Annotations: 5L80

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF18609	e5l80A2	A: alpha arrays	X: HhH/H2TH	H: SAM/DNA-glycosylase	T: SAM domain-like	F: PF18609	ECOD (1.6)
A	PF22123	e5l80A1	A: mixed a+b and a/b	X: Ribonuclease H-like	H: Ribonuclease H-like (From Topology)	T: Ribonuclease H-like	F: PF22123	ECOD (1.6)
B	PF18609	e5l80B2	A: alpha arrays	X: HhH/H2TH	H: SAM/DNA-glycosylase	T: SAM domain-like	F: PF18609	ECOD (1.6)
B	PF22123	e5l80B1	A: mixed a+b and a/b	X: Ribonuclease H-like	H: Ribonuclease H-like (From Topology)	T: Ribonuclease H-like	F: PF22123	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF18609	Exuperantia SAM-like domain (SAM_Exu)	Exuperantia SAM-like domain	Exuperantia (Exu) is associated with localization of bicoid (bcd) mRNA and required for its localization at the anterior pole of the oocyte. Crystal structure of Exu reveals a dimeric assembly with each monomer consisting of a 3'-5' EXO-like domain a ...	Exuperantia (Exu) is associated with localization of bicoid (bcd) mRNA and required for its localization at the anterior pole of the oocyte. Crystal structure of Exu reveals a dimeric assembly with each monomer consisting of a 3'-5' EXO-like domain and a sterile alpha motif (SAM)-like domain. The SAM-like domain interacts with its target RNA as a homodimer and is required for RNA binding activity [1].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	Maternal protein exuperantia,Maternal protein exuperantia	identical protein binding protein binding binding protein homodimerization activity protein dimerization activity RNA binding organic cyclic compound binding nucleic acid binding single-stranded RNA binding	developmental process multicellular organism development multicellular organismal process embryo development ending in birth or egg hatching anatomical structure development embryo development embryonic development via the syncytial blastoderm spermatogenesis sexual reproduction reproductive process multicellular organismal reproductive process developmental process involved in reproduction male gamete generation gamete generation developmental process multicellular organism development multicellular organismal process embryo development ending in birth or egg hatching anatomical structure development embryo development embryonic development via the syncytial blastoderm spermatogenesis sexual reproduction reproductive process multicellular organismal reproductive process developmental process involved in reproduction male gamete generation gamete generation RNA splicing cellular biosynthetic process cellular metabolic process RNA metabolic process primary metabolic process gene expression mRNA processing mRNA metabolic process macromolecule biosynthetic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process biosynthetic process RNA splicing, via transesterification reactions mRNA splicing, via spliceosome organic substance biosynthetic process metabolic process cellular process RNA splicing, via transesterification reactions with bulged adenosine as nucleophile macromolecule metabolic process RNA processing blastoderm segmentation bicoid mRNA localization anterior/posterior pattern specification anterior/posterior axis specification, embryo cellular process involved in reproduction in multicellular organism female gamete generation oocyte development localization cell differentiation cellular macromolecule localization cell maturation RNA localization embryonic pattern specification oocyte anterior/posterior axis specification developmental maturation anatomical structure maturation maternal determination of anterior/posterior axis, embryo germ cell development intracellular mRNA localization involved in anterior/posterior axis specification axis specification cellular localization cellular developmental process segmentation pattern specification process cell development tripartite regional subdivision embryonic axis specification anterior/posterior axis specification oocyte axis specification oocyte construction intracellular mRNA localization oogenesis regionalization intracellular mRNA localization involved in pattern specification process macromolecule localization oocyte differentiation regulation of localization regulation of cellular process pole plasm oskar mRNA localization cellular component biogenesis cellular component assembly pole plasm mRNA localization regulation of biological process pole plasm RNA localization regulation of intracellular mRNA localization cytoplasm organization cellular component organization regulation of pole plasm oskar mRNA localization cellular component organization or biogenesis biological regulation pole plasm assembly regulation of cellular localization transport establishment of localization ovarian nurse cell to oocyte transport	intracellular organelle intracellular anatomical structure organelle intracellular non-membrane-bounded organelle cytoplasmic ribonucleoprotein granule cellular anatomical entity cytoplasm supramolecular complex non-membrane-bounded organelle ribonucleoprotein granule membrane-bounded organelle protein-containing complex nucleus nuclear protein-containing complex intracellular organelle intracellular anatomical structure organelle intracellular non-membrane-bounded organelle cytoplasmic ribonucleoprotein granule cellular anatomical entity cytoplasm supramolecular complex non-membrane-bounded organelle ribonucleoprotein granule membrane-bounded organelle protein-containing complex nucleus nuclear protein-containing complex intracellular membrane-bounded organelle spliceosomal complex ribonucleoprotein complex precatalytic spliceosome P-body

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR036397	Ribonuclease H superfamily	Homologous Superfamily
A, B	IPR040941	Exuperantia, SAM-like domain	Domain
A, B	IPR037998	Maternal protein exuperantia	Family

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.