	IPR036322	WD40-repeat-containing domain superfamily	Homologous Superfamily
L [auth J]	IPR015943	WD40/YVTN repeat-like-containing domain superfamily	Homologous Superfamily
N [auth L]	IPR001748	Pre-mRNA-splicing factor BUD31	Family
N [auth L]	IPR018230	BUD31/G10-related, conserved site	Conserved Site
O [auth M]	IPR039171	Pre-mRNA-splicing factor Cwc2/Slt11	Family
O [auth M]	IPR034181	Pre-mRNA-splicing factor Cwc2, RNA recognition motif	Domain
O [auth M]	IPR000504	RNA recognition motif domain	Domain
O [auth M]	IPR032297	Torus domain	Domain
O [auth M]	IPR000571	Zinc finger, CCCH-type	Domain
O [auth M]	IPR012677	Nucleotide-binding alpha-beta plait domain superfamily	Homologous Superfamily
O [auth M]	IPR035979	RNA-binding domain superfamily	Homologous Superfamily
P [auth N]	IPR039171	Pre-mRNA-splicing factor Cwc2/Slt11	Family
P [auth N]	IPR034356	Slt11, RNA recognition motif	Domain
P [auth N]	IPR048995	STL11/RBM22-like, N-terminal domain	Domain
Q [auth O]	IPR047240	Pre-mRNA splicing factor component CDC5L/Cef1, second SANT/myb-like domain	Domain
Q [auth O]	IPR017930	Myb domain	Domain
Q [auth O]	IPR009057	Homeobox-like domain superfamily	Homologous Superfamily
Q [auth O]	IPR047242	Pre-mRNA splicing factor component CDC5L/Cef1	Family
Q [auth O]	IPR001005	SANT/Myb domain	Domain
Q [auth O]	IPR021786	Pre-mRNA splicing factor component Cdc5p/Cef1, C-terminal	Domain
R [auth P]	IPR006973	Pre-mRNA-splicing factor Cwf15/Cwc15	Family
S [auth R]	IPR013170	mRNA splicing factor Cwf21 domain	Domain
T [auth S]	IPR011990	Tetratricopeptide-like helical domain superfamily	Homologous Superfamily
T [auth S]	IPR003107	HAT (Half-A-TPR) repeat	Repeat
T [auth S]	IPR045075	Pre-mRNA-splicing factor Syf1-like	Family
U [auth T]	IPR011990	Tetratricopeptide-like helical domain superfamily	Homologous Superfamily
U [auth T]	IPR003107	HAT (Half-A-TPR) repeat	Repeat
U [auth T]	IPR045075	Pre-mRNA-splicing factor Syf1-like	Family
EA [auth k], V [auth b]	IPR001163	Sm domain, eukaryotic/archaea-type	Domain
EA [auth k], V [auth b]	IPR047575	Sm domain	Domain
EA [auth k], V [auth b]	IPR010920	LSM domain superfamily	Homologous Superfamily
HA [auth n], W [auth d]	IPR027141	Like-Sm (LSM) domain containing protein, LSm4/SmD1/SmD3	Family
HA [auth n], W [auth d]	IPR034099	Small nuclear ribonucleoprotein Sm D3	Family
HA [auth n], W [auth d]	IPR001163	Sm domain, eukaryotic/archaea-type	Domain
HA [auth n], W [auth d]	IPR047575	Sm domain	Domain
HA [auth n], W [auth d]	IPR010920	LSM domain superfamily	Homologous Superfamily
IA [auth p], X [auth e]	IPR027078	Small nuclear ribonucleoprotein E	Family
IA [auth p], X [auth e]	IPR001163	Sm domain, eukaryotic/archaea-type	Domain
IA [auth p], X [auth e]	IPR047575	Sm domain	Domain
IA [auth p], X [auth e]	IPR010920	LSM domain superfamily	Homologous Superfamily
KA [auth r], Z [auth g]	IPR044641	Sm-like protein Lsm7/SmG	Family
KA [auth r], Z [auth g]	IPR034098	Small nuclear ribonucleoprotein G	Family
KA [auth r], Z [auth g]	IPR001163	Sm domain, eukaryotic/archaea-type	Domain
KA [auth r], Z [auth g]	IPR047575	Sm domain	Domain
KA [auth r], Z [auth g]	IPR010920	LSM domain superfamily	Homologous Superfamily
AA [auth h], FA [auth l]	IPR027141	Like-Sm (LSM) domain containing protein, LSm4/SmD1/SmD3	Family
AA [auth h], FA [auth l]	IPR001163	Sm domain, eukaryotic/archaea-type	Domain
AA [auth h], FA [auth l]	IPR047575	Sm domain	Domain
AA [auth h], FA [auth l]	IPR010920	LSM domain superfamily	Homologous Superfamily
BA [auth j], GA [auth m]	IPR001163	Sm domain, eukaryotic/archaea-type	Domain
BA [auth j], GA [auth m]	IPR047575	Sm domain	Domain
BA [auth j], GA [auth m]	IPR027248	Small nuclear ribonucleoprotein Sm D2	Family
BA [auth j], GA [auth m]	IPR010920	LSM domain superfamily	Homologous Superfamily
CA [auth W]	IPR032675	Leucine-rich repeat domain superfamily	Homologous Superfamily
CA [auth W]	IPR001611	Leucine-rich repeat	Repeat
CA [auth W]	IPR003603	U2A'/phosphoprotein 32 family A, C-terminal	Domain
DA [auth Y]	IPR012677	Nucleotide-binding alpha-beta plait domain superfamily	Homologous Superfamily
DA [auth Y]	IPR000504	RNA recognition motif domain	Domain
DA [auth Y]	IPR035979	RNA-binding domain superfamily	Homologous Superfamily
F [auth A]	IPR012984	PROCT domain	Domain
F [auth A]	IPR012591	PRO8NT domain	Domain
F [auth A]	IPR019580	Pre-mRNA-processing-splicing factor 8, U6-snRNA-binding	Domain
F [auth A]	IPR027652	Pre-mRNA-processing-splicing factor 8	Family
F [auth A]	IPR043172	Prp8 RNase domain IV, palm region	Homologous Superfamily
F [auth A]	IPR012592	PROCN domain	Domain
F [auth A]	IPR012337	Ribonuclease H-like superfamily	Homologous Superfamily
F [auth A]	IPR043173	Prp8 RNase domain IV, fingers region	Homologous Superfamily
F [auth A]	IPR021983	PRP8 domain IV core	Domain
F [auth A]	IPR019581	Pre-mRNA-processing-splicing factor 8, U5-snRNA-binding	Domain
F [auth A]	IPR037518	MPN domain	Domain
F [auth A]	IPR019582	RNA recognition motif, spliceosomal PrP8	Domain
F [auth A]	IPR042516	Pre-mRNA-processing-splicing factor 8, U5-snRNA-binding domain superfamily	Homologous Superfamily
F [auth A]	IPR000555	JAB1/MPN/MOV34 metalloenzyme domain	Domain
G [auth D]	IPR043701	Splicing factor Yju2	Family
G [auth D]	IPR007590	Saf4/Yju2 protein	Family
H [auth F]	IPR019339	CBF1-interacting co-repressor CIR, N-terminal domain	Domain
H [auth F]	IPR022209	Pre-mRNA splicing factor	Family
I [auth C]	IPR005517	Translation elongation factor EFG/EF2, domain IV	Domain
I [auth C]	IPR000795	Translational (tr)-type GTP-binding domain	Domain
I [auth C]	IPR035647	EF-G domain III/V-like	Homologous Superfamily
I [auth C]	IPR035655	116kDa U5 small nuclear ribonucleoprotein component, C-terminal	Domain
I [auth C]	IPR009000	Translation protein, beta-barrel domain superfamily	Homologous Superfamily
I [auth C]	IPR020568	Ribosomal protein uS5 domain 2-type superfamily	Homologous Superfamily
I [auth C]	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily
I [auth C]	IPR014721	Small ribosomal subunit protein uS5 domain 2-type fold, subgroup	Homologous Superfamily
I [auth C]	IPR031950	116kDa U5 small nuclear ribonucleoprotein component, N-terminal	Domain
I [auth C]	IPR000640	Elongation factor EFG, domain V-like	Domain
I [auth C]	IPR044121	Snu114, GTP-binding domain	Domain