5L9U

Model of human Anaphase-promoting complex/Cyclosome (APC/C-CDH1) with a cross linked Ubiquitin variant-substrate-UBE2C (UBCH10) complex representing key features of multiubiquitination

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
I	SCOP2B Superfamily	WD40 repeat-like	8106386	3001694	SCOP2B (2022-06-29)
I	SCOP2B Superfamily	WD40 repeat-like	8106386	3001694	SCOP2B (2022-06-29)
N	SCOP2B Superfamily	Winged helix DNA-binding domain	8084656	3000034	SCOP2B (2022-06-29)
L	SCOP2B Superfamily	galactose-binding domain-like	8037020	3000087	SCOP2B (2022-06-29)
Q [auth R]	SCOP2B Superfamily	WD40 repeat-like	8106390	3001694	SCOP2B (2022-06-29)
S [auth U]	SCOP2B Superfamily	UBC-like	8033738	3000570	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	RING/U-box like	8082719	3000160	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	TPR-like	8057064	3001345	SCOP2B (2022-06-29)
P	SCOP2B Superfamily	TPR-like	8057064	3001345	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	Anaphase-promoting complex subunit 16-like	8053719	3002218	SCOP2B (2022-06-29)
G	SCOP2B Superfamily	CDC26-like	8053843	3002235	SCOP2B (2022-06-29)
T [auth W]	SCOP2B Superfamily	CDC26-like	8053843	3002235	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
F	TPR_11_7	e5l9uF1	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: TPR_11_7	ECOD (1.6)
H	TPR_11_7	e5l9uH1	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: TPR_11_7	ECOD (1.6)
I	ANAPC4_WD40	e5l9uI2	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 7-bladed	F: ANAPC4_WD40	ECOD (1.6)
I	ANAPC4	e5l9uI1	A: alpha bundles	X: Four-helical up-and-down bundle	H: Helical bundle domain in anaphase-promoting complex subunit 4 (From Topology)	T: Helical bundle domain in anaphase-promoting complex subunit 4	F: ANAPC4	ECOD (1.6)
J	TPR_11_7	e5l9uJ1	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: TPR_11_7	ECOD (1.6)
K	TPR_11_7	e5l9uK1	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: TPR_11_7	ECOD (1.6)
N	ANAPC2	e5l9uN5	A: alpha arrays	X: HTH	H: HTH	T: winged	F: ANAPC2	ECOD (1.6)
N	Cullin_4th	e5l9uN4	A: alpha arrays	X: HTH	H: HTH	T: winged	F: Cullin_4th	ECOD (1.6)
N	Cullin_2nd	e5l9uN1	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: Cullin_2nd	ECOD (1.6)
N	KOG2165	e5l9uN2	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: KOG2165	ECOD (1.6)
N	Cullin_3rd	e5l9uN3	A: a+b duplicates or obligate multimers	X: a+b domain in cullin-like proteins (From Topology)	H: a+b domain in cullin-like proteins (From Topology)	T: a+b domain in cullin-like proteins	F: Cullin_3rd	ECOD (1.6)
O	Apc5_N	e5l9uO1	A: alpha arrays	X: SHQ1 C-terminal domain-like	H: Anaphase-promoting complex subunit 5 N-terminal domain (From Topology)	T: Anaphase-promoting complex subunit 5 N-terminal domain	F: Apc5_N	ECOD (1.6)
O	ANAPC5	e5l9uO2	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: ANAPC5	ECOD (1.6)
A	ANAPC1	e5l9uA2	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 7-bladed	F: ANAPC1	ECOD (1.6)
A	KOG1858_2nd	e5l9uA1	A: alpha superhelices	X: Repetitive alpha hairpins	H: Proteasome/cyclosome (PC) repeat (From Topology)	T: Proteasome/cyclosome (PC) repeat	F: KOG1858_2nd	ECOD (1.6)
A	KOG1858_1st	e5l9uA3	A: alpha superhelices	X: Repetitive alpha hairpins	H: Anaphase-promoting complex subunit 1 first helical domain (From Topology)	T: Anaphase-promoting complex subunit 1 first helical domain	F: KOG1858_1st	ECOD (1.6)
A	KOG1858_4th	e5l9uA4	A: alpha superhelices	X: Repetitive alpha hairpins	H: Anaphase-promoting complex subunit 1 second helical domain (From Topology)	T: Anaphase-promoting complex subunit 1 second helical domain	F: KOG1858_4th	ECOD (1.6)
L	ANAPC10	e5l9uL1	A: beta sandwiches	X: jelly-roll	H: Concanavalin A-like	T: Galactose-binding domain-like	F: ANAPC10	ECOD (1.6)
Q [auth R]	ANAPC4_WD40_1	e5l9uR1	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 7-bladed	F: ANAPC4_WD40_1	ECOD (1.6)
S [auth U]	UQ_con	e5l9uU1	A: a+b two layers	X: UBC-like	H: UBC-like (From Topology)	T: UBC-like	F: UQ_con	ECOD (1.6)
U [auth X]	TPR_19,ANAPC8	e5l9uX1	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: TPR_19,ANAPC8	ECOD (1.6)
V [auth Y]	TPR_19,ANAPC8	e5l9uY1	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: TPR_19,ANAPC8	ECOD (1.6)
B	zf-rbx1	e5l9uB1	A: few secondary structure elements	X: RING/U-box-like	H: RING/U-box-like	T: RING/U-box	F: zf-rbx1	ECOD (1.6)
C	KOG1155,ANAPC8	e5l9uC1	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: KOG1155,ANAPC8	ECOD (1.6)
P	ANAPC8	e5l9uP1	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: ANAPC8	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
F, H	PF12895	Anaphase-promoting complex, cyclosome, subunit 3 (ANAPC3)	Anaphase-promoting complex, cyclosome, subunit 3	-	Repeat
F, H	PF00515	Tetratricopeptide repeat (TPR_1)	Tetratricopeptide repeat	-	Repeat
I	PF12894	Anaphase-promoting complex subunit 4 WD40 domain (ANAPC4_WD40)	Anaphase-promoting complex subunit 4 WD40 domain	-	Repeat
J, K	PF13424	Tetratricopeptide repeat (TPR_12)	Tetratricopeptide repeat	-	Repeat
N	PF08672	Anaphase promoting complex (APC) subunit 2 (ANAPC2)	Anaphase promoting complex (APC) subunit 2	The anaphase promoting complex or cyclosome (APC2) is an E3 ubiquitin ligase which is part of the SCF family of ubiquitin ligases. Ubiquitin ligases catalyse the transfer of ubiquitin from the ubiquitin conjugating enzyme (E2), to the substrate prot ...	The anaphase promoting complex or cyclosome (APC2) is an E3 ubiquitin ligase which is part of the SCF family of ubiquitin ligases. Ubiquitin ligases catalyse the transfer of ubiquitin from the ubiquitin conjugating enzyme (E2), to the substrate protein.	Domain
O	PF12862	Anaphase-promoting complex subunit 5 (ANAPC5)	Anaphase-promoting complex subunit 5	-	Repeat
O	PF21371	Anaphase-promoting complex subunit 5, N-terminal domain (Apc5_N)	Anaphase-promoting complex subunit 5, N-terminal domain	This domain is found at the N-terminal end of Anaphase-promoting complex subunit 5 from humans (Apc5), a component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitos ...	This domain is found at the N-terminal end of Anaphase-promoting complex subunit 5 from humans (Apc5), a component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. This domain has an alpha-helical fold [1-4]. It is normally found in association with Pfam:PF12862.	Domain
R [auth S]	PF00240	Ubiquitin family (ubiquitin)	Ubiquitin family	This family contains a number of ubiquitin-like proteins: SUMO (smt3 homologue) (see Swiss:Q02724), Nedd8 (see Swiss:P29595), Elongin B (see Swiss:Q15370), Rub1 (see Swiss:Q9SHE7), and Parkin (see Swiss:O60260). A number of them are thought to carry ...	This family contains a number of ubiquitin-like proteins: SUMO (smt3 homologue) (see Swiss:Q02724), Nedd8 (see Swiss:P29595), Elongin B (see Swiss:Q15370), Rub1 (see Swiss:Q9SHE7), and Parkin (see Swiss:O60260). A number of them are thought to carry a distinctive five-residue motif termed the proteasome-interacting motif (PIM), which may have a biologically significant role in protein delivery to proteasomes and recruitment of proteasomes to transcription sites [5].	Domain
A	PF20518	Anaphase-promoting complex subunit 1 middle domain (Apc1_MidN)	Anaphase-promoting complex subunit 1 middle domain	-	Repeat
A	PF21282	APC1 beta sandwich domain (APC1_3rd)	APC1 beta sandwich domain	This domain is found close to the C-terminus of the APC1 protein which is a component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the ce ...	This domain is found close to the C-terminus of the APC1 protein which is a component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle.	Domain
L	PF03256	Anaphase-promoting complex, subunit 10 (APC10) (ANAPC10)	Anaphase-promoting complex, subunit 10 (APC10)	-	Family
M	PF05839	Apc13p protein (Apc13p)	Apc13p protein	-	Family
Q [auth R]	PF12894	Anaphase-promoting complex subunit 4 WD40 domain (ANAPC4_WD40)	Anaphase-promoting complex subunit 4 WD40 domain	-	Repeat
Q [auth R]	PF00400	WD domain, G-beta repeat (WD40)	WD domain, G-beta repeat	-	Repeat
S [auth U]	PF00179	Ubiquitin-conjugating enzyme (UQ_con)	Ubiquitin-conjugating enzyme	Proteins destined for proteasome-mediated degradation may be ubiquitinated. Ubiquitination follows conjugation of ubiquitin to a conserved cysteine residue of UBC homologues. TSG101 is one of several UBC homologues that lacks this active site cystein ...	Proteins destined for proteasome-mediated degradation may be ubiquitinated. Ubiquitination follows conjugation of ubiquitin to a conserved cysteine residue of UBC homologues. TSG101 is one of several UBC homologues that lacks this active site cysteine [4, 5].	Domain
U [auth X], V [auth Y]	PF13181	Tetratricopeptide repeat (TPR_8)	Tetratricopeptide repeat	-	Repeat
B	PF12861	Anaphase-promoting complex subunit 11 RING-H2 finger (zf-ANAPC11)	Anaphase-promoting complex subunit 11 RING-H2 finger	-	Family
C, P	PF04049	Anaphase promoting complex subunit 8 / Cdc23 (ANAPC8)	Anaphase promoting complex subunit 8 / Cdc23	-	Repeat
D	PF15243	Anaphase-promoting complex subunit 15 (ANAPC15)	Anaphase-promoting complex subunit 15	-	Family
E	PF17256	Anaphase-promoting complex, subunit 16 (ANAPC16)	Anaphase-promoting complex, subunit 16	-	Family
G, T [auth W]	PF10471	Anaphase-promoting complex APC subunit CDC26 (ANAPC_CDC26)	Anaphase-promoting complex APC subunit CDC26	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
F, H	Cell division cycle protein 27 homolog	protein phosphatase binding phosphatase binding protein binding binding enzyme binding	regulation of mitotic cell cycle regulation of biological process regulation of cellular process biological regulation cellular process cell cycle regulation of cell cycle mitotic cell cycle regulation of chromosome segregation regulation of cellular component organization cell cycle phase transition cellular component organization cellular component organization or biogenesis chromosome segregation regulation of mitotic cell cycle regulation of biological process regulation of cellular process biological regulation cellular process cell cycle regulation of cell cycle mitotic cell cycle regulation of chromosome segregation regulation of cellular component organization cell cycle phase transition cellular component organization cellular component organization or biogenesis chromosome segregation cell cycle process regulation of cell cycle process chromosome organization sister chromatid segregation regulation of chromosome organization regulation of organelle organization organelle organization mitotic cell cycle process regulation of sister chromatid segregation nuclear chromosome segregation metaphase/anaphase transition of mitotic cell cycle metaphase/anaphase transition of cell cycle mitotic cell cycle phase transition organonitrogen compound catabolic process organonitrogen compound metabolic process catabolic process proteolysis involved in protein catabolic process primary metabolic process proteasomal protein catabolic process protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process macromolecule catabolic process organic substance metabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis anaphase-promoting complex-dependent catabolic process ubiquitin-dependent protein catabolic process metabolic process protein metabolic process macromolecule metabolic process organic substance catabolic process protein K11-linked ubiquitination protein polyubiquitination protein ubiquitination macromolecule modification post-translational protein modification protein modification process protein modification by small protein conjugation protein modification by small protein conjugation or removal cell division regulation of meiotic cell cycle sexual reproduction regulation of reproductive process reproductive process meiotic cell cycle	intracellular organelle centrosome microtubule organizing center intracellular anatomical structure cytoskeleton organelle intracellular non-membrane-bounded organelle cellular anatomical entity microtubule cytoskeleton non-membrane-bounded organelle membrane-bounded organelle protein-containing complex ubiquitin ligase complex catalytic complex intracellular organelle centrosome microtubule organizing center intracellular anatomical structure cytoskeleton organelle intracellular non-membrane-bounded organelle cellular anatomical entity microtubule cytoskeleton non-membrane-bounded organelle membrane-bounded organelle protein-containing complex ubiquitin ligase complex catalytic complex nucleus nuclear protein-containing complex intracellular membrane-bounded organelle transferase complex anaphase-promoting complex cullin-RING ubiquitin ligase complex nuclear ubiquitin ligase complex intracellular protein-containing complex cytoplasm cytosol spindle mitotic spindle membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen
I	Anaphase-promoting complex subunit 4	aminoacyltransferase activity ubiquitin-like protein transferase activity catalytic activity, acting on a protein acyltransferase activity transferase activity catalytic activity ubiquitin-protein transferase activity protein phosphatase binding phosphatase binding protein binding binding enzyme binding	cellular process cell cycle regulation of chromosome segregation regulation of cell cycle phase transition regulation of cellular process regulation of metaphase/anaphase transition of cell cycle regulation of cellular component organization cell cycle phase transition regulation of mitotic metaphase/anaphase transition mitotic cell cycle cellular component organization regulation of mitotic cell cycle cellular component organization or biogenesis regulation of cell cycle cellular process cell cycle regulation of chromosome segregation regulation of cell cycle phase transition regulation of cellular process regulation of metaphase/anaphase transition of cell cycle regulation of cellular component organization cell cycle phase transition regulation of mitotic metaphase/anaphase transition mitotic cell cycle cellular component organization regulation of mitotic cell cycle cellular component organization or biogenesis regulation of cell cycle chromosome segregation cell cycle process regulation of biological process regulation of cell cycle process biological regulation chromosome organization sister chromatid segregation regulation of chromosome organization regulation of organelle organization regulation of mitotic cell cycle phase transition organelle organization mitotic cell cycle process regulation of sister chromatid segregation nuclear chromosome segregation metaphase/anaphase transition of mitotic cell cycle metaphase/anaphase transition of cell cycle mitotic cell cycle phase transition organonitrogen compound catabolic process organonitrogen compound metabolic process catabolic process proteolysis involved in protein catabolic process primary metabolic process proteasomal protein catabolic process protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process macromolecule catabolic process organic substance metabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis anaphase-promoting complex-dependent catabolic process ubiquitin-dependent protein catabolic process metabolic process protein metabolic process macromolecule metabolic process organic substance catabolic process protein K11-linked ubiquitination protein polyubiquitination protein ubiquitination macromolecule modification post-translational protein modification protein modification process protein modification by small protein conjugation protein modification by small protein conjugation or removal cell division regulation of meiotic cell cycle sexual reproduction regulation of reproductive process reproductive process meiotic cell cycle	membrane-bounded organelle protein-containing complex intracellular anatomical structure ubiquitin ligase complex catalytic complex nucleus nuclear protein-containing complex intracellular membrane-bounded organelle cellular anatomical entity transferase complex anaphase-promoting complex intracellular organelle cullin-RING ubiquitin ligase complex nuclear ubiquitin ligase complex membrane-bounded organelle protein-containing complex intracellular anatomical structure ubiquitin ligase complex catalytic complex nucleus nuclear protein-containing complex intracellular membrane-bounded organelle cellular anatomical entity transferase complex anaphase-promoting complex intracellular organelle cullin-RING ubiquitin ligase complex nuclear ubiquitin ligase complex organelle intracellular protein-containing complex cytoplasm cytosol membrane-enclosed lumen intracellular organelle lumen organelle lumen nuclear periphery nuclear lumen nucleoplasm
J, K	Cell division cycle protein 16 homolog	-	cellular process cell cycle regulation of mitotic cell cycle regulation of biological process regulation of cellular process biological regulation regulation of cell cycle mitotic cell cycle organonitrogen compound catabolic process organonitrogen compound metabolic process catabolic process proteolysis involved in protein catabolic process primary metabolic process proteasomal protein catabolic process cellular process cell cycle regulation of mitotic cell cycle regulation of biological process regulation of cellular process biological regulation regulation of cell cycle mitotic cell cycle organonitrogen compound catabolic process organonitrogen compound metabolic process catabolic process proteolysis involved in protein catabolic process primary metabolic process proteasomal protein catabolic process protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process macromolecule catabolic process organic substance metabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis anaphase-promoting complex-dependent catabolic process ubiquitin-dependent protein catabolic process metabolic process protein metabolic process macromolecule metabolic process organic substance catabolic process positive regulation of organelle organization regulation of cell cycle phase transition regulation of mitotic nuclear division positive regulation of mitotic nuclear division positive regulation of mitotic metaphase/anaphase transition positive regulation of mitotic cell cycle phase transition mitotic sister chromatid separation chromosome segregation regulation of cell cycle process positive regulation of nuclear division sister chromatid segregation regulation of chromosome organization regulation of organelle organization regulation of mitotic cell cycle phase transition mitotic cell cycle process regulation of chromosome separation regulation of chromosome segregation regulation of metaphase/anaphase transition of cell cycle regulation of cellular component organization regulation of mitotic sister chromatid separation positive regulation of cellular component organization positive regulation of biological process cell cycle phase transition regulation of mitotic metaphase/anaphase transition cellular component organization positive regulation of metaphase/anaphase transition of cell cycle mitotic sister chromatid segregation positive regulation of cell cycle process positive regulation of mitotic cell cycle cellular component organization or biogenesis positive regulation of cellular process cell cycle process mitotic nuclear division organelle fission chromosome organization positive regulation of cell cycle organelle organization nuclear division chromosome separation regulation of sister chromatid segregation positive regulation of cell cycle phase transition positive regulation of mitotic sister chromatid separation regulation of nuclear division nuclear chromosome segregation metaphase/anaphase transition of mitotic cell cycle positive regulation of chromosome separation metaphase/anaphase transition of cell cycle mitotic cell cycle phase transition protein K11-linked ubiquitination protein polyubiquitination protein ubiquitination macromolecule modification post-translational protein modification protein modification process protein modification by small protein conjugation protein modification by small protein conjugation or removal cell division regulation of meiotic cell cycle sexual reproduction regulation of reproductive process reproductive process meiotic cell cycle	intracellular organelle centrosome microtubule organizing center intracellular anatomical structure cytoskeleton organelle intracellular non-membrane-bounded organelle cellular anatomical entity microtubule cytoskeleton non-membrane-bounded organelle membrane-bounded organelle protein-containing complex ubiquitin ligase complex catalytic complex intracellular organelle centrosome microtubule organizing center intracellular anatomical structure cytoskeleton organelle intracellular non-membrane-bounded organelle cellular anatomical entity microtubule cytoskeleton non-membrane-bounded organelle membrane-bounded organelle protein-containing complex ubiquitin ligase complex catalytic complex nucleus nuclear protein-containing complex intracellular membrane-bounded organelle transferase complex anaphase-promoting complex cullin-RING ubiquitin ligase complex nuclear ubiquitin ligase complex intracellular protein-containing complex cytoplasm cytosol mitotic spindle spindle membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen
N	Anaphase-promoting complex subunit 2	ubiquitin protein ligase binding protein binding binding ubiquitin-like protein ligase binding enzyme binding	developmental process cellular developmental process cell differentiation cellular process multicellular organismal process regulation of cellular component organization regulation of cellular process positive regulation of cellular component organization regulation of developmental process positive regulation of biological process cellular component organization positive regulation of developmental process multicellular organism development anatomical structure development developmental process cellular developmental process cell differentiation cellular process multicellular organismal process regulation of cellular component organization regulation of cellular process positive regulation of cellular component organization regulation of developmental process positive regulation of biological process cellular component organization positive regulation of developmental process multicellular organism development anatomical structure development regulation of synapse structure or activity synapse organization cellular component organization or biogenesis regulation of biological quality positive regulation of cellular process system development regulation of biological process biological regulation nervous system development developmental maturation synapse maturation regulation of synapse organization regulation of synapse maturation cell junction organization positive regulation of synapse maturation regulation of mitotic cell cycle cell cycle regulation of cell cycle mitotic cell cycle regulation of chromosome segregation cell cycle phase transition chromosome segregation cell cycle process regulation of cell cycle process chromosome organization sister chromatid segregation regulation of chromosome organization regulation of organelle organization organelle organization mitotic cell cycle process regulation of sister chromatid segregation nuclear chromosome segregation metaphase/anaphase transition of mitotic cell cycle metaphase/anaphase transition of cell cycle mitotic cell cycle phase transition organonitrogen compound catabolic process organonitrogen compound metabolic process catabolic process proteolysis involved in protein catabolic process primary metabolic process proteasomal protein catabolic process protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process macromolecule catabolic process organic substance metabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis anaphase-promoting complex-dependent catabolic process ubiquitin-dependent protein catabolic process metabolic process protein metabolic process macromolecule metabolic process organic substance catabolic process protein K11-linked ubiquitination protein polyubiquitination protein ubiquitination macromolecule modification post-translational protein modification protein modification process protein modification by small protein conjugation protein modification by small protein conjugation or removal cell division axon extension positive regulation of nervous system development regulation of growth axonogenesis regulation of cellular component size developmental growth cell projection organization regulation of cell differentiation regulation of neurogenesis neuron projection development regulation of cell development cell projection morphogenesis neuron differentiation neuron projection morphogenesis positive regulation of cell projection organization positive regulation of developmental growth regulation of cell projection organization positive regulation of cell development developmental growth involved in morphogenesis generation of neurons positive regulation of multicellular organismal process regulation of neuron projection development plasma membrane bounded cell projection morphogenesis cell development cell growth cell morphogenesis regulation of axon extension regulation of nervous system development neurogenesis regulation of extent of cell growth positive regulation of cell differentiation regulation of axonogenesis positive regulation of neurogenesis regulation of multicellular organismal process positive regulation of axon extension positive regulation of axonogenesis regulation of anatomical structure morphogenesis regulation of cell size neuron projection extension regulation of multicellular organismal development regulation of developmental growth plasma membrane bounded cell projection organization developmental cell growth growth positive regulation of cell growth axon development regulation of cell growth cell morphogenesis involved in neuron differentiation anatomical structure morphogenesis positive regulation of growth neuron development regulation of plasma membrane bounded cell projection organization regulation of anatomical structure size cellular biosynthetic process negative regulation of biological process negative regulation of cellular metabolic process organic substance biosynthetic process negative regulation of cellular process negative regulation of macromolecule metabolic process regulation of biosynthetic process cellular metabolic process negative regulation of metabolic process regulation of cellular metabolic process regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process negative regulation of cellular biosynthetic process regulation of cellular biosynthetic process regulation of gene expression negative regulation of gene expression biosynthetic process negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process regulation of macromolecule biosynthetic process regulation of metabolic process regulation of synaptic plasticity trans-synaptic signaling regulation of signaling modulation of chemical synaptic transmission signaling cell-cell signaling chemical synaptic transmission cell communication positive regulation of synaptic plasticity synaptic signaling regulation of trans-synaptic signaling anterograde trans-synaptic signaling regulation of cell communication regulation of cell morphogenesis regulation of dendrite morphogenesis positive regulation of cell morphogenesis regulation of dendrite development dendrite development positive regulation of dendrite morphogenesis dendrite morphogenesis regulation of meiotic cell cycle sexual reproduction regulation of reproductive process reproductive process meiotic cell cycle	membrane-bounded organelle protein-containing complex intracellular anatomical structure ubiquitin ligase complex catalytic complex nucleus nuclear protein-containing complex intracellular membrane-bounded organelle cellular anatomical entity transferase complex anaphase-promoting complex intracellular organelle cullin-RING ubiquitin ligase complex nuclear ubiquitin ligase complex membrane-bounded organelle protein-containing complex intracellular anatomical structure ubiquitin ligase complex catalytic complex nucleus nuclear protein-containing complex intracellular membrane-bounded organelle cellular anatomical entity transferase complex anaphase-promoting complex intracellular organelle cullin-RING ubiquitin ligase complex nuclear ubiquitin ligase complex organelle intracellular protein-containing complex cytoplasm cytosol membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen
O	Anaphase-promoting complex subunit 5	protein phosphatase binding phosphatase binding protein binding binding enzyme binding	cellular process cell cycle regulation of mitotic cell cycle regulation of biological process regulation of cellular process biological regulation regulation of cell cycle mitotic cell cycle organonitrogen compound catabolic process organonitrogen compound metabolic process catabolic process proteolysis involved in protein catabolic process primary metabolic process proteasomal protein catabolic process cellular process cell cycle regulation of mitotic cell cycle regulation of biological process regulation of cellular process biological regulation regulation of cell cycle mitotic cell cycle organonitrogen compound catabolic process organonitrogen compound metabolic process catabolic process proteolysis involved in protein catabolic process primary metabolic process proteasomal protein catabolic process protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process macromolecule catabolic process organic substance metabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis anaphase-promoting complex-dependent catabolic process ubiquitin-dependent protein catabolic process metabolic process protein metabolic process macromolecule metabolic process organic substance catabolic process positive regulation of organelle organization regulation of cell cycle phase transition regulation of mitotic nuclear division positive regulation of mitotic nuclear division positive regulation of mitotic metaphase/anaphase transition positive regulation of mitotic cell cycle phase transition mitotic sister chromatid separation chromosome segregation regulation of cell cycle process positive regulation of nuclear division sister chromatid segregation regulation of chromosome organization regulation of organelle organization regulation of mitotic cell cycle phase transition mitotic cell cycle process regulation of chromosome separation regulation of chromosome segregation regulation of metaphase/anaphase transition of cell cycle regulation of cellular component organization regulation of mitotic sister chromatid separation positive regulation of cellular component organization positive regulation of biological process cell cycle phase transition regulation of mitotic metaphase/anaphase transition cellular component organization positive regulation of metaphase/anaphase transition of cell cycle mitotic sister chromatid segregation positive regulation of cell cycle process positive regulation of mitotic cell cycle cellular component organization or biogenesis positive regulation of cellular process cell cycle process mitotic nuclear division organelle fission chromosome organization positive regulation of cell cycle organelle organization nuclear division chromosome separation regulation of sister chromatid segregation positive regulation of cell cycle phase transition positive regulation of mitotic sister chromatid separation regulation of nuclear division nuclear chromosome segregation metaphase/anaphase transition of mitotic cell cycle positive regulation of chromosome separation metaphase/anaphase transition of cell cycle mitotic cell cycle phase transition protein K11-linked ubiquitination protein polyubiquitination protein ubiquitination macromolecule modification post-translational protein modification protein modification process protein modification by small protein conjugation protein modification by small protein conjugation or removal cell division regulation of meiotic cell cycle sexual reproduction regulation of reproductive process reproductive process meiotic cell cycle	membrane-bounded organelle protein-containing complex intracellular anatomical structure ubiquitin ligase complex catalytic complex nucleus nuclear protein-containing complex intracellular membrane-bounded organelle cellular anatomical entity transferase complex anaphase-promoting complex intracellular organelle cullin-RING ubiquitin ligase complex nuclear ubiquitin ligase complex membrane-bounded organelle protein-containing complex intracellular anatomical structure ubiquitin ligase complex catalytic complex nucleus nuclear protein-containing complex intracellular membrane-bounded organelle cellular anatomical entity transferase complex anaphase-promoting complex intracellular organelle cullin-RING ubiquitin ligase complex nuclear ubiquitin ligase complex organelle intracellular protein-containing complex cytoplasm cytosol cytoskeleton spindle intracellular non-membrane-bounded organelle microtubule cytoskeleton non-membrane-bounded organelle membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen
R [auth S]	Hsl1(substrate)_peptide-Ubiquitin_variant fusion	protein binding binding enzyme binding protease binding protein tag activity molecular tag activity ubiquitin protein ligase binding ubiquitin-like protein ligase binding structural molecule activity structural constituent of ribosome adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding protein binding binding enzyme binding protease binding protein tag activity molecular tag activity ubiquitin protein ligase binding ubiquitin-like protein ligase binding structural molecule activity structural constituent of ribosome adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding catalytic activity, acting on a protein kinase activity protein kinase activity transferase activity catalytic activity phosphotransferase activity, alcohol group as acceptor transferase activity, transferring phosphorus-containing groups protein serine/threonine kinase activity protein serine kinase activity	organonitrogen compound catabolic process organonitrogen compound metabolic process catabolic process proteolysis involved in protein catabolic process primary metabolic process protein catabolic process macromolecule catabolic process organic substance metabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis ubiquitin-dependent protein catabolic process metabolic process protein metabolic process organonitrogen compound catabolic process organonitrogen compound metabolic process catabolic process proteolysis involved in protein catabolic process primary metabolic process protein catabolic process macromolecule catabolic process organic substance metabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis ubiquitin-dependent protein catabolic process metabolic process protein metabolic process macromolecule metabolic process organic substance catabolic process protein ubiquitination macromolecule modification post-translational protein modification protein modification process protein modification by small protein conjugation protein modification by small protein conjugation or removal protein localization cellular localization protein localization to cell periphery localization protein localization to cytoskeleton protein localization to organelle cellular macromolecule localization macromolecule localization protein localization to septin ring cellular process protein localization to cell cortex phosphorylation cellular metabolic process phosphate-containing compound metabolic process phosphorus metabolic process regulation of biological process regulation of cellular process biological regulation cell cycle regulation of cell cycle cellular response to stimulus response to stimulus signaling signal transduction intracellular signal transduction cell communication cell cycle G2/M phase transition mitotic cell cycle process G2/M transition of mitotic cell cycle cell cycle phase transition mitotic cell cycle cell cycle process mitotic cell cycle phase transition regulation of cell cycle phase transition negative regulation of biological process negative regulation of cell cycle negative regulation of mitotic cell cycle regulation of mitotic cell cycle negative regulation of cellular process negative regulation of cell cycle phase transition regulation of cell cycle process negative regulation of cell cycle process cell cycle checkpoint signaling mitotic cell cycle checkpoint signaling mitotic morphogenesis checkpoint signaling	membrane-bounded organelle intracellular anatomical structure mitochondrial membrane mitochondrion membrane organelle outer membrane cellular anatomical entity intracellular membrane-bounded organelle intracellular organelle organelle envelope bounding membrane of organelle organelle mitochondrial envelope mitochondrial outer membrane membrane-bounded organelle intracellular anatomical structure mitochondrial membrane mitochondrion membrane organelle outer membrane cellular anatomical entity intracellular membrane-bounded organelle intracellular organelle organelle envelope bounding membrane of organelle organelle mitochondrial envelope mitochondrial outer membrane outer membrane cytoplasm organelle membrane cytosolic small ribosomal subunit protein-containing complex small ribosomal subunit ribosomal subunit cytosolic ribosome ribonucleoprotein complex intracellular non-membrane-bounded organelle ribosome cytosol non-membrane-bounded organelle nucleus cell division site cell cortex cellular bud neck cellular bud septin ring cleavage apparatus septin structure cell periphery cytoskeleton cellular bud neck septin structure cellular bud neck septin ring septin cytoskeleton site of polarized growth
A	Anaphase-promoting complex subunit 1	molecular adaptor activity	regulation of mitotic cell cycle regulation of biological process regulation of cellular process biological regulation cellular process cell cycle regulation of cell cycle mitotic cell cycle regulation of chromosome segregation regulation of cellular component organization cell cycle phase transition cellular component organization cellular component organization or biogenesis chromosome segregation regulation of mitotic cell cycle regulation of biological process regulation of cellular process biological regulation cellular process cell cycle regulation of cell cycle mitotic cell cycle regulation of chromosome segregation regulation of cellular component organization cell cycle phase transition cellular component organization cellular component organization or biogenesis chromosome segregation cell cycle process regulation of cell cycle process chromosome organization sister chromatid segregation regulation of chromosome organization regulation of organelle organization organelle organization mitotic cell cycle process regulation of sister chromatid segregation nuclear chromosome segregation metaphase/anaphase transition of mitotic cell cycle metaphase/anaphase transition of cell cycle mitotic cell cycle phase transition organonitrogen compound catabolic process organonitrogen compound metabolic process catabolic process proteolysis involved in protein catabolic process primary metabolic process proteasomal protein catabolic process protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process macromolecule catabolic process organic substance metabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis anaphase-promoting complex-dependent catabolic process ubiquitin-dependent protein catabolic process metabolic process protein metabolic process macromolecule metabolic process organic substance catabolic process protein K11-linked ubiquitination protein polyubiquitination protein ubiquitination macromolecule modification post-translational protein modification protein modification process protein modification by small protein conjugation protein modification by small protein conjugation or removal cell division regulation of meiotic cell cycle sexual reproduction regulation of reproductive process reproductive process meiotic cell cycle	membrane-bounded organelle protein-containing complex intracellular anatomical structure ubiquitin ligase complex catalytic complex nucleus nuclear protein-containing complex intracellular membrane-bounded organelle cellular anatomical entity transferase complex anaphase-promoting complex intracellular organelle cullin-RING ubiquitin ligase complex nuclear ubiquitin ligase complex membrane-bounded organelle protein-containing complex intracellular anatomical structure ubiquitin ligase complex catalytic complex nucleus nuclear protein-containing complex intracellular membrane-bounded organelle cellular anatomical entity transferase complex anaphase-promoting complex intracellular organelle cullin-RING ubiquitin ligase complex nuclear ubiquitin ligase complex organelle intracellular protein-containing complex cytoplasm cytosol membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen
L	Anaphase-promoting complex subunit 10	-	cellular process cell cycle regulation of mitotic cell cycle regulation of biological process regulation of cellular process biological regulation regulation of cell cycle mitotic cell cycle organonitrogen compound catabolic process organonitrogen compound metabolic process catabolic process proteolysis involved in protein catabolic process primary metabolic process proteasomal protein catabolic process cellular process cell cycle regulation of mitotic cell cycle regulation of biological process regulation of cellular process biological regulation regulation of cell cycle mitotic cell cycle organonitrogen compound catabolic process organonitrogen compound metabolic process catabolic process proteolysis involved in protein catabolic process primary metabolic process proteasomal protein catabolic process protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process macromolecule catabolic process organic substance metabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis anaphase-promoting complex-dependent catabolic process ubiquitin-dependent protein catabolic process metabolic process protein metabolic process macromolecule metabolic process organic substance catabolic process protein K11-linked ubiquitination protein polyubiquitination protein ubiquitination macromolecule modification post-translational protein modification protein modification process protein modification by small protein conjugation protein modification by small protein conjugation or removal regulation of meiotic cell cycle sexual reproduction regulation of reproductive process reproductive process meiotic cell cycle cell division	intracellular anatomical structure cytoplasm cellular anatomical entity cytosol membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle nucleoplasm organelle lumen organelle nuclear lumen intracellular anatomical structure cytoplasm cellular anatomical entity cytosol membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle nucleoplasm organelle lumen organelle nuclear lumen protein-containing complex ubiquitin ligase complex catalytic complex nuclear protein-containing complex transferase complex anaphase-promoting complex cullin-RING ubiquitin ligase complex nuclear ubiquitin ligase complex intracellular protein-containing complex
M	Anaphase-promoting complex subunit 13	-	cellular process cell cycle regulation of mitotic cell cycle regulation of biological process regulation of cellular process biological regulation regulation of cell cycle mitotic cell cycle organonitrogen compound catabolic process organonitrogen compound metabolic process catabolic process proteolysis involved in protein catabolic process primary metabolic process proteasomal protein catabolic process cellular process cell cycle regulation of mitotic cell cycle regulation of biological process regulation of cellular process biological regulation regulation of cell cycle mitotic cell cycle organonitrogen compound catabolic process organonitrogen compound metabolic process catabolic process proteolysis involved in protein catabolic process primary metabolic process proteasomal protein catabolic process protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process macromolecule catabolic process organic substance metabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis anaphase-promoting complex-dependent catabolic process ubiquitin-dependent protein catabolic process metabolic process protein metabolic process macromolecule metabolic process organic substance catabolic process protein K11-linked ubiquitination protein polyubiquitination protein ubiquitination macromolecule modification post-translational protein modification protein modification process protein modification by small protein conjugation protein modification by small protein conjugation or removal regulation of meiotic cell cycle sexual reproduction regulation of reproductive process reproductive process meiotic cell cycle cell division	membrane-bounded organelle protein-containing complex intracellular anatomical structure ubiquitin ligase complex catalytic complex nucleus nuclear protein-containing complex intracellular membrane-bounded organelle cellular anatomical entity transferase complex anaphase-promoting complex intracellular organelle cullin-RING ubiquitin ligase complex nuclear ubiquitin ligase complex membrane-bounded organelle protein-containing complex intracellular anatomical structure ubiquitin ligase complex catalytic complex nucleus nuclear protein-containing complex intracellular membrane-bounded organelle cellular anatomical entity transferase complex anaphase-promoting complex intracellular organelle cullin-RING ubiquitin ligase complex nuclear ubiquitin ligase complex organelle intracellular protein-containing complex
Q [auth R]	Fizzy-related protein homolog	enzyme regulator activity ubiquitin ligase activator activity enzyme activator activity ubiquitin-protein transferase regulator activity molecular function activator activity molecular function regulator activity ubiquitin-protein transferase activator activity ubiquitin-like ligase-substrate adaptor activity enzyme-substrate adaptor activity protein-macromolecule adaptor activity molecular adaptor activity protein-containing complex binding anaphase-promoting complex binding binding	positive regulation of proteasomal protein catabolic process catabolic process regulation of anaphase-promoting complex-dependent catabolic process proteolysis involved in protein catabolic process positive regulation of protein metabolic process positive regulation of biological process proteasome-mediated ubiquitin-dependent protein catabolic process macromolecule catabolic process regulation of ubiquitin-dependent protein catabolic process regulation of primary metabolic process positive regulation of metabolic process organic substance metabolic process regulation of proteolysis involved in protein catabolic process regulation of proteolysis positive regulation of ubiquitin-dependent protein catabolic process positive regulation of proteasomal protein catabolic process catabolic process regulation of anaphase-promoting complex-dependent catabolic process proteolysis involved in protein catabolic process positive regulation of protein metabolic process positive regulation of biological process proteasome-mediated ubiquitin-dependent protein catabolic process macromolecule catabolic process regulation of ubiquitin-dependent protein catabolic process regulation of primary metabolic process positive regulation of metabolic process organic substance metabolic process regulation of proteolysis involved in protein catabolic process regulation of proteolysis positive regulation of ubiquitin-dependent protein catabolic process modification-dependent macromolecule catabolic process proteolysis positive regulation of macromolecule metabolic process protein metabolic process organonitrogen compound catabolic process regulation of biological process organonitrogen compound metabolic process regulation of protein metabolic process biological regulation primary metabolic process proteasomal protein catabolic process protein catabolic process regulation of macromolecule metabolic process regulation of catabolic process positive regulation of protein catabolic process positive regulation of proteolysis involved in protein catabolic process positive regulation of catabolic process regulation of proteasomal ubiquitin-dependent protein catabolic process modification-dependent protein catabolic process regulation of proteasomal protein catabolic process positive regulation of proteolysis positive regulation of anaphase-promoting complex-dependent catabolic process anaphase-promoting complex-dependent catabolic process ubiquitin-dependent protein catabolic process metabolic process positive regulation of proteasomal ubiquitin-dependent protein catabolic process macromolecule metabolic process organic substance catabolic process regulation of metabolic process regulation of protein catabolic process developmental process multicellular organismal process epithelium development cellular developmental process sensory organ development eye development animal organ development visual system development tissue development epithelial cell differentiation multicellular organism development cell differentiation anatomical structure development camera-type eye development lens fiber cell differentiation cellular process sensory system development lens development in camera-type eye system development regulation of mitotic cell cycle regulation of cellular process cell cycle regulation of cell cycle mitotic cell cycle cell division regulation of meiotic cell cycle sexual reproduction regulation of reproductive process reproductive process meiotic cell cycle regulation of protein modification process regulation of catalytic activity regulation of protein ubiquitination regulation of transferase activity positive regulation of post-translational protein modification regulation of ubiquitin protein ligase activity positive regulation of molecular function positive regulation of ubiquitin protein ligase activity positive regulation of protein modification process protein ubiquitination regulation of ubiquitin-protein transferase activity regulation of protein modification by small protein conjugation or removal protein modification process positive regulation of protein modification by small protein conjugation or removal positive regulation of protein ubiquitination positive regulation of transferase activity regulation of post-translational protein modification positive regulation of catalytic activity positive regulation of ubiquitin-protein transferase activity regulation of molecular function macromolecule modification post-translational protein modification protein modification by small protein conjugation protein modification by small protein conjugation or removal cell population proliferation positive regulation of cell population proliferation regulation of cell population proliferation positive regulation of cellular process cellular response to stimulus regulation of cell cycle phase transition DNA damage checkpoint signaling response to stimulus signaling G2/M transition of mitotic cell cycle mitotic G2 DNA damage checkpoint signaling negative regulation of biological process negative regulation of cell cycle cell cycle phase transition intracellular signal transduction negative regulation of mitotic cell cycle mitotic G2/M transition checkpoint cell communication mitotic DNA integrity checkpoint signaling cellular response to stress response to stress mitotic DNA damage checkpoint signaling negative regulation of cellular process negative regulation of cell cycle phase transition signal transduction cell cycle process cell cycle G2/M phase transition negative regulation of mitotic cell cycle phase transition regulation of G2/M transition of mitotic cell cycle regulation of cell cycle process DNA integrity checkpoint signaling regulation of cell cycle G2/M phase transition negative regulation of cell cycle process cell cycle checkpoint signaling regulation of mitotic cell cycle phase transition mitotic cell cycle checkpoint signaling mitotic cell cycle process DNA damage response negative regulation of cell cycle G2/M phase transition signal transduction in response to DNA damage negative regulation of G2/M transition of mitotic cell cycle mitotic cell cycle phase transition DNA metabolic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process DNA repair regulation of cellular senescence cellular metabolic process negative regulation of metabolic process cellular senescence regulation of cellular metabolic process negative regulation of cellular metabolic process negative regulation of cellular senescence protein K11-linked ubiquitination protein polyubiquitination regulation of cellular component organization meiotic cell cycle process cellular component organization meiotic nuclear division cellular component organization or biogenesis organelle fission regulation of organelle organization regulation of meiotic nuclear division organelle organization nuclear division regulation of nuclear division	membrane-bounded organelle intracellular anatomical structure nuclear membrane membrane nucleus cellular anatomical entity intracellular membrane-bounded organelle endomembrane system intracellular organelle organelle envelope organelle nuclear envelope organelle membrane cytoplasm membrane-bounded organelle intracellular anatomical structure nuclear membrane membrane nucleus cellular anatomical entity intracellular membrane-bounded organelle endomembrane system intracellular organelle organelle envelope organelle nuclear envelope organelle membrane cytoplasm cytosol membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen protein-containing complex ubiquitin ligase complex catalytic complex nuclear protein-containing complex transferase complex anaphase-promoting complex cullin-RING ubiquitin ligase complex nuclear ubiquitin ligase complex intracellular protein-containing complex
S [auth U]	Ubiquitin-conjugating enzyme E2 C	ubiquitin conjugating enzyme activity aminoacyltransferase activity ubiquitin-like protein transferase activity catalytic activity, acting on a protein acyltransferase activity ubiquitin-like protein conjugating enzyme activity transferase activity catalytic activity ubiquitin-protein transferase activity ubiquitin-like protein ligase activity ubiquitin protein ligase activity binding adenyl ribonucleotide binding nucleotide binding ubiquitin conjugating enzyme activity aminoacyltransferase activity ubiquitin-like protein transferase activity catalytic activity, acting on a protein acyltransferase activity ubiquitin-like protein conjugating enzyme activity transferase activity catalytic activity ubiquitin-protein transferase activity ubiquitin-like protein ligase activity ubiquitin protein ligase activity binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding protein binding ubiquitin-like protein ligase binding enzyme binding	regulation of chromosome segregation regulation of cell cycle phase transition regulation of cellular process regulation of metaphase/anaphase transition of cell cycle regulation of cellular component organization cell cycle phase transition regulation of mitotic metaphase/anaphase transition mitotic cell cycle cellular component organization regulation of mitotic cell cycle cell cycle cellular component organization or biogenesis regulation of cell cycle chromosome segregation regulation of chromosome segregation regulation of cell cycle phase transition regulation of cellular process regulation of metaphase/anaphase transition of cell cycle regulation of cellular component organization cell cycle phase transition regulation of mitotic metaphase/anaphase transition mitotic cell cycle cellular component organization regulation of mitotic cell cycle cell cycle cellular component organization or biogenesis regulation of cell cycle chromosome segregation cell cycle process regulation of biological process regulation of cell cycle process biological regulation chromosome organization sister chromatid segregation regulation of chromosome organization regulation of organelle organization regulation of mitotic cell cycle phase transition organelle organization mitotic cell cycle process regulation of sister chromatid segregation nuclear chromosome segregation metaphase/anaphase transition of mitotic cell cycle cellular process metaphase/anaphase transition of cell cycle mitotic cell cycle phase transition organonitrogen compound catabolic process organonitrogen compound metabolic process catabolic process proteolysis involved in protein catabolic process primary metabolic process proteasomal protein catabolic process protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process macromolecule catabolic process organic substance metabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis anaphase-promoting complex-dependent catabolic process ubiquitin-dependent protein catabolic process metabolic process protein metabolic process macromolecule metabolic process organic substance catabolic process positive regulation of organelle organization regulation of mitotic nuclear division positive regulation of mitotic nuclear division positive regulation of mitotic metaphase/anaphase transition positive regulation of mitotic cell cycle phase transition mitotic sister chromatid separation positive regulation of nuclear division regulation of chromosome separation regulation of mitotic sister chromatid separation positive regulation of cellular component organization positive regulation of biological process positive regulation of metaphase/anaphase transition of cell cycle mitotic sister chromatid segregation positive regulation of cell cycle process positive regulation of mitotic cell cycle positive regulation of cellular process mitotic nuclear division organelle fission positive regulation of cell cycle nuclear division chromosome separation positive regulation of cell cycle phase transition positive regulation of mitotic sister chromatid separation regulation of nuclear division positive regulation of chromosome separation cell division exit from mitosis positive regulation of exit from mitosis regulation of exit from mitosis protein ubiquitination macromolecule modification post-translational protein modification protein modification process protein modification by small protein conjugation protein modification by small protein conjugation or removal protein polymerization protein-containing complex organization homeostatic process free ubiquitin chain polymerization cellular component biogenesis cellular component assembly cellular homeostasis protein-containing complex assembly ubiquitin recycling regulation of protein modification process regulation of catalytic activity positive regulation of protein metabolic process regulation of protein ubiquitination regulation of transferase activity positive regulation of post-translational protein modification regulation of primary metabolic process regulation of ubiquitin protein ligase activity positive regulation of metabolic process positive regulation of molecular function positive regulation of ubiquitin protein ligase activity positive regulation of protein modification process positive regulation of macromolecule metabolic process regulation of ubiquitin-protein transferase activity regulation of protein modification by small protein conjugation or removal positive regulation of protein modification by small protein conjugation or removal positive regulation of protein ubiquitination positive regulation of transferase activity regulation of post-translational protein modification regulation of protein metabolic process positive regulation of catalytic activity regulation of macromolecule metabolic process positive regulation of ubiquitin-protein transferase activity regulation of molecular function regulation of metabolic process protein polyubiquitination protein K11-linked ubiquitination protein K48-linked ubiquitination	intracellular anatomical structure cytoplasm cellular anatomical entity cytosol cell periphery plasma membrane membrane membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle nucleoplasm intracellular anatomical structure cytoplasm cellular anatomical entity cytosol cell periphery plasma membrane membrane membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle nucleoplasm organelle lumen organelle nuclear lumen protein-containing complex ubiquitin ligase complex catalytic complex nuclear protein-containing complex transferase complex anaphase-promoting complex cullin-RING ubiquitin ligase complex nuclear ubiquitin ligase complex intracellular protein-containing complex
U [auth X], V [auth Y]	Anaphase-promoting complex subunit 7	enzyme-substrate adaptor activity protein-macromolecule adaptor activity molecular adaptor activity protein phosphatase binding phosphatase binding protein binding binding enzyme binding	cellular process cell cycle developmental process multicellular organism development multicellular organismal process head development central nervous system development anatomical structure development animal organ development brain development nervous system development system development regulation of mitotic cell cycle regulation of biological process cellular process cell cycle developmental process multicellular organism development multicellular organismal process head development central nervous system development anatomical structure development animal organ development brain development nervous system development system development regulation of mitotic cell cycle regulation of biological process regulation of cellular process biological regulation regulation of cell cycle mitotic cell cycle organonitrogen compound catabolic process organonitrogen compound metabolic process catabolic process proteolysis involved in protein catabolic process primary metabolic process proteasomal protein catabolic process protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process macromolecule catabolic process organic substance metabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis anaphase-promoting complex-dependent catabolic process ubiquitin-dependent protein catabolic process metabolic process protein metabolic process macromolecule metabolic process organic substance catabolic process positive regulation of organelle organization regulation of cell cycle phase transition regulation of mitotic nuclear division positive regulation of mitotic nuclear division positive regulation of mitotic metaphase/anaphase transition positive regulation of mitotic cell cycle phase transition mitotic sister chromatid separation chromosome segregation regulation of cell cycle process positive regulation of nuclear division sister chromatid segregation regulation of chromosome organization regulation of organelle organization regulation of mitotic cell cycle phase transition mitotic cell cycle process regulation of chromosome separation regulation of chromosome segregation regulation of metaphase/anaphase transition of cell cycle regulation of cellular component organization regulation of mitotic sister chromatid separation positive regulation of cellular component organization positive regulation of biological process cell cycle phase transition regulation of mitotic metaphase/anaphase transition cellular component organization positive regulation of metaphase/anaphase transition of cell cycle mitotic sister chromatid segregation positive regulation of cell cycle process positive regulation of mitotic cell cycle cellular component organization or biogenesis positive regulation of cellular process cell cycle process mitotic nuclear division organelle fission chromosome organization positive regulation of cell cycle organelle organization nuclear division chromosome separation regulation of sister chromatid segregation positive regulation of cell cycle phase transition positive regulation of mitotic sister chromatid separation regulation of nuclear division nuclear chromosome segregation metaphase/anaphase transition of mitotic cell cycle positive regulation of chromosome separation metaphase/anaphase transition of cell cycle mitotic cell cycle phase transition protein K11-linked ubiquitination protein polyubiquitination protein ubiquitination macromolecule modification post-translational protein modification protein modification process protein modification by small protein conjugation protein modification by small protein conjugation or removal cell division regulation of meiotic cell cycle sexual reproduction regulation of reproductive process reproductive process meiotic cell cycle	protein-containing complex intracellular anatomical structure protein-DNA complex chromatin chromosome cellular anatomical entity heterochromatin intracellular organelle organelle intracellular non-membrane-bounded organelle non-membrane-bounded organelle membrane-bounded organelle ubiquitin ligase complex catalytic complex protein-containing complex intracellular anatomical structure protein-DNA complex chromatin chromosome cellular anatomical entity heterochromatin intracellular organelle organelle intracellular non-membrane-bounded organelle non-membrane-bounded organelle membrane-bounded organelle ubiquitin ligase complex catalytic complex nucleus nuclear protein-containing complex intracellular membrane-bounded organelle transferase complex anaphase-promoting complex cullin-RING ubiquitin ligase complex nuclear ubiquitin ligase complex intracellular protein-containing complex cytoplasm cytosol cytoskeleton spindle microtubule cytoskeleton membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen
B	Anaphase-promoting complex subunit 11	aminoacyltransferase activity ubiquitin-like protein transferase activity catalytic activity, acting on a protein acyltransferase activity ubiquitin-ubiquitin ligase activity ubiquitin-like protein ligase activity ubiquitin protein ligase activity transferase activity catalytic activity ubiquitin-protein transferase activity protein binding binding cullin family protein binding cation binding aminoacyltransferase activity ubiquitin-like protein transferase activity catalytic activity, acting on a protein acyltransferase activity ubiquitin-ubiquitin ligase activity ubiquitin-like protein ligase activity ubiquitin protein ligase activity transferase activity catalytic activity ubiquitin-protein transferase activity protein binding binding cullin family protein binding cation binding transition metal ion binding zinc ion binding ion binding metal ion binding small molecule binding	cellular process cell cycle mitotic cell cycle organonitrogen compound catabolic process organonitrogen compound metabolic process catabolic process proteolysis involved in protein catabolic process primary metabolic process protein catabolic process macromolecule catabolic process organic substance metabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis cellular process cell cycle mitotic cell cycle organonitrogen compound catabolic process organonitrogen compound metabolic process catabolic process proteolysis involved in protein catabolic process primary metabolic process protein catabolic process macromolecule catabolic process organic substance metabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis ubiquitin-dependent protein catabolic process metabolic process protein metabolic process macromolecule metabolic process organic substance catabolic process regulation of mitotic cell cycle regulation of biological process regulation of cellular process biological regulation regulation of cell cycle proteasomal protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process anaphase-promoting complex-dependent catabolic process positive regulation of organelle organization regulation of cell cycle phase transition regulation of mitotic nuclear division positive regulation of mitotic nuclear division positive regulation of mitotic metaphase/anaphase transition positive regulation of mitotic cell cycle phase transition mitotic sister chromatid separation chromosome segregation regulation of cell cycle process positive regulation of nuclear division sister chromatid segregation regulation of chromosome organization regulation of organelle organization regulation of mitotic cell cycle phase transition mitotic cell cycle process regulation of chromosome separation regulation of chromosome segregation regulation of metaphase/anaphase transition of cell cycle regulation of cellular component organization regulation of mitotic sister chromatid separation positive regulation of cellular component organization positive regulation of biological process cell cycle phase transition regulation of mitotic metaphase/anaphase transition cellular component organization positive regulation of metaphase/anaphase transition of cell cycle mitotic sister chromatid segregation positive regulation of cell cycle process positive regulation of mitotic cell cycle cellular component organization or biogenesis positive regulation of cellular process cell cycle process mitotic nuclear division organelle fission chromosome organization positive regulation of cell cycle organelle organization nuclear division chromosome separation regulation of sister chromatid segregation positive regulation of cell cycle phase transition positive regulation of mitotic sister chromatid separation regulation of nuclear division nuclear chromosome segregation metaphase/anaphase transition of mitotic cell cycle positive regulation of chromosome separation metaphase/anaphase transition of cell cycle mitotic cell cycle phase transition protein K11-linked ubiquitination protein polyubiquitination protein ubiquitination macromolecule modification post-translational protein modification protein modification process protein modification by small protein conjugation protein modification by small protein conjugation or removal cell division regulation of meiotic cell cycle sexual reproduction regulation of reproductive process reproductive process meiotic cell cycle	membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle cellular anatomical entity nucleolus intracellular organelle lumen intracellular organelle organelle lumen organelle intracellular non-membrane-bounded organelle nuclear lumen non-membrane-bounded organelle membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle cellular anatomical entity nucleolus intracellular organelle lumen intracellular organelle organelle lumen organelle intracellular non-membrane-bounded organelle nuclear lumen non-membrane-bounded organelle protein-containing complex ubiquitin ligase complex catalytic complex nuclear protein-containing complex transferase complex anaphase-promoting complex cullin-RING ubiquitin ligase complex nuclear ubiquitin ligase complex intracellular protein-containing complex cytoplasm cytosol nucleoplasm
C, P	Cell division cycle protein 23 homolog	aminoacyltransferase activity ubiquitin-like protein transferase activity catalytic activity, acting on a protein acyltransferase activity transferase activity catalytic activity ubiquitin-protein transferase activity	cellular process cell cycle mitotic cell cycle organonitrogen compound catabolic process organonitrogen compound metabolic process catabolic process proteolysis involved in protein catabolic process primary metabolic process protein catabolic process macromolecule catabolic process organic substance metabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis cellular process cell cycle mitotic cell cycle organonitrogen compound catabolic process organonitrogen compound metabolic process catabolic process proteolysis involved in protein catabolic process primary metabolic process protein catabolic process macromolecule catabolic process organic substance metabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis ubiquitin-dependent protein catabolic process metabolic process protein metabolic process macromolecule metabolic process organic substance catabolic process regulation of chromosome segregation regulation of cell cycle phase transition regulation of cellular process regulation of metaphase/anaphase transition of cell cycle regulation of cellular component organization cell cycle phase transition regulation of mitotic metaphase/anaphase transition cellular component organization regulation of mitotic cell cycle cellular component organization or biogenesis regulation of cell cycle chromosome segregation cell cycle process regulation of biological process regulation of cell cycle process biological regulation chromosome organization sister chromatid segregation regulation of chromosome organization regulation of organelle organization regulation of mitotic cell cycle phase transition organelle organization mitotic cell cycle process regulation of sister chromatid segregation nuclear chromosome segregation metaphase/anaphase transition of mitotic cell cycle metaphase/anaphase transition of cell cycle mitotic cell cycle phase transition proteasomal protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process anaphase-promoting complex-dependent catabolic process positive regulation of organelle organization regulation of mitotic nuclear division positive regulation of mitotic nuclear division positive regulation of mitotic metaphase/anaphase transition positive regulation of mitotic cell cycle phase transition mitotic sister chromatid separation positive regulation of nuclear division regulation of chromosome separation regulation of mitotic sister chromatid separation positive regulation of cellular component organization positive regulation of biological process positive regulation of metaphase/anaphase transition of cell cycle mitotic sister chromatid segregation positive regulation of cell cycle process positive regulation of mitotic cell cycle positive regulation of cellular process mitotic nuclear division organelle fission positive regulation of cell cycle nuclear division chromosome separation positive regulation of cell cycle phase transition positive regulation of mitotic sister chromatid separation regulation of nuclear division positive regulation of chromosome separation protein K11-linked ubiquitination protein polyubiquitination protein ubiquitination macromolecule modification post-translational protein modification protein modification process protein modification by small protein conjugation protein modification by small protein conjugation or removal exit from mitosis regulation of exit from mitosis cell division establishment of organelle localization cellular localization mitotic metaphase chromosome alignment metaphase chromosome alignment localization chromosome localization organelle localization establishment of localization in cell establishment of localization establishment of chromosome localization regulation of meiotic cell cycle sexual reproduction regulation of reproductive process reproductive process meiotic cell cycle	membrane-bounded organelle protein-containing complex intracellular anatomical structure ubiquitin ligase complex catalytic complex nucleus nuclear protein-containing complex intracellular membrane-bounded organelle cellular anatomical entity transferase complex anaphase-promoting complex intracellular organelle cullin-RING ubiquitin ligase complex nuclear ubiquitin ligase complex membrane-bounded organelle protein-containing complex intracellular anatomical structure ubiquitin ligase complex catalytic complex nucleus nuclear protein-containing complex intracellular membrane-bounded organelle cellular anatomical entity transferase complex anaphase-promoting complex intracellular organelle cullin-RING ubiquitin ligase complex nuclear ubiquitin ligase complex organelle intracellular protein-containing complex cytoplasm cytosol membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen
D	Anaphase-promoting complex subunit 15	-	cellular process cell cycle regulation of mitotic cell cycle regulation of biological process regulation of cellular process biological regulation regulation of cell cycle mitotic cell cycle organonitrogen compound catabolic process organonitrogen compound metabolic process catabolic process proteolysis involved in protein catabolic process primary metabolic process proteasomal protein catabolic process cellular process cell cycle regulation of mitotic cell cycle regulation of biological process regulation of cellular process biological regulation regulation of cell cycle mitotic cell cycle organonitrogen compound catabolic process organonitrogen compound metabolic process catabolic process proteolysis involved in protein catabolic process primary metabolic process proteasomal protein catabolic process protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process macromolecule catabolic process organic substance metabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis anaphase-promoting complex-dependent catabolic process ubiquitin-dependent protein catabolic process metabolic process protein metabolic process macromolecule metabolic process organic substance catabolic process regulation of meiotic cell cycle sexual reproduction regulation of reproductive process reproductive process meiotic cell cycle cell division cellular response to stimulus regulation of cell cycle phase transition response to stimulus negative regulation of biological process spindle checkpoint signaling negative regulation of cell cycle regulation of signal transduction regulation of mitotic nuclear division intracellular signal transduction negative regulation of mitotic cell cycle cell communication regulation of cell cycle checkpoint negative regulation of mitotic sister chromatid segregation negative regulation of chromosome organization negative regulation of cell cycle phase transition mitotic spindle checkpoint signaling signal transduction mitotic sister chromatid separation chromosome segregation negative regulation of sister chromatid segregation mitotic spindle assembly checkpoint signaling negative regulation of cellular component organization regulation of cell cycle process regulation of spindle checkpoint sister chromatid segregation regulation of chromosome organization regulation of organelle organization regulation of mitotic cell cycle phase transition regulation of mitotic sister chromatid segregation mitotic cell cycle process regulation of response to stimulus regulation of chromosome separation negative regulation of mitotic nuclear division regulation of chromosome segregation regulation of cellular component organization regulation of mitotic sister chromatid separation regulation of metaphase/anaphase transition of cell cycle regulation of mitotic spindle checkpoint signaling regulation of mitotic cell cycle spindle assembly checkpoint spindle assembly checkpoint signaling cell cycle phase transition regulation of mitotic metaphase/anaphase transition cellular component organization regulation of intracellular signal transduction negative regulation of cellular process mitotic sister chromatid segregation negative regulation of mitotic metaphase/anaphase transition cellular component organization or biogenesis negative regulation of chromosome separation cell cycle process mitotic nuclear division regulation of signaling negative regulation of mitotic cell cycle phase transition organelle fission chromosome organization negative regulation of cell cycle process cell cycle checkpoint signaling mitotic cell cycle checkpoint signaling organelle organization nuclear division negative regulation of chromosome segregation chromosome separation negative regulation of organelle organization negative regulation of nuclear division regulation of sister chromatid segregation negative regulation of mitotic sister chromatid separation regulation of nuclear division negative regulation of metaphase/anaphase transition of cell cycle nuclear chromosome segregation metaphase/anaphase transition of mitotic cell cycle regulation of cell communication metaphase/anaphase transition of cell cycle mitotic cell cycle phase transition	intracellular anatomical structure cytoplasm cellular anatomical entity cytosol membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle nucleoplasm organelle lumen organelle nuclear lumen intracellular anatomical structure cytoplasm cellular anatomical entity cytosol membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle nucleoplasm organelle lumen organelle nuclear lumen protein-containing complex ubiquitin ligase complex catalytic complex nuclear protein-containing complex transferase complex anaphase-promoting complex cullin-RING ubiquitin ligase complex nuclear ubiquitin ligase complex intracellular protein-containing complex
E	Anaphase-promoting complex subunit 16	-	cellular process cell cycle organonitrogen compound metabolic process primary metabolic process organic substance metabolic process protein ubiquitination macromolecule modification metabolic process protein metabolic process macromolecule metabolic process post-translational protein modification protein modification process protein modification by small protein conjugation protein modification by small protein conjugation or removal cellular process cell cycle organonitrogen compound metabolic process primary metabolic process organic substance metabolic process protein ubiquitination macromolecule modification metabolic process protein metabolic process macromolecule metabolic process post-translational protein modification protein modification process protein modification by small protein conjugation protein modification by small protein conjugation or removal regulation of mitotic cell cycle regulation of biological process regulation of cellular process biological regulation regulation of cell cycle mitotic cell cycle organonitrogen compound catabolic process catabolic process proteolysis involved in protein catabolic process proteasomal protein catabolic process protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process macromolecule catabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis anaphase-promoting complex-dependent catabolic process ubiquitin-dependent protein catabolic process organic substance catabolic process regulation of meiotic cell cycle sexual reproduction regulation of reproductive process reproductive process meiotic cell cycle cell division	intracellular anatomical structure cytoplasm cellular anatomical entity cytosol chromosome chromosomal region kinetochore intracellular organelle organelle intracellular non-membrane-bounded organelle chromosome, centromeric region condensed chromosome, centromeric region supramolecular complex condensed chromosome intracellular anatomical structure cytoplasm cellular anatomical entity cytosol chromosome chromosomal region kinetochore intracellular organelle organelle intracellular non-membrane-bounded organelle chromosome, centromeric region condensed chromosome, centromeric region supramolecular complex condensed chromosome non-membrane-bounded organelle membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen protein-containing complex ubiquitin ligase complex catalytic complex nuclear protein-containing complex transferase complex anaphase-promoting complex cullin-RING ubiquitin ligase complex nuclear ubiquitin ligase complex intracellular protein-containing complex
G, T [auth W]	Anaphase-promoting complex subunit CDC26	-	cellular process cell cycle regulation of mitotic cell cycle regulation of biological process regulation of cellular process biological regulation regulation of cell cycle mitotic cell cycle organonitrogen compound catabolic process organonitrogen compound metabolic process catabolic process proteolysis involved in protein catabolic process primary metabolic process proteasomal protein catabolic process cellular process cell cycle regulation of mitotic cell cycle regulation of biological process regulation of cellular process biological regulation regulation of cell cycle mitotic cell cycle organonitrogen compound catabolic process organonitrogen compound metabolic process catabolic process proteolysis involved in protein catabolic process primary metabolic process proteasomal protein catabolic process protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process macromolecule catabolic process organic substance metabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis anaphase-promoting complex-dependent catabolic process ubiquitin-dependent protein catabolic process metabolic process protein metabolic process macromolecule metabolic process organic substance catabolic process protein K11-linked ubiquitination protein polyubiquitination protein ubiquitination macromolecule modification post-translational protein modification protein modification process protein modification by small protein conjugation protein modification by small protein conjugation or removal regulation of meiotic cell cycle sexual reproduction regulation of reproductive process reproductive process meiotic cell cycle cell division	intracellular anatomical structure cytoplasm cellular anatomical entity cytosol membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle nucleoplasm organelle lumen organelle nuclear lumen intracellular anatomical structure cytoplasm cellular anatomical entity cytosol membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle nucleoplasm organelle lumen organelle nuclear lumen protein-containing complex ubiquitin ligase complex catalytic complex nuclear protein-containing complex transferase complex anaphase-promoting complex cullin-RING ubiquitin ligase complex nuclear ubiquitin ligase complex intracellular protein-containing complex

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
F, H	IPR011990	Tetratricopeptide-like helical domain superfamily	Homologous Superfamily
F, H	IPR001440	TPR_1	Unknown
F, H	IPR019734	Tetratricopeptide repeat	Repeat
I	IPR017169	Anaphase-promoting complex subunit 4, metazoa	Family
I	IPR024977	Anaphase-promoting complex subunit 4-like, WD40 domain	Domain
I	IPR036322	WD40-repeat-containing domain superfamily	Homologous Superfamily
I	IPR024789	Anaphase-promoting complex subunit 4	Family
I	IPR024790	Anaphase-promoting complex subunit 4, long domain	Domain
I	IPR015943	WD40/YVTN repeat-like-containing domain superfamily	Homologous Superfamily
J, K	IPR011990	Tetratricopeptide-like helical domain superfamily	Homologous Superfamily
J, K	IPR019734	Tetratricopeptide repeat	Repeat
N	IPR014786	Anaphase-promoting complex subunit 2, C-terminal	Domain
N	IPR016158	Cullin homology domain	Domain
N	IPR036388	Winged helix-like DNA-binding domain superfamily	Homologous Superfamily
N	IPR036390	Winged helix DNA-binding domain superfamily	Homologous Superfamily
N	IPR036317	Cullin homology domain superfamily	Homologous Superfamily
N	IPR044554	Anaphase-promoting complex subunit 2	Family
N	IPR001373	Cullin, N-terminal	Domain
O	IPR026000	Anaphase-promoting complex subunit 5 domain	Domain
O	IPR011990	Tetratricopeptide-like helical domain superfamily	Homologous Superfamily
O	IPR037679	Anaphase-promoting complex subunit 5	Family
O	IPR019734	Tetratricopeptide repeat	Repeat
O	IPR048968	Anaphase-promoting complex subunit 5, N-terminal domain	Domain
R [auth S]	IPR019954	Ubiquitin conserved site	Conserved Site
R [auth S]	IPR000626	Ubiquitin-like domain	Domain
R [auth S]	IPR019956	Ubiquitin domain	Domain
R [auth S]	IPR029071	Ubiquitin-like domain superfamily	Homologous Superfamily
R [auth S]	IPR017441	Protein kinase, ATP binding site	Binding Site
R [auth S]	IPR011009	Protein kinase-like domain superfamily	Homologous Superfamily
R [auth S]	IPR000719	Protein kinase domain	Domain
R [auth S]	IPR008271	Serine/threonine-protein kinase, active site	Active Site
A	IPR041221	Anaphase-promoting complex subunit 1, C-terminal	Domain
A	IPR046794	Anaphase-promoting complex subunit 1, middle domain	Domain
A	IPR024990	Anaphase-promoting complex subunit 1	Family
A	IPR048971	Anaphase-promoting complex subunit 1, beta-sandwich domain	Domain
A	IPR049255	Anaphase-promoting complex subunit 1, N-terminal domain	Domain
A	IPR011989	Armadillo-like helical	Homologous Superfamily
L	IPR016901	Anaphase-promoting complex subunit APC10/Doc1	Family
L	IPR004939	APC10/DOC domain	Domain
L	IPR008979	Galactose-binding-like domain superfamily	Homologous Superfamily
M	IPR008401	Apc13	Family
Q [auth R]	IPR019775	WD40 repeat, conserved site	Conserved Site
Q [auth R]	IPR015943	WD40/YVTN repeat-like-containing domain superfamily	Homologous Superfamily
Q [auth R]	IPR024977	Anaphase-promoting complex subunit 4-like, WD40 domain	Domain
Q [auth R]	IPR036322	WD40-repeat-containing domain superfamily	Homologous Superfamily
Q [auth R]	IPR001680	WD40 repeat	Repeat
Q [auth R]	IPR033010	WD repeat Cdc20/Fizzy	Family
S [auth U]	IPR016135	Ubiquitin-conjugating enzyme/RWD-like	Homologous Superfamily
S [auth U]	IPR000608	Ubiquitin-conjugating enzyme E2	Domain
S [auth U]	IPR023313	Ubiquitin-conjugating enzyme, active site	Active Site
U [auth X], V [auth Y]	IPR011990	Tetratricopeptide-like helical domain superfamily	Homologous Superfamily
U [auth X], V [auth Y]	IPR019734	Tetratricopeptide repeat	Repeat
B	IPR013083	Zinc finger, RING/FYVE/PHD-type	Homologous Superfamily
B	IPR024991	Anaphase-promoting complex subunit 11, RING-H2 finger	Domain
B	IPR001841	Zinc finger, RING-type	Domain
C, P	IPR011990	Tetratricopeptide-like helical domain superfamily	Homologous Superfamily
C, P	IPR007192	Cdc23	Domain
C, P	IPR019734	Tetratricopeptide repeat	Repeat
D	IPR026182	Anaphase-promoting complex subunit 15	Family
E	IPR029641	Anaphase-promoting complex subunit 16	Family
G, T [auth W]	IPR018860	Anaphase-promoting complex, subunit CDC26	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
F, H	Pharos: P30260	prostate cancer atypical teratoid rhabdoid tumor large cell medulloblastoma medulloblastoma ulcerative colitis Crohn disease lung cancer osteosarcoma Prostatic Neoplasms glioblastoma ovarian cancer psoriasis
I	Pharos: Q9UJX5	colorectal cancer pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia osteosarcoma ovarian cancer
J, K	Pharos: Q13042	lymphoplasmacytic lymphoma nodular sclerosis classical Hodgkin lymphoma pancreatic ductal adenocarcinoma malignant colon neoplasm osteosarcoma Pick disease medulloblastoma ovarian cancer
N	Pharos: Q9UJX6	glioblastoma malignant ependymoma oligodendroglioma
O	Pharos: Q9UJX4	non-small cell lung carcinoma ovarian cancer psoriasis adrenal cortex carcinoma bipolar disorder endogenous depression interstitial lung disease lung adenocarcinoma malignant ependymoma medulloblastoma oligodendroglioma pancreatic ductal adenocarcinoma Sjogren syndrome astrocytic tumor congestive heart failure non-small cell lung carcinoma ovarian cancer psoriasis adrenal cortex carcinoma bipolar disorder endogenous depression interstitial lung disease lung adenocarcinoma malignant ependymoma medulloblastoma oligodendroglioma pancreatic ductal adenocarcinoma Sjogren syndrome astrocytic tumor congestive heart failure Gaucher disease juvenile dermatomyositis lung cancer Malignant neoplasm of breast myopathy osteosarcoma Pick disease atypical teratoid rhabdoid tumor diabetes mellitus glioblastoma large cell medulloblastoma lung carcinoma MALT lymphoma
A	Pharos: Q9H1A4	Alcoholic Intoxication, Chronic heart disease atopic eczema hypotrichosis glioblastoma
L	Pharos: Q9UM13	atrial fibrillation large cell medulloblastoma psoriasis colorectal adenoma non-alcoholic fatty liver disease colorectal cancer ovarian cancer
M	Pharos: Q9BS18	breast cancer plasma cell myeloma malignant mesothelioma ovarian cancer
Q [auth R]	Pharos: Q9UM11	polyploidy cutaneous melanoma psoriasis osteosarcoma
S [auth U]	Pharos: O00762	breast carcinoma Chromosome Aberrations breast cancer malignant pancreatic neoplasm medulloblastoma pancreatic intraductal papillary-mucinous carcinoma psoriasis adrenal cortex carcinoma esophageal adenocarcinoma invasive ductal breast carcinoma lung cancer malignant mesothelioma non-small cell lung carcinoma pancreatic intraductal papillary-mucinous neoplasm atopic eczema breast carcinoma Chromosome Aberrations breast cancer malignant pancreatic neoplasm medulloblastoma pancreatic intraductal papillary-mucinous carcinoma psoriasis adrenal cortex carcinoma esophageal adenocarcinoma invasive ductal breast carcinoma lung cancer malignant mesothelioma non-small cell lung carcinoma pancreatic intraductal papillary-mucinous neoplasm atopic eczema ductal breast carcinoma in situ glioblastoma large cell medulloblastoma malignant ependymoma ovarian cancer primitive neuroectodermal tumor atypical teratoid rhabdoid tumor endometriosis hepatocellular carcinoma lung adenocarcinoma malignant glioma
U [auth X], V [auth Y]	Pharos: Q9UJX3	anorexia nervosa osteosarcoma autism spectrum disorder pancreatic intraductal papillary-mucinous neoplasm bipolar disorder Pick disease
B	Pharos: Q9NYG5	attention deficit hyperactivity disorder, inattentive type
C, P	Pharos: Q9UJX2	adrenal cortex carcinoma dermatomyositis ovarian cancer Sjogren syndrome astrocytic tumor invasive ductal breast carcinoma pancreatic intraductal papillary-mucinous carcinoma atrial fibrillation medulloblastoma pancreatic intraductal papillary-mucinous neoplasm
D	Pharos: P60006	astrocytic tumor osteosarcoma psoriasis
E	Pharos: Q96DE5	malignant ependymoma ovarian cancer pancreatic intraductal papillary-mucinous neoplasm non-small cell lung carcinoma pancreatic ductal adenocarcinoma Sjogren syndrome osteosarcoma pancreatic intraductal papillary-mucinous carcinoma
G, T [auth W]	Pharos: Q8NHZ8	diabetes mellitus