Annotations: 5LF2

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF21199	e5lf2A2	A: beta sandwiches	X: jelly-roll	H: Galactose-binding domain-like (From Topology)	T: Galactose-binding domain-like	F: PF21199	ECOD (1.6)
A	PF00053	e5lf2A1	A: few secondary structure elements	X: EGF-like	H: EGF-related	T: EGF/Laminin	F: PF00053	ECOD (1.6)
B	PF21199	e5lf2B3	A: beta sandwiches	X: jelly-roll	H: Galactose-binding domain-like (From Topology)	T: Galactose-binding domain-like	F: PF21199	ECOD (1.6)
B	PF00053	e5lf2B2	A: few secondary structure elements	X: EGF-like	H: EGF-related	T: EGF/Laminin	F: PF00053	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	2.10.25.10	Mainly Beta	Ribbon	Laminin	Laminin	CATH (4.3.0)
B	2.10.25.10	Mainly Beta	Ribbon	Laminin	Laminin	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF21199	Laminin IV type B domain (LAMININ_IV_B)	Laminin IV type B domain	Laminins are a major constituent of all basement membranes. The polymerisation of laminins at the cell surface is mediated by the three short arms of the cross-shaped laminin heterotrimer. The short arms contain repeats of laminin-type epidermal grow ...	Laminins are a major constituent of all basement membranes. The polymerisation of laminins at the cell surface is mediated by the three short arms of the cross-shaped laminin heterotrimer. The short arms contain repeats of laminin-type epidermal growth factor-like (LE) domains, interspersed with globular domains [1]. This domain consists of a beta-sandwich related to bacterial family 35 carbohydrate binding modules, and more distantly to the L4 domains present in the short arms of laminin alpha and gamma chains [1].	Domain
A, B	PF00053	Laminin EGF domain (Laminin_EGF)	Laminin EGF domain	This family is like Pfam:PF00008 but has 8 conserved cysteines instead of six.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	Laminin subunit beta-2	structural molecule activity extracellular matrix structural constituent structural constituent of synapse-associated extracellular matrix cell adhesion molecule binding protein-containing complex binding protein binding binding integrin binding signaling receptor binding	developmental process anatomical structure development tissue development anatomical structure morphogenesis animal organ development animal organ morphogenesis multicellular organismal process sensory organ development eye development retina development in camera-type eye visual system development multicellular organism development camera-type eye development sensory system development developmental process anatomical structure development tissue development anatomical structure morphogenesis animal organ development animal organ morphogenesis multicellular organismal process sensory organ development eye development retina development in camera-type eye visual system development multicellular organism development camera-type eye development sensory system development system development cellular developmental process peripheral nervous system development cell development nervous system development glial cell development neurogenesis Schwann cell development gliogenesis glial cell differentiation cell differentiation cellular process Schwann cell differentiation cell adhesion substrate adhesion-dependent cell spreading cell-substrate adhesion cellular component organization cell junction organization neuromuscular junction development synapse organization cellular component organization or biogenesis cell migration cell motility astrocyte differentiation astrocyte development central nervous system development cell morphogenesis cellular response to stimulus axon extension axonogenesis response to stimulus developmental growth cell projection organization plasma membrane bounded cell projection morphogenesis neuron projection development regeneration cell growth response to axon injury neuron projection regeneration cell projection morphogenesis axon regeneration neuron differentiation cellular response to stress neuron projection morphogenesis response to stress sprouting of injured axon response to wounding neuron projection extension plasma membrane bounded cell projection organization developmental cell growth growth axon development cell morphogenesis involved in neuron differentiation developmental growth involved in morphogenesis generation of neurons neuron development axon extension involved in regeneration axon guidance neuron projection guidance renal filtration cell differentiation metanephric glomerular epithelial cell development kidney epithelium development glomerular epithelial cell differentiation metanephric glomerulus development metanephric epithelium development epithelial cell differentiation renal system development metanephric glomerular epithelium development metanephros development metanephric glomerular epithelial cell differentiation nephron development metanephric nephron development metanephric nephron epithelium development nephron epithelium development epithelial cell differentiation involved in kidney development epithelium development metanephric podocyte development glomerular epithelium development cell differentiation involved in metanephros development glomerulus development podocyte development epithelial cell development cell differentiation involved in kidney development metanephric podocyte differentiation glomerular epithelial cell development podocyte differentiation kidney development extracellular matrix organization cellular component biogenesis cellular component assembly basement membrane assembly extracellular matrix assembly basement membrane organization extracellular structure organization external encapsulating structure organization glomerular basement membrane development metanephric glomerular basement membrane development sensory perception of light stimulus system process sensory perception nervous system process visual perception	basement membrane cell periphery extracellular matrix external encapsulating structure collagen-containing extracellular matrix cellular anatomical entity synaptic cleft extracellular region laminin complex protein-containing complex neuromuscular junction synapse cell junction laminin-3 complex

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR008211	Laminin, N-terminal	Domain
A, B	IPR013015	Laminin IV type B	Domain
A, B	IPR002049	Laminin-type EGF domain	Domain
A, B	IPR000742	EGF-like domain	Domain

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.