5LBS
structural basis of Zika and Dengue virus potent antibody cross-neutralization
External Resource: Annotation
- Domain Annotation: SCOP/SCOPe Classification
- Domain Annotation: SCOP2 Classification
- Domain Annotation: ECOD Classification
- Domain Annotation: CATH
- IMGT Antibody Annotation
- SAbDab Antibody Annotation
- Protein Family Annotation
- Gene Ontology: Gene Product Annotation
- InterPro: Protein Family Classification
- Membrane Protein Annotation: OPM
Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage
Chains | Domain Info | Class | Fold | Superfamily | Family | Domain | Species | Provenance Source (Version) |
---|---|---|---|---|---|---|---|---|
C [auth H] | d5lbsh_ | All beta proteins | Immunoglobulin-like beta-sandwich | Immunoglobulin | V set domains (antibody variable domain-like) | automated matches | HUMAN (Homo sapiens ) [TaxId: 9606 ], | SCOPe (2.08) |
D [auth I] | d5lbsi_ | All beta proteins | Immunoglobulin-like beta-sandwich | Immunoglobulin | V set domains (antibody variable domain-like) | automated matches | HUMAN (Homo sapiens ) [TaxId: 9606 ], | SCOPe (2.08) |
E [auth L] | d5lbsl_ | All beta proteins | Immunoglobulin-like beta-sandwich | Immunoglobulin | automated matches | automated matches | HUMAN (Homo sapiens ) [TaxId: 9606 ], | SCOPe (2.08) |
F [auth M] | d5lbsm_ | All beta proteins | Immunoglobulin-like beta-sandwich | Immunoglobulin | automated matches | automated matches | HUMAN (Homo sapiens ) [TaxId: 9606 ], | SCOPe (2.08) |
Domain Annotation: ECOD Classification ECOD Database Homepage
Chains | Family Name | Domain Identifier | Architecture | Possible Homology | Homology | Topology | Family | Provenance Source (Version) |
---|---|---|---|---|---|---|---|---|
A | PF02832 | e5lbsA2 | A: beta sandwiches | X: Immunoglobulin-like beta-sandwich | H: Immunoglobulin-related | T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like | F: PF02832 | ECOD (1.6) |
A | PF00869 | e5lbsA1 | A: beta complex topology | X: Viral glycoprotein, central and dimerisation domains-like | H: Viral glycoprotein, central and dimerisation domains (From Topology) | T: Viral glycoprotein, central and dimerisation domains | F: PF00869 | ECOD (1.6) |
B | PF02832 | e5lbsB1 | A: beta sandwiches | X: Immunoglobulin-like beta-sandwich | H: Immunoglobulin-related | T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like | F: PF02832 | ECOD (1.6) |
B | PF00869 | e5lbsB2 | A: beta complex topology | X: Viral glycoprotein, central and dimerisation domains-like | H: Viral glycoprotein, central and dimerisation domains (From Topology) | T: Viral glycoprotein, central and dimerisation domains | F: PF00869 | ECOD (1.6) |
C [auth H] | PF07686 | e5lbsH1 | A: beta sandwiches | X: Immunoglobulin-like beta-sandwich | H: Immunoglobulin-related | T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like | F: PF07686 | ECOD (1.6) |
D [auth I] | PF07686 | e5lbsI1 | A: beta sandwiches | X: Immunoglobulin-like beta-sandwich | H: Immunoglobulin-related | T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like | F: PF07686 | ECOD (1.6) |
E [auth L] | PF07686 | e5lbsL1 | A: beta sandwiches | X: Immunoglobulin-like beta-sandwich | H: Immunoglobulin-related | T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like | F: PF07686 | ECOD (1.6) |
F [auth M] | PF07686 | e5lbsM1 | A: beta sandwiches | X: Immunoglobulin-like beta-sandwich | H: Immunoglobulin-related | T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like | F: PF07686 | ECOD (1.6) |
Domain Annotation: CATH CATH Database Homepage
IMGT Antibody Annotation IMGT Database Homepage
Chain | Protein Name | Description | Organism Name | Gene Allele Name(s) | Domain Name(s) | Receptor Type | Receptor Description | Provenance Source |
---|---|---|---|---|---|---|---|---|
C [auth H], D [auth I] | Fv EDE1 C8 | VH | Homo sapiens (human) | IGHV3-64*03, IGHV3-64*05, IGHV3-64D*06, IGHJ3*01 | V-DOMAIN VH | IG | FV-HEAVY_KAPPA | IMGT (202416-0) |
E [auth L], F [auth M] | Fv EDE1 C8 | V-KAPPA | Homo sapiens (human) | IGKV3-11*01, IGKJ1*01, IGKJ2*01 | V-DOMAIN V-KAPPA | IG | FV-HEAVY_KAPPA | IMGT (202416-0) |
SAbDab Antibody Annotation SAbDab Database Homepage
Chain | Chain Class | Chain Subclass | Chain Type | Antigen Name(s) | Provenance Source |
---|---|---|---|---|---|
C [auth H], D [auth I] | Heavy Chain | IGHV3 | - | envelope protein e | SAbDab (2024-04-26) |
E [auth L], F [auth M] | Light Chain | IGKV3 | Kappa | envelope protein e | SAbDab (2024-04-26) |
Protein Family Annotation Pfam Database Homepage
Chains | Accession | Name | Description | Comments | Source |
---|---|---|---|---|---|
PF00869 | Flavivirus glycoprotein, central and dimerisation domains (Flavi_glycoprot) | Flavivirus glycoprotein, central and dimerisation domains | - | Domain | |
PF02832 | Flavivirus glycoprotein, immunoglobulin-like domain (Flavi_glycop_C) | Flavivirus glycoprotein, immunoglobulin-like domain | - | Domain | |
Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage
InterPro: Protein Family Classification InterPro Database Homepage
Membrane Protein Annotation: OPM OPM Database Homepage
Chains | External Link | Type | Class | Superfamily | Family |
---|---|---|---|---|---|
OPM | Transmembrane | Bitopic proteins | Viral membrane fusion glycoprotein | Flavivirus glycoprotein |